Research Topics
| G SzaboSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
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Publications
Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infectionShashi Bala
Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
J Transl Med 10:151. 2012..Chronic liver inflammation leads to progressive liver damage. MicroRNAs (miRNA) regulate inflammation (miR-155, -146a and -125b) as well as hepatocyte function (miR-122)...
Inflammasomes in liver diseasesGyongyi Szabo
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 USA
J Hepatol 57:642-54. 2012..The importance of inflammasome activation in various forms of liver diseases in relation to liver damage, steatosis, inflammation and fibrosis is discussed in this review...- MicroRNA silencing and the development of novel therapies for liver diseaseGyongyi Szabo
Department of Medicine, University of Massachusetts Medical School, MA 01605, United States
J Hepatol 57:462-6. 2012..In this review, we highlight the latest advances in the field of microRNA biology and their potential as emerging therapeutic targets in liver disease... - Induction of Bcl-3 by acute binge alcohol results in toll-like receptor 4/LPS toleranceShashi Bala
Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
J Leukoc Biol 92:611-20. 2012.... - Molecular hepatic carcinogenesis: impact of inflammationGyongyi Szabo
Department of Medicine, University of Massachusetts Medical School, Worcester, USA
Dig Dis 30:243-8. 2012..This review summarizes the key points and discusses recent findings related to the role of inflammation in cancer and HCC development... - Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytesMaoyin Pang
Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
BMC Immunol 12:55. 2011..Here we hypothesized that alcohol exposure modulates TLR8- and TLR4-ligand-induced monocyte activation and affects both type I IFN and inflammatory cytokine induction... - Effect of ethanol on inflammatory responses. Implications for pancreatitisGyongyi Szabo
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Pancreatology 7:115-23. 2007..Alcohol use alters inflammatory cell responses. While alcohol has direct effects on pancreatic acinar cells, activation of inflammatory cells is a major component of the pathology of alcoholic pancreatitis... - Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damageGyongyi Szabo
Department of Medicine, LRB215 University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Alcohol Clin Exp Res 34:1675-86. 2010..Alteration of these processes by alcohol and HCV produces an environment of impaired antiviral immune response, greater hepatocellular injury, and activation of cell proliferation and dedifferentiation... 
TLR4, ethanol, and lipid rafts: a new mechanism of ethanol action with implications for other receptor-mediated effectsGyongyi Szabo
University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 178:1243-9. 2007..EtOH provides an example of an immunomodulatory drug that acts at least in part by modifying lipid rafts, and it could represent a model to probe the relationships between rafts, receptor complexes, and signaling...- HCV immunopathogenesis: virus-induced strategies against host immunityGyongyi Szabo
Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, LRB 215, Worcester, MA 01605 2324, USA
Clin Liver Dis 10:753-71. 2006..It is believed that both viral and host factors contribute to the inability of the host immune system to clear the initial infection and lead to the high propensity of chronic HCV infection... - Pattern recognition receptors: a contemporary view on liver diseasesGyongyi Szabo
Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Hepatology 44:287-98. 2006..This review discusses the role of different PRRs in pathogen recognition in the liver, and focuses on the role of PRRs in hepatic inflammation, cholestasis, ischemia, repair and fibrosis. PRRs as novel therapeutic targets are evaluated... - Hepatitis C infection and alcohol use: A dangerous mix for the liver and antiviral immunityGyongyi Szabo
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Alcohol Clin Exp Res 30:709-19. 2006..This symposium summarizes the state of knowledge of cellular and molecular pathways by which alcohol and HCV have pathogenic interactions resulting in depression of the immune response and liver damage in chronic HCV infection... - Altered innate immunity in chronic hepatitis C infection: cause or effect?Gyongyi Szabo
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Hepatology 46:1279-90. 2007 - Innate immune response and hepatic inflammationGyongyi Szabo
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Semin Liver Dis 27:339-50. 2007..The specificity of Toll-like receptors and the mechanisms of innate immune cell activation are discussed in relation to acute and chronic liver injury including viral, alcoholic, nonalcoholic, and drug-induced hepatitis... - The role of plasmacytoid dendritic cell-derived IFN alpha in antiviral immunityGyongyi Szabo
Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Crit Rev Immunol 28:61-94. 2008..Specifically, we address the mechanisms of IFNalpha induction and the cooperation between PDC, PDC-derived IFNalpha and T cells, B cells, NK, iNKT, and myeloid dendric cells in antiviral immune responses... - Hepatitis C and innate immunity: recent advancesGyongyi Szabo
Department of Medicine LRB215, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
Clin Liver Dis 12:675-92, x. 2008..Finally, current and emerging therapeutic approaches targeting innate immune pathways are evaluated... - A recent perspective on alcohol, immunity, and host defenseGyongyi Szabo
Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Alcohol Clin Exp Res 33:220-32. 2009..Multiple line of clinical and experimental evidence demonstrates that both acute, moderate, and chronic, excessive alcohol use result in various abnormalities in the functions of the immune system... - Alcoholic liver disease and the gut-liver axisGyongyi Szabo
Department of Medicine, University of Massachusetts Medical School, LRB 215, Worcester, MA 01605, USA
World J Gastroenterol 16:1321-9. 2010..The role of the Toll-like receptor 4 (TLR4) complex in LPS recognition and the importance of the TLR4-induced signaling pathways are evaluated in ALD... - The unfolding web of innate immune dysregulation in alcoholic liver injuryG Szabo
University of Massachusetts Medical School, Worcester, 01605, USA
Alcohol Clin Exp Res 35:782-6. 2011..In alcohol-induced liver disease we discuss the role of MyD88-independent but IRF3-mediated TLR4 signaling in alcohol-related liver inflammation and liver damage... - Gut-liver axis and sensing microbesGyongyi Szabo
University of Massachusetts Medical School, Worcester, Mass, USA
Dig Dis 28:737-44. 2010..Thus, understanding the cell-specific recognition and intracellular signaling events in sensing gut-derived microbes will help to achieve an optimal balance in the gut-liver axis and ameliorate liver diseases... - Mechanisms of alcohol-mediated hepatotoxicity in human-immunodeficiency-virus-infected patientsGyongyi Szabo
Department of Medicine, LRB 208, University of Massachusetts Medical School, Worcester, MA 01605, United States
World J Gastroenterol 17:2500-6. 2011..Finally, alcohol, HIV and antiretroviral therapy affect hepatocyte functions, which contributes to liver damage. The common targets of alcohol and HIV infection in liver disease are discussed in this mini-review... - Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4Gyongyi Szabo
Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Alcohol Clin Exp Res 29:140S-145S. 2005..These results demonstrate that TLR2 deficiency results in increased liver injury in association with nonalcoholic steatohepatitis and may suggest a protective role for TLR2-mediated signals in liver injury... - Interferon alpha and alcohol augment nuclear regulatory factor-kappaB activation in HepG2 cells, and interferon alpha increases pro-inflammatory cytokine productionG Szabo
Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Alcohol Clin Exp Res 25:1188-97. 2001..We investigated the hypothesis that IFNalpha and alcohol regulate cells both in the liver parenchyma and the immune system... - Pathogenic interactions between alcohol and hepatitis CGyongyi Szabo
Hepatology and Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, 365 Plantation Street, Worcester, MA 01605, USA
Curr Gastroenterol Rep 5:86-92. 2003..Further investigation of these and other pathways by which alcohol and HCV interact should unravel the mechanisms that accelerate the progression of liver disease... - Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infectionGyongyi Szabo
Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605 2324, USA
Immunobiology 210:237-47. 2005..These data demonstrate that both PDC and MDC functions are impaired in patients with chronic HCV infection and DC defects are likely related to interaction of HCV viral products with innate immune cells... - Acute alcohol consumption inhibits accessory cell function of monocytes and dendritic cellsGyongyi Szabo
Department of Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts, USA
Alcohol Clin Exp Res 28:824-8. 2004..In this study, we investigated the effects of acute, moderate alcohol consumption on antigen presenting cell function of blood monocytes and monocyte-derived myeloid dendritic cells... - Ethanol-mediated regulation of transcription factors in immunocompetent cellsGyongyi Szabo
Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605 2324, USA
Front Biosci 7:a80-9. 2002.... - Inhibition of antigen-presenting cell functions by alcohol: implications for hepatitis C virus infectionGyongyi Szabo
Liver Center, Division of Gastroenterology, University of Massachusetts Medical School LRB215, 364 Plantation Street, Worcester, MA 01604, USA
