G Szabo

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Effect of ethanol on inflammatory responses. Implications for pancreatitis
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Pancreatology 7:115-23. 2007
  2. pmc Type III interferons, IL-28 and IL-29, are increased in chronic HCV infection and induce myeloid dendritic cell-mediated FoxP3+ regulatory T cells
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 7:e44915. 2012
  3. pmc Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice
    Dora Lippai
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS ONE 8:e70945. 2013
  4. pmc MicroRNA Signature in Alcoholic Liver Disease
    Shashi Bala
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Int J Hepatol 2012:498232. 2012
  5. pmc Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation
    Dora Lippai
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Leukoc Biol 94:171-82. 2013
  6. pmc Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection
    Shashi Bala
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    J Transl Med 10:151. 2012
  7. doi request reprint Inflammasomes in liver diseases
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 USA
    J Hepatol 57:642-54. 2012
  8. doi request reprint MicroRNA silencing and the development of novel therapies for liver disease
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, MA 01605, United States
    J Hepatol 57:462-6. 2012
  9. pmc Induction of Bcl-3 by acute binge alcohol results in toll-like receptor 4/LPS tolerance
    Shashi Bala
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    J Leukoc Biol 92:611-20. 2012
  10. doi request reprint Molecular hepatic carcinogenesis: impact of inflammation
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, USA
    Dig Dis 30:243-8. 2012

Research Grants

  1. TLR4 Signaling in alcoholic liver disease
    Gyongyi Szabo; Fiscal Year: 2009
  2. ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSION
    Gyongyi Szabo; Fiscal Year: 2002
  3. ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSION
    Gyongyi Szabo; Fiscal Year: 2003
  4. Ethanols role in mediation of monocyte suppression
    Gyongyi Szabo; Fiscal Year: 2009
  5. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2006
  6. Ethanols role in mediation of monocyte suppression
    Gyongyi Szabo; Fiscal Year: 2006
  7. Hepatitis C Virus, Alcohol and Host Defense
    Gyongyi Szabo; Fiscal Year: 2007
  8. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2009
  9. ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSION
    Gyongyi Szabo; Fiscal Year: 2001
  10. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2001

Detail Information

Publications92

  1. pmc Effect of ethanol on inflammatory responses. Implications for pancreatitis
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Pancreatology 7:115-23. 2007
    ..Alcohol use alters inflammatory cell responses. While alcohol has direct effects on pancreatic acinar cells, activation of inflammatory cells is a major component of the pathology of alcoholic pancreatitis...
  2. pmc Type III interferons, IL-28 and IL-29, are increased in chronic HCV infection and induce myeloid dendritic cell-mediated FoxP3+ regulatory T cells
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 7:e44915. 2012
    ..We hypothesized that IFN-λ have immunomodulatory effects in HCV- infected individuals...
  3. pmc Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice
    Dora Lippai
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS ONE 8:e70945. 2013
    ..Inflammation is a highly regulated process. Recent studies suggest that microRNAs (miRNAs) play crucial role in fine tuning gene expression and miR-155 is a major regulator of inflammation in immune cells after TLR stimulation...
  4. pmc MicroRNA Signature in Alcoholic Liver Disease
    Shashi Bala
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Int J Hepatol 2012:498232. 2012
    ..Our novel finding of the alcohol-induced increase of miRNAs in hepatocytes and KCs after alcohol feeding provides further insight into the evolving knowledge regarding the role of miRNAs in ALD...
  5. pmc Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation
    Dora Lippai
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Leukoc Biol 94:171-82. 2013
    ..Increased levels of acetylated and phosphorylated HMGB1 may contribute to alcoholic neuroinflammation...
  6. pmc Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection
    Shashi Bala
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    J Transl Med 10:151. 2012
    ..Chronic liver inflammation leads to progressive liver damage. MicroRNAs (miRNA) regulate inflammation (miR-155, -146a and -125b) as well as hepatocyte function (miR-122)...
  7. doi request reprint Inflammasomes in liver diseases
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 USA
    J Hepatol 57:642-54. 2012
    ..The importance of inflammasome activation in various forms of liver diseases in relation to liver damage, steatosis, inflammation and fibrosis is discussed in this review...
  8. doi request reprint MicroRNA silencing and the development of novel therapies for liver disease
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, MA 01605, United States
    J Hepatol 57:462-6. 2012
    ..In this review, we highlight the latest advances in the field of microRNA biology and their potential as emerging therapeutic targets in liver disease...
  9. pmc Induction of Bcl-3 by acute binge alcohol results in toll-like receptor 4/LPS tolerance
    Shashi Bala
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    J Leukoc Biol 92:611-20. 2012
    ....
  10. doi request reprint Molecular hepatic carcinogenesis: impact of inflammation
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, USA
    Dig Dis 30:243-8. 2012
    ..This review summarizes the key points and discusses recent findings related to the role of inflammation in cancer and HCC development...
