Danuta Szczesna

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Ca2+ binding, and phosphorylation
    D Szczesna
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 276:7086-92. 2001
  2. ncbi request reprint Regulatory light chains of striated muscle myosin. Structure, function and malfunction
    Danuta Szczesna
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, FL 33136, USA
    Curr Drug Targets Cardiovasc Haematol Disord 3:187-97. 2003
  3. ncbi request reprint Familial hypertrophic cardiomyopathy-linked alterations in Ca2+ binding of human cardiac myosin regulatory light chain affect cardiac muscle contraction
    Danuta Szczesna-Cordary
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 279:3535-42. 2004
  4. ncbi request reprint Degradation of myosin light chain in isolated rat hearts subjected to ischemia-reperfusion injury: a new intracellular target for matrix metalloproteinase-2
    Grzegorz Sawicki
    Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada
    Circulation 112:544-52. 2005
  5. ncbi request reprint F110I and R278C troponin T mutations that cause familial hypertrophic cardiomyopathy affect muscle contraction in transgenic mice and reconstituted human cardiac fibers
    Olga M Hernandez
    Department of Pharmacology, Georgetown University Medical Center, Washington, D C 20057, USA
    J Biol Chem 280:37183-94. 2005
  6. pmc Structural and functional aspects of the myosin essential light chain in cardiac muscle contraction
    Priya Muthu
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
    FASEB J 25:4394-405. 2011
  7. ncbi request reprint Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients
    Danuta Szczesna-Cordary
    University of Miami School of Medicine, Department of Molecular and Cellular Pharmacology R 189, P O Box 016189, 1600 NW 10 Ave, Rm 6113, Miami, FL 33101, USA
    FASEB J 21:3974-85. 2007
  8. ncbi request reprint The E22K mutation of myosin RLC that causes familial hypertrophic cardiomyopathy increases calcium sensitivity of force and ATPase in transgenic mice
    Danuta Szczesna-Cordary
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, FL 33136, USA
    J Cell Sci 118:3675-83. 2005
  9. ncbi request reprint Phosphorylation of the regulatory light chains of myosin affects Ca2+ sensitivity of skeletal muscle contraction
    Danuta Szczesna
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Appl Physiol 92:1661-70. 2002
  10. ncbi request reprint Prolonged Ca2+ and force transients in myosin RLC transgenic mouse fibers expressing malignant and benign FHC mutations
    Ying Wang
    Department of Physiology and Biophysics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    J Mol Biol 361:286-99. 2006

Research Grants

  1. Functional Consequences of FHC-linked RLC Mutations
    Danuta Szczesna Cordary; Fiscal Year: 2006
  2. Functional Consequences of FHC-linked RLC Mutations.
    Danuta Szczesna Cordary; Fiscal Year: 2010

