Karen L Swisshelm

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Antimetastatic gene expression profiles mediated by retinoic acid receptor beta 2 in MDA-MB-435 breast cancer cells
    Brett Wallden
    Department of Pathology, University of Washington, Box 357470, Seattle, WA, USA
    BMC Cancer 5:140. 2005
  2. ncbi request reprint SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamily
    K Swisshelm
    Department of Pathology, University of Washington, Box 357470, Seattle WA 98195, USA
    Gene 226:285-95. 1999
  3. ncbi request reprint Role of claudins in tumorigenesis
    Karen Swisshelm
    Department of Pathology, Box 357470, University of Washington, Seattle, WA 98195 7470, USA
    Adv Drug Deliv Rev 57:919-28. 2005
  4. ncbi request reprint Retinoic acid receptor beta2 inhibition of metastasis in mouse mammary gland xenografts
    Piper M Treuting
    Department of Pathology, University of Washington, Seattle 98195, USA
    Breast Cancer Res Treat 72:79-88. 2002
  5. ncbi request reprint Truncated RAR beta isoform enhances proliferation and retinoid resistance
    Mari E Swift
    Department of Pathology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    J Cell Physiol 209:718-25. 2006
  6. pmc Radiation cataracts: mechanisms involved in their long delayed occurrence but then rapid progression
    Norman Wolf
    Department of Pathology, University of Washington, Seattle, WA 98195 7475, USA
    Mol Vis 14:274-85. 2008
  7. ncbi request reprint Dickkopf-1 mediated tumor suppression in human breast carcinoma cells
    Andrei M Mikheev
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA
    Breast Cancer Res Treat 112:263-73. 2008
  8. pmc Werner syndrome protein limits MYC-induced cellular senescence
    Carla Grandori
    Basic Sciences, Human Biology and Clinical Divisions, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 17:1569-74. 2003
  9. ncbi request reprint Distinct patterns of mitochondrial changes precede induction of apoptosis by all-trans-retinoic acid and N-(4-hydroxyphenyl)retinamide in MCF7 breast cancer cells
    Martin Poot
    Department of Pathology, University of Washington, Seatle, Washington 98195 7705, USA
    Exp Cell Res 279:128-40. 2002
  10. ncbi request reprint Insulin-like growth factor binding protein-related protein 1 inhibits proliferation of MCF-7 breast cancer cells via a senescence-like mechanism
    Heather Marie P Wilson
    Department of Pathology, University of Washington School of Medicine, Seattle 98195, USA
    Cell Growth Differ 13:205-13. 2002