  11. pmc Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes
    Maoyin Pang
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    BMC Immunol 12:55. 2011
    ..Here we hypothesized that alcohol exposure modulates TLR8- and TLR4-ligand-induced monocyte activation and affects both type I IFN and inflammatory cytokine induction...
  12. ncbi request reprint Altered innate immunity in chronic hepatitis C infection: cause or effect?
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Hepatology 46:1279-90. 2007
  13. pmc A recent perspective on alcohol, immunity, and host defense
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Alcohol Clin Exp Res 33:220-32. 2009
    ..Multiple line of clinical and experimental evidence demonstrates that both acute, moderate, and chronic, excessive alcohol use result in various abnormalities in the functions of the immune system...
  14. ncbi request reprint TLR4, ethanol, and lipid rafts: a new mechanism of ethanol action with implications for other receptor-mediated effects
    Gyongyi Szabo
    University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 178:1243-9. 2007
    ..EtOH provides an example of an immunomodulatory drug that acts at least in part by modifying lipid rafts, and it could represent a model to probe the relationships between rafts, receptor complexes, and signaling...
  15. ncbi request reprint Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4
    Gyongyi Szabo
    Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Alcohol Clin Exp Res 29:140S-145S. 2005
    ..These results demonstrate that TLR2 deficiency results in increased liver injury in association with nonalcoholic steatohepatitis and may suggest a protective role for TLR2-mediated signals in liver injury...
  16. pmc Hepatitis C and innate immunity: recent advances
    Gyongyi Szabo
    Department of Medicine LRB215, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Clin Liver Dis 12:675-92, x. 2008
    ..Finally, current and emerging therapeutic approaches targeting innate immune pathways are evaluated...
  17. ncbi request reprint The role of plasmacytoid dendritic cell-derived IFN alpha in antiviral immunity
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Crit Rev Immunol 28:61-94. 2008
    ..Specifically, we address the mechanisms of IFNalpha induction and the cooperation between PDC, PDC-derived IFNalpha and T cells, B cells, NK, iNKT, and myeloid dendric cells in antiviral immune responses...
  18. ncbi request reprint Innate immune response and hepatic inflammation
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Semin Liver Dis 27:339-50. 2007
    ..The specificity of Toll-like receptors and the mechanisms of innate immune cell activation are discussed in relation to acute and chronic liver injury including viral, alcoholic, nonalcoholic, and drug-induced hepatitis...
  19. ncbi request reprint Pattern recognition receptors: a contemporary view on liver diseases
    Gyongyi Szabo
    Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Hepatology 44:287-98. 2006
    ..This review discusses the role of different PRRs in pathogen recognition in the liver, and focuses on the role of PRRs in hepatic inflammation, cholestasis, ischemia, repair and fibrosis. PRRs as novel therapeutic targets are evaluated...
  20. ncbi request reprint Hepatitis C infection and alcohol use: A dangerous mix for the liver and antiviral immunity
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Alcohol Clin Exp Res 30:709-19. 2006
    ..This symposium summarizes the state of knowledge of cellular and molecular pathways by which alcohol and HCV have pathogenic interactions resulting in depression of the immune response and liver damage in chronic HCV infection...
  21. ncbi request reprint Pathogenic interactions between alcohol and hepatitis C
    Gyongyi Szabo
    Hepatology and Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, 365 Plantation Street, Worcester, MA 01605, USA
    Curr Gastroenterol Rep 5:86-92. 2003
    ..Further investigation of these and other pathways by which alcohol and HCV interact should unravel the mechanisms that accelerate the progression of liver disease...
  22. pmc Alcoholic liver disease and the gut-liver axis
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, LRB 215, Worcester, MA 01605, USA
    World J Gastroenterol 16:1321-9. 2010
    ..The role of the Toll-like receptor 4 (TLR4) complex in LPS recognition and the importance of the TLR4-induced signaling pathways are evaluated in ALD...
  23. pmc Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damage
    Gyongyi Szabo
    Department of Medicine, LRB215 University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Alcohol Clin Exp Res 34:1675-86. 2010
    ..Alteration of these processes by alcohol and HCV produces an environment of impaired antiviral immune response, greater hepatocellular injury, and activation of cell proliferation and dedifferentiation...
  24. ncbi request reprint Interferon alpha and alcohol augment nuclear regulatory factor-kappaB activation in HepG2 cells, and interferon alpha increases pro-inflammatory cytokine production
    G Szabo
    Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Alcohol Clin Exp Res 25:1188-97. 2001
    ..We investigated the hypothesis that IFNalpha and alcohol regulate cells both in the liver parenchyma and the immune system...
