A J Szalai

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Human C-reactive protein is protective against fatal Salmonella enterica serovar typhimurium infection in transgenic mice
    A J Szalai
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 68:5652-6. 2000
  2. ncbi request reprint Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level
    A J Szalai
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Mol Med (Berl) 83:440-7. 2005
  3. ncbi request reprint The biological functions of C-reactive protein
    Alexander J Szalai
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, THT 437B, Birmingham, AL 35294 0006, USA
    Vascul Pharmacol 39:105-7. 2002
  4. ncbi request reprint Varied biologic functions of C-reactive protein: lessons learned from transgenic mice
    Alexander J Szalai
    Department of Medicine, University of Alabama at Birmingham, 35294 0006, USA
    Immunol Res 26:279-87. 2002
  5. ncbi request reprint Experimental allergic encephalomyelitis is inhibited in transgenic mice expressing human C-reactive protein
    Alexander J Szalai
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 168:5792-7. 2002
  6. ncbi request reprint The antimicrobial activity of C-reactive protein
    Alexander J Szalai
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
    Microbes Infect 4:201-5. 2002
  7. ncbi request reprint Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene
    A J Szalai
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Genes Immun 3:14-9. 2002
  8. ncbi request reprint Systemic lupus erythematosus in a multiethnic US Cohort (LUMINA). XXX: association between C-reactive protein (CRP) gene polymorphisms and vascular events
    A J Szalai
    The University of Alabama, Birmingham, AL 35294 3408, USA
    Rheumatology (Oxford) 44:864-8. 2005
  9. ncbi request reprint Complement-dependent acute-phase expression of C-reactive protein and serum amyloid P-component
    A J Szalai
    Division of Clinical Immunology and Rheumatology, Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 165:1030-5. 2000
  10. ncbi request reprint The Arthus reaction in rodents: species-specific requirement of complement
    A J Szalai
    Department of Medicine, University of Alabama, Birmingham 35294, USA
    J Immunol 164:463-8. 2000

