Research Topics
| E R SwensonSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Nitric oxide (NO) in normal and hypoxic vascular regulation of the spiny dogfish, Squalus acanthiasKai E Swenson
Mt Desert Island Biological Laboratory, Salsbury Cove, Maine 04672, USA
J Exp Zool A Comp Exp Biol 303:154-60. 2005..In acute hypoxia, there is a rapid up-regulation of vascular NO production that appears to be responsible for hypoxic vasodilation...
Anemia in critical illness: insights into etiology, consequences, and managementShailaja J Hayden
Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, Washington, USA
Am J Respir Crit Care Med 185:1049-57. 2012....
Pathogenesis of high-altitude pulmonary edema: inflammation is not an etiologic factorErik R Swenson
Pulmonary and Critical Care Section, S 111 Pulm, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
JAMA 287:2228-35. 2002....
Inhibition of aquaporin-mediated CO2 diffusion and voltage-gated H+ channels by zinc does not alter rabbit lung CO2 and NO excretionErik R Swenson
Department of Medicine, VA Puget Sound Health Care System, University of Washington, Seattle, WA 98108, USA
Clin Sci (Lond) 103:567-75. 2002..Therefore we conclude that red cell and lung AQs and voltage-gated H(+) channels in the alveolar epithelium contribute minimally to normal physiological CO(2) elimination...
Carbonic anhydrase inhibitors and hypoxic pulmonary vasoconstrictionErik R Swenson
Department of Medicine, University of Washington, Seattle, WA 98195, USA
Respir Physiol Neurobiol 151:209-16. 2006....
14th International Hypoxia Symposium, February 23-27, 2005, Chateau Lake Louise, Alberta, CanadaErik R Swenson
Pulmonary Section 111-B, Department of Medicine, University of Washington, Veterans Administration Medical Center, 1660 S. Columbian Way, Seattle, WA 98108-1597, USA
High Alt Med Biol 6:181-8. 2005
Biochemical, histological, and inhibitor studies of membrane carbonic anhydrase in frog gastric acid secretionE R Swenson
Department of Medicine, Department of Veterans Affairs Medical Center, University of Washington, Seattle, Washington 98108, USA
Am J Physiol Gastrointest Liver Physiol 281:G61-8. 2001....
Metabolic acidosisE R Swenson
School of Medicine, University of Washington, Seattle, USA
Respir Care 46:342-53. 2001..Theoretical and clinical evidence are discussed for alkalinizing agents, whose use remains controversial except in the treatment of metabolic acidosis associated with hyperkalemia and certain drug or toxin ingestions...
A comparative approach to carbonic anhydrase: the work of Thomas H. MarenErik R Swenson
Pulmonary and Critical Care Medicine, S 111 Pulm, VA Puget Sound Health Care System, Department of Medicine, University of Washington, 1660 South Columbian Way, Seattle, WA 98108, USA
Comp Biochem Physiol A Mol Integr Physiol 136:229-41. 2003..Using marine fish whose kidneys have very little CA, he uncovered mechanisms of acid-base transfer independent of CA that help to explain why CA inhibition does not lead to total bicarbonate depletion...
Hemodilution during venous gas embolization improves gas exchange, without altering V(A)/Q or pulmonary blood flow distributionsS Deem
Department of Anesthesiology, Harborview Medical Center, University of Washington, Seattle 98104 2499, USA
Anesthesiology 91:1861-72. 1999..In the current study, the authors characterized the effects of hemodilution on gas exchange in a distinct model of diffuse lung injury: venous gas embolization...
Effects of carbonic anhydrase inhibition on ventilation-perfusion matching in the dog lungE R Swenson
Department of Medicine, University of Washington, Seattle 98195
J Clin Invest 92:702-9. 1993..These results support the concept that lung CA subserves VA/Q matching in the normal lung...
Acetazolamide reduces hypoxic pulmonary vasoconstriction in isolated perfused rabbit lungsS Deem
Department of Anesthesiology, The University of Washington and Puget Sound Veterans Affairs Health Care System, Seattle, WA, USA
Respir Physiol 123:109-19. 2000..Acetazolamide did not affect expired nitric oxide concentrations. We conclude that acetazolamide reduces both the magnitude and kinetics of HPV by a mechanism that does not involve nitric oxide...
In vivo quantitation of carbonic anhydrase and band 3 protein contributions to pulmonary gas exchangeE R Swenson
Department of Medicine, University of Washington, Seattle 98195
J Appl Physiol 74:838-48. 1993....
Effects of the RBC membrane and increased perfusate viscosity on hypoxic pulmonary vasoconstrictionS Deem
Departments of Anesthesiology and Medicine, University of Washington, Washington 98195, USA
J Appl Physiol 88:1520-8. 2000..In conclusion, the RBC membrane provides a barrier to NO scavenging and augmentation of HPV by Hb. Increased perfusate viscosity inhibits HPV by an undetermined mechanism...