  25. ncbi request reprint Tacrolimus and cyclosporine A inhibit allostimulatory capacity and cytokine production of human myeloid dendritic cells
    G Szabo
    Division of Gastroenterology, Memorial Health Center, University of Massachusetts Medical School, Worcester 01655, USA
    J Investig Med 49:442-9. 2001
    ..Thus, tacrolimus and CsA can inhibit recognition of alloantigens by decreasing the accessory-cell capacity of monocyte-derived myeloid DCs...
  26. ncbi request reprint Reduced alloreactive T-cell activation after alcohol intake is due to impaired monocyte accessory cell function and correlates with elevated IL-10, IL-13, and decreased IFNgamma levels
    G Szabo
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Alcohol Clin Exp Res 25:1766-72. 2001
    ..The severity of hepatitis C is increased by alcohol consumption. Thus, we investigated the effects of alcohol consumption on accessory cell activity of monocytes in supporting alloreactive T-cell proliferation...
  27. ncbi request reprint Ethanol-mediated regulation of transcription factors in immunocompetent cells
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605 2324, USA
    Front Biosci 7:a80-9. 2002
    ....
  28. ncbi request reprint Acute alcohol consumption inhibits accessory cell function of monocytes and dendritic cells
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts, USA
    Alcohol Clin Exp Res 28:824-8. 2004
    ..In this study, we investigated the effects of acute, moderate alcohol consumption on antigen presenting cell function of blood monocytes and monocyte-derived myeloid dendritic cells...
  29. pmc Mechanisms of alcohol-mediated hepatotoxicity in human-immunodeficiency-virus-infected patients
    Gyongyi Szabo
    Department of Medicine, LRB 208, University of Massachusetts Medical School, Worcester, MA 01605, United States
    World J Gastroenterol 17:2500-6. 2011
    ..Finally, alcohol, HIV and antiretroviral therapy affect hepatocyte functions, which contributes to liver damage. The common targets of alcohol and HIV infection in liver disease are discussed in this mini-review...
  30. pmc Gut-liver axis and sensing microbes
    Gyongyi Szabo
    University of Massachusetts Medical School, Worcester, Mass, USA
    Dig Dis 28:737-44. 2010
    ..Thus, understanding the cell-specific recognition and intracellular signaling events in sensing gut-derived microbes will help to achieve an optimal balance in the gut-liver axis and ameliorate liver diseases...
  31. pmc The unfolding web of innate immune dysregulation in alcoholic liver injury
    G Szabo
    University of Massachusetts Medical School, Worcester, 01605, USA
    Alcohol Clin Exp Res 35:782-6. 2011
    ..In alcohol-induced liver disease we discuss the role of MyD88-independent but IRF3-mediated TLR4 signaling in alcohol-related liver inflammation and liver damage...
  32. ncbi request reprint Inhibition of antigen-presenting cell functions by alcohol: implications for hepatitis C virus infection
    Gyongyi Szabo
    Liver Center, Division of Gastroenterology, University of Massachusetts Medical School LRB215, 364 Plantation Street, Worcester, MA 01604, USA
    Alcohol 33:241-9. 2004
    ....
  33. ncbi request reprint Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605 2324, USA
    Immunobiology 210:237-47. 2005
    ..These data demonstrate that both PDC and MDC functions are impaired in patients with chronic HCV infection and DC defects are likely related to interaction of HCV viral products with innate immune cells...
  34. ncbi request reprint HCV immunopathogenesis: virus-induced strategies against host immunity
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, LRB 215, Worcester, MA 01605 2324, USA
    Clin Liver Dis 10:753-71. 2006
    ..It is believed that both viral and host factors contribute to the inability of the host immune system to clear the initial infection and lead to the high propensity of chronic HCV infection...
  35. pmc Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection
    Angela Dolganiuc
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Gastroenterology 133:1627-36. 2007
    ..Persistent inflammation contributes to progression of liver damage in chronic HCV (cHCV) infection. Repeated exposure to toll-like receptor (TLR) ligands results in tolerance, a protective mechanism aimed at limiting inflammation...
  36. ncbi request reprint Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins
    Serena Chang
    Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605 2324, USA
    J Leukoc Biol 82:479-87. 2007
    ..These results imply that multiple pattern recognition receptors could participate in cellular activation by HCV proteins...
  37. ncbi request reprint Diverse regulation of NF-kappaB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liver
    Laszlo Romics
    Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Hepatology 40:376-85. 2004
    ..Thus, an imbalance between PPAR-mediated anti-inflammatory and NF-kappaB-mediated proinflammatory signals may contribute to increased inflammation in the fatty liver...
  38. doi request reprint The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88
    Istvan Hritz
    Department of Medicine, University of Massachusetts Medical School, University of Massachusetts, Worcester, MA 01605, USA
    Hepatology 48:1224-31. 2008
    ..However, the induction of IRF7, an IRF3-inducible gene, was found in Kupffer cells of alcohol-fed WT mice. Alcohol feeding also induced nuclear factor-kappaB activation in a TLR4-dependent MyD88-independent manner...