Research Grants

  1. C REACTIVE PROTEIN IN HOST DEFENSE
    ALEXANDER SZALAI; Fiscal Year: 2002

Collaborators

Detail Information

Publications40

  1. pmc Human C-reactive protein is protective against fatal Salmonella enterica serovar typhimurium infection in transgenic mice
    A J Szalai
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 68:5652-6. 2000
    ..In addition, as the beneficial effect of CRP includes enhancement of the host's humoral immune response, CRP may also contribute indirectly to host defense during later stages of infection...
  2. ncbi request reprint Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level
    A J Szalai
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Mol Med (Berl) 83:440-7. 2005
    ..Ultimately, development of genetic tests to screen for CRP expression variants could allow categorization of healthy people into groups at high versus low future risk of inflammatory disease...
  3. ncbi request reprint The biological functions of C-reactive protein
    Alexander J Szalai
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, THT 437B, Birmingham, AL 35294 0006, USA
    Vascul Pharmacol 39:105-7. 2002
    ..The relevance of this finding is underlined by the observation that subtle elevation of blood CRP is associated with significantly increased risk of cardiac disease...
  4. ncbi request reprint Varied biologic functions of C-reactive protein: lessons learned from transgenic mice
    Alexander J Szalai
    Department of Medicine, University of Alabama at Birmingham, 35294 0006, USA
    Immunol Res 26:279-87. 2002
    ..In this article, we discuss these and other observations we have made during the last 5 yr and summarize our ongoing studies and future plans related to CRP biology...
  5. ncbi request reprint Experimental allergic encephalomyelitis is inhibited in transgenic mice expressing human C-reactive protein
    Alexander J Szalai
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 168:5792-7. 2002
    ....
  6. ncbi request reprint The antimicrobial activity of C-reactive protein
    Alexander J Szalai
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
    Microbes Infect 4:201-5. 2002
    ..However, in transgenic mice protection also requires the alternative pathway of complement, and FcgammaRI is dispensable...
  7. ncbi request reprint Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene
    A J Szalai
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Genes Immun 3:14-9. 2002
    ..On the other hand, the fact that baseline CRP does have a genetic component suggests that in coronary disease, stratification of risk assessment based on CRP levels might be enhanced by consideration of this polymorphism...
  8. ncbi request reprint Systemic lupus erythematosus in a multiethnic US Cohort (LUMINA). XXX: association between C-reactive protein (CRP) gene polymorphisms and vascular events
    A J Szalai
    The University of Alabama, Birmingham, AL 35294 3408, USA
    Rheumatology (Oxford) 44:864-8. 2005
    ..To determine if a polymorphic GTn repeat in the intron of the C-reactive protein (CRP) gene associates with occurrence of vascular arterial events in systemic lupus erythematosus (SLE)...
  9. ncbi request reprint Complement-dependent acute-phase expression of C-reactive protein and serum amyloid P-component
    A J Szalai
    Division of Clinical Immunology and Rheumatology, Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 165:1030-5. 2000
    ..Based on these data, we conclude that during the APR, C5a generated as a consequence of complement activation acts in concert with IL-6 and/or IL-1beta to promote up-regulation of the CRP and SAP genes...
  10. ncbi request reprint The Arthus reaction in rodents: species-specific requirement of complement
    A J Szalai
    Department of Medicine, University of Alabama, Birmingham 35294, USA
    J Immunol 164:463-8. 2000
    ....
  11. ncbi request reprint Bioluminescence imaging reveals a significant role for complement in liver transduction following intravenous delivery of adenovirus
    K R Zinn
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Gene Ther 11:1482-6. 2004
    ..05) increased transduction of mouse liver cells, as compared to preincubation with C3-/- sera or PBS. These results suggest the classical or alternate complement pathway enhances Ad5-mediated liver transduction...
  12. ncbi request reprint C-reactive protein: structural biology and host defense function
    A J Szalai
    Department of Medicine, University of Alabama at Birmingham, 35294 0006, USA
    Clin Chem Lab Med 37:265-70. 1999
    ..This was attributable to an up to 400-fold reduction in bacteremia mediated mainly by the interaction of C-reactive protein with complement. A complement-independent host protective effect was also demonstrated...
  13. ncbi request reprint Overexpression of innate immune response genes in a model of recessive polycystic kidney disease
    M Mrug
    Division of Genetic and Translational Medicine, Department of Medicine, The University of Alabama at Birmingham, 720 20th Street South, Birmingham, AL 35294, USA
    Kidney Int 73:63-76. 2008
    ..We also found elevated complement component 3 activation in two other mouse-recessive models and human-recessive PKD. Our results suggest that abnormal complement component 3 activation is a key element of progression in PKD...
  14. ncbi request reprint Attenuation of experimental autoimmune demyelination in complement-deficient mice
    S Nataf
    Departments of Microbiology, Pathology, and Medicine, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 165:5867-73. 2000
    ..These results suggest that complement might be a target for the therapeutic treatment of inflammatory demyelinating diseases of the CNS...
  15. ncbi request reprint Estrogen treatment abrogates neointima formation in human C-reactive protein transgenic mice
    Dajun Wang
    Division of Cardiovascular Disease, University of Alabama, Birmingham, Alabama 35294 0006, USA
    Arterioscler Thromb Vasc Biol 25:2094-9. 2005
    ..Herein we tested the hypothesis that E2 modulates vascular injury in the CRPtg mouse...
  16. ncbi request reprint C3a expressed in the central nervous system protects against LPS-induced shock
    Laura Boos
    Department of Microbiology, University of Alabama at Birmingham, 845 19th St S, BBRB 842, Birmingham, AL 35294, USA
    Neurosci Lett 387:68-71. 2005
    ..Surprisingly, C3a/GFAPxC3aR-/- hybrids were also significantly protected, indicating that C3a exerts its protective anti-inflammatory effect either directly or via an as yet unidentified non-canonical C3aR...
  17. ncbi request reprint Genetic deficiency of C3 as well as CNS-targeted expression of the complement inhibitor sCrry ameliorates experimental autoimmune uveoretinitis
    Russell W Read
    Department of Ophthalmology, The University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294 1150, USA
    Exp Eye Res 82:389-94. 2006
    ..18 versus 1.85, respectively, p=0.0054). A genetic deficiency of C3 and production of a soluble complement inhibitor targeted to the CNS and eye are protective against EAU...
  18. pmc Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (Fc gamma RI)-dependent
    Dongqi Xing
    Vascular Biology and Hypertension Program, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Pathol 172:22-30. 2008
    ..The exaggerated response to vascular injury provoked by CRP in OVX CRPtg depends on Fc gamma RI and probably requires its expression by F4/80+ cells...
  19. ncbi request reprint Requirement of the Fc receptor common gamma-chain for gamma delta T cell-mediated promotion of murine experimental autoimmune encephalomyelitis
    Alexander J Szalai
    Department of Medicine at The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Eur J Immunol 35:3487-92. 2005
    ..Expression of the common gamma-chain by gammadelta T cells, probably in conjunction with the T cell receptor/CD3 complex, is likely the key requirement for full development of EAE...
  20. ncbi request reprint Complement and demyelinating disease: no MAC needed?
    Scott R Barnum
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Brain Res Rev 52:58-68. 2006
    ..Based on these newer data, we posit that C3-derived biologically active fragments, rather than C5 and the MAC, are central players in the pathophysiology of complement in EAE...
  21. ncbi request reprint Experimental autoimmune uveitis in the C57BL/6 mouse
    Russell W Read
    Exp Eye Res 83:229-30; author reply 231. 2006
  22. ncbi request reprint Induction of leptin resistance through direct interaction of C-reactive protein with leptin
    Ke Chen
    Department of Cell Biology and Physiology, University of Pittsburgh, 3500 Terrace Street, BST S 326, Pittsburgh, Pennsylvania 15261, USA
    Nat Med 12:425-32. 2006
    ..Thus, our results suggest a potential mechanism contributing to leptin resistance, by which circulating CRP binds to leptin and attenuates its physiological functions...
  23. ncbi request reprint C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk
    Fadi G Hage
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Am Coll Cardiol 50:1115-22. 2007
    ..Some of these variations are associated with clinical correlates of cardiovascular disease. If future studies can establish with certainty that CRP influences cardiovascular biology, then CRP gene profiling could have clinical utility...
  24. pmc PspA and PspC minimize immune adherence and transfer of pneumococci from erythrocytes to macrophages through their effects on complement activation
    Jie Li
    Department of Microbiology, University of Alabama at Birmingham, AL 35294, USA
    Infect Immun 75:5877-85. 2007
    ..These data provide new insight into how PspA and PspC act in synergy to protect pneumococci from complement-dependent clearance during invasive infection...
  25. ncbi request reprint The virulence function of Streptococcus pneumoniae surface protein A involves inhibition of complement activation and impairment of complement receptor-mediated protection
    Bing Ren
    Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 173:7506-12. 2004
    ..Our new results suggest that complement receptors CR1/2, CR3, and CR4 all play important roles in host defense against pneumococcal infection...
  26. pmc Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae
    Bing Ren
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 71:75-85. 2003
    ..These results suggest that family 1 and family 2 PspA proteins play similar roles in virulence and that surface accessibility of PspA is important for their function...
  27. ncbi request reprint Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene
    Alexander J Szalai
    The University of Alabama at Birmingham
    Arthritis Rheum 48:1602-11. 2003
    ..To test whether CRP participates in the pathogenesis of systemic lupus erythematosus (SLE), we examined disease development in lupus-prone (NZB x NZW)F(1) (NZB/NZW) mice expressing a human CRP transgene (hCRPtg/BW)...
  28. ncbi request reprint Fc gamma Rs modulate cytotoxicity of anti-Fas antibodies: implications for agonistic antibody-based therapeutics
    Yuanyuan Xu
    Division of Clinical Immunology and Rheumatology, Department of Medicine and Laboratory for MultiModality Imaging Assessment, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 171:562-8. 2003
    ..Recognizing this fact should facilitate development of safer and more efficacious agonistic Abs...
  29. ncbi request reprint Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice
    Haim D Danenberg
    Harvard MIT Division of Health Sciences and Technology, Cambridge, Mass 02139, USA
    Circulation 108:512-5. 2003
    ..To determine whether CRP directly modulates vascular cell function in vivo, we subjected wild-type mice, which do not express CRP, and human CRP-transgenic (CRPtg) mice to 2 models of arterial injury...
  30. pmc Effects of PspA and antibodies to PspA on activation and deposition of complement on the pneumococcal surface
    Bing Ren
    Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 72:114-22. 2004
    ..Antibodies to PspA could overcome the anticomplementary effect of PspA, allowing for increased complement activation and C3 deposition onto PspA+ bacteria...
  31. ncbi request reprint C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice
    Antoni Paul
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA
    Circulation 109:647-55. 2004
    ..Plasma C-reactive protein (CRP) concentration is a strong predictor of atherosclerosis. However, to date, there is no in vivo evidence that CRP is proatherogenic...
  32. ncbi request reprint Evidence for anti-inflammatory activity of statins and PPARalpha activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro
    Robert Kleemann
    Gaubius Laboratory, TNO Prevention and Health, PO Box 2215, 2301 CE Leiden, The Netherlands
    Blood 103:4188-94. 2004
    ..Our results provide conclusive evidence for a direct suppressive effect of statins and PPARalpha activators on huCRP expression independent of cholesterol lowering and atherogenesis...
  33. ncbi request reprint Fc receptors and the common gamma-chain in experimental autoimmune encephalomyelitis
    Alexander J Szalai
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Neurosci Res 75:597-602. 2004
    ..These studies support previous evidence implicating a pathogenic role for gammadelta T cells in EAE...
  34. ncbi request reprint Murine complement C4 is not required for experimental autoimmune encephalomyelitis
    Laura A Boos
    Department of Microbiology, University of Alabama, Birmingham, Alabama 35294, USA
    Glia 49:158-60. 2005
    ..These results support the conclusion that the contribution of murine complement to the pathogenesis of demyelinating disease is realized via the alternative pathway...
  35. ncbi request reprint Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice
    Lars Verschuren
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 25:161-7. 2005
    ..To evaluate whether low-dose atorvastatin suppresses atherosclerotic lesion progression and inflammation in apolipoprotein E*3 (apoE*3)-Leiden mice beyond its cholesterol-lowering effect...
  36. pmc C-reactive protein (CRP) and autoimmune disease: facts and conjectures
    Alexander J Szalai
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
    Clin Dev Immunol 11:221-6. 2004
    ..A mechanistic hypothesis is presented to account for this cause-and-effect relationship...
  37. ncbi request reprint Complement in BuB/BnJ mice revisited: serum C3 levels and complement opsonic activity are not elevated
    Inga Osmers
    Department of Microbiology, 845 19th St S BBRB 842, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Immunol 43:1722-5. 2006
    ..In contrast hemolytic assays indicate BuB/BnJ sera to be most active. These results indicate that accepted views regarding mouse serum complement activity need to be re-examined...
  38. pmc Complement in experimental autoimmune encephalomyelitis revisited: C3 is required for development of maximal disease
    Alexander J Szalai
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States
    Mol Immunol 44:3132-6. 2007
    ..Our results confirm a requirement for C3 for maximal development of EAE and suggest that receptors for C3-derived activation fragments might be a viable therapeutic target for prevention and treatment demyelinating disease...
  39. ncbi request reprint Complement as a biomarker in multiple sclerosis
    Scott R Barnum
    J Neuropathol Exp Neurol 64:741. 2005
  40. pmc Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion
    Xinrui Li
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 181:1012-8. 2008
    ..These results provide a mechanism by which Fcgamma receptors can elevate circulating BLyS levels and promote autoantibody production in immune complex-mediated autoimmune diseases...

Research Grants1

  1. C REACTIVE PROTEIN IN HOST DEFENSE
    ALEXANDER SZALAI; Fiscal Year: 2002
    ..These studies will increase the understanding of innate host defense mechanisms and their interaction with acquired immunity. ..