Hypocapnia-induced ventilation/perfusion mismatch: a direct CO2 or pH-mediated effect?K B Domino
Department of Anesthesiology, University of Washington School of Medicine, Seattle, USA
Am J Respir Crit Care Med 152:1534-9. 1995..Therefore, we conclude that hypocapnia-induced VA/Q mismatch in hyperventilated dogs is pH-mediated and is not a function of PCO2 per se...
Mechanisms of improvement in pulmonary gas exchange during isovolemic hemodilutionS Deem
Department of Anesthesiology, University of Washington, Seattle, Washington 98195, USA
J Appl Physiol 87:132-41. 1999..In turn, this may be a result of favorable changes in pulmonary blood flow distribution, as assessed by the fractal dimension and spatial correlation of blood flow and as a result of increased NO availability...
Hemoglobin and red blood cells alter the response of expired nitric oxide to mechanical forcesJ T Berg
Departments of Medicine and Anesthesiology, Veterans Affairs Puget Sound Health Care System and the University of Washington, Seattle, Washington 98108, USA
Am J Physiol Heart Circ Physiol 279:H2947-53. 2000..We conclude that blood and systemic responses render it difficult to use NO(e) changes as an accurate measure of lung tissue NO production...
Renal carbonic anhydrase inhibition reduces high altitude sleep periodic breathingE R Swenson
Department of Medicine, University of Washington, Seattle 98195
Respir Physiol 86:333-43. 1991..We conclude that metabolic acidosis occurring with all CA inhibitors is one of the major stimulant actions of these drugs on ventilation while awake and during sleep at high altitude...
Effects of S-nitrosation of hemoglobin on hypoxic pulmonary vasoconstriction and nitric oxide fluxS Deem
Departments of Anesthesiology and Medicine Pulmonary and Critical Care, University of Washington and Puget Sound Veterans Affairs Health Care System, Seattle, Washington, USA
Am J Respir Crit Care Med 163:1164-70. 2001..NO released from SNO-Hb in the presence of GSH does not produce measurable vascular effects in the lung or changes in eNO because of immediate oxidation and metHb formation...
Travel to high altitude with pre-existing lung diseaseA M Luks
Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA 98108, USA
Eur Respir J 29:770-92. 2007....
Ventilation heterogeneity is increased in hypocapnic dogs but not pigsK B Domino
Department of Anesthesiology, University of Washington, Seattle 98195 6540, USA
Respir Physiol 111:89-100. 1998..05) in pigs. We conclude that hypocapnia increases ventilation heterogeneity in dogs but not in pigs, most likely related to an interspecies difference in collateral ventilation...
Red-blood-cell augmentation of hypoxic pulmonary vasoconstriction: hematocrit dependence and the importance of nitric oxideS Deem
Department of Anesthesiology, Puget Sound Veterans Affairs Health System and the University of Washington, Seattle 98195 6540, USA
Am J Respir Crit Care Med 157:1181-6. 1998..Adenosine-receptor blockade did not affect the RBC-dependence of HPV. We conclude that HPV is dependent on Hct, and that this phenomenon may be related to scavenging of NO but not adenosine by RBCs...
Identification and characterization of human neutrophil carbonic anhydraseA R Campbell
Department of Veterans Affairs Medical Center, University of Washington, Seattle
J Leukoc Biol 55:343-8. 1994....
The lung and carbon dioxide: implications for permissive and therapeutic hypercapniaD A Kregenow
Division of Pulmonary and Critical Care Medicine. University of Washington, Seattle, USA
Eur Respir J 20:6-11. 2002
Acetazolamide 125 mg BD is not significantly different from 375 mg BD in the prevention of acute mountain sickness: the prophylactic acetazolamide dosage comparison for efficacy (PACE) trialBuddha Basnyat
Himalayan Rescue Association and Nepal International Clinic, Kathmandu, Nepal
High Alt Med Biol 7:17-27. 2006..02). We conclude that 125 mg bd of acetazolamide is not significantly different from 375 mg bd in the prevention of AMS; 125 mg bd should be considered the preferred dosage when indicated for persons ascending to altitudes above 2500 m...
Hypercapnic acidosis and mortality in acute lung injuryDavid A Kregenow
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA, USA
Crit Care Med 34:1-7. 2006..These results are consistent with a protective effect of hypercapnic acidosis against ventilator-associated lung injury that was not found when the further ongoing injury was reduced by 6 mL/kg predicted body weight tidal volumes...
Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenumYasutada Akiba
Department of Medicine, School of Medicine, University of California Los Angeles, USA
Gastroenterology 131:142-52. 2006..We examined the hyperemic response to elevated luminal PCO(2) in the duodenum of anesthetized rats luminally exposed to high CO(2) saline to help elucidate luminal acid-sensing mechanisms...