  39. doi request reprint Human monocytes, macrophages, and dendritic cells: alcohol treatment methods
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Methods Mol Biol 447:113-24. 2008
    ..Here, we summarize the different effects of acute and chronic alcohol on monocyte, macrophage, and dendritic cell functions in humans and describe methods for separation and functional evaluation of these cell types...
  40. ncbi request reprint Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Gastroenterology 127:1513-24. 2004
    ..The aim of this study was to investigate the role of TLRs in innate immune cell activation by core and NS3 proteins...
  41. ncbi request reprint Moderate alcohol intake in humans attenuates monocyte inflammatory responses: inhibition of nuclear regulatory factor kappa B and induction of interleukin 10
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605, USA
    Alcohol Clin Exp Res 30:135-9. 2006
    ..Here, we determine in vivo effects of acute alcohol consumption on inflammatory cytokine production and nuclear regulatory factor kappaB (NF-kappaB) binding in human monocytes...
  42. ncbi request reprint Additive inhibition of dendritic cell allostimulatory capacity by alcohol and hepatitis C is not restored by DC maturation and involves abnormal IL-10 and IL-2 induction
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, 01605 2324, USA
    Alcohol Clin Exp Res 27:1023-31. 2003
    ..Here we investigated the effects of HCV infection and alcohol on myeloid dendritic cells (DC) that are critical in antiviral immunity...
  43. ncbi request reprint Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 170:5615-24. 2003
    ..Our results reveal that HCV core and NS3 proteins activate monocytes and inhibit DC differentiation in the absence of the intact virus and mediate some of the immunoinhibitory effects of HCV via IL-10 induction...
  44. ncbi request reprint Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection
    Angela Dolganiuc
    University of Massachusetts Medical School, Department of Medicine, Worcester, MA 01605, USA
    J Immunol 177:6758-68. 2006
    ..These mechanisms are likely to contribute to HCV viral escape from immune responses...
  45. pmc MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Alcohol Clin Exp Res 33:1704-10. 2009
    ..Each miRNA controls the expression of multiple targets; miRNAs have been linked to regulation of lipid metabolism and inflammation...
  46. ncbi request reprint TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes
    Shilpa Oak
    Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, 01605, USA
    J Immunol 176:7628-35. 2006
    ..Thus, the complexity of TLR-mediated signals may determine attenuation or augmentation of inflammatory responses by acute alcohol...
  47. doi request reprint Myeloid dendritic cells of patients with chronic HCV infection induce proliferation of regulatory T lymphocytes
    Angela Dolganiuc
    University of Massachusetts Medical School, Department of Medicine, Worcester, Massachusetts 01605 2324, USA
    Gastroenterology 135:2119-27. 2008
    ..This study analyzed the activities of myeloid DCs and distinct CD4(+) T-cell populations in samples collected from patients with HCV...
  48. ncbi request reprint RSA 2004: combined basic research satellite symposium - session four: hepatitis virus and alcohol interactions in immunity and liver disease
    Gyongyi Szabo
    University of Massachusetts Medical Center, Department of Medicine, Worcester, MA 01605 2324, USA
    Alcohol Clin Exp Res 29:1753-7. 2005
    ....
  49. ncbi request reprint Inhibition of lipopolysaccharide-mediated NFkappaB activation by ethanol in human monocytes
    P Mandrekar
    Division of Rheumatology, Department of Medicine, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA 01655, USA
    Int Immunol 11:1781-90. 1999
    ..Consequently, these results suggest that physiologically relevant concentrations of alcohol interfere with NFkappaB activation and thereby may affect the regulation of NFkappaB-controlled gene activation...
  50. doi request reprint Dendritic cells in hepatitis C infection: can they (help) win the battle?
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, LRB 270 H, Worcester, MA 01605, USA
    J Gastroenterol 46:432-47. 2011
    ....
  51. pmc Emerging role of microRNAs in liver diseases
    Shashi Bala
    Department of Medicine, University of Massachusetts Medical School, LRB 215, Worcester, MA 01605, USA
    World J Gastroenterol 15:5633-40. 2009
    ..This review highlights the role of microRNAs in liver diseases and their potential use as therapeutic molecules...
  52. doi request reprint Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells
    Serena Chang
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Hepatology 51:35-42. 2010
    ..Stimulation with the TLR7 ligand R837 resulted in significant IRF7 nuclear translocation in control cells. In contrast, HCV-replicating cells showed attenuated TLR7 ligand-induced IRF7 activation...
  53. pmc In vitro and in vivo models of acute alcohol exposure
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States
    World J Gastroenterol 15:1168-77. 2009
    ..The present manuscript summarizes the interdisciplinary advantages and disadvantages of currently available human and non-human models of acute alcohol abuse, and identifies their suitability for biomedical research...
