Research Topics
Genomes and Genes
| Eva Szomolanyi-TsudaSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
Research Grants
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Detail Information
Publications
The role of CD40-CD154 interaction in antiviral T cell-independent IgG responsesE Szomolanyi-Tsuda
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 164:5877-82. 2000..Our studies demonstrate that, although about half of the TI IgG responses to PyV are independent of CD40-CD40L interactions, these interactions occur in T cell-deficient mice and enhance antiviral TI Ab responses...
Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivoEva Szomolanyi-Tsuda
Department of Pathology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, Massachusetts 01655, USA
J Virol 80:4286-91. 2006..Our studies suggest that in addition to the reported involvement of TLR9 and TLR3, TLR2 is also involved in innate immune responses to MCMV infection...- T cell-independent and T cell-dependent immunoglobulin G responses to polyomavirus infection are impaired in complement receptor 2-deficient miceEva Szomolanyi-Tsuda
Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Virology 352:52-60. 2006..Thus, our studies revealed a profound dependence of TI and TD antiviral antibody responses on CR2-mediated signals in PyV-infected mice, where the viral antigen is abundant and persistent... - Antiviral T-cell-independent type 2 antibody responses induced in vivo in the absence of T and NK cellsE Szomolanyi-Tsuda
Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, USA
Virology 280:160-8. 2001.... - The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytesKishore R Alugupalli
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 170:3819-27. 2003..hermsii. Together these results support the model that B1b cells generate the T-independent IgM required for the control and resolution of relapsing fever borreliosis... - Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infectionChristopher C Kemball
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 176:1814-24. 2006..Taken together, these data indicate that CD8+ T cells primed within the distinct microenvironments of acute vs persistent virus infection differ in their costimulation requirements... - NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumorsRabinarayan Mishra
Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
PLoS Pathog 6:e1000924. 2010..Our findings demonstrate a protective role for NK and gammadelta T cells against naturally occurring virus-induced tumors and suggest the involvement of NKG2D-mediated mechanisms... - Generation of protective T cell-independent antiviral antibody responses in SCID mice reconstituted with follicular or marginal zone B cellsHeath M Guay
Department of Pathology, University of Massachusetts Medical School, Worcester, 01655, USA
J Immunol 183:518-23. 2009..These findings demonstrate the plasticity of the B cell subsets in virus-infected hosts and show for the first time that B cells derived exclusively from Fo B cells can effectively function in antiviral TI-2 responses... - MyD88 is required for the formation of long-term humoral immunity to virus infectionHeath M Guay
Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 178:5124-31. 2007..Our findings show that MyD88-dependent signaling pathways in B cells are essential for effectively generating long-term Ab responses and implicate a role for TLR in the formation of long-term humoral immunity... - The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infectionChristopher C Kemball
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
J Immunol 179:1113-21. 2007..In summary, these studies show that CD4(+) T cells differentially affect CD8(+) T cell responses over the course of a persistent virus infection... - Dynamics and magnitude of virus-induced polyclonal B cell activation mediated by BCR-independent presentation of viral antigenEvan R Jellison
Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Eur J Immunol 37:119-28. 2007..This approach, therefore, formally demonstrates and quantifies a virus-induced polyclonal proliferation and differentiation of B cells, which, due to their high proportion, would mostly have BCR not specific for the virus... - Immunological memory to viral infectionsRaymond M Welsh
Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Annu Rev Immunol 22:711-43. 2004..Here we describe how T and B cell memory is generated in response to virus infections and how these cells respond when the host is infected again by similar or different viruses... - Allogeneic differences in the dependence on CD4+ T-cell help for virus-specific CD8+ T-cell differentiationChristopher C Kemball
Department of Pathology, Emory University School of Medicine, Woodruff Memorial Research Building, Room 7307, 101 Woodruff Circle, Atlanta, GA 30322, USA
J Virol 81:13743-53. 2007..Our findings demonstrate that dependence on CD4(+) T-cell help for antiviral CD8(+) T-cell effector differentiation can vary among allogeneic strains of inbred mice... - Immunity to polyomavirus infection: the polyomavirus-mouse modelPhillip A Swanson
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
Semin Cancer Biol 19:244-51. 2009.... - The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA virusesVijay A K Rathinam
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Nat Immunol 11:395-402. 2010..Collectively, our observations demonstrate the importance of AIM2 in the sensing of both bacterial and viral pathogens and in triggering innate immunity... - p53 represses class switch recombination to IgG2a through its antioxidant functionJeroen E J Guikema
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 184:6177-87. 2010..Finally, we show that p53 inhibits DNA breaks and mutations in S regions in B cells undergoing CSR, suggesting that p53 inhibits the activity of activation-induced cytidine deaminase... - Judging a virus by its coverEva Szomolanyi-Tsuda
Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Clin Invest 114:895-7. 2004.... 
Rapid recruitment and activation of macrophages by anti-Gal/α-Gal liposome interaction accelerates wound healingKim M Wigglesworth
Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 186:4422-32. 2011..The study suggests that α-gal liposome and α-gal nanoparticle treatment may enhance wound healing in the clinic because of the presence of high complement activity and high anti-Gal Ab titers in humans...- B cell memory: sapping the T cellRaymond M Welsh
Nat Med 9:164-6. 2003 - Tumor viral escape from inhibited T cellsRaymond M Welsh
Nat Immunol 3:112-4. 2002
Research Grants
- POLYOMAVIRUS INFECTION IN IMMUNODEFICIENT MICEEva Szomolanyi Tsuda; Fiscal Year: 2010..These basic questions are important for the design of vaccines with high efficacy. ..
- POLYOMAVIRUS INFECTION IN IMMUNODEFICIENT MICEEva Szomolanyi Tsuda; Fiscal Year: 2009..These basic questions are important for the design of vaccines with high efficacy. ..
- Polyomavirus Infection in Immunodedicient MiceEva Szomolanyi Tsuda; Fiscal Year: 2006..These basic questions are important for the design of vaccines with high efficacy. ..
- POLYOMAVIRUS INFECTION IN IMMUNODEFICIENT MICEEva Szomolanyi Tsuda; Fiscal Year: 1999..Polyoma is non-pathogenic in its immunocompetant natural host. Studying its pathogenesis in immunodeficient hosts can provide basic information which can help to understand processes induced by viruses in immunocompromised individuals. ..
- POLYOMAVIRUS INFECTION IN IMMUNODEFICIENT MICEEva Szomolanyi Tsuda; Fiscal Year: 2009..These basic questions are important for the design of vaccines with high efficacy. ..