Eva Szomolanyi-Tsuda

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint The role of CD40-CD154 interaction in antiviral T cell-independent IgG responses
    E Szomolanyi-Tsuda
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 164:5877-82. 2000
  2. pmc Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivo
    Eva Szomolanyi-Tsuda
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, Massachusetts 01655, USA
    J Virol 80:4286-91. 2006
  3. ncbi request reprint T cell-independent and T cell-dependent immunoglobulin G responses to polyomavirus infection are impaired in complement receptor 2-deficient mice
    Eva Szomolanyi-Tsuda
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Virology 352:52-60. 2006
  4. ncbi request reprint Antiviral T-cell-independent type 2 antibody responses induced in vivo in the absence of T and NK cells
    E Szomolanyi-Tsuda
    Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, USA
    Virology 280:160-8. 2001
  5. ncbi request reprint The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes
    Kishore R Alugupalli
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 170:3819-27. 2003
  6. ncbi request reprint Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection
    Christopher C Kemball
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 176:1814-24. 2006
  7. pmc NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors
    Rabinarayan Mishra
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Pathog 6:e1000924. 2010
  8. pmc Generation of protective T cell-independent antiviral antibody responses in SCID mice reconstituted with follicular or marginal zone B cells
    Heath M Guay
    Department of Pathology, University of Massachusetts Medical School, Worcester, 01655, USA
    J Immunol 183:518-23. 2009
  9. ncbi request reprint MyD88 is required for the formation of long-term humoral immunity to virus infection
    Heath M Guay
    Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 178:5124-31. 2007
  10. ncbi request reprint The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection
    Christopher C Kemball
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 179:1113-21. 2007

Research Grants

  1. POLYOMAVIRUS INFECTION IN IMMUNODEFICIENT MICE
    Eva Szomolanyi Tsuda; Fiscal Year: 2010
  2. POLYOMAVIRUS INFECTION IN IMMUNODEFICIENT MICE
    Eva Szomolanyi Tsuda; Fiscal Year: 2009
  3. Polyomavirus Infection in Immunodedicient Mice
    Eva Szomolanyi Tsuda; Fiscal Year: 2006
  4. POLYOMAVIRUS INFECTION IN IMMUNODEFICIENT MICE
    Eva Szomolanyi Tsuda; Fiscal Year: 1999
  5. POLYOMAVIRUS INFECTION IN IMMUNODEFICIENT MICE
    Eva Szomolanyi Tsuda; Fiscal Year: 2009