  54. ncbi request reprint Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression
    Laszlo Romics
    Liver Center, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01606, USA
    Alcohol Clin Exp Res 29:1018-26. 2005
    ....
  55. pmc The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes
    Pranoti Mandrekar
    University of Massachusetts Medical School, Department of Medicine, Worcester, MA 01605, USA
    J Immunol 183:1320-7. 2009
    ..Our data indicate that IRAK-M is a central player in the opposite regulation of LPS signaling by different lengths of alcohol exposure in monocytes...
  56. pmc Signalling pathways in alcohol-induced liver inflammation
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    J Hepatol 50:1258-66. 2009
    ..In this review we describe the key signalling intermediates leading to alcohol-induced inflammation in alcoholic liver disease...
  57. ncbi request reprint Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes
    Laszlo Romics
    Liver Center, Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605 2324, USA
    J Leukoc Biol 78:1255-64. 2005
    ..These results suggest that although P. acnes triggers TLR2-mediated cell activation, TLR2-independent but MyD88-dependent mechanisms mediate in vivo sensitization by P. acnes for LPS-induced liver injury...
  58. ncbi request reprint Liver in sepsis and systemic inflammatory response syndrome
    Gyongyi Szabo
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, NRB Floor 2, Room 215, Worcester, MA 01605 2324, USA
    Clin Liver Dis 6:1045-66, x. 2002
    ..This article summarizes the functional changes that take place in the liver during sepsis and systemic inflammatory response syndrome and discusses the cellular and molecular mechanisms that underlie clinical outcomes...
  59. ncbi request reprint Inhibition of NF-kappa B binding correlates with increased nuclear glucocorticoid receptor levels in acute alcohol-treated human monocytes
    Pranoti Mandrekar
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester 01605, USA
    Alcohol Clin Exp Res 26:1872-9. 2002
    ..Here, we show for the first time that acute alcohol (25 mM) exposure modulates GR activation in monocytes...
  60. doi request reprint Acute alcohol intake induces SOCS1 and SOCS3 and inhibits cytokine-induced STAT1 and STAT3 signaling in human monocytes
    Oxana Norkina
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Alcohol Clin Exp Res 32:1565-73. 2008
    ..Here we aimed to explore the effect of acute alcohol on induction of SOCS1/SOCS3 and regulation of STAT3/STAT1 pathways induced by IL-6 or IFNs in human monocytes...
  61. pmc T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, LRB 270J, 364 Plantation St, Worcester, MA 01605, USA
    J Leukoc Biol 84:614-22. 2008
    ..In this review, we summarize the current knowledge about Tregs as they relate to HCV infection...
  62. ncbi request reprint Acute alcohol exposure exerts anti-inflammatory effects by inhibiting IkappaB kinase activity and p65 phosphorylation in human monocytes
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    J Immunol 178:7686-93. 2007
    ..These findings further implicate an important role for IKKbeta in the acute effects of alcohol in immune cells...
  63. doi request reprint Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: implications for immunity
    Bharath Nath
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Semin Liver Dis 29:166-77. 2009
    ....
  64. ncbi request reprint Acute ethanol treatment modulates Toll-like receptor-4 association with lipid rafts
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Alcohol Clin Exp Res 30:76-85. 2006
    ..Alcohol, a substance that is most frequently abused, suppresses innate immune responses to microbial pathogens. The host senses pathogens via Toll-like receptors (TLRs). Recent studies indicate that alcohol affects TLR signaling...
  65. ncbi request reprint Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 production
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 173:3398-407. 2004
    ..Taken together, alcohol both in vitro and in vivo can impair generation of Th1 immune responses via inhibition of DC differentiation and accessory cell function through mechanisms that involve decreased IL-12 induction...
  66. pmc Evolution of hepatic steatosis in patients with advanced hepatitis C: results from the hepatitis C antiviral long-term treatment against cirrhosis (HALT-C) trial
    Anna S Lok
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Hepatology 49:1828-37. 2009
    ....
  67. pmc Incidence of hepatocellular carcinoma and associated risk factors in hepatitis C-related advanced liver disease
    Anna S Lok
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Gastroenterology 136:138-48. 2009
    ..We evaluated the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) cohort for the incidence of HCC and associated risk factors...
  68. pmc Human monoclonal antibody MBL-HCV1 delays HCV viral rebound following liver transplantation: a randomized controlled study
    R T Chung
    Department of Transplant Surgery, Massachusetts General Hospital, Boston, MA, USA
    Am J Transplant 13:1047-54. 2013
    ..7 days vs. 2.4 days, p<0.001). As with other HCV monotherapies, antibody-treated subjects had resistance-associated variants at the time of viral rebound. A combination study of MBL-HCV1 with a direct-acting antiviral is underway...