Alcohol 33:241-9. 2004.... - Reduced alloreactive T-cell activation after alcohol intake is due to impaired monocyte accessory cell function and correlates with elevated IL-10, IL-13, and decreased IFNgamma levelsG Szabo
Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
Alcohol Clin Exp Res 25:1766-72. 2001..The severity of hepatitis C is increased by alcohol consumption. Thus, we investigated the effects of alcohol consumption on accessory cell activity of monocytes in supporting alloreactive T-cell proliferation... - Tacrolimus and cyclosporine A inhibit allostimulatory capacity and cytokine production of human myeloid dendritic cellsG Szabo
Division of Gastroenterology, Memorial Health Center, University of Massachusetts Medical School, Worcester 01655, USA
J Investig Med 49:442-9. 2001..Thus, tacrolimus and CsA can inhibit recognition of alloantigens by decreasing the accessory-cell capacity of monocyte-derived myeloid DCs... - Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infectionAngela Dolganiuc
University of Massachusetts Medical School, Worcester, Massachusetts, USA
Gastroenterology 133:1627-36. 2007..Persistent inflammation contributes to progression of liver damage in chronic HCV (cHCV) infection. Repeated exposure to toll-like receptor (TLR) ligands results in tolerance, a protective mechanism aimed at limiting inflammation... - Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteinsSerena Chang
Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605 2324, USA
J Leukoc Biol 82:479-87. 2007..These results imply that multiple pattern recognition receptors could participate in cellular activation by HCV proteins... - Diverse regulation of NF-kappaB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liverLaszlo Romics
Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA
Hepatology 40:376-85. 2004..Thus, an imbalance between PPAR-mediated anti-inflammatory and NF-kappaB-mediated proinflammatory signals may contribute to increased inflammation in the fatty liver... - Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activationAngela Dolganiuc
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Gastroenterology 127:1513-24. 2004..The aim of this study was to investigate the role of TLRs in innate immune cell activation by core and NS3 proteins... - Human monocytes, macrophages, and dendritic cells: alcohol treatment methodsGyongyi Szabo
Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Methods Mol Biol 447:113-24. 2008..Here, we summarize the different effects of acute and chronic alcohol on monocyte, macrophage, and dendritic cell functions in humans and describe methods for separation and functional evaluation of these cell types... - The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88Istvan Hritz
Department of Medicine, University of Massachusetts Medical School, University of Massachusetts, Worcester, MA 01605, USA
Hepatology 48:1224-31. 2008..These results suggest that the common TLR adapter, MyD88, is dispensable in TLR4-mediated liver injury in ALD... - Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiationAngela Dolganiuc
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 170:5615-24. 2003..Our results reveal that HCV core and NS3 proteins activate monocytes and inhibit DC differentiation in the absence of the intact virus and mediate some of the immunoinhibitory effects of HCV via IL-10 induction... - Additive inhibition of dendritic cell allostimulatory capacity by alcohol and hepatitis C is not restored by DC maturation and involves abnormal IL-10 and IL-2 inductionAngela Dolganiuc
Department of Medicine, University of Massachusetts Medical School, Worcester, 01605-2324, USA
Alcohol Clin Exp Res 27:1023-31. 2003..HCV and alcohol interact to modulate innate and adaptive immune responses via dendritic cells... - Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infectionAngela Dolganiuc
University of Massachusetts Medical School, Department of Medicine, Worcester, MA 01605, USA
J Immunol 177:6758-68. 2006..These mechanisms are likely to contribute to HCV viral escape from immune responses... - MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in miceAngela Dolganiuc
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
Alcohol Clin Exp Res 33:1704-10. 2009..Each miRNA controls the expression of multiple targets; miRNAs have been linked to regulation of lipid metabolism and inflammation... - Moderate alcohol intake in humans attenuates monocyte inflammatory responses: inhibition of nuclear regulatory factor kappa B and induction of interleukin 10Pranoti Mandrekar
Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605, USA
Alcohol Clin Exp Res 30:135-9. 2006..These mechanisms may contribute to the beneficial effects of moderate alcohol use on atherosclerosis... - TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytesShilpa Oak
Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, 01605, USA
