Research Topics
| Karen L SwisshelmSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
Antimetastatic gene expression profiles mediated by retinoic acid receptor beta 2 in MDA-MB-435 breast cancer cellsBrett Wallden
Department of Pathology, University of Washington, Box 357470, Seattle, WA, USA
BMC Cancer 5:140. 2005..We investigated both cultured cells and xenograft tumors in order to delineate the gene expression profiles responsible for an antimetastatic phenotype...- SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamilyK Swisshelm
Department of Pathology, University of Washington, Box 357470, Seattle WA 98195, USA
Gene 226:285-95. 1999.... - Role of claudins in tumorigenesisKaren Swisshelm
Department of Pathology, Box 357470, University of Washington, Seattle, WA 98195 7470, USA
Adv Drug Deliv Rev 57:919-28. 2005..Future goals include understanding the biochemical and physiological mechanisms that are perturbed as a consequence of CLDN alterations in the progression of solid tumors... - Retinoic acid receptor beta2 inhibition of metastasis in mouse mammary gland xenograftsPiper M Treuting
Department of Pathology, University of Washington, Seattle 98195, USA
Breast Cancer Res Treat 72:79-88. 2002..000001). Our findings suggest that RARbeta2 may play a role in inhibiting the metastatic cascade in a mouse mammary gland xenograft tumor model and is a potential candidate for therapeutic intervention in human breast cancer... - Truncated RAR beta isoform enhances proliferation and retinoid resistanceMari E Swift
Department of Pathology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
J Cell Physiol 209:718-25. 2006.... - Radiation cataracts: mechanisms involved in their long delayed occurrence but then rapid progressionNorman Wolf
Department of Pathology, University of Washington, Seattle, WA 98195 7475, USA
Mol Vis 14:274-85. 2008.... - Dickkopf-1 mediated tumor suppression in human breast carcinoma cellsAndrei M Mikheev
Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA
Breast Cancer Res Treat 112:263-73. 2008..Thus, our study supports the hypothesis that DKK-1 mediated tumor suppressor effect is independent of beta-catenin dependent transcription and identified the CamKII pathway that contributes into DKK-1 signaling... - Werner syndrome protein limits MYC-induced cellular senescenceCarla Grandori
Basic Sciences, Human Biology and Clinical Divisions, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Genes Dev 17:1569-74. 2003..We propose that WRN up-regulation by MYC may promote MYC-driven tumorigenesis by preventing cellular senescence... - Distinct patterns of mitochondrial changes precede induction of apoptosis by all-trans-retinoic acid and N-(4-hydroxyphenyl)retinamide in MCF7 breast cancer cellsMartin Poot
Department of Pathology, University of Washington, Seatle, Washington 98195 7705, USA
Exp Cell Res 279:128-40. 2002..We conclude that atRA and 4HPR induce apoptosis in MCF7 cells by two distinct and novel biochemical mechanisms... - Insulin-like growth factor binding protein-related protein 1 inhibits proliferation of MCF-7 breast cancer cells via a senescence-like mechanismHeather Marie P Wilson
Department of Pathology, University of Washington School of Medicine, Seattle 98195, USA
Cell Growth Differ 13:205-13. 2002..These findings indicate that IGFBP-rP1 is an inhibitor of MCF-7 breast cancer cell proliferation and may act via a cellular senescence-like mechanism... - Downstream codons in the retinoic acid receptor beta -2 and beta -4 mRNAs initiate translation of a protein isoform that disrupts retinoid-activated transcriptionLucinda I Chen
Department of Pathology, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 277:35411-21. 2002..This repression required the presence of acidic amino acids within the AF2 domain. These findings demonstrate an antagonistic role for RARbeta' in signaling by retinoic acid... - Functional link between Myc and the Werner gene in tumorigenesisCarla Grandori
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cell Cycle 3:22-5. 2004..In addition, we address the apparent paradox of why patients with WS, lacking WRN function, have increased incidence of certain cancers... - Cis-retinol dehydrogenase: 9-cis-retinol metabolism and its effect on proliferation of human MCF7 breast cancer cellsJisun Paik
Department of Pathobiology, University of Washington, Seattle, WA 98195, United States
Exp Cell Res 303:183-96. 2005..Our studies demonstrate that 9-cis-retinol in combination with cRDH inhibits breast cancer cell proliferation by production of retinol metabolites other than RA... - Werner syndrome gene variants in human sarcomasJessica J Hsu
Department of Pathology, The Gottstein Memorial Cancer Research Center, University of Washington, Seattle, Washington, USA
Mol Carcinog 49:166-74. 2010..We show that P204L WRN exhibits a reduction of WRN exonuclease activity; the specific activity is approximately 10-fold lower than that of wild-type WRN. In contrast, the helicase activity of P204L WRN is reduced less than twofold...
Research Grants
- RETINOIC ACID RECEPTOR BETA AND BREAST CANCERKaren Swisshelm; Fiscal Year: 2003..These studies will provide the cytological and molecular basis for enhancing potential novel retinoid-directed therapies for human breast carcinoma as well as the basis for RARbeta as a diagnostic or prognostic tool. ..