J D Symons

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. doi request reprint Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide
    J David Symons
    College of Health, University of Utah, School of Medicine, Salt Lake City, UT, USA
    Rev Endocr Metab Disord 14:59-68. 2013
  2. ncbi request reprint Hyperhomocysteinemia increases arterial permeability and stiffness in mice
    Adam E Mullick
    Univ of Utah School of Medicine, Bldg 585, Rm 152, 30 N 2030 E, Salt Lake City, UT 84132 e mail
    Am J Physiol Regul Integr Comp Physiol 291:R1349-54. 2006
  3. pmc Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload
    J David Symons
    College of Health, and Univ of Utah School of Medicine, Bldg 585, Rm 168, 30 N 2030 E Salt Lake City, UT 84132, USA
    Am J Physiol Heart Circ Physiol 300:H374-81. 2011
  4. pmc Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure
    J David Symons
    College of Health, University of Utah School of Medicine, 30 N 2030 E, Salt Lake City, UT 84132, USA
    Circ Res 104:1085-94. 2009
  5. ncbi request reprint Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia
    J David Symons
    College of Health, University of Utah, Salt Lake City, Utah, USA
    Arterioscler Thromb Vasc Biol 26:814-8. 2006
  6. ncbi request reprint Vascular dysfunction produced by hyperhomocysteinemia is more severe in the presence of low folate
    J David Symons
    College of Health, Univ of Utah, Salt Lake City, UT, USA
    Am J Physiol Heart Circ Physiol 290:H181-91. 2006
  7. ncbi request reprint Improved coronary vascular function evoked by high-intensity treadmill training is maintained in arteries exposed to ischemia and reperfusion
    J David Symons
    University of Utah, College of Health, 250 S 1850 E Rm 241, Salt Lake City, UT 84112, USA
    J Appl Physiol 95:1638-47. 2003
  8. ncbi request reprint Hyperhomocysteinemia evoked by folate depletion: effects on coronary and carotid arterial function
    J David Symons
    College of Health, University of Utah, Salt Lake City, Utah 84112, USA
    Arterioscler Thromb Vasc Biol 22:772-80. 2002
  9. ncbi request reprint Volume overload left ventricular hypertrophy: effects on coronary microvascular reactivity in rabbits
    J D Symons
    Department of Internal Medicine, Division of Cardiovascular Medicine, University of California, TB 172, One Shields Avenue, Davis, CA 95616, USA
    Exp Physiol 86:725-32. 2001
  10. ncbi request reprint Microvascular and myocardial contractile responses to ischemia: influence of exercise training
    J D Symons
    Department of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis 95616, USA
    J Appl Physiol 88:433-42. 2000

Collaborators

Detail Information

Publications25

  1. doi request reprint Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide
    J David Symons
    College of Health, University of Utah, School of Medicine, Salt Lake City, UT, USA
    Rev Endocr Metab Disord 14:59-68. 2013
    ..This review will examine the contribution from elevated circulating fatty acids in these subjects that lead to lipotoxicity. Particular focus will be placed on the fatty acid metabolite ceramide...
  2. ncbi request reprint Hyperhomocysteinemia increases arterial permeability and stiffness in mice
    Adam E Mullick
    Univ of Utah School of Medicine, Bldg 585, Rm 152, 30 N 2030 E, Salt Lake City, UT 84132 e mail
    Am J Physiol Regul Integr Comp Physiol 291:R1349-54. 2006
    ..05) by simultaneous incubation with DEANO or tiron. Thus, acute HHcy increases arterial permeability by generating O2- to an extent whereby nitric oxide bioavailability is reduced...
  3. pmc Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload
    J David Symons
    College of Health, and Univ of Utah School of Medicine, Bldg 585, Rm 168, 30 N 2030 E Salt Lake City, UT 84132, USA
    Am J Physiol Heart Circ Physiol 300:H374-81. 2011
    ..g., increased eNOS transcript and protein) to maintain coronary endothelial function in the setting of pressure overload...
  4. pmc Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure
    J David Symons
    College of Health, University of Utah School of Medicine, 30 N 2030 E, Salt Lake City, UT 84132, USA
    Circ Res 104:1085-94. 2009
    ....
  5. ncbi request reprint Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia
    J David Symons
    College of Health, University of Utah, Salt Lake City, Utah, USA
    Arterioscler Thromb Vasc Biol 26:814-8. 2006
    ....
  6. ncbi request reprint Vascular dysfunction produced by hyperhomocysteinemia is more severe in the presence of low folate
    J David Symons
    College of Health, Univ of Utah, Salt Lake City, UT, USA
    Am J Physiol Heart Circ Physiol 290:H181-91. 2006
    ..We conclude that HHcy + LF evokes greater dysfunction than either HHcy alone (aortas, mesentery) or LF alone (aortas, mesentery, coronary), likely by producing more O2(-) within the vasculature and thereby reducing NO bioavailability...
  7. ncbi request reprint Improved coronary vascular function evoked by high-intensity treadmill training is maintained in arteries exposed to ischemia and reperfusion
    J David Symons
    University of Utah, College of Health, 250 S 1850 E Rm 241, Salt Lake City, UT 84112, USA
    J Appl Physiol 95:1638-47. 2003
    ..These findings suggest that Etr-evoked improvements in coronary function are maintained in small arteries even when exposed to ischemia and reperfusion...
  8. ncbi request reprint Hyperhomocysteinemia evoked by folate depletion: effects on coronary and carotid arterial function
    J David Symons
    College of Health, University of Utah, Salt Lake City, Utah 84112, USA
    Arterioscler Thromb Vasc Biol 22:772-80. 2002
    ..HHcy may produce these effects by a mechanism associated with increased oxidative and glycoxidative stress...
  9. ncbi request reprint Volume overload left ventricular hypertrophy: effects on coronary microvascular reactivity in rabbits
    J D Symons
    Department of Internal Medicine, Division of Cardiovascular Medicine, University of California, TB 172, One Shields Avenue, Davis, CA 95616, USA
    Exp Physiol 86:725-32. 2001
    ..These results indicate that while coronary resistance vessel function is similar between groups, our estimate of basal nitric oxide production is greater in vessels from LV hypertrophy than control rabbits...
  10. ncbi request reprint Microvascular and myocardial contractile responses to ischemia: influence of exercise training
    J D Symons
    Department of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis 95616, USA
    J Appl Physiol 88:433-42. 2000
    ..However, training did not preserve endothelial function of coronary resistance vessels, or myocardial contractile function, after ischemia and reperfusion...
  11. ncbi request reprint Regional blood flow responses to acute ANG II infusion: effects of nitric oxide synthase inhibition
    J D Symons
    Department of Internal Medicine, University of California, Davis 95616, USA
    J Cardiovasc Pharmacol 34:116-23. 1999
    ..Taken together, our results indicate that the ability of NO to oppose ANG II-induced constriction is not homogeneous among regional circulations...
  12. ncbi request reprint Na(+)/H(+) exchange subtype 1 inhibition reduces endothelial dysfunction in vessels from stunned myocardium
    J D Symons
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis 95616, USA
    Am J Physiol Heart Circ Physiol 281:H1575-82. 2001
    ..These findings suggest that NHE(1) inhibition before coronary occlusion lessens ischemia-induced microvascular dysfunction for 15-60 min after reperfusion but does not alter myocardial contractile function in the area at risk...
  13. pmc Distinct functions of vascular endothelial and smooth muscle PPARgamma in regulation of blood pressure and vascular tone
    Ningning Wang
    Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT 84132, USA
    Toxicol Pathol 37:21-7. 2009
    ..Our results demonstrated endothelium but not smooth muscle as the site for TZD-induced BP-lowering effect and also uncovered distinct functions of endothelial and smooth muscle PPARgamma in regulation of vascular tone...
  14. pmc Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases
    Quan Jiang Zhang
    College of Health, University of Utah, Salt Lake City, UT 84132, USA
    J Physiol 587:3911-20. 2009
    ..These findings indicate that Akt and AMPK contribute importantly to vascular eNOS S1177 phosphorylation during treadmill-running, and that AMPK is sufficient to activate p-eNOS S1177 in the presence of PI3K inhibition...
  15. ncbi request reprint Effects of red wine, alcohol, and quercetin on coronary resistance and conductance arteries
    S V Rendig
    Department of Internal Medicine, University of California, Davis, Sacramento 95817, USA
    J Cardiovasc Pharmacol 38:219-27. 2001
    ..Quercetin elicits marked coronary vasorelaxation that is endothelium-independent. However, the concentrations of quercetin necessary to achieve this action are not attained with moderate red wine consumption...
  16. ncbi request reprint Interactions between angiotensin II and nitric oxide during exercise in normal and heart failure rats
    J D Symons
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, California 95616, USA
    J Appl Physiol 87:574-81. 1999
    ..05) similarly in both groups by combined inhibition. These findings indicate that NO opposes ANG II-induced increases in arterial pressure and in renal and skeletal muscle resistance during dynamic exercise...
  17. ncbi request reprint Vasopressin contributes to the cardiovascular response to dynamic exercise
    C L Stebbins
    Department of Internal Medicine, University of California, Davis 95616
    Am J Physiol 264:H1701-7. 1993
    ..However, HR and myocardial contractile responses to exercise were not affected. These results suggest that vasopressin contributes to increases in MAP and to the redistribution of cardiac output during dynamic exercise in the miniswine...
  18. ncbi request reprint Reducing arginase activity via dietary manganese deficiency enhances endothelium-dependent vasorelaxation of rat aorta
    Jodi L Ensunsa
    Department of Nutrition, University of California at Davis, CA 95616, USA
    Exp Biol Med (Maywood) 229:1143-53. 2004
    ..These findings support our hypothesis that endothelium-dependent vasorelaxation is greater in aortic segments from rats that consume Mn- versus Mn+ diets; however, responses from small coronary arteries were unaffected...
  19. ncbi request reprint Effects of statins on myocardial and coronary artery response to ischemia-reperfusion
    Stephen V Rendig
    Department of Internal Medicine, University of California, Davis 95616, USA
    Can J Physiol Pharmacol 81:1064-71. 2003
    ....
  20. ncbi request reprint Endogenous prostaglandins limit angiotensin-II induced regional vasoconstriction in conscious rats
    Charles L Stebbins
    University of California, Department of Internal Medicine, Division of Cardiovascular Medicine, Davis, California 95616, USA
    J Cardiovasc Pharmacol 42:10-6. 2003
    ..Consequently, prostaglandins may limit vasoconstriction and potential ischemia caused by elevated levels of this hormone...
  21. doi request reprint Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1
    Ningning Wang
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Cell Metab 8:482-91. 2008
    ..These studies have uncovered a role for vascular PPARgamma as a peripheral factor participating in regulation of cardiovascular rhythms...
  22. ncbi request reprint A quercetin supplemented diet does not prevent cardiovascular complications in spontaneously hypertensive rats
    Justin Carlstrom
    College of Health, University of Utah, Salt Lake City, UT 84112, USA
    J Nutr 137:628-33. 2007
    ..02) and SHR (168 +/- 3, P < 0.001). These data suggest that mode of delivery is a critical determinant in whether quercetin provides cardiovascular benefits...
  23. ncbi request reprint Quercetin reduces blood pressure in hypertensive subjects
    Randi L Edwards
    Division of Nutrition, University of Utah, Salt Lake City, UT 84112, USA
    J Nutr 137:2405-11. 2007
    ..Contrary to animal-based studies, there was no quercetin-evoked reduction in systemic markers of oxidative stress...
  24. pmc Nitro-oleic acid protects the mouse kidney from ischemia and reperfusion injury
    Haiying Liu
    Department of Internal Medicine, University of Utah and Salt Lake Veteran Affairs Medical Center, 30 N 1900 E, Rm 4R312, Salt Lake City, UT 84132, USA
    Am J Physiol Renal Physiol 295:F942-9. 2008
    ..Together, delayed administration of nitrated fatty acid OA-NO2 attenuates renal I/R injury in the mouse likely via inhibition of the inflammatory response...
  25. pmc Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats
    Will Soesanto
    College of Health, University of Utah, Salt Lake City, UT 84112, USA
    Hypertension 54:1321-7. 2009
    ..These data show that mammalian target of rapamycin is required for the development of cardiac hypertrophy evoked by rising blood pressure in SHRs...