J Immunol 176:7628-35. 2006..Thus, the complexity of TLR-mediated signals may determine attenuation or augmentation of inflammatory responses by acute alcohol... - RSA 2004: combined basic research satellite symposium - session four: hepatitis virus and alcohol interactions in immunity and liver diseaseGyongyi Szabo
University of Massachusetts Medical Center, Department of Medicine, Worcester, MA 01605-2324, USA
Alcohol Clin Exp Res 29:1753-7. 2005.... - Myeloid dendritic cells of patients with chronic HCV infection induce proliferation of regulatory T lymphocytesAngela Dolganiuc
University of Massachusetts Medical School, Department of Medicine, Worcester, Massachusetts 01605 2324, USA
Gastroenterology 135:2119-27. 2008..This study analyzed the activities of myeloid DCs and distinct CD4(+) T-cell populations in samples collected from patients with HCV... - Dendritic cells in hepatitis C infection: can they (help) win the battle?Angela Dolganiuc
Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, LRB 270 H, Worcester, MA 01605, USA
J Gastroenterol 46:432-47. 2011.... - Inhibition of NF-kappa B binding correlates with increased nuclear glucocorticoid receptor levels in acute alcohol-treated human monocytesPranoti Mandrekar
Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester 01605, USA
Alcohol Clin Exp Res 26:1872-9. 2002..Here, we show for the first time that acute alcohol (25 mM) exposure modulates GR activation in monocytes... - Acute alcohol exposure exerts anti-inflammatory effects by inhibiting IkappaB kinase activity and p65 phosphorylation in human monocytesPranoti Mandrekar
Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
J Immunol 178:7686-93. 2007..These findings further implicate an important role for IKKbeta in the acute effects of alcohol in immune cells... - The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytesPranoti Mandrekar
University of Massachusetts Medical School, Department of Medicine, Worcester, MA 01605, USA
J Immunol 183:1320-7. 2009..Our data indicate that IRAK-M is a central player in the opposite regulation of LPS signaling by different lengths of alcohol exposure in monocytes... - Emerging role of microRNAs in liver diseasesShashi Bala
Department of Medicine, University of Massachusetts Medical School, LRB 215, Worcester, MA 01605, USA
World J Gastroenterol 15:5633-40. 2009..This review highlights the role of microRNAs in liver diseases and their potential use as therapeutic molecules... - Liver in sepsis and systemic inflammatory response syndromeGyongyi Szabo
Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, NRB Floor 2, Room 215, Worcester, MA 01605 2324, USA
Clin Liver Dis 6:1045-66, x. 2002..This article summarizes the functional changes that take place in the liver during sepsis and systemic inflammatory response syndrome and discusses the cellular and molecular mechanisms that underlie clinical outcomes... - Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: implications for immunityBharath Nath
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Semin Liver Dis 29:166-77. 2009.... - Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cellsSerena Chang
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
Hepatology 51:35-42. 2010..These results suggest a role for TLR7 in HCV-mediated evasion of host immune surveillance... - Signalling pathways in alcohol-induced liver inflammationPranoti Mandrekar
Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
J Hepatol 50:1258-66. 2009..In this review we describe the key signalling intermediates leading to alcohol-induced inflammation in alcoholic liver disease... - Acute alcohol intake induces SOCS1 and SOCS3 and inhibits cytokine-induced STAT1 and STAT3 signaling in human monocytesOxana Norkina
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Alcohol Clin Exp Res 32:1565-73. 2008..Here we aimed to explore the effect of acute alcohol on induction of SOCS1/SOCS3 and regulation of STAT3/STAT1 pathways induced by IL-6 or IFNs in human monocytes... - T cells with regulatory activity in hepatitis C virus infection: what we know and what we don'tAngela Dolganiuc
Department of Medicine, University of Massachusetts Medical School, LRB 270J, 364 Plantation St, Worcester, MA 01605, USA
J Leukoc Biol 84:614-22. 2008..In this review, we summarize the current knowledge about Tregs as they relate to HCV infection... - Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expressionLaszlo Romics
Liver Center, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01606, USA
Alcohol Clin Exp Res 29:1018-26. 2005..CONCLUSION: These results imply that the increased sensitivity of AFL to LPS occurs without up-regulation of TLR2 or TLR4 genes and may be related to an imbalance of pro-inflammatory/oxidative and cytoprotective mechanisms... - Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnesLaszlo Romics
Liver Center, Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605 2324, USA
