William R Swindell

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Integrative RNA-seq and microarray data analysis reveals GC content and gene length biases in the psoriasis transcriptome
    William R Swindell
    Department of Dermatology, University of Michigan School of Medicine, Ann Arbor, Michigan
    Physiol Genomics 46:533-46. 2014
  2. pmc Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era
    William R Swindell
    Department of Dermatology, University of Michigan School of Medicine, Ann Arbor, MI 48109 2200, USA
    BMC Med Genomics 7:27. 2014
  3. pmc Dissecting the psoriasis transcriptome: inflammatory- and cytokine-driven gene expression in lesions from 163 patients
    William R Swindell
    Department of Dermatology, University of Michigan School of Medicine, Ann Arbor, MI 48109 2200, USA
    BMC Genomics 14:527. 2013
  4. pmc Robust shifts in S100a9 expression with aging: a novel mechanism for chronic inflammation
    William R Swindell
    Department of Dermatology, University of Michigan School of Medicine, Ann Arbor, MI 48109 2200, USA
    Sci Rep 3:1215. 2013
  5. pmc Indicators of "healthy aging" in older women (65-69 years of age). A data-mining approach based on prediction of long-term survival
    William R Swindell
    Department of Pathology, University of Michigan, School of Medicine, Ann Arbor, MI 48109 2200, USA
    BMC Geriatr 10:55. 2010
  6. pmc In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene
    William R Swindell
    University of Michigan, Department of Pathology and Geriatrics Center, Ann Arbor, MI 48109 2200, USA
    Exp Gerontol 45:366-74. 2010
  7. pmc Heat shock proteins in long-lived worms and mice with insulin/insulin-like signaling mutations
    William R Swindell
    University of Michigan, Departments of Pathology and Geriatrics, Ann Arbor MI 48109, USA
    Aging (Albany NY) 1:573-7. 2009
  8. pmc Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse
    William R Swindell
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    BMC Genomics 10:585. 2009
  9. pmc Accelerated failure time models provide a useful statistical framework for aging research
    William R Swindell
    Departments of Pathology and Geriatrics, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Exp Gerontol 44:190-200. 2009
  10. pmc How long will my mouse live? Machine learning approaches for prediction of mouse life span
    William R Swindell
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 63:895-906. 2008

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Integrative RNA-seq and microarray data analysis reveals GC content and gene length biases in the psoriasis transcriptome
    William R Swindell
    Department of Dermatology, University of Michigan School of Medicine, Ann Arbor, Michigan
    Physiol Genomics 46:533-46. 2014
    ..Our results also highlight factors affecting correspondence between technologies, and we have established that gene length is a major determinant of differential expression in psoriasis lesions. ..
  2. pmc Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era
    William R Swindell
    Department of Dermatology, University of Michigan School of Medicine, Ann Arbor, MI 48109 2200, USA
    BMC Med Genomics 7:27. 2014
    ..For many identified genes, however, the cell type mediating disease activity is uncertain, which has limited our ability to design gene functional studies based on genomic findings...
  3. pmc Dissecting the psoriasis transcriptome: inflammatory- and cytokine-driven gene expression in lesions from 163 patients
    William R Swindell
    Department of Dermatology, University of Michigan School of Medicine, Ann Arbor, MI 48109 2200, USA
    BMC Genomics 14:527. 2013
    ..Our aims were to identify mechanisms that drive differential expression and to characterize heterogeneity among lesions in this large sample...
  4. pmc Robust shifts in S100a9 expression with aging: a novel mechanism for chronic inflammation
    William R Swindell
    Department of Dermatology, University of Michigan School of Medicine, Ann Arbor, MI 48109 2200, USA
    Sci Rep 3:1215. 2013
    ..1. Sparse occurrence of SATB1 motifs was also a strong predictor of S100a9 coexpression. These findings offer support for a novel mechanism by which a SPI1/PU.1-S100a9 axis sustains chronic inflammation during aging...
  5. pmc Indicators of "healthy aging" in older women (65-69 years of age). A data-mining approach based on prediction of long-term survival
    William R Swindell
    Department of Pathology, University of Michigan, School of Medicine, Ann Arbor, MI 48109 2200, USA
    BMC Geriatr 10:55. 2010
    ..The aims of this study were to identify predictors of long-term survival in older women and to develop a multivariable model based upon longitudinal data from the Study of Osteoporotic Fractures (SOF)...
  6. pmc In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene
    William R Swindell
    University of Michigan, Department of Pathology and Geriatrics Center, Ann Arbor, MI 48109 2200, USA
    Exp Gerontol 45:366-74. 2010
    ....
  7. pmc Heat shock proteins in long-lived worms and mice with insulin/insulin-like signaling mutations
    William R Swindell
    University of Michigan, Departments of Pathology and Geriatrics, Ann Arbor MI 48109, USA
    Aging (Albany NY) 1:573-7. 2009
    ..elegans daf-2 mutants. This result, in combination with other recent findings, underscores the possibility that systemic overexpression of chaperones will have dissimilar effects on longevity in vertebrate and invertebrate systems...
  8. pmc Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse
    William R Swindell
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    BMC Genomics 10:585. 2009
    ..Furthermore, CR is thought to oppose age-associated gene expression patterns, but detailed statistical investigations of this hypothesis have not been carried out...
  9. pmc Accelerated failure time models provide a useful statistical framework for aging research
    William R Swindell
    Departments of Pathology and Geriatrics, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Exp Gerontol 44:190-200. 2009
    ..In addition, from the standpoint of aging research, these statistical approaches have appealing properties and provide valuable tools for the analysis of survivorship data...
  10. pmc How long will my mouse live? Machine learning approaches for prediction of mouse life span
    William R Swindell
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 63:895-906. 2008
    ..Future work in this direction can provide tools for aging research and will shed light on associations between phenotypic traits and longevity...
  11. pmc Genes regulated by caloric restriction have unique roles within transcriptional networks
    William R Swindell
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Mech Ageing Dev 129:580-92. 2008
    ..These findings contribute to a systems-level picture of how CR influences transcription within mammalian cells, and point towards a comprehensive understanding of CR in terms of its influence on biological networks...
  12. pmc Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms
    Bingshan Li
    1 Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, USA 2 Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
    J Invest Dermatol 134:1828-38. 2014
    ..These results show the power of WGCNA to elucidate gene regulatory circuits in psoriasis, and emphasize the influence of tissue architecture in both differential expression and coexpression analysis. ..
  13. pmc Modulation of epidermal transcription circuits in psoriasis: new links between inflammation and hyperproliferation
    William R Swindell
    Department of Dermatology, University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e79253. 2013
    ..Pathway analysis, however, is complicated by the fact that expression profiles have been derived from bulk skin biopsies with RNA derived from multiple cell types...
  14. pmc Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice
    William R Swindell
    University of Michigan, Department of Pathology and Geriatrics Center, Ann Arbor, MI 48109 2200, USA
    Mech Ageing Dev 130:393-400. 2009
    ..Contributions of chaperones to longevity in mice may be more complex than those inferred from C. elegans...
  15. pmc Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis
    Andrew Johnston
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
    Hum Mol Genet 22:1807-15. 2013
    ....
  16. pmc Alteration of the EphA2/Ephrin-A signaling axis in psoriatic epidermis
    Kristin Gordon
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Invest Dermatol 133:712-22. 2013
    ..These findings suggest that ephrin-A1-mediated downregulation of EphA2 supports keratinocyte differentiation in the context of cytokine perturbation...
  17. pmc Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues
    William R Swindell
    Department of Pathology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48103, United States
    Mech Ageing Dev 129:138-53. 2008
    ..These analyses shed light on the systemic transcriptional activity associated with CR diets, and also illustrate new approaches for comparative analysis of microarray datasets in the context of aging biology...
  18. pmc Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging
    William R Swindell
    Department of Pathology, University of Michigan, 3118 BSRB, Ann Arbor, MI, USA
    BMC Genomics 8:353. 2007
    ..Points of overlap with the effects of calorie restriction (CR), CR mimetic compounds, low fat diets, gender dimorphism and aging were also examined...
  19. pmc Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
    Kevin J Pearson
    Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Cell Metab 8:157-68. 2008
    ..Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife...
  20. pmc Transcriptional profiling of Arabidopsis heat shock proteins and transcription factors reveals extensive overlap between heat and non-heat stress response pathways
    William R Swindell
    Department of Statistics and Probability, Michigan State University, East Lansing, MI 48824, USA
    BMC Genomics 8:125. 2007
    ....
  21. pmc Inbreeding depression and male survivorship in Drosophila: implications for senescence theory
    William R Swindell
    Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA
    Genetics 172:317-27. 2006
    ..These findings provide insights into the genetic basis of longevity as a quantitative trait and have implications regarding the mutation-accumulation evolutionary explanation of senescence...