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Ca2+ binding, and phosphorylation
    D Szczesna
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 276:7086-92. 2001
    ....
  2. ncbi request reprint Regulatory light chains of striated muscle myosin. Structure, function and malfunction
    Danuta Szczesna
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, FL 33136, USA
    Curr Drug Targets Cardiovasc Haematol Disord 3:187-97. 2003
    ..Further in vivo studies are necessary to investigate the mechanisms involved in the pathogenesis of RLC-linked FHC...
  3. ncbi request reprint Familial hypertrophic cardiomyopathy-linked alterations in Ca2+ binding of human cardiac myosin regulatory light chain affect cardiac muscle contraction
    Danuta Szczesna-Cordary
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 279:3535-42. 2004
    ..These results suggest the importance of the intact Ca(2+) binding site of HCRLC in the regulation of cardiac muscle contraction and imply its possible role in the regulatory light chain-linked pathogenesis of FHC...
  4. ncbi request reprint Degradation of myosin light chain in isolated rat hearts subjected to ischemia-reperfusion injury: a new intracellular target for matrix metalloproteinase-2
    Grzegorz Sawicki
    Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada
    Circulation 112:544-52. 2005
    ..MMP-2 not only remodels the extracellular matrix but also acts intracellularly in I/R by degrading troponin I. Whether other intracellular targets exist for MMP-2 during I/R is unknown...
  5. ncbi request reprint F110I and R278C troponin T mutations that cause familial hypertrophic cardiomyopathy affect muscle contraction in transgenic mice and reconstituted human cardiac fibers
    Olga M Hernandez
    Department of Pharmacology, Georgetown University Medical Center, Washington, D C 20057, USA
    J Biol Chem 280:37183-94. 2005
    ..The combination of increased Ca(2+) sensitivity and energy cost in the F110I hearts may be responsible for the greater severity of this phenotype compared with the R278C mutation...
  6. pmc Structural and functional aspects of the myosin essential light chain in cardiac muscle contraction
    Priya Muthu
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
    FASEB J 25:4394-405. 2011
    ..Subtle changes in the ELC sequence were sufficient to alter cross-bridge properties and lead to pathological phenotypes...
  7. ncbi request reprint Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients
    Danuta Szczesna-Cordary
    University of Miami School of Medicine, Department of Molecular and Cellular Pharmacology R 189, P O Box 016189, 1600 NW 10 Ave, Rm 6113, Miami, FL 33101, USA
    FASEB J 21:3974-85. 2007
    ..These changes when placed in vivo would result in higher workloads and consequently cardiac hypertrophy...
  8. ncbi request reprint The E22K mutation of myosin RLC that causes familial hypertrophic cardiomyopathy increases calcium sensitivity of force and ATPase in transgenic mice
    Danuta Szczesna-Cordary
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, FL 33136, USA
    J Cell Sci 118:3675-83. 2005
    ....
  9. ncbi request reprint Phosphorylation of the regulatory light chains of myosin affects Ca2+ sensitivity of skeletal muscle contraction
    Danuta Szczesna
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Appl Physiol 92:1661-70. 2002
    ..In conclusion, our results suggest that, although Ca2+ binding to the troponin-tropomyosin complex is the primary regulator of skeletal muscle contraction, RLC play an important modulatory role in this process...
  10. ncbi request reprint Prolonged Ca2+ and force transients in myosin RLC transgenic mouse fibers expressing malignant and benign FHC mutations
    Ying Wang
    Department of Physiology and Biophysics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    J Mol Biol 361:286-99. 2006
    ....
  11. ncbi request reprint The role of troponins in muscle contraction
    Aldrin V Gomes
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101, USA
    IUBMB Life 54:323-33. 2002
    ..This review addresses the physiological significance of the multiple Tn isoforms in skeletal and cardiac muscles as well as their role in the regulation of contraction...
  12. pmc The role of the N-terminus of the myosin essential light chain in cardiac muscle contraction
    Katarzyna Kazmierczak
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Mol Biol 387:706-25. 2009
    ....
  13. pmc Malignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice
    W Glenn L Kerrick
    Dept of Physiology and Biophysics, University of Miami, Miller School of Medicine, Miami, FL 33101, USA
    FASEB J 23:855-65. 2009
    ..Profound cellular changes observed in Tg-D166V myocardium when placed in vivo could trigger a series of pathological responses and result in poor prognosis for D166V-positive patients...
  14. ncbi request reprint The role of troponin in the Ca(2+)-regulation of skeletal muscle contraction
    Danuta Szczesna
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, 1600 N W 10th Ave, Miami, Florida 33136, USA
    Results Probl Cell Differ 36:171-90. 2002
  15. ncbi request reprint Fast skeletal muscle regulatory light chain is required for fast and slow skeletal muscle development
    Yingcai Wang
    Department of Molecular and Cellular Pharmacology, University of Miami, Miller School of Medicine, 1600 NW 10 Ave, Miami, FL 33136, USA
    FASEB J 21:2205-14. 2007
    ..In conclusion, in this study we demonstrate that the Mylpf gene is critically important for fast and slow skeletal muscle development...
  16. ncbi request reprint Myosin essential light chain in health and disease
    Olga M Hernandez
    Department of Molecular and Cellular Pharmacology, University of Miami, Leonard M Miller School of Medicine, Miami Florida 33136, USA
    Am J Physiol Heart Circ Physiol 292:H1643-54. 2007
    ..This review summarizes the functional roles of striated muscle ELC in normal healthy muscle and in disease. Transgenic animal models and phenotypic characterization of ELC-mediated remodeling of the heart are also discussed...

Research Grants7

  1. Functional Consequences of FHC-linked RLC Mutations
    Danuta Szczesna Cordary; Fiscal Year: 2006
    ..These studies will correlate the observed effects of the RLC mutations in the proposed animal models with the pathogenesis of FHC in humans and will decipher the key mechanisms of the RLC-linked FHC. ..
  2. Functional Consequences of FHC-linked RLC Mutations.
    Danuta Szczesna Cordary; Fiscal Year: 2010
    ....