Research Topics
Species | Lidia S SzczepaniakSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Bulk magnetic susceptibility effects on the assessment of intra- and extramyocellular lipids in vivoLidia S Szczepaniak
Department of Radiology, University of Texas, Southwestern Medical Center at Dallas, Dallas, Texas 75390 8586, USA
Magn Reson Med 47:607-10. 2002..It was found that the chemical shift of IntralipidTM is independent of the BMS effects, while the resonance of soybean oil shifts in a predictable manner determined by the geometry of the compartment...- Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general populationLidia S Szczepaniak
DW Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8899, USA
Am J Physiol Endocrinol Metab 288:E462-8. 2005..6%. Thus MRS provides a sensitive, quantitative, noninvasive method to measure HTGC and, when applied to a large urban US population, revealed a strikingly high prevalence of hepatic steatosis... - Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imagingLidia S Szczepaniak
Department of Internal Medicine, University of Texas, Southwestern Medical Center at Dallas, USA
Magn Reson Med 49:417-23. 2003..Increased myocardial triglyceride content was accompanied by elevated LV mass and suppressed septal wall thickening as measured by cardiac imaging... 
The effects of rosiglitazone on myocardial triglyceride content in patients with type 2 diabetes: a randomised, placebo-controlled trialJonathan McGavock
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, TX 75235 9047, USA
Diab Vasc Dis Res 9:131-7. 2012..Compared with placebo, treatment with rosiglitazone for 6 months had no discernible effect on mTG or left ventricular function in this population with long-standing diabetes and CVD...- Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy studyJonathan M McGavock
Department of Internal Medicine, Divisions of Hypertension, University of Texas Southwestern Medical Center at Dallas, Dallas, Tex, USA
Circulation 116:1170-5. 2007..Whether cardiac steatosis precedes the onset of cardiomyopathy in individuals with impaired glucose tolerance or in patients with type 2 diabetes mellitus is unknown... - Effect of pioglitazone therapy on myocardial and hepatic steatosis in insulin-treated patients with type 2 diabetesIvana Zib
Division of Endocrinology, Diabetes and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8899, USA
J Investig Med 55:230-6. 2007..The addition of pioglitazone to insulin therapy reduced myocardial and hepatic steatosis, consistent with the reported ability of the thiazolidinedione agents to redistribute fat from nonadipose to subcutaneous adipose depots... 
Randomized comparison of the effects of rosiglitazone vs. placebo on peak integrated cardiovascular performance, cardiac structure, and functionDarren K McGuire
Cardiovascular Division, University of Texas Southwestern Medical Center, 5909 Harry Hines Blvd, Room HA9 133, Dallas, TX 75235 9047, USA
Eur Heart J 31:2262-70. 2010..To assess the effect of rosiglitazone on cardiovascular performance and cardiac function...- Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusionRobert L Dobbins
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9135, USA
Am J Physiol Endocrinol Metab 284:E778-87. 2003..In conclusion, activation of the SNS by leptin increases energy expenditure by augmenting the resting metabolic rate... - Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicityJeffrey D Browning
Donald W. Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9046, USA
Hepatology 40:1387-95. 2004..In conclusion, the significant ethnic and sex differences in the prevalence of hepatic steatosis documented in this study may have a profound impact on susceptibility to steatosis-related liver disease... - The effect of rosiglitazone on integrated cardiovascular performance, cardiac structure, function and myocardial triglyceride: trial design and rationaleDarren K McGuire
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9047, USA
Diab Vasc Dis Res 6:43-50. 2009..The present study will combine a series of state-of-the-art assessments to evaluate the cardiac effects of rosiglitazone treatment... - Noninvasive quantification of pancreatic fat in humansIldiko Lingvay
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Clin Endocrinol Metab 94:4070-6. 2009.... - Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in AmericaLidia S Szczepaniak
Department of Internal Medicine, Division of Hypertension, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
Circ Res 101:759-67. 2007.... - Effects of N-3 fatty acids on hepatic triglyceride content in humansGloria Lena Vega
Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9052, USA
J Investig Med 56:780-5. 2008..Because dietary N-3 fatty acids reduce plasma triglycerides, they may also decrease hepatic triglyceride content. If so, N-3 fatty acids might constitute a therapy for fatty liver... - Determination of triglyceride in the human myocardium by magnetic resonance spectroscopy: reproducibility and sensitivity of the methodJason S Reingold
Department of Internal Medicine, Univ. of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-8899, USA
Am J Physiol Endocrinol Metab 289:E935-9. 2005..60). 1H-MRS is a reliable method for the determination of myocardial TG in humans and is relatively unaffected by the consumption of one high-fat meal but sensitive to changes following a prolonged fast... - The fatty hearts of patients with diabetesIldiko Lingvay
UT Southwestern Medical Center, Dallas, TX, USA
Nat Rev Cardiol 6:268-9. 2009..Magnetic Resonance Spectroscopy is a novel research tool used to noninvasively quantify myocardial triglyceride content. This method provides the opportunity to study myocardial steatosis in patients with diabetes... - Potential of electron beam computed tomography for coronary artery calcium screening to evaluate fatty liver: comparison with 1H magnetic resonance spectroscopy in the Dallas Heart StudySusan Matulevicius
Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center at Dallas, 75390 9047, USA
J Investig Med 59:780-6. 2011..We compared quantitative estimates of hepatic steatosis measured by EBCT with those obtained by a well-validated, accurate-measure, magnetic resonance spectroscopy ((1)H MRS)... - Adiposity-independent sympathetic activity in black menAamer Abbas
Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, U9 400, Dallas, TX 75390 8586, USA
J Appl Physiol 108:1613-8. 2010..05). In conclusion, these new data from this prospective study provide strong support for a major adiposity-independent sympathetic activity in black men and adiposity-related sympathetic activity in black women... - Effect of insulin-metformin combination on hepatic steatosis in patients with type 2 diabetesIldiko Lingvay
Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
J Diabetes Complications 21:137-42. 2007..We evaluated the change in hepatic steatosis following the initiation of insulin and metformin in patients with type 2 diabetes... - Adiposity of the heart, revisitedJonathan M McGavock
University of Texas Southwestern Medical Center, Dallas, Texas 75390-8899, USA
Ann Intern Med 144:517-24. 2006..These studies parallel the observations in obese animals and provide evidence that myocardial lipid content may be a biomarker and putative therapeutic target for cardiac disease in obese patients... - Metabolic correlates of nonalcoholic fatty liver in women and menGloria Lena Vega
The Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9052, USA
Hepatology 46:716-22. 2007.... - Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophyVinaya Simha
Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9052, USA
Diabetes Care 26:30-5. 2003..CONCLUSIONS: Reduction in IMCL and intrahepatic lipid content may partly explain leptin-induced improvement in insulin sensitivity in patients with generalized lipodystrophy... - Magnetic resonance spectroscopy of renal and other retroperitoneal tumorsPamela Nurenberg
Department of Radiology, University of Texas, Southwestern Medical Center at Dallas, 5801 Forest Park Road, Dallas, Texas, USA
Curr Opin Urol 12:375-80. 2002..This paper focuses on demonstrating the power of magnetic resonance spectroscopy when used as a clinical tool in the medical sciences. The main goal is to illustrate the potential of proton magnetic resonance spectroscopy in renal oncology... - The composition of dietary fat directly influences glucose-stimulated insulin secretion in ratsRobert L Dobbins
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9135, USA
Diabetes 51:1825-33. 2002..Inferences regarding the impact of fatty acids on GSIS that are based on models using unsaturated fat may not reflect the effects of saturated fat... - Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesityGregor Majdic
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Endocrinology 143:607-14. 2002..These SF-1 KO mice are a genetic model of late-onset obesity that may help elucidate the role of the VMH in weight regulation... - Effect of insulin versus triple oral therapy on the progression of hepatic steatosis in type 2 diabetesIldiko Lingvay
Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8857, USA
J Investig Med 60:1059-63. 2012..It is unknown if treatment with exogenous insulin in patients with type 2 diabetes, who are most prone to hepatic fat accumulation, would promote the occurrence or worsening of nonalcoholic fatty liver disease... - Cardiac dysfunction in mice lacking cytochrome-c oxidase subunit VIaHNina B Radford
The Cooper Clinic, Dallas, Texas 75230, USA
Am J Physiol Heart Circ Physiol 282:H726-33. 2002..These findings suggest that a genetic deficiency of COXVIaH has a measurable impact on myocardial diastolic performance despite the presence of normal cellular ATP levels...
Research Grants
- In Vivo Evaluation of Myocardial LipidsLIDIA SZCZEPANIAK; Fiscal Year: 2006..In contrast, I predict that functional cardiac abnormalities will be unaffected when diabetic subjects are treated with sulfonylureases that have no effect on PPAR-gamma. ..