Pulmonary vasodilation by acetazolamide during hypoxia is unrelated to carbonic anhydrase inhibitionClaudia Höhne
Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum und Campus Mitte, Augustenburger Platz 1, D 13353 Berlin, Germany
Am J Physiol Lung Cell Mol Physiol 292:L178-84. 2007....
Physiological aspects of high-altitude pulmonary edemaPeter Bartsch
Department of Internal Medicine VII, Division of Sports Medicine, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
J Appl Physiol 98:1101-10. 2005..The combination of high flow at higher pressure results in pressures, which exceed the structural and dynamic capacity of the alveolar capillary barrier to maintain normal alveolar fluid balance...
Red blood cells prevent inhibition of hypoxic pulmonary vasoconstriction by nitrite in isolated, perfused rat lungsSteven Deem
Department of Anesthesiology, University of Washington, Seattle, WA, USA
Am J Physiol Heart Circ Physiol 292:H963-70. 2007....
Prevention of acute mountain sickness by acetazolamide: as yet an unfinished storyErik R Swenson
J Appl Physiol 102:1305-7. 2007
Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibitionLarissa A Shimoda
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
Am J Physiol Lung Cell Mol Physiol 292:L1002-12. 2007..These results suggest that AZ attenuates HPV by selectively inhibiting hypoxia-induced Ca2+ responses via a mechanism independent of CA inhibition, changes in pH(i), or membrane potential...
An ultracyclist with pulmonary edema during the Bicycle Race Across AmericaAndrew M Luks
Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA 98108, USA
Med Sci Sports Exerc 39:8-12. 2007....
Therapeutic hypercapnia and ventilation-perfusion matching in acute lung injury: low minute ventilation vs inspired CO2Scott E Sinclair
Department of Medicine, University of Tennessee, 956 Court Ave, Room H314, Memphis, TN 38163, USA
Chest 130:85-92. 2006..We hypothesized the presence of hypercapnic acidosis from inspired carbon dioxide (ICD) would improve gas exchange in ALI and would be superior to that of low minute ventilation (LVe) produced by reduced respiratory rate, rather than Vt...
CO2 relaxes parenchyma in the liquid-filled rat lungMichael J Emery
Department of Physiology, University of Washington School of Medicine, USA
J Appl Physiol 103:710-6. 2007....
Leukotriene receptor blockade does not prevent acute mountain sickness induced by normobaric hypoxiaAndrew M Luks
Pulmonary and Critical Care Division, Department of Medicine, University of Washington, Seattle, Washington 98195 6522, USA
High Alt Med Biol 8:131-8. 2007..A 4-day course of leukotriene receptor blockade does not prevent symptoms of AMS. These results suggest that leukotrienes do not play a causal role in the pathophysiology of AMS...
A patient with vanishing lung syndrome and remarkable tolerance to high altitudeAndrew Mark Luks
Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA 98195 6522, USA
Med Sci Sports Exerc 39:1891-5. 2007..Such travel may, in fact, be safe as long as the patient has undergone appropriate pretravel evaluation, and we provide recommendations regarding such evaluation in patients with chronic obstructive pulmonary disease...
Medication and dosage considerations in the prophylaxis and treatment of high-altitude illnessAndrew M Luks
Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA 98195 6522, USA
Chest 133:744-55. 2008..By giving these issues adequate consideration, clinicians can increase the chances that properly evaluated patients with underlying medical conditions will enjoy a safe trip to high altitude...
Pulmonary vascular effects of red blood cells containing S-nitrosated hemoglobinSteven Deem
Dept of Anesthesiology, PO Box 359724, Harborview Medical Center, Seattle, WA 98104 2499, USA
Am J Physiol Heart Circ Physiol 287:H2561-8. 2004....
High altitude pulmonary oedemaPeter Bartsch
Department of Internal Medicine, Medical University Clinic Heidelberg, Germany
Swiss Med Wkly 133:377-84. 2003..Even susceptible individuals can avoid HAPE if they ascend slowly with an average gain of altitude not exceeding 300-350 m/day above an altitude of 2500 m...
Salmeterol for the prevention of high-altitude pulmonary edemaErik R Swenson
N Engl J Med 347:1282-5; author reply 1282-5. 2002
Nasal epithelium potential difference at high altitude (4,559 m): evidence for secretionHeimo Mairbäurl
Division of Sports Medicine, Department of Medicine, University of Heidelberg, Luisenstrasse 5, Geb 4100, 69115 Heidelberg, Germany
Am J Respir Crit Care Med 167:862-7. 2003..It is therefore uncertain whether similar changes also occur at the alveolar epithelium...
Contributions of nitric oxide synthase isozymes to exhaled nitric oxide and hypoxic pulmonary vasoconstriction in rabbit lungsDavid J Vaughan
Department of Pediatrics, Children's Hospital and Regional Medical Center, Seattle 98105, USA
Am J Physiol Lung Cell Mol Physiol 284:L834-43. 2003..Our findings show virtually all exhaled NO in the rabbit lung is produced by eNOS, which is present throughout the airways, alveoli, and vessels. Both vascular and epithelial-derived NO modulate HPV...
Hypoxic ventilatory response, ventilation, gas exchange, and fluid balance in acute mountain sicknessPeter Bartsch
Department of Internal Medicine, Division of Sports Medicine, Medical University Clinic, Heidelberg, Germany
High Alt Med Biol 3:361-76. 2002....
Altered ion transporter expression in bronchial epithelium in mountaineers with high-altitude pulmonary edemaHeimo Mairbäurl
Division of Sports Medicine, Department of Medicine, University of Heidelberg, Germany
J Appl Physiol 95:1843-50. 2003..It is therefore unclear whether these differences are related to the pathophysiology of HAPE...
Carbon dioxide added late in inspiration reduces ventilation-perfusion heterogeneity without causing respiratory acidosisThomas V Brogan
Department of Pediatrics, Children s Hospital and Regional Medical Center, 4800 Sand Point Way NE, CH 05, Seattle, WA 98105 0371, USA
J Appl Physiol 96:1894-8. 2004..21). In conclusion, we have established that the majority of the improvement in gas exchange efficiency with inspired CO2 can be achieved by limiting its application to the conducting airways and does not require systemic acidosis...
Hyperuricemia, hypertension, and proteinuria associated with high-altitude polycythemiaJ Ashley Jefferson
Department of Medicine and Laboratory Medicine, University of Washington Medical Center, Seattle, WA, USA
Am J Kidney Dis 39:1135-42. 2002..The increase in uric acid levels appears to be caused by increased urate generation secondary to systemic hypoxia, although a relative impairment in renal excretion also may contribute...
Inhibitors of hypoxic pulmonary vasoconstriction prevent high-altitude pulmonary edema in ratsJohn T Berg
Department of Pharmacology, University of Hawaii, Honolulu, HI 96822, USA
Wilderness Environ Med 15:32-7. 2004..05, saline vs HPV-inhibited group). CONCLUSION: The results demonstrate that treatment with NiCl2 or acetazolamide prevents HAPE in rats and are consistent with a role for elevated pulmonary artery pressure in the pathogenesis of HAPE...
Acetazolamide prevents hypoxic pulmonary vasoconstriction in conscious dogsClaudia Höhne
Experimentelle Anaesthesie, Department of Anesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353 Berlin, Germany
J Appl Physiol 97:515-21. 2004..The effect is not due to Acz-induced hyperventilation and higher alveolar Po(2), nor to changes in plasma endothelin-1, angiotensin-II, or potassium, and HPV suppression occurs despite the systemic acidosis with CA inhibition...
Hemorrhage during isoflurane-nitrous oxide anesthesia: effects of endothelin-A or angiotensin II receptor blockade or bothClaudia Höhne
Clinic of Anesthesiology and Intensive Care Medicine, Campus Virchow Klinikum, Charite, Humboldt University of Berlin, Germany
Anesthesiology 100:885-93. 2004....
Excessive erythrocytosis, chronic mountain sickness, and serum cobalt levelsJ Ashley Jefferson
Division of Nephrology, University of Washington Medical Center, Seattle, WA, USA
Lancet 359:407-8. 2002..In the mining community of Cerro de Pasco, cobalt toxicity might be an important contributor to excessive erythrocytosis...
Increased oxidative stress following acute and chronic high altitude exposureJ Ashley Jefferson
University of Washington, Division of Nephrology, Seattle, WA 98195, USA
High Alt Med Biol 5:61-9. 2004..In conclusion, oxidative stress is increased following both acute exposure to high altitude without exercise and with chronic residence at high altitude...
A dose-response study of acetazolamide for acute mountain sickness prophylaxis in vacationing tourists at 12,000 feet (3630 m)Chris Carlsten
Department of Medicine, Medicine Residency Program, University of Washington School of Medicine, Seattle, WA 98122, USA
High Alt Med Biol 5:33-9. 2004..These results suggest that the dosing of acetazolamide for AMS prevention in nonmountaineering tourists at altitudes below 3700 m should not be lowered below 250 mg twice daily...
Effects of S-nitrosation and cross-linking of hemoglobin on hypoxic pulmonary vasoconstriction in isolated rat lungsSteven Deem
Department of Anesthesiology, University of Washington and the Veterans Affairs Puget Sound Health Care Center, Seattle, Wash, USA
Circ Res 91:626-32. 2002..However, release of NO from SNO-Hb was not influenced by deoxygenation-mediated allosