Russell Swerdlow

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. pmc Glycolysis-respiration relationships in a neuroblastoma cell line
    Russell H Swerdlow
    Department of Neurology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    Biochim Biophys Acta 1830:2891-8. 2013
  2. pmc Effect of exercise on mouse liver and brain bioenergetic infrastructures
    Lezi E
    Department of Physical Therapy and Rehabilitation Sciences, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Exp Physiol 98:207-19. 2013
  3. pmc Alzheimer's disease pathologic cascades: who comes first, what drives what
    Russell H Swerdlow
    Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Neurotox Res 22:182-94. 2012
  4. pmc Mitochondria and cell bioenergetics: increasingly recognized components and a possible etiologic cause of Alzheimer's disease
    Russell H Swerdlow
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA
    Antioxid Redox Signal 16:1434-55. 2012
  5. pmc Does mitochondrial DNA play a role in Parkinson's disease? A review of cybrid and other supportive evidence
    Russell H Swerdlow
    Departments of Neurology, Biochemistry and Molecular Biology, and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA
    Antioxid Redox Signal 16:950-64. 2012
  6. pmc Role and treatment of mitochondrial DNA-related mitochondrial dysfunction in sporadic neurodegenerative diseases
    Russell H Swerdlow
    Department of Neurology, University of Kansas School of Medicine, Kansas City, 66160, USA
    Curr Pharm Des 17:3356-73. 2011
  7. pmc The Alzheimer's disease mitochondrial cascade hypothesis: an update
    Russell H Swerdlow
    Department of Neurology, University of Kansas School of Medicine, Kansas City, USA
    Exp Neurol 218:308-15. 2009
  8. pmc The neurodegenerative mitochondriopathies
    Russell H Swerdlow
    Department of Neurology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    J Alzheimers Dis 17:737-51. 2009
  9. pmc PET sheds light on Alzheimer's disease genetic risk
    Russell H Swerdlow
    Departments of Neurology and Molecular and Integrative Physiology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    Proc Natl Acad Sci U S A 104:18881-2. 2007
  10. doi request reprint Autosomal dominant subcortical gliosis presenting as frontotemporal dementia
    R H Swerdlow
    University of Kansas School of Medicine, Landon Center on Aging, MS 2012, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Neurology 72:260-7. 2009

Research Grants

  1. Cytochrome Oxidase Polymorphisms in Aging
    Russell Swerdlow; Fiscal Year: 2007

Collaborators

  • Jeffrey Burns
  • Shaharyar M Khan
  • Isaac G Onyango
  • R A Honea
  • Eric D Vidoni
  • STEPHEN JOHN KISH
  • W M Brooks
  • B B Worrall
  • JAMES PEPPER BENNETT
  • David K Johnson
  • W Davis Parker
  • Lezi E
  • Sandra M Cardoso
  • Jianghua Lu
  • Anisha A Gupte
  • Diana Berry
  • Sangeeta Ghosh
  • Teresa Cunha-Oliveira
  • Kai Xuan Wang
  • Daniel R Binder
  • Patricia A Trimmer
  • Matthew J Barrett
  • Mariana Rodova
  • Adam Crafter
  • Raquel Esteves
  • JOSEPH FONTES
  • Kaixuan Wang
  • Matthew Barrett
  • Paige C Geiger
  • Gregory L Bomhoff
  • Janice K Parks
  • Sina Sadeghi
  • Geoffrey Horwitz
  • Douglas Rahn
  • Nishant Patel
  • Jenna McAllister
  • Catarina R de Oliveira
  • Fernanda Borges
  • A Cristina Rego
  • Tice Macedo
  • William H Dunn
  • Jatanna Almeida
  • Janice P Parks
  • M Kate Borland
  • Catarina R Oliveira
  • Lien Phan
  • Isabel Santana
  • Vinessa Alones
  • Paula M Keeney
  • Frederic A Simon