J Leukoc Biol 78:1255-64. 2005..These results suggest that although P. acnes triggers TLR2-mediated cell activation, TLR2-independent but MyD88-dependent mechanisms mediate in vivo sensitization by P. acnes for LPS-induced liver injury... - In vitro and in vivo models of acute alcohol exposureAngela Dolganiuc
Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States
World J Gastroenterol 15:1168-77. 2009..The present manuscript summarizes the interdisciplinary advantages and disadvantages of currently available human and non-human models of acute alcohol abuse, and identifies their suitability for biomedical research... - Evolution of hepatic steatosis in patients with advanced hepatitis C: results from the hepatitis C antiviral long-term treatment against cirrhosis (HALT-C) trialAnna S Lok
Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
Hepatology 49:1828-37. 2009..Decreased alcohol intake and improved metabolic parameters are associated with a decline in steatosis and may modulate hepatitis C progression... - Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 productionPranoti Mandrekar
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 173:3398-407. 2004..Taken together, alcohol both in vitro and in vivo can impair generation of Th1 immune responses via inhibition of DC differentiation and accessory cell function through mechanisms that involve decreased IL-12 induction... - Incidence of hepatocellular carcinoma and associated risk factors in hepatitis C-related advanced liver diseaseAnna S Lok
Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Gastroenterology 136:138-48. 2009..We evaluated the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) cohort for the incidence of HCC and associated risk factors... - Acute ethanol treatment modulates Toll-like receptor-4 association with lipid raftsAngela Dolganiuc
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605-2324, USA
Alcohol Clin Exp Res 30:76-85. 2006..We propose that alcohol-induced effects on lipid rafts may contribute to modulation of TLR4-CD14-triggered early cellular responses... - Distinct Toll-like receptor expression in monocytes and T cells in chronic HCV infectionAngela Dolganiuc
University of Massachusetts Medical School, Department of Medicine, 364 Plantation Street, Worcester, MA 01605-2324, United States
World J Gastroenterol 12:1198-204. 2006..CONCLUSION: Our data reveal novel details on TLR expression that likely relates to innate recognition of pathogens and immune defense in HCV-infected individuals... - FcgammaR cross-linking mediates NF-kappaB activation, reduced antigen presentation capacity, and decreased IL-12 production in monocytes without modulation of myeloid dendritic cell developmentYvonne Drechsler
Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605, USA
J Leukoc Biol 72:657-67. 2002..These results suggest that signals mediated via FcgammaRI, -II, and -III have overlapping yet distinct effects on MO, which are likely to be involved in the fine-tuning of the immune responses to various stimuli... - RSA 2004: combined basic research satellite symposium - session two: toll-like receptors and organ damagePranoti Mandrekar
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA
Alcohol Clin Exp Res 29:1744-8. 2005.... - Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytesYvonne Drechsler
Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
J Immunol 177:2592-600. 2006..Thus, HO-1 activation is a key mediator of the anti-inflammatory effects of acute alcohol on monocytes... - Critical role of toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injuryArumugam Velayudham
Liver Center, Department of Medicine, University of Massachusetts Medical School, Plantation Street, Worcester, MA 01605, USA
J Hepatol 45:813-24. 2006..Toll-like receptors (TLR) recognize pathogens and regulate innate immune activation. Here, we investigated the roles of TLR9 and the common TLR adaptor, MyD88, in liver injury... - Acute alcohol inhibits the induction of nuclear regulatory factor kappa B activation through CD14/toll-like receptor 4, interleukin-1, and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation?Pranoti Mandrekar
University of Massachusetts Medical School, Department of Medicine, Worcester 01605 2324, USA
Alcohol Clin Exp Res 26:1609-14. 2002..Here we investigated whether acute alcohol treatment of human monocytes also inhibits NF-kappaB when induced through activation of the interleukin (IL)-1 or tumor necrosis factor (TNF) receptors... - Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytesOxana Norkina
University of Massachusetts Medical School, Department of Medicine, LRB 215, 364 Plantation Street, Worcester, MA 01605, USA
J Leukoc Biol 82:752-62. 2007..Our data suggest that acute alcohol activates Src/STAT3 and Src/MAPK/STAT3, AP-1, and Sp-1 pathways as important mechanisms for IL-10-mediated immunomodulation after acute alcohol use... - Bone marrow-derived immune cells mediate sensitization to liver injury in a myeloid differentiation factor 88-dependent fashionIstvan Hritz
