P Szot

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. doi request reprint Common factors among Alzheimer's disease, Parkinson's disease, and epilepsy: possible role of the noradrenergic nervous system
    Patricia Szot
    Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, U S A
    Epilepsia 53:61-6. 2012
  2. ncbi request reprint Norepinephrine is required for the anticonvulsant effect of the ketogenic diet
    P Szot
    Geriatric Research, Education and Clinical Center GRECC 182B, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Brain Res Dev Brain Res 129:211-4. 2001
  3. ncbi request reprint Behavioral and metabolic features of repetitive seizures in immature and mature rats
    P Szot
    Geriatric Research, Education and Clinical Center 182B, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Epilepsy Res 46:191-203. 2001
  4. ncbi request reprint Effect of pentylenetetrazol on the expression of tyrosine hydroxylase mRNA and norepinephrine and dopamine transporter mRNA
    P Szot
    Veterans Affair Medical Center, Seattle, WA 98108, USA
    Brain Res Mol Brain Res 44:46-54. 1997
  5. ncbi request reprint Chronic cortisol suppresses pituitary and hypothalamic peptide message expression in pigtailed macaques
    P Szot
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    Neuroscience 126:241-6. 2004
  6. ncbi request reprint The anticonvulsant and proconvulsant effects of alpha2-adrenoreceptor agonists are mediated by distinct populations of alpha2A-adrenoreceptors
    P Szot
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98108, USA
    Neuroscience 126:795-803. 2004
  7. ncbi request reprint Valproic acid, but not lamotrigine, suppresses seizure-induced c-fos and c-Jun mRNA expression
    Patricia Szot
    Mental Illness Research Education and Clinical Center MIRECC, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Brain Res Mol Brain Res 135:285-9. 2005
  8. ncbi request reprint Alpha1-adrenoreceptor in human hippocampus: binding and receptor subtype mRNA expression
    Patricia Szot
    Northwest Network Mental Illness Research, Education and Clinical Center S 116, VA Puget Sound Health Care System, S 116 MIRECC, 1660 S Columbian Way, Seattle, WA 98108, USA
    Brain Res Mol Brain Res 139:367-71. 2005
  9. ncbi request reprint Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies
    Patricia Szot
    Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Neurosci 26:467-78. 2006
  10. pmc Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes
    P Szot
    Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, and Department of Psychiatry and Behavioral Science, University of Washington, Seattle 98195, USA
    Neuroscience 146:471-80. 2007

Collaborators

Detail Information

Publications33

  1. doi request reprint Common factors among Alzheimer's disease, Parkinson's disease, and epilepsy: possible role of the noradrenergic nervous system
    Patricia Szot
    Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, U S A
    Epilepsia 53:61-6. 2012
    ..This article describes common symptoms among these three neurologic disorders and a possible role of the noradrenergic nervous system...
  2. ncbi request reprint Norepinephrine is required for the anticonvulsant effect of the ketogenic diet
    P Szot
    Geriatric Research, Education and Clinical Center GRECC 182B, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Brain Res Dev Brain Res 129:211-4. 2001
    ..These results suggest that an intact, functional noradrenergic nervous system is required for the KD to exert an anticonvulsant effect...
  3. ncbi request reprint Behavioral and metabolic features of repetitive seizures in immature and mature rats
    P Szot
    Geriatric Research, Education and Clinical Center 182B, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Epilepsy Res 46:191-203. 2001
    ..The consequences of repetitive seizures in the immature animal results in distinctly different seizure behavior and neuronal activity pattern (c-fos expression) than that observed in the mature animal...
  4. ncbi request reprint Effect of pentylenetetrazol on the expression of tyrosine hydroxylase mRNA and norepinephrine and dopamine transporter mRNA
    P Szot
    Veterans Affair Medical Center, Seattle, WA 98108, USA
    Brain Res Mol Brain Res 44:46-54. 1997
    ..These results indicate that the chemoconvulsant PTZ has differential effects on the mRNA expression of regulatory systems (TH and neurotransporter proteins) in noradrenergic and dopaminergic neurons...