Detail Information

Publications35

  1. pmc Glycolysis-respiration relationships in a neuroblastoma cell line
    Russell H Swerdlow
    Department of Neurology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    Biochim Biophys Acta 1830:2891-8. 2013
    ..Although some reciprocal glycolysis-respiration relationships are well recognized, the relationship between reduced glycolysis flux and mitochondrial respiration has not been critically characterized...
  2. pmc Effect of exercise on mouse liver and brain bioenergetic infrastructures
    Lezi E
    Department of Physical Therapy and Rehabilitation Sciences, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Exp Physiol 98:207-19. 2013
    ..Also, it appears that, at least in the liver, a dissociated mitochondrial biogenesis, in which some components are strategically enhanced while others are minimized, can occur...
  3. pmc Alzheimer's disease pathologic cascades: who comes first, what drives what
    Russell H Swerdlow
    Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Neurotox Res 22:182-94. 2012
    ..It is important to accurately define the AD pathology hierarchy because treatments targeting the true apex of its pathologic cascade arguably have the best chance of preventing, mitigating, or even curing this disease...
  4. pmc Mitochondria and cell bioenergetics: increasingly recognized components and a possible etiologic cause of Alzheimer's disease
    Russell H Swerdlow
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA
    Antioxid Redox Signal 16:1434-55. 2012
    ..Mitochondria and brain bioenergetics are increasingly thought to play an important role in Alzheimer's disease (AD)...
  5. pmc Does mitochondrial DNA play a role in Parkinson's disease? A review of cybrid and other supportive evidence
    Russell H Swerdlow
    Departments of Neurology, Biochemistry and Molecular Biology, and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA
    Antioxid Redox Signal 16:950-64. 2012
    ..Mitochondria are currently believed to play an important role in the neurodysfunction and neurodegeneration that underlie Parkinson's disease (PD)...
  6. pmc Role and treatment of mitochondrial DNA-related mitochondrial dysfunction in sporadic neurodegenerative diseases
    Russell H Swerdlow
    Department of Neurology, University of Kansas School of Medicine, Kansas City, 66160, USA
    Curr Pharm Des 17:3356-73. 2011
    ..Approaches for manipulating mitochondrial function and minimizing the downstream consequences of mitochondrial dysfunction are discussed...
  7. pmc The Alzheimer's disease mitochondrial cascade hypothesis: an update
    Russell H Swerdlow
    Department of Neurology, University of Kansas School of Medicine, Kansas City, USA
    Exp Neurol 218:308-15. 2009
    ..We now review the reasoning used to formulate the hypothesis, discuss pertinent interim data, and update its tenants. Readers are invited to consider the conceptual strengths and weaknesses of this hypothesis...
  8. pmc The neurodegenerative mitochondriopathies
    Russell H Swerdlow
    Department of Neurology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    J Alzheimers Dis 17:737-51. 2009
    ....
  9. pmc PET sheds light on Alzheimer's disease genetic risk
    Russell H Swerdlow
    Departments of Neurology and Molecular and Integrative Physiology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    Proc Natl Acad Sci U S A 104:18881-2. 2007
  10. doi request reprint Autosomal dominant subcortical gliosis presenting as frontotemporal dementia
    R H Swerdlow
    University of Kansas School of Medicine, Landon Center on Aging, MS 2012, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Neurology 72:260-7. 2009
    ..To describe a multigenerational kindred with a frontotemporal dementia clinical syndrome (FTDS), extensive subcortical gliosis pathology, and autosomal dominant genetics...
  11. pmc The Alzheimer's disease mitochondrial cascade hypothesis
    Russell H Swerdlow
    Departments of Neurology and Molecular and Integrative Physiology, University of Kansas School of Medicine, Kansas City, KS, USA
    J Alzheimers Dis 20:S265-79. 2010
    ..Even if the mitochondrial cascade hypothesis proves incorrect, considering its assumptions could potentially advance our understanding of sporadic, late-onset AD...
  12. pmc Brain aging, Alzheimer's disease, and mitochondria
    Russell H Swerdlow
    Department of Neurology, University of Kansas School of Medicine, Kansas City, KS, USA
    Biochim Biophys Acta 1812:1630-9. 2011
    ....
  13. doi request reprint Nerve growth factor attenuates oxidant-induced β-amyloid neurotoxicity in sporadic Alzheimer's disease cybrids
    Isaac G Onyango
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA
    J Neurochem 114:1605-18. 2010
    ....
  14. doi request reprint Regulation of neuron mitochondrial biogenesis and relevance to brain health
    Isaac G Onyango
    Department of Neurology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    Biochim Biophys Acta 1802:228-34. 2010
    ..We review data pertinent to the mitochondrial biogenesis field, and discuss implications for brain aging and neurodegenerative disease research efforts...
  15. pmc Pathogenesis of Alzheimer's disease
    Russell H Swerdlow
    Department of Neurology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Clin Interv Aging 2:347-59. 2007
    ..In doing so, it focuses on clinical and molecular relationships between AD and aging. A better understanding of these relationships could inform and impact future development of AD-directed treatment strategies...
  16. pmc Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease
    Robyn A Honea
    Department of Neurology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    Neurology 76:822-9. 2011
    ..This longitudinal brain imaging study examines whether there are differential patterns of regional gray matter atrophy in cognitively healthy elderly subjects with (FH+) and without (FH-) a family history of late-onset AD...
  17. ncbi request reprint A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease
    Russell H Swerdlow
    Department of Neurology, McKim Hall, University of Virginia Health System, PO Box 800394, 1 Hospital Drive, Charlottesville, VA, USA
    Med Hypotheses 63:8-20. 2004
    ....
  18. pmc Reduced lean mass in early Alzheimer disease and its association with brain atrophy
    Jeffrey M Burns
    Department of Neurology, University of Kansas School of Medicine, 3599 Rainbow Blvd, Kansas City, KS 66160, USA
    Arch Neurol 67:428-33. 2010
    ..To examine body composition in individuals with early AD and without dementia and its relation to cognition and brain volume...
  19. ncbi request reprint Mitochondria in Alzheimer's disease
    Russell H Swerdlow
    Department of Neurology, University of Virginia, Charlottesville, Virginia 22908, USA
    Int Rev Neurobiol 53:341-85. 2002
  20. pmc Complex I deficiency in Parkinson's disease frontal cortex
    W Davis Parker
    Department of Neurology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Brain Res 1189:215-8. 2008
    ..Complex I deficiency in PD brain is not confined to substantia nigra. Methodological issues are critical in demonstrating this loss of activity...
  21. pmc Complex I polymorphisms, bigenomic heterogeneity, and family history in Virginians with Parkinson's disease
    Russell H Swerdlow
    Department of Neurology, 800394, University of Virginia Health System, McKim Hall, 1 Hospital Drive, Charlottesville, VA 22908, USA
    J Neurol Sci 247:224-30. 2006
    ..Complex I compound genotype variation commonly occurs and may explain why particular complex I gene polymorphisms associate with PD in some populations but not others...
  22. ncbi request reprint The thiazolidinedione pioglitazone alters mitochondrial function in human neuron-like cells
    Sangeeta Ghosh
    Department of Neurology, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Mol Pharmacol 71:1695-702. 2007
    ..For these reasons pioglitazone may prove useful in the treatment of mitochondriopathies...
  23. ncbi request reprint Dystonia with and without deafness is caused by TIMM8A mutation
    Russell H Swerdlow
    Department of Neurology, University of Virginia Health System, Charlottesville, Virginia, USA
    Adv Neurol 94:147-54. 2004
  24. ncbi request reprint Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies
    Russell H Swerdlow
    Department of Neurology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Neurosci Res 85:3416-28. 2007
    ..Although interpreting cybrid data requires awareness of technique limitations, valuable insights into mtDNA genotype-functional phenotype relationships are suggested...
  25. pmc Polymorphic variation in cytochrome oxidase subunit genes
    Jianghua Lu
    Department of Neurology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    J Alzheimers Dis 21:141-54. 2010
    ..Our findings indicate COX subunit gene heterogeneity is pervasive and may mediate COX functional variation...
  26. ncbi request reprint Treating neurodegeneration by modifying mitochondria: potential solutions to a "complex" problem
    Russell H Swerdlow
    Department of Neurology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Antioxid Redox Signal 9:1591-603. 2007
    ..This review will discuss the role of mitochondrial function and dysfunction in aging and neurodegenerative diseases, and will focus on potential treatment strategies...
  27. ncbi request reprint Mitochondria-derived oxidative stress induces a heat shock protein response
    Matthew J Barrett
    Department of Neurology, University of Virginia Health System, 1 Hospital Drive, Charlottesville, VA 22908, USA
    J Neurosci Res 78:420-9. 2004
    ..We conclude that mitochondrial electron transport chain dysfunction activates a heat shock protein response, and that this response is mediated by oxidative stress...
  28. ncbi request reprint Molecular characterization of mtDNA depleted and repleted NT2 cell lines
    Daniel R Binder
    Department of Neurology, University of Virginia Health System, 1 Hospital Drive, Charlottesville, VA 22908, USA
    Mitochondrion 5:255-65. 2005
    ..Eight weeks after exogenous mtDNA transfer cybrids showed no evidence of endogenous mtDNA reversion, and heteroplasmic ratios of a single nucleotide substitution roughly reflected that of the blood samples used to repopulate their mtDNA...
  29. ncbi request reprint Mitochondrial DNA depletion analysis by pseudogene ratioing
    Russell H Swerdlow
    Department of Neurology, University of Virginia Health System, Box 394, Charlottesville, VA 22908, USA
    J Neurosci Methods 150:265-71. 2006
    ....
  30. pmc Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet
    Anisha A Gupte
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA
    Diabetes 58:567-78. 2009
    ..The purpose of this study is to determine whether in vivo heat treatment can prevent skeletal muscle insulin resistance...
  31. ncbi request reprint Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity
    Sandra M Cardoso
    Laboratory of Biochemistry, Faculty of Medicine and Center for Neurosciences and Cell Biology, University Hospital, University of Coimbra, 3005 504 Coimbra, Portugal
    J Neurochem 89:1417-26. 2004
    ....
  32. ncbi request reprint Mitochondrial abnormalities in cybrid cell models of sporadic Alzheimer's disease worsen with passage in culture
    Patricia A Trimmer
    Center for the Study of Neurodegenerative Diseases, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Neurobiol Dis 15:29-39. 2004
    ..Metabolically deleterious SAD mitochondrial genes, like those in yeast, may have a replicative advantage over nondeleterious mitochondrial genes that assume dominance in CTL cybrids...
  33. ncbi request reprint Is aging part of Alzheimer's disease, or is Alzheimer's disease part of aging?
    Russell H Swerdlow
    Department of Neurology, University of Virginia Health System, McKim Hall, 1 Hospital Drive, P O Box 800394, Charlottesville, VA 22908, United States
    Neurobiol Aging 28:1465-80. 2007
    ..Since the question of whether both forms of AD share a common pathogenesis could profoundly impact diagnostic and treatment development efforts, it seems worthwhile to revisit this debate...
  34. ncbi request reprint Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine
    Teresa Cunha-Oliveira
    Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Brain Res 1089:44-54. 2006
    ..Our results demonstrate that although both amphetamine and cocaine activate the mitochondrial apoptotic pathway in cortical neurons, amphetamine is more likely to promote apoptosis...

Research Grants4

  1. Cytochrome Oxidase Polymorphisms in Aging
    Russell Swerdlow; Fiscal Year: 2007
    ..This work could help explain why complex genetic diseases are sometimes associated with mitochondrial dysfunction. ..