Department of Medicine, University of Massachusetts, Medical School, Worcester, MA 01605 2324, USA
Hepatology 48:1342-7. 2008..These results demonstrate that MyD88 in immune cells rather than in liver parenchymal cells plays an important role in inflammatory cell recruitment and liver injury... - Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in miceLaszlo Romics
Liver Center, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Hepatology 40:555-64. 2004..In conclusion, P. acnes priming to selective TLR4-mediated liver injury is associated with up-regulation of TLR4 and MD-2 and is likely to involve IFN-gamma and prevent TLR4 desensitization by P. acnes... - Factors that determine the development and progression of gastroesophageal varices in patients with chronic hepatitis CRobert J Fontana
Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0362, USA
Gastroenterology 138:2321-31, 2331.e1-2. 2010..We aimed to identify the incidence and predictors of de novo gastroesophageal variceal formation and progression in a large cohort of patients with chronic hepatitis C and advanced fibrosis... - VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in miceArumugam Velayudham
Department of Medicine, Liver Center, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
Hepatology 49:989-97. 2009..The mechanisms of VSL#3-mediated protection from MCD diet-induced liver fibrosis likely include modulation of collagen expression and impaired TGFbeta signaling... - Identification and characterization of broadly neutralizing human monoclonal antibodies directed against the E2 envelope glycoprotein of hepatitis C virusTeresa J Broering
MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts 02130, USA
J Virol 83:12473-82. 2009.... - Intervention at the level of the neuroendocrine-immune axis and postoperative pneumonia rate in long-term alcoholicsClaudia Spies
Department of Anesthesiology and Intensive Care Medicine, Charite University Medicine Berlin, Campus Charité Virchow Klinikum and Campus Charité Mitte, Augustenburger Platz 1, 13353 Berlin, Germany
Am J Respir Crit Care Med 174:408-14. 2006..Long-term alcohol use leads to an altered perioperative hypothalamus-pituitary-adrenal (HPA) axis and immunity... - Hepatitis C core protein - the "core" of immune deception?Gyongyi Szabo
J Hepatol 48:8-11. 2008 - Hepatitis C virus NS5A protein--a master regulator?Gyongyi Szabo
Gastroenterology 130:995-9. 2006 - Cytokines and alcoholFulton T Crews
Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
Alcohol Clin Exp Res 30:720-30. 2006..Together these studies suggest that ethanol disruption of cytokines and inflammation contribute in multiple ways to a diversity of alcoholic pathologies... - Modulation of immunity and viral-host interactions by alcoholGeoffrey M Thiele
Department of Internal Medicine at the University of Nebraska Medical Center, Omaha VA Medical Center, Research Services 68105, USA
Alcohol Clin Exp Res 26:1897-908. 2002..Thiele; and (6) Mechanisms of impaired accessory cell functions due to alcohol exposure and hepatitis C infection, by Gyongyi Szabo... - Severe cholestatic hepatitis caused by thiazolidinediones: risks associated with substituting rosiglitazone for troglitazoneHerbert L Bonkovsky
University of Massachusetts Medical School, Worcester 01655, USA
Dig Dis Sci 47:1632-7. 2002..It is important to monitor the serum alkaline phosphatase in addition to the serum aminotransferases in patients taking thiazolidinediones... - Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) TrialLeonard B Seeff
Division of Digestive Diseases and Nutrition, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Hepatology 47:605-12. 2008..Because its use among these HALT-C participants was self-motivated and uncontrolled, however, only a well-designed prospective study can determine whether silymarin provides benefit to persons with chronic hepatitis C... - RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and deathGyongyi Szabo
Thomas Jefferson University (JBH, GH, Department of Pathology, Anatomy and Cell Biology, Philadelphia, PA 19107-6799, USA
Alcohol Clin Exp Res 29:1749-52. 2005.... - Hepatitis C virus infection--pathobiology and implications for new therapeutic optionsGary L Davis
4 Roberts, Hepatology, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75246, USA
Dig Dis Sci 52:857-75. 2007..This report summarizes each of the presentations sections... - Acute and chronic alcohol abuse modulate immunityLou Ann S Brown
Department of Pediatrics, Emory University, Atlanta, Georgia, USA
Alcohol Clin Exp Res 30:1624-31. 2006..Nagy, and (8) Hepatitis C Virus Infection and Alcohol Use by Gyongyi Szabo. Meeting coorganizers were Elizabeth J. Kovacs, Lou Ann S. Brown, Thomas R. Jerrells, and Robert T. Cook...