Collaborators

Detail Information

Publications21

  1. ncbi request reprint The role of CD40-CD154 interaction in antiviral T cell-independent IgG responses
    E Szomolanyi-Tsuda
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 164:5877-82. 2000
    ..Our studies demonstrate that, although about half of the TI IgG responses to PyV are independent of CD40-CD40L interactions, these interactions occur in T cell-deficient mice and enhance antiviral TI Ab responses...
  2. pmc Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivo
    Eva Szomolanyi-Tsuda
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, Massachusetts 01655, USA
    J Virol 80:4286-91. 2006
    ..Our studies suggest that in addition to the reported involvement of TLR9 and TLR3, TLR2 is also involved in innate immune responses to MCMV infection...
  3. ncbi request reprint T cell-independent and T cell-dependent immunoglobulin G responses to polyomavirus infection are impaired in complement receptor 2-deficient mice
    Eva Szomolanyi-Tsuda
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Virology 352:52-60. 2006
    ..Thus, our studies revealed a profound dependence of TI and TD antiviral antibody responses on CR2-mediated signals in PyV-infected mice, where the viral antigen is abundant and persistent...
  4. ncbi request reprint Antiviral T-cell-independent type 2 antibody responses induced in vivo in the absence of T and NK cells
    E Szomolanyi-Tsuda
    Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, USA
    Virology 280:160-8. 2001
    ....
  5. ncbi request reprint The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes
    Kishore R Alugupalli
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 170:3819-27. 2003
    ..hermsii. Together these results support the model that B1b cells generate the T-independent IgM required for the control and resolution of relapsing fever borreliosis...
  6. ncbi request reprint Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection
    Christopher C Kemball
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 176:1814-24. 2006
    ..Taken together, these data indicate that CD8+ T cells primed within the distinct microenvironments of acute vs persistent virus infection differ in their costimulation requirements...
  7. pmc NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors
    Rabinarayan Mishra
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Pathog 6:e1000924. 2010
    ..Our findings demonstrate a protective role for NK and gammadelta T cells against naturally occurring virus-induced tumors and suggest the involvement of NKG2D-mediated mechanisms...
  8. pmc Generation of protective T cell-independent antiviral antibody responses in SCID mice reconstituted with follicular or marginal zone B cells
    Heath M Guay
    Department of Pathology, University of Massachusetts Medical School, Worcester, 01655, USA
    J Immunol 183:518-23. 2009
    ..These findings demonstrate the plasticity of the B cell subsets in virus-infected hosts and show for the first time that B cells derived exclusively from Fo B cells can effectively function in antiviral TI-2 responses...
  9. ncbi request reprint MyD88 is required for the formation of long-term humoral immunity to virus infection
    Heath M Guay
    Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 178:5124-31. 2007
    ..Our findings show that MyD88-dependent signaling pathways in B cells are essential for effectively generating long-term Ab responses and implicate a role for TLR in the formation of long-term humoral immunity...
  10. ncbi request reprint The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection
    Christopher C Kemball
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 179:1113-21. 2007
    ..In summary, these studies show that CD4(+) T cells differentially affect CD8(+) T cell responses over the course of a persistent virus infection...
  11. ncbi request reprint Dynamics and magnitude of virus-induced polyclonal B cell activation mediated by BCR-independent presentation of viral antigen
    Evan R Jellison
    Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Eur J Immunol 37:119-28. 2007
    ..This approach, therefore, formally demonstrates and quantifies a virus-induced polyclonal proliferation and differentiation of B cells, which, due to their high proportion, would mostly have BCR not specific for the virus...
  12. pmc The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
    Vijay A K Rathinam
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Immunol 11:395-402. 2010
    ..Collectively, our observations demonstrate the importance of AIM2 in the sensing of both bacterial and viral pathogens and in triggering innate immunity...
  13. ncbi request reprint Immunological memory to viral infections
    Raymond M Welsh
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Annu Rev Immunol 22:711-43. 2004
    ..Here we describe how T and B cell memory is generated in response to virus infections and how these cells respond when the host is infected again by similar or different viruses...
  14. pmc Allogeneic differences in the dependence on CD4+ T-cell help for virus-specific CD8+ T-cell differentiation
    Christopher C Kemball
    Department of Pathology, Emory University School of Medicine, Woodruff Memorial Research Building, Room 7307, 101 Woodruff Circle, Atlanta, GA 30322, USA
    J Virol 81:13743-53. 2007
    ..Our findings demonstrate that dependence on CD4(+) T-cell help for antiviral CD8(+) T-cell effector differentiation can vary among allogeneic strains of inbred mice...
  15. pmc Immunity to polyomavirus infection: the polyomavirus-mouse model
    Phillip A Swanson
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Semin Cancer Biol 19:244-51. 2009
    ....
  16. pmc p53 represses class switch recombination to IgG2a through its antioxidant function
    Jeroen E J Guikema
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 184:6177-87. 2010
    ..Finally, we show that p53 inhibits DNA breaks and mutations in S regions in B cells undergoing CSR, suggesting that p53 inhibits the activity of activation-induced cytidine deaminase...
  17. pmc Inflammatory cytokine-mediated evasion of virus-induced tumors from NK cell control
    Rabinarayan Mishra
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 191:961-70. 2013
    ..Thus, our data suggest a new mechanism whereby inflammatory cytokines generated in the tumor environment lead to evasion of NK cell-mediated control of virus-induced tumors. ..
  18. pmc Judging a virus by its cover
    Eva Szomolanyi-Tsuda
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Clin Invest 114:895-7. 2004
    ....
  19. doi request reprint Rapid recruitment and activation of macrophages by anti-Gal/α-Gal liposome interaction accelerates wound healing
    Kim M Wigglesworth
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 186:4422-32. 2011
    ..The study suggests that α-gal liposome and α-gal nanoparticle treatment may enhance wound healing in the clinic because of the presence of high complement activity and high anti-Gal Ab titers in humans...
  20. ncbi request reprint B cell memory: sapping the T cell
    Raymond M Welsh
    Nat Med 9:164-6. 2003
  21. ncbi request reprint Tumor viral escape from inhibited T cells
    Raymond M Welsh
    Nat Immunol 3:112-4. 2002

Research Grants14

  1. POLYOMAVIRUS INFECTION IN IMMUNODEFICIENT MICE
    Eva Szomolanyi Tsuda; Fiscal Year: 2010
    ..These basic questions are important for the design of vaccines with high efficacy. ..
  2. POLYOMAVIRUS INFECTION IN IMMUNODEFICIENT MICE
    Eva Szomolanyi Tsuda; Fiscal Year: 2009
    ..These basic questions are important for the design of vaccines with high efficacy. ..
  3. Polyomavirus Infection in Immunodedicient Mice
    Eva Szomolanyi Tsuda; Fiscal Year: 2006
    ..These basic questions are important for the design of vaccines with high efficacy. ..
  4. POLYOMAVIRUS INFECTION IN IMMUNODEFICIENT MICE
    Eva Szomolanyi Tsuda; Fiscal Year: 1999
    ..Polyoma is non-pathogenic in its immunocompetant natural host. Studying its pathogenesis in immunodeficient hosts can provide basic information which can help to understand processes induced by viruses in immunocompromised individuals. ..
  5. POLYOMAVIRUS INFECTION IN IMMUNODEFICIENT MICE
    Eva Szomolanyi Tsuda; Fiscal Year: 2009
    ..These basic questions are important for the design of vaccines with high efficacy. ..