  69. ncbi request reprint Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice
    Laszlo Romics
    Liver Center, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Hepatology 40:555-64. 2004
    ..In conclusion, P. acnes priming to selective TLR4-mediated liver injury is associated with up-regulation of TLR4 and MD-2 and is likely to involve IFN-gamma and prevent TLR4 desensitization by P. acnes...
  70. ncbi request reprint Acute alcohol inhibits the induction of nuclear regulatory factor kappa B activation through CD14/toll-like receptor 4, interleukin-1, and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation?
    Pranoti Mandrekar
    University of Massachusetts Medical School, Department of Medicine, Worcester 01605 2324, USA
    Alcohol Clin Exp Res 26:1609-14. 2002
    ..Here we investigated whether acute alcohol treatment of human monocytes also inhibits NF-kappaB when induced through activation of the interleukin (IL)-1 or tumor necrosis factor (TNF) receptors...
  71. ncbi request reprint FcgammaR cross-linking mediates NF-kappaB activation, reduced antigen presentation capacity, and decreased IL-12 production in monocytes without modulation of myeloid dendritic cell development
    Yvonne Drechsler
    Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605, USA
    J Leukoc Biol 72:657-67. 2002
    ..These results suggest that signals mediated via FcgammaRI, -II, and -III have overlapping yet distinct effects on MO, which are likely to be involved in the fine-tuning of the immune responses to various stimuli...
  72. ncbi request reprint RSA 2004: combined basic research satellite symposium - session two: toll-like receptors and organ damage
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Alcohol Clin Exp Res 29:1744-8. 2005
    ....
  73. ncbi request reprint Critical role of toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury
    Arumugam Velayudham
    Liver Center, Department of Medicine, University of Massachusetts Medical School, Plantation Street, Worcester, MA 01605, USA
    J Hepatol 45:813-24. 2006
    ..Toll-like receptors (TLR) recognize pathogens and regulate innate immune activation. Here, we investigated the roles of TLR9 and the common TLR adaptor, MyD88, in liver injury...
  74. ncbi request reprint Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes
    Oxana Norkina
    University of Massachusetts Medical School, Department of Medicine, LRB 215, 364 Plantation Street, Worcester, MA 01605, USA
    J Leukoc Biol 82:752-62. 2007
    ..Our data suggest that acute alcohol activates Src/STAT3 and Src/MAPK/STAT3, AP-1, and Sp-1 pathways as important mechanisms for IL-10-mediated immunomodulation after acute alcohol use...
  75. doi request reprint Bone marrow-derived immune cells mediate sensitization to liver injury in a myeloid differentiation factor 88-dependent fashion
    Istvan Hritz
    Department of Medicine, University of Massachusetts, Medical School, Worcester, MA 01605 2324, USA
    Hepatology 48:1342-7. 2008
    ..These results demonstrate that MyD88 in immune cells rather than in liver parenchymal cells plays an important role in inflammatory cell recruitment and liver injury...
  76. ncbi request reprint Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes
    Yvonne Drechsler
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    J Immunol 177:2592-600. 2006
    ..Thus, HO-1 activation is a key mediator of the anti-inflammatory effects of acute alcohol on monocytes...
  77. ncbi request reprint Distinct Toll-like receptor expression in monocytes and T cells in chronic HCV infection
    Angela Dolganiuc
    University of Massachusetts Medical School, Department of Medicine, 364 Plantation Street, Worcester, MA 01605 2324, United States
    World J Gastroenterol 12:1198-204. 2006
    ..Recent studies suggest that viral and bacterial infections are more common in HCV-infected patients compared to controls. Pathogens are recognized by Toll-like receptors (TLRs) to shape adaptive and innate immune responses...
  78. pmc Factors that determine the development and progression of gastroesophageal varices in patients with chronic hepatitis C
    Robert J Fontana
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0362, USA
    Gastroenterology 138:2321-31, 2331.e1-2. 2010
    ..We aimed to identify the incidence and predictors of de novo gastroesophageal variceal formation and progression in a large cohort of patients with chronic hepatitis C and advanced fibrosis...
  79. pmc VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice
    Arumugam Velayudham
    Department of Medicine, Liver Center, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Hepatology 49:989-97. 2009
    ..The mechanisms of VSL#3-mediated protection from MCD diet-induced liver fibrosis likely include modulation of collagen expression and impaired TGFbeta signaling...
  80. pmc Identification and characterization of broadly neutralizing human monoclonal antibodies directed against the E2 envelope glycoprotein of hepatitis C virus
    Teresa J Broering
    MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts 02130, USA
    J Virol 83:12473-82. 2009
    ....