  5. ncbi request reprint Chronic cortisol suppresses pituitary and hypothalamic peptide message expression in pigtailed macaques
    P Szot
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    Neuroscience 126:241-6. 2004
    ..Chronic therapeutic administration of glucocorticoids in humans may have unintended consequences for hypothalamic and pituitary function...
  6. ncbi request reprint The anticonvulsant and proconvulsant effects of alpha2-adrenoreceptor agonists are mediated by distinct populations of alpha2A-adrenoreceptors
    P Szot
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98108, USA
    Neuroscience 126:795-803. 2004
    ..These data help to clarify the inconsistent effects of alpha2-AR agonists on seizure activity...
  7. ncbi request reprint Valproic acid, but not lamotrigine, suppresses seizure-induced c-fos and c-Jun mRNA expression
    Patricia Szot
    Mental Illness Research Education and Clinical Center MIRECC, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Brain Res Mol Brain Res 135:285-9. 2005
    ..The consequence of this suppression of IEGs following a generalized seizure may be viewed either as a neuroprotective or detrimental effect upon the brain...
  8. ncbi request reprint Alpha1-adrenoreceptor in human hippocampus: binding and receptor subtype mRNA expression
    Patricia Szot
    Northwest Network Mental Illness Research, Education and Clinical Center S 116, VA Puget Sound Health Care System, S 116 MIRECC, 1660 S Columbian Way, Seattle, WA 98108, USA
    Brain Res Mol Brain Res 139:367-71. 2005
    ..These results confirm a difference in hippocampal alpha1-AR localization between rat and humans and further describe a difference in the localization of the alpha1A- and alpha1D-AR mRNA subtype between rats and humans...
  9. ncbi request reprint Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies
    Patricia Szot
    Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Neurosci 26:467-78. 2006
    ....
  10. pmc Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes
    P Szot
    Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, and Department of Psychiatry and Behavioral Science, University of Washington, Seattle 98195, USA
    Neuroscience 146:471-80. 2007
    ..These changes in postsynaptic AR would suggest a reduced function of the PFC. Consequence of this reduced function of the PFC in dementia is still unknown but it may affect memory and behavior...
  11. doi request reprint A comprehensive analysis of the effect of DSP4 on the locus coeruleus noradrenergic system in the rat
    P Szot
    Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA
    Neuroscience 166:279-91. 2010
    ..However, since DSP4 did not result in a loss of noradrenergic neurons, it is not considered an adequate model for noradrenergic neuronal loss observed in AD and PD...
  12. ncbi request reprint Tyrosine hydroxylase and norepinephrine transporter mRNA expression in the locus coeruleus in Alzheimer's disease
    P Szot
    Northwest Network Mental Illness Research, Education and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA
    Brain Res Mol Brain Res 84:135-40. 2000
    ..These preliminary results suggest an upregulation of NE biosynthetic capacity in at least some LC neurons in AD prior to the very late stage of the disease...
  13. ncbi request reprint Reduced gene expression for dopamine biosynthesis and transport in midbrain neurons of adult male rats exposed prenatally to ethanol
    P Szot
    Geriatric Research, Education and Clinical Center, Puget Sound Health Care System, and the Department of Psychiatry, University of Washington, Seattle 98108, USA
    Alcohol Clin Exp Res 23:1643-9. 1999
    ..Prenatal ethanol exposure affects brain dopaminergic neuronal systems, and many of these alterations are permanent...
  14. ncbi request reprint Alterations in mRNA expression of systems that regulate neurotransmitter synaptic content in seizure-naive genetically epilepsy-prone rat (GEPR): transporter proteins and rate-limiting synthesizing enzymes for norepinephrine, dopamine and serotonin
    P Szot
    Veterans Affair Medical Center, University of Washington, Seattle 98108, USA
    Brain Res Mol Brain Res 43:233-45. 1996
    ..This indicates a possible involvement of DA in regulating the seizure susceptibility of these animals...
