Affiliation: University of Nebraska Medical Center
- Predictive value of HIV-1 viral load on risk for opportunistic infectionSusan Swindells
University of Nebraska Medical Center, Omaha 68198 5400, USA
J Acquir Immune Defic Syndr 30:154-8. 2002....
- Lower CD4 cell count and higher virus load, but not antiretroviral drug resistance, are associated with AIDS-defining events and mortality: an ACTG Longitudinal Linked Randomized Trials (ALLRT) analysisSusan Swindells
University of Nebraska Medical Center, Omaha, NE, USA
HIV Clin Trials 12:79-88. 2011..We hypothesized that drug resistance mutations would impact clinical outcomes associated with HIV-1 infection...
- Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253S Swindells
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 8106, USA
Int J Tuberc Lung Dis 17:532-9. 2013..Improved tuberculosis (TB) screening is urgently needed for human immunodeficiency virus (HIV) infected patients...
- Regimen simplification to atazanavir-ritonavir alone as maintenance antiretroviral therapy after sustained virologic suppressionSusan Swindells
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
JAMA 296:806-14. 2006..Maintenance therapy with ritonavir-boosted atazanavir alone is a possible option because of low pill burden, once-daily dosing, safety, and unique resistance profile...
- Abacavir, efavirenz, didanosine, with or without hydroxyurea, in HIV-infected adults failing initial nucleoside/protease inhibitor-containing regimensSusan Swindells
HIV Clinic, University of Nebraska Medical Center, Omaha, NE, USA
BMC Infect Dis 5:23. 2005....
- Measurement of plasma and intracellular concentrations of raltegravir in patients with HIV infectionUriel Sandkovsky
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
AIDS 26:2257-9. 2012..i.d. group. Lower plasma and intracellular concentrations may contribute to inferior virologic suppression rates observed with once daily raltegravir dosing...
- Impact of race/ethnicity on survival among HIV-infected patients in careGregory Lopez
University of Nebraska Medical Center, USA
J Health Care Poor Underserved 20:982-95. 2009..To determine the prognostic influence of race/ethnicity on survival among patients infected with HIV infection...
- Development of a rapid autopsy program for studies of brain immunityAnuja Ghorpade
Laboratory of Cellular Neuroimmunology, 985215 Nebraska Medical Center, Omaha, NE, 68198 5215, USA
J Neuroimmunol 163:135-44. 2005..The challenges in developing this initiative, reflecting experiences from 69 autopsies over 4 years, are presented...
- The effect of HIV protease inhibitors on amyloid-β peptide degradation and synthesis in human cells and Alzheimer's disease animal modelXiqian Lan
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
J Neuroimmune Pharmacol 7:412-23. 2012..These data demonstrated that ART drugs can inhibit Aβ clearance in macrophages and Aβ production in neurons, but these effects did not significantly alter Aβ accumulation in the mouse brain...
- Clinical evaluation of a dried blood spot assay for atazanavirTrevor Van Schooneveld
Department of Internal Medicine, Section of Infectious Diseases, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198 4031, USA
Antimicrob Agents Chemother 54:4124-8. 2010..DBS use offers a convenient alternative for measuring plasma concentrations of ATV and may have utility in monitoring of drug concentrations in clinical practice and in future studies...
- Clinical utility of interferon gamma assay in the diagnosis of tuberculosisMiguel G Madariaga
HIV Clinic, Section of Infectious Diseases, University of Nebraska Medical Center, Omaha NE 68198, USA
J Am Board Fam Med 20:540-7. 2007..This study discusses the potential benefits and drawbacks in patients, including those who are immunocompromised...
- Acceptable plasma concentrations of raltegravir and etravirine when administered by gastrostomy tube in a patient with advanced multidrug-resistant human immunodeficiency virus infectionUriel Sandkovsky
Division of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 8106, USA
Pharmacotherapy 32:142-7. 2012..To determine whether the absorption of four antiretroviral agents-raltegravir, etravirine, emtricitabine, and tenofovir-is compromised when administered by gastrostomy tube...
- Racial/ethnic differences in CD4 T cell count and viral load at presentation for medical care and in follow-up after HIV-1 infectionSusan Swindells
Department of Internal Medicine, Universitsity of Nebraska Medical Center, Omaha, NE, USA
AIDS 16:1832-4. 2002..08), who were also more likely to present with major opportunistic infections (P < 0.004). Once in care, changes in CD4 T cell counts and viral loads over time did not differ significantly between groups...
- Neuroinflammatory responses from microglia recovered from HIV-1-infected and seronegative subjectsAnuja Ghorpade
Laboratory of Cellular Neuroimmunology, 985215 Nebraska Medical Center, Omaha, NE, 68198 5215, USA
J Neuroimmunol 163:145-56. 2005..Monocytes from seronegative donors paralleled these diminished immune responses following repeated LPS-activation. These results demonstrate changes in innate microglial function following viral infection or chronic immune activation...
- Extensively drug-resistant tuberculosisMiguel G Madariaga
Section of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE 68198 8106, USA
Am J Med 121:835-44. 2008..Infection control measures do not differ from those used for susceptible cases but may require more stringent application...
- Malacoplakia of the cranium and cerebrum in a human immunodeficiency virus-infected man. Case reportEdna Toubes-Klingler
Department of Internal Medicine Section of Infectious Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 5400, USA
J Neurosurg 104:432-5. 2006..A complete resection of the lesion, antibiotic therapy, and treatment of his underlying HIV infection had a salutary effect, with the patient faring well more than 9 months postoperatively...
- HIV education needs among Sudanese immigrants and refugees in the Midwestern United StatesMarc Tompkins
College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-5400, USA
AIDS Behav 10:319-23. 2006..Appropriate educational materials are lacking, and there is a pressing need for improved access to culturally appropriate HIV education for this vulnerable population...
- Subgroup analyses of maraviroc in previously treated R5 HIV-1 infectionGerd Fatkenheuer
Universitätsklinik Köln, Cologne, Germany
N Engl J Med 359:1442-55. 2008....
- Maraviroc for previously treated patients with R5 HIV-1 infectionRoy M Gulick
Weill Cornell Medical College, New York, NY 10065, USA
N Engl J Med 359:1429-41. 2008..CC chemokine receptor 5 antagonists are a new class of antiretroviral agents...
- Randomized controlled study of tenofovir and adefovir in chronic hepatitis B virus and HIV infection: ACTG A5127Marion G Peters
University of California, San Francisco, San Francisco, CA, USA
Hepatology 44:1110-6. 2006..In conclusion, over 48 weeks, treatment with either ADV or TDF resulted in clinically important suppression of serum HBV DNA. Both drugs are safe and efficacious for patients coinfected with HBV and HIV...
- Class-sparing regimens for initial treatment of HIV-1 infectionSharon A Riddler
University of Pittsburgh, Pittsburgh, USA
N Engl J Med 358:2095-106. 2008..The alternative regimen of lopinavir-ritonavir plus efavirenz may prevent toxic effects associated with NRTIs...
- Potential risks and benefits of HIV treatment simplification: a simulation model of a proposed clinical trialBruce R Schackman
Department of Public Health, Weill Cornell Medical College, New York, NY 10021, USA
Clin Infect Dis 45:1062-70. 2007..We projected the long-term outcomes of this treatment simplification strategy to inform the design of a proposed multicenter, randomized clinical trial...
- Discrepant results of 2 screening tests for anti-HIV antibodyDouglas F Stickle
Clin Infect Dis 35:773-4; author reply 774-5. 2002
- Alendronate with calcium and vitamin D supplementation is safe and effective for the treatment of decreased bone mineral density in HIVGrace A McComsey
Rainbow Babies and Children s Hospital and Case Western Reserve University, Cleveland, Ohio, USA
AIDS 21:2473-82. 2007..Bisphosphonates are currently the mainstay of treatment for postmenopausal and male osteoporosis in HIV-uninfected individuals; however, their efficacy and safety in HIV-infected patients remains unclear...
- Oxazolidinones and human immunodeficiency virusMiguel G Madariaga
Antimicrob Agents Chemother 51:1130; author reply 1130. 2007
- HIV-1-associated dementia: a basic science and clinical perspectiveThomas S Diesing
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
AIDS Read 12:358-68. 2002..Improvements in antiretroviral and adjunctive therapies have decreased HAD incidence, but cognitive dysfunction remains a cause of morbidity in many infected persons...
- Stabilization of white blood cells and immunologic markers for extended analysis using flow cytometryDominic E Warrino
Streck, 7002 S. 109th Street, Omaha, NE 68128, United States
J Immunol Methods 305:107-19. 2005..96 or greater) from samples collected in K3EDTA tubes and tested at 6 h. We conclude that whole blood samples collected in Cyto-Chex BCT are stabilized for their marker phenotype for at least 7 days after phlebotomy...
- Fragility fractures in HIV-infected patients: need for better understanding of diagnosis and managementGrace A McComsey
Case Western Reserve University, Cleveland, OH, USA
J Int Assoc Physicians AIDS Care (Chic) 3:86-91. 2004..In HIV and ART, osteopenia and osteoporosis are multifactorial, and health promotion or medical health maintenance should anticipate and prevent morbidity of bone fragility fractures...