  81. ncbi request reprint Intervention at the level of the neuroendocrine-immune axis and postoperative pneumonia rate in long-term alcoholics
    Claudia Spies
    Department of Anesthesiology and Intensive Care Medicine, Charite University Medicine Berlin, Campus Charité Virchow Klinikum and Campus Charité Mitte, Augustenburger Platz 1, 13353 Berlin, Germany
    Am J Respir Crit Care Med 174:408-14. 2006
    ..Long-term alcohol use leads to an altered perioperative hypothalamus-pituitary-adrenal (HPA) axis and immunity...
  82. ncbi request reprint Cytokines and alcohol
    Fulton T Crews
    Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 30:720-30. 2006
    ..Together these studies suggest that ethanol disruption of cytokines and inflammation contribute in multiple ways to a diversity of alcoholic pathologies...
  83. ncbi request reprint Hepatitis C virus NS5A protein--a master regulator?
    Gyongyi Szabo
    Gastroenterology 130:995-9. 2006
  84. ncbi request reprint Hepatitis C core protein - the "core" of immune deception?
    Gyongyi Szabo
    J Hepatol 48:8-11. 2008
  85. ncbi request reprint Modulation of immunity and viral-host interactions by alcohol
    Geoffrey M Thiele
    Department of Internal Medicine at the University of Nebraska Medical Center, Omaha VA Medical Center, Research Services 68105, USA
    Alcohol Clin Exp Res 26:1897-908. 2002
    ..Thiele; and (6) Mechanisms of impaired accessory cell functions due to alcohol exposure and hepatitis C infection, by Gyongyi Szabo...
  86. ncbi request reprint Hepatitis C virus infection--pathobiology and implications for new therapeutic options
    Gary L Davis
    4 Roberts, Hepatology, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75246, USA
    Dig Dis Sci 52:857-75. 2007
    ..This report summarizes each of the presentations sections...
  87. ncbi request reprint Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial
    Leonard B Seeff
    Division of Digestive Diseases and Nutrition, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hepatology 47:605-12. 2008
    ..Because its use among these HALT-C participants was self-motivated and uncontrolled, however, only a well-designed prospective study can determine whether silymarin provides benefit to persons with chronic hepatitis C...
  88. ncbi request reprint Acute and chronic alcohol abuse modulate immunity
    Lou Ann S Brown
    Department of Pediatrics, Emory University, Atlanta, Georgia, USA
    Alcohol Clin Exp Res 30:1624-31. 2006
    ..Nagy, and (8) Hepatitis C Virus Infection and Alcohol Use by Gyongyi Szabo. Meeting coorganizers were Elizabeth J. Kovacs, Lou Ann S. Brown, Thomas R. Jerrells, and Robert T. Cook...
  89. ncbi request reprint RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and death
    Gyongyi Szabo
    Thomas Jefferson University JBH, GH, Department of Pathology, Anatomy and Cell Biology, Philadelphia, PA 19107 6799, USA
    Alcohol Clin Exp Res 29:1749-52. 2005
    ....
  90. ncbi request reprint Severe cholestatic hepatitis caused by thiazolidinediones: risks associated with substituting rosiglitazone for troglitazone
    Herbert L Bonkovsky
    University of Massachusetts Medical School, Worcester 01655, USA
    Dig Dis Sci 47:1632-7. 2002
    ..It is important to monitor the serum alkaline phosphatase in addition to the serum aminotransferases in patients taking thiazolidinediones...

Research Grants42

  1. TLR4 Signaling in alcoholic liver disease
    Gyongyi Szabo; Fiscal Year: 2009
    ..Our results suggest that the absence of TLR4 but not of the MyD88 adaptor protects mice from alcoholic liver disease. ..
  2. ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSION
    Gyongyi Szabo; Fiscal Year: 2002
    ..These experiments will define monocyte alterations leading to the combined immunosuppressive effects of in vivo ethanol uptake and trauma. ..
  3. ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSION
    Gyongyi Szabo; Fiscal Year: 2003
    ..These experiments will define monocyte alterations leading to the combined immunosuppressive effects of in vivo ethanol uptake and trauma. ..
  4. Ethanols role in mediation of monocyte suppression
    Gyongyi Szabo; Fiscal Year: 2009
    ..Investigation of the modulation of IL-10 and IL-12 by alcohol in dendritic cell function may identify biomarkers of alcohol-induced immune depression and reveal potential targets for therapy. ..
  5. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2006
    ..abstract_text> ..
  6. Ethanols role in mediation of monocyte suppression
    Gyongyi Szabo; Fiscal Year: 2006
    ..Investigation of the modulation of IL-10 and IL-12 by alcohol in dendritic cell function may identify biomarkers of alcohol-induced immune depression and reveal potential targets for therapy. ..
  7. Hepatitis C Virus, Alcohol and Host Defense
    Gyongyi Szabo; Fiscal Year: 2007
    ..Results from these studies should reveal molecular and cellular mechanisms by which alcohol interacts with HCV infection to accelerate disease persistence and progression. ..
  8. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2009
    ....
  9. ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSION
    Gyongyi Szabo; Fiscal Year: 2001
    ..These experiments will define monocyte alterations leading to the combined immunosuppressive effects of in vivo ethanol uptake and trauma. ..
  10. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2001
    ..These studies should delineate the effect of in vivo acute alcohol on NF-kB signaling in monocytes relevant to inflammation, cirrhosis, atherosclerosis, and HIV infection. ..
  11. ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSION
    Gyongyi Szabo; Fiscal Year: 1999
    ..Results from these experiments will improve the understanding of the immunomodulatory effects of acute, moderate alcohol use in humans. ..
  12. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 1999
    ..These studies should delineate the effect of in vivo acute alcohol on NF-kB signaling in monocytes relevant to inflammation, cirrhosis, atherosclerosis, and HIV infection. ..
  13. ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSION
    Gyongyi Szabo; Fiscal Year: 2001
    ..These experiments will define monocyte alterations leading to the combined immunosuppressive effects of in vivo ethanol uptake and trauma. ..
  14. Ethanols role in mediation of monocyte suppression
    Gyongyi Szabo; Fiscal Year: 2007
    ..Investigation of the modulation of IL-10 and IL-12 by alcohol in dendritic cell function may identify biomarkers of alcohol-induced immune depression and reveal potential targets for therapy. ..
  15. Toll like receptor - Mediated pathways in liver injury
    Gyongyi Szabo; Fiscal Year: 2009
    ..Thus, our study may help to design new therapeutic approaches to prevent liver diseases with granulomas and to attenuate sensitization to liver injury caused by infectious pathogens. ..
  16. HCV, Alcohol and Host Defense
    Gyongyi Szabo; Fiscal Year: 2005
    ..Results from these studies should reveal molecular and cellular mechanisms by which alcohol interacts with HCV infection to accelerate disease persistence and progression. ..
  17. Toll like receptor - Mediated pathways in liver injury
    Gyongyi Szabo; Fiscal Year: 2010
    ..Thus, our study may help to design new therapeutic approaches to prevent liver diseases with granulomas and to attenuate sensitization to liver injury caused by infectious pathogens. ..
  18. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2010
    ....
  19. HCV, Alcohol and Host Defense
    Gyongyi Szabo; Fiscal Year: 2006
    ..Results from these studies should reveal molecular and cellular mechanisms by which alcohol interacts with HCV infection to accelerate disease persistence and progression. ..
  20. Ethanols role in mediation of monocyte suppression
    Gyongyi Szabo; Fiscal Year: 2007
    ..Investigation of the modulation of IL-10 and IL-12 by alcohol in dendritic cell function may identify biomarkers of alcohol-induced immune depression and reveal potential targets for therapy. ..
  21. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2003
    ..abstract_text> ..
  22. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2000
    ..These studies should delineate the effect of in vivo acute alcohol on NF-kB signaling in monocytes relevant to inflammation, cirrhosis, atherosclerosis, and HIV infection. ..
  23. Hepatitis C Virus, Alcohol and Host Defense
    Gyongyi Szabo; Fiscal Year: 2003
    ..Results from these studies should reveal molecular and cellular mechanisms by which alcohol interacts with HCV infection to accelerate disease persistence and progression. ..
  24. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2004
    ..abstract_text> ..
  25. HCV, Alcohol and Host Defense
    Gyongyi Szabo; Fiscal Year: 2004
    ..Results from these studies should reveal molecular and cellular mechanisms by which alcohol interacts with HCV infection to accelerate disease persistence and progression. ..
  26. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2005
    ..abstract_text> ..
  27. Ethanols role in mediation of monocyte suppression
    Gyongyi Szabo; Fiscal Year: 2005
    ..Investigation of the modulation of IL-10 and IL-12 by alcohol in dendritic cell function may identify biomarkers of alcohol-induced immune depression and reveal potential targets for therapy. ..
  28. Mechanisms of Alcohol Mediated Organ and Tissue Damage
    Gyongyi Szabo; Fiscal Year: 2005
    ..3. Increase the involvement of young investigators in the study of alcohol research. 4. Provide an educational forum to participants. ..
  29. ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSION
    Gyongyi Szabo; Fiscal Year: 2000
    ..These experiments will define monocyte alterations leading to the combined immunosuppressive effects of in vivo ethanol uptake and trauma. ..
  30. HCV, Alcohol and Host Defense
    Gyongyi Szabo; Fiscal Year: 2006
    ..Results from these studies should reveal molecular and cellular mechanisms by which alcohol interacts with HCV infection to accelerate disease persistence and progression. ..
  31. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2007
    ..abstract_text> ..
  32. TLR4 Signaling in alcoholic liver disease
    Gyongyi Szabo; Fiscal Year: 2010
    ..Our results suggest that the absence of TLR4 but not of the MyD88 adaptor protects mice from alcoholic liver disease. ..