Research Grants
- TLR4 Signaling in alcoholic liver diseaseGyongyi Szabo; Fiscal Year: 2010..Our results suggest that the absence of TLR4 but not of the MyD88 adaptor protects mice from alcoholic liver disease. ..
- Hepatitis C Virus, Alcohol and Host DefenseGyongyi Szabo; Fiscal Year: 2007..Results from these studies should reveal molecular and cellular mechanisms by which alcohol interacts with HCV infection to accelerate disease persistence and progression. ..
- Ethanols role in mediation of monocyte suppressionGyongyi Szabo; Fiscal Year: 2007..Investigation of the modulation of IL-10 and IL-12 by alcohol in dendritic cell function may identify biomarkers of alcohol-induced immune depression and reveal potential targets for therapy. ..
- ALCOHOL AND MONOCYTE SIGNALINGGyongyi Szabo; Fiscal Year: 2007..abstract_text> ..
- ALCOHOL AND MONOCYTE SIGNALINGGyongyi Szabo; Fiscal Year: 2010....
- Toll like receptor - Mediated pathways in liver injuryGyongyi Szabo; Fiscal Year: 2010..Thus, our study may help to design new therapeutic approaches to prevent liver diseases with granulomas and to attenuate sensitization to liver injury caused by infectious pathogens. ..
- TLR4 Signaling in alcoholic liver diseaseGyongyi Szabo; Fiscal Year: 2009..Our results suggest that the absence of TLR4 but not of the MyD88 adaptor protects mice from alcoholic liver disease. ..
- Ethanols role in mediation of monocyte suppressionGyongyi Szabo; Fiscal Year: 2009..Investigation of the modulation of IL-10 and IL-12 by alcohol in dendritic cell function may identify biomarkers of alcohol-induced immune depression and reveal potential targets for therapy. ..
- Ethanols role in mediation of monocyte suppressionGyongyi Szabo; Fiscal Year: 2007..Investigation of the modulation of IL-10 and IL-12 by alcohol in dendritic cell function may identify biomarkers of alcohol-induced immune depression and reveal potential targets for therapy. ..
- Mechanisms of Alcohol Mediated Organ and Tissue DamageGyongyi Szabo; Fiscal Year: 2005..3. Increase the involvement of young investigators in the study of alcohol research. 4. Provide an educational forum to participants. ..
- ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSIONGyongyi Szabo; Fiscal Year: 1999..Results from these experiments will improve the understanding of the immunomodulatory effects of acute, moderate alcohol use in humans. ..
- ALCOHOL AND MONOCYTE SIGNALINGGyongyi Szabo; Fiscal Year: 2001..These studies should delineate the effect of in vivo acute alcohol on NF-kB signaling in monocytes relevant to inflammation, cirrhosis, atherosclerosis, and HIV infection. ..
- ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSIONGyongyi Szabo; Fiscal Year: 2003..These experiments will define monocyte alterations leading to the combined immunosuppressive effects of in vivo ethanol uptake and trauma. ..