Lidia S Szczepaniak

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Bulk magnetic susceptibility effects on the assessment of intra- and extramyocellular lipids in vivo
    Lidia S Szczepaniak
    Department of Radiology, University of Texas, Southwestern Medical Center at Dallas, Dallas, Texas 75390 8586, USA
    Magn Reson Med 47:607-10. 2002
  2. ncbi request reprint Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population
    Lidia S Szczepaniak
    DW Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8899, USA
    Am J Physiol Endocrinol Metab 288:E462-8. 2005
  3. ncbi request reprint Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging
    Lidia S Szczepaniak
    Department of Internal Medicine, University of Texas, Southwestern Medical Center at Dallas, USA
    Magn Reson Med 49:417-23. 2003
  4. doi request reprint The effects of rosiglitazone on myocardial triglyceride content in patients with type 2 diabetes: a randomised, placebo-controlled trial
    Jonathan McGavock
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, TX 75235 9047, USA
    Diab Vasc Dis Res 9:131-7. 2012
  5. ncbi request reprint Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study
    Jonathan M McGavock
    Department of Internal Medicine, Divisions of Hypertension, University of Texas Southwestern Medical Center at Dallas, Dallas, Tex, USA
    Circulation 116:1170-5. 2007
  6. ncbi request reprint Effect of pioglitazone therapy on myocardial and hepatic steatosis in insulin-treated patients with type 2 diabetes
    Ivana Zib
    Division of Endocrinology, Diabetes and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8899, USA
    J Investig Med 55:230-6. 2007
  7. pmc Randomized comparison of the effects of rosiglitazone vs. placebo on peak integrated cardiovascular performance, cardiac structure, and function
    Darren K McGuire
    Cardiovascular Division, University of Texas Southwestern Medical Center, 5909 Harry Hines Blvd, Room HA9 133, Dallas, TX 75235 9047, USA
    Eur Heart J 31:2262-70. 2010
  8. pmc Effect of insulin versus triple oral therapy on the progression of hepatic steatosis in type 2 diabetes
    Ildiko Lingvay
    Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8857, USA
    J Investig Med 60:1059-63. 2012
  9. ncbi request reprint Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion
    Robert L Dobbins
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9135, USA
    Am J Physiol Endocrinol Metab 284:E778-87. 2003
  10. ncbi request reprint Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    Jeffrey D Browning
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9046, USA
    Hepatology 40:1387-95. 2004

Research Grants

  1. In Vivo Evaluation of Myocardial Lipids
    LIDIA SZCZEPANIAK; Fiscal Year: 2006

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Bulk magnetic susceptibility effects on the assessment of intra- and extramyocellular lipids in vivo
    Lidia S Szczepaniak
    Department of Radiology, University of Texas, Southwestern Medical Center at Dallas, Dallas, Texas 75390 8586, USA
    Magn Reson Med 47:607-10. 2002
    ..It was found that the chemical shift of IntralipidTM is independent of the BMS effects, while the resonance of soybean oil shifts in a predictable manner determined by the geometry of the compartment...
  2. ncbi request reprint Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population
    Lidia S Szczepaniak
    DW Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8899, USA
    Am J Physiol Endocrinol Metab 288:E462-8. 2005
    ..6%. Thus MRS provides a sensitive, quantitative, noninvasive method to measure HTGC and, when applied to a large urban US population, revealed a strikingly high prevalence of hepatic steatosis...
  3. ncbi request reprint Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging
    Lidia S Szczepaniak
    Department of Internal Medicine, University of Texas, Southwestern Medical Center at Dallas, USA
    Magn Reson Med 49:417-23. 2003
    ..Increased myocardial triglyceride content was accompanied by elevated LV mass and suppressed septal wall thickening as measured by cardiac imaging...
  4. doi request reprint The effects of rosiglitazone on myocardial triglyceride content in patients with type 2 diabetes: a randomised, placebo-controlled trial
    Jonathan McGavock
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, TX 75235 9047, USA
    Diab Vasc Dis Res 9:131-7. 2012
    ..Compared with placebo, treatment with rosiglitazone for 6 months had no discernible effect on mTG or left ventricular function in this population with long-standing diabetes and CVD...
  5. ncbi request reprint Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study
    Jonathan M McGavock
    Department of Internal Medicine, Divisions of Hypertension, University of Texas Southwestern Medical Center at Dallas, Dallas, Tex, USA
    Circulation 116:1170-5. 2007
    ..Whether cardiac steatosis precedes the onset of cardiomyopathy in individuals with impaired glucose tolerance or in patients with type 2 diabetes mellitus is unknown...
  6. ncbi request reprint Effect of pioglitazone therapy on myocardial and hepatic steatosis in insulin-treated patients with type 2 diabetes
    Ivana Zib
    Division of Endocrinology, Diabetes and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8899, USA
    J Investig Med 55:230-6. 2007
    ..The addition of pioglitazone to insulin therapy reduced myocardial and hepatic steatosis, consistent with the reported ability of the thiazolidinedione agents to redistribute fat from nonadipose to subcutaneous adipose depots...
  7. pmc Randomized comparison of the effects of rosiglitazone vs. placebo on peak integrated cardiovascular performance, cardiac structure, and function
    Darren K McGuire
    Cardiovascular Division, University of Texas Southwestern Medical Center, 5909 Harry Hines Blvd, Room HA9 133, Dallas, TX 75235 9047, USA
    Eur Heart J 31:2262-70. 2010
    ..To assess the effect of rosiglitazone on cardiovascular performance and cardiac function...
  8. pmc Effect of insulin versus triple oral therapy on the progression of hepatic steatosis in type 2 diabetes
    Ildiko Lingvay
    Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8857, USA
    J Investig Med 60:1059-63. 2012
    ..It is unknown if treatment with exogenous insulin in patients with type 2 diabetes, who are most prone to hepatic fat accumulation, would promote the occurrence or worsening of nonalcoholic fatty liver disease...
  9. ncbi request reprint Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion
    Robert L Dobbins
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9135, USA
    Am J Physiol Endocrinol Metab 284:E778-87. 2003
    ..In conclusion, activation of the SNS by leptin increases energy expenditure by augmenting the resting metabolic rate...
  10. ncbi request reprint Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    Jeffrey D Browning
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9046, USA
    Hepatology 40:1387-95. 2004
    ..In conclusion, the significant ethnic and sex differences in the prevalence of hepatic steatosis documented in this study may have a profound impact on susceptibility to steatosis-related liver disease...
  11. doi request reprint The effect of rosiglitazone on integrated cardiovascular performance, cardiac structure, function and myocardial triglyceride: trial design and rationale
    Darren K McGuire
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9047, USA
    Diab Vasc Dis Res 6:43-50. 2009
    ..The present study will combine a series of state-of-the-art assessments to evaluate the cardiac effects of rosiglitazone treatment...
  12. pmc Noninvasive quantification of pancreatic fat in humans
    Ildiko Lingvay
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 94:4070-6. 2009
    ....
  13. ncbi request reprint Determination of triglyceride in the human myocardium by magnetic resonance spectroscopy: reproducibility and sensitivity of the method
    Jason S Reingold
    Department of Internal Medicine, Univ of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8899, USA
    Am J Physiol Endocrinol Metab 289:E935-9. 2005
    ..60). 1H-MRS is a reliable method for the determination of myocardial TG in humans and is relatively unaffected by the consumption of one high-fat meal but sensitive to changes following a prolonged fast...
  14. doi request reprint The fatty hearts of patients with diabetes
    Ildiko Lingvay
    UT Southwestern Medical Center, Dallas, TX, USA
    Nat Rev Cardiol 6:268-9. 2009
    ..Magnetic Resonance Spectroscopy is a novel research tool used to noninvasively quantify myocardial triglyceride content. This method provides the opportunity to study myocardial steatosis in patients with diabetes...
  15. doi request reprint Effects of N-3 fatty acids on hepatic triglyceride content in humans
    Gloria Lena Vega
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9052, USA
    J Investig Med 56:780-5. 2008
    ..Because dietary N-3 fatty acids reduce plasma triglycerides, they may also decrease hepatic triglyceride content. If so, N-3 fatty acids might constitute a therapy for fatty liver...
  16. ncbi request reprint Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in America
    Lidia S Szczepaniak
    Department of Internal Medicine, Division of Hypertension, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Circ Res 101:759-67. 2007
    ....
  17. doi request reprint Potential of electron beam computed tomography for coronary artery calcium screening to evaluate fatty liver: comparison with 1H magnetic resonance spectroscopy in the Dallas Heart Study
    Susan Matulevicius
    Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center at Dallas, 75390 9047, USA
    J Investig Med 59:780-6. 2011
    ..We compared quantitative estimates of hepatic steatosis measured by EBCT with those obtained by a well-validated, accurate-measure, magnetic resonance spectroscopy ((1)H MRS)...
  18. pmc Adiposity-independent sympathetic activity in black men
    Aamer Abbas
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, U9 400, Dallas, TX 75390 8586, USA
    J Appl Physiol 108:1613-8. 2010
    ..05). In conclusion, these new data from this prospective study provide strong support for a major adiposity-independent sympathetic activity in black men and adiposity-related sympathetic activity in black women...
  19. ncbi request reprint Metabolic correlates of nonalcoholic fatty liver in women and men
    Gloria Lena Vega
    The Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9052, USA
    Hepatology 46:716-22. 2007
    ..Obese subjects with hepatic steatosis had higher ratios of truncal-to-lower body fat and other indicators of adipose tissue dysfunction compared with obese subjects without steatosis...
  20. pmc Effect of insulin-metformin combination on hepatic steatosis in patients with type 2 diabetes
    Ildiko Lingvay
    Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    J Diabetes Complications 21:137-42. 2007
    ..We evaluated the change in hepatic steatosis following the initiation of insulin and metformin in patients with type 2 diabetes...
  21. ncbi request reprint Adiposity of the heart, revisited
    Jonathan M McGavock
    University of Texas Southwestern Medical Center, Dallas, Texas 75390 8899, USA
    Ann Intern Med 144:517-24. 2006
    ..These studies parallel the observations in obese animals and provide evidence that myocardial lipid content may be a biomarker and putative therapeutic target for cardiac disease in obese patients...
  22. ncbi request reprint Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy
    Vinaya Simha
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9052, USA
    Diabetes Care 26:30-5. 2003
    ....
  23. ncbi request reprint Magnetic resonance spectroscopy of renal and other retroperitoneal tumors
    Pamela Nurenberg
    Department of Radiology, University of Texas, Southwestern Medical Center at Dallas, 5801 Forest Park Road, Dallas, Texas, USA
    Curr Opin Urol 12:375-80. 2002
    ..This paper focuses on demonstrating the power of magnetic resonance spectroscopy when used as a clinical tool in the medical sciences. The main goal is to illustrate the potential of proton magnetic resonance spectroscopy in renal oncology...
  24. ncbi request reprint The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats
    Robert L Dobbins
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9135, USA
    Diabetes 51:1825-33. 2002
    ..Inferences regarding the impact of fatty acids on GSIS that are based on models using unsaturated fat may not reflect the effects of saturated fat...
  25. ncbi request reprint Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity
    Gregor Majdic
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Endocrinology 143:607-14. 2002
    ..These SF-1 KO mice are a genetic model of late-onset obesity that may help elucidate the role of the VMH in weight regulation...
  26. ncbi request reprint Cardiac dysfunction in mice lacking cytochrome-c oxidase subunit VIaH
    Nina B Radford
    The Cooper Clinic, Dallas, Texas 75230, USA
    Am J Physiol Heart Circ Physiol 282:H726-33. 2002
    ..These findings suggest that a genetic deficiency of COXVIaH has a measurable impact on myocardial diastolic performance despite the presence of normal cellular ATP levels...

Research Grants1

  1. In Vivo Evaluation of Myocardial Lipids
    LIDIA SZCZEPANIAK; Fiscal Year: 2006
    ..In contrast, I predict that functional cardiac abnormalities will be unaffected when diabetic subjects are treated with sulfonylureases that have no effect on PPAR-gamma. ..