  15. ncbi request reprint Norepinephrine-deficient mice have increased susceptibility to seizure-inducing stimuli
    P Szot
    Department of Psychiatry, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 19:10985-92. 1999
    ....
  16. ncbi request reprint Development of a model of status epilepticus in pigtailed macaque infant monkeys
    V M Gunderson
    Center on Human Development and Disability, Regional Primate Research Center, University of Washington, Seattle 98195 7920, USA
    Dev Neurosci 21:352-64. 1999
    ..Measures included MRI, electrophysiology, behavior and morphology. Our results suggest that monkey models of SE may provide useful tools for understanding the effects of prolonged seizures during infancy and the origins of TLE in humans...
  17. ncbi request reprint Genetic comparison of seizure control by norepinephrine and neuropeptide Y
    D Weinshenker
    Departments of Howard Hughes Medical Institute, Biochemistry, Clinical Center, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 21:7764-9. 2001
    ..These data suggest that NE is a more potent endogenous anticonvulsant than NPY, and that NPY has the greatest contribution under conditions of extreme neuronal excitability...
  18. ncbi request reprint Alpha(1) and beta(2) adrenoreceptor agonists inhibit pentylenetetrazole-induced seizures in mice lacking norepinephrine
    D Weinshenker
    Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    J Pharmacol Exp Ther 298:1042-8. 2001
    ..Endogenous NE probably does not activate the beta(2)AR under these conditions, but exogenous activation of the beta(2)AR produces an anticonvulsant effect...
  19. pmc Lesioning noradrenergic neurons of the locus coeruleus in C57Bl/6 mice with unilateral 6-hydroxydopamine injection, to assess molecular, electrophysiological and biochemical changes in noradrenergic signaling
    P Szot
    Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA washington edu
    Neuroscience 216:143-57. 2012
    ..These studies indicate that unilateral stereotaxic injection of 6OHDA into mice reduces noradrenergic LC neurons and reduces noradrenergic innervation to many forebrain regions, including the contralateral side...
  20. ncbi request reprint Bupropion and desipramine increase dopamine transporter mRNA expression in the ventral tegmental area/substantia nigra of rat brain
    E C Petrie
    Mental Health Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    Prog Neuropsychopharmacol Biol Psychiatry 22:845-56. 1998
    ..3. BUP and DMI both increased DAT mRNA expression in the ventral tegmental area/substantia nigra. 4. These findings suggest that DAT mRNA expression in the brain may be regulated by both noradrenergic and dopaminergic mechanisms...
  21. ncbi request reprint Tyrosine hydroxylase mRNA is increased in old age and norepinephrine uptake transporter mRNA is decreased in middle age in locus coeruleus of Brown-Norway rats
    M M Shores
    Geriatric Research, Education and Clinical Center GRECC, VA Puget Sound Health Care System, 1660 S Columbian Way 182B, Seattle, WA 98195, USA
    Brain Res 826:143-7. 1999
    ..These findings suggest that multiple regulatory components are used to maintain stable noradrenergic synaptic levels despite neuronal loss. Published by Elsevier Science B.V...
  22. ncbi request reprint Morphological plasticity in an infant monkey model of temporal lobe epilepsy
    H Jürgen Wenzel
    Department of Neurological Surgery Pathology, University of Washington School of Medicine, Seattle 98195, USA
    Epilepsia 41:S70-5. 2000
    ..To examine the consequences of early seizures, we elicited status epilepticus in immature, 5.5- to 7.0-month-old pigtailed macaques by unilateral microinfusion of bicuculline methiodide into the entorhinal cortex...
  23. ncbi request reprint Developmental seizure susceptibility of kv1.1 potassium channel knockout mice
    J M Rho
    Department of Neurology and Pediatrics, Geriatric Research, Education and Clinical Center, Puget Sound Health Care System, University of Washington, Seattle, WA, USA
    Dev Neurosci 21:320-7. 1999
    ..The Kv1. 1 knockout mouse possesses many features desirable in a developmental animal epilepsy model and represents a clinically relevant model of early-onset epilepsies...
  24. ncbi request reprint Dopamine transporter mRNA is increased in the CNS of Zucker fatty (fa/fa) rats
    D P Figlewicz
    Division of Endocrinology Metabolism, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Brain Res Bull 46:199-202. 1998
    ..These findings suggest that increased DA clearance, and perhaps decreased DA signaling, may occur in the obese Zucker fa/fa rat...
  25. pmc Stress-induced activity in the locus coeruleus is not sensitive to stressor controllability
    Ross A McDevitt
    Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, Washington, USA
    Brain Res 1285:109-18. 2009
    ..To the extent that the expression of these genes reflects degree of neuronal activation, our results suggest that stress-induced activity of noradrenergic cell bodies in the LC is not sensitive to stressor controllability...
  26. ncbi request reprint Neurotransmitter transporters: target for endocrine regulation
    D P Figlewicz
    Dept of Psychology, University of Washington, Seattle, USA
    Horm Metab Res 31:335-9. 1999
    ..Future directions should permit evaluation of the role of endocrine regulation in neurotransmitter clearance, and thus in the maintenance of normal CNS aminergic signaling...
  27. ncbi request reprint Regulation of norepinephrine transporter abundance by catecholamines and desipramine in vivo
    David Weinshenker
    Howard Hughes Medical Institute, Box 357370, University of Washington, Seattle 98195, USA
    Brain Res 946:239-46. 2002
    ..There are some qualitative and quantitative differences in the down-regulation of the NET by catecholamine depletion and DMI treatment, suggesting that different mechanisms may be involved...
  28. ncbi request reprint Analysis of brain adrenergic receptors in dopamine-beta-hydroxylase knockout mice
    Jeff D Sanders
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5800, and Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA
    Brain Res 1109:45-53. 2006
    ..These findings indicate that regulation of noradrenergic receptors by endogenous norepinephrine depends on receptor type and neuroanatomical region...
  29. ncbi request reprint The role of catecholamines in seizure susceptibility: new results using genetically engineered mice
    David Weinshenker
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195, USA
    Pharmacol Ther 94:213-33. 2002
    ..New results from genetically engineered mice with altered catecholamine signaling, as well as possibilities for future experiments, are discussed...
  30. doi request reprint Age-dependent changes in noradrenergic locus coeruleus system in wild-type and APP23 transgenic mice
    Patricia Szot
    Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, and Department of Psychiatry and Behavioral Science, University of Washington, Seattle 98195, USA
    Neurosci Lett 463:93-7. 2009
    ....
  31. ncbi request reprint Age-dependent differences in flurothyl-induced c-fos and c-jun mRNA expression in the mouse brain
    Thomas W Storey
    Keck Graduate Institute, Claremont, Calif, USA
    Dev Neurosci 24:294-9. 2002
    ..We conclude that the c-fos and c-jun are not reliable indicators of seizure activity in immature mice, whereas they remain indirect markers of neuronal activity in mature mice...
  32. ncbi request reprint Changes in 5-HT(7) serotonin receptor mRNA expression with aging in rat brain
    R Kohen
    VA Puget Sound Health Care System, Geriatric Research, Education and Clinical Center, GRECC 182B, Seattle, WA 98108, USA
    Brain Res Mol Brain Res 79:163-8. 2000
    ..In other brain areas 5-HT(7) mRNA expression is unaffected by age...
  33. ncbi request reprint The ketogenic diet does not alter brain expression of orexigenic neuropeptides
    Kroshona Tabb
    Department of Human Genetics, Emory University School of Medicine, Whitehead Building, Suite 301, 615 Michael Street, Atlanta, GA 30322, USA
    Epilepsy Res 62:35-9. 2004
    ..In situ hybridization revealed no effect of the KD on NPY or galanin mRNA expression, suggesting that increased expression of NPY and galanin do not contribute to the anticonvulsant effect of the KD...