Research Grants

  1. RETINOIC ACID RECEPTOR BETA AND BREAST CANCER
    Karen Swisshelm; Fiscal Year: 2003

Collaborators

Detail Information

Publications14

  1. pmc Antimetastatic gene expression profiles mediated by retinoic acid receptor beta 2 in MDA-MB-435 breast cancer cells
    Brett Wallden
    Department of Pathology, University of Washington, Box 357470, Seattle, WA, USA
    BMC Cancer 5:140. 2005
    ..We investigated both cultured cells and xenograft tumors in order to delineate the gene expression profiles responsible for an antimetastatic phenotype...
  2. ncbi request reprint SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamily
    K Swisshelm
    Department of Pathology, University of Washington, Box 357470, Seattle WA 98195, USA
    Gene 226:285-95. 1999
    ....
  3. ncbi request reprint Role of claudins in tumorigenesis
    Karen Swisshelm
    Department of Pathology, Box 357470, University of Washington, Seattle, WA 98195 7470, USA
    Adv Drug Deliv Rev 57:919-28. 2005
    ..Future goals include understanding the biochemical and physiological mechanisms that are perturbed as a consequence of CLDN alterations in the progression of solid tumors...
  4. ncbi request reprint Retinoic acid receptor beta2 inhibition of metastasis in mouse mammary gland xenografts
    Piper M Treuting
    Department of Pathology, University of Washington, Seattle 98195, USA
    Breast Cancer Res Treat 72:79-88. 2002
    ..000001). Our findings suggest that RARbeta2 may play a role in inhibiting the metastatic cascade in a mouse mammary gland xenograft tumor model and is a potential candidate for therapeutic intervention in human breast cancer...
  5. ncbi request reprint Truncated RAR beta isoform enhances proliferation and retinoid resistance
    Mari E Swift
    Department of Pathology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    J Cell Physiol 209:718-25. 2006
    ....
  6. pmc Radiation cataracts: mechanisms involved in their long delayed occurrence but then rapid progression
    Norman Wolf
    Department of Pathology, University of Washington, Seattle, WA 98195 7475, USA
    Mol Vis 14:274-85. 2008
    ....
  7. ncbi request reprint Dickkopf-1 mediated tumor suppression in human breast carcinoma cells
    Andrei M Mikheev
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA
    Breast Cancer Res Treat 112:263-73. 2008
    ..Thus, our study supports the hypothesis that DKK-1 mediated tumor suppressor effect is independent of beta-catenin dependent transcription and identified the CamKII pathway that contributes into DKK-1 signaling...
  8. pmc Werner syndrome protein limits MYC-induced cellular senescence
    Carla Grandori
    Basic Sciences, Human Biology and Clinical Divisions, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 17:1569-74. 2003
    ..We propose that WRN up-regulation by MYC may promote MYC-driven tumorigenesis by preventing cellular senescence...
  9. ncbi request reprint Distinct patterns of mitochondrial changes precede induction of apoptosis by all-trans-retinoic acid and N-(4-hydroxyphenyl)retinamide in MCF7 breast cancer cells
    Martin Poot
    Department of Pathology, University of Washington, Seatle, Washington 98195 7705, USA
    Exp Cell Res 279:128-40. 2002
    ..We conclude that atRA and 4HPR induce apoptosis in MCF7 cells by two distinct and novel biochemical mechanisms...
  10. ncbi request reprint Insulin-like growth factor binding protein-related protein 1 inhibits proliferation of MCF-7 breast cancer cells via a senescence-like mechanism
    Heather Marie P Wilson
    Department of Pathology, University of Washington School of Medicine, Seattle 98195, USA
    Cell Growth Differ 13:205-13. 2002
    ..These findings indicate that IGFBP-rP1 is an inhibitor of MCF-7 breast cancer cell proliferation and may act via a cellular senescence-like mechanism...
  11. ncbi request reprint Downstream codons in the retinoic acid receptor beta -2 and beta -4 mRNAs initiate translation of a protein isoform that disrupts retinoid-activated transcription
    Lucinda I Chen
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 277:35411-21. 2002
    ..This repression required the presence of acidic amino acids within the AF2 domain. These findings demonstrate an antagonistic role for RARbeta' in signaling by retinoic acid...
  12. ncbi request reprint Functional link between Myc and the Werner gene in tumorigenesis
    Carla Grandori
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cell Cycle 3:22-5. 2004
    ..In addition, we address the apparent paradox of why patients with WS, lacking WRN function, have increased incidence of certain cancers...
  13. ncbi request reprint Cis-retinol dehydrogenase: 9-cis-retinol metabolism and its effect on proliferation of human MCF7 breast cancer cells
    Jisun Paik
    Department of Pathobiology, University of Washington, Seattle, WA 98195, United States
    Exp Cell Res 303:183-96. 2005
    ..Our studies demonstrate that 9-cis-retinol in combination with cRDH inhibits breast cancer cell proliferation by production of retinol metabolites other than RA...
  14. pmc Werner syndrome gene variants in human sarcomas
    Jessica J Hsu
    Department of Pathology, The Gottstein Memorial Cancer Research Center, University of Washington, Seattle, Washington, USA
    Mol Carcinog 49:166-74. 2010
    ..We show that P204L WRN exhibits a reduction of WRN exonuclease activity; the specific activity is approximately 10-fold lower than that of wild-type WRN. In contrast, the helicase activity of P204L WRN is reduced less than twofold...

Research Grants5

  1. RETINOIC ACID RECEPTOR BETA AND BREAST CANCER
    Karen Swisshelm; Fiscal Year: 2003
    ..These studies will provide the cytological and molecular basis for enhancing potential novel retinoid-directed therapies for human breast carcinoma as well as the basis for RARbeta as a diagnostic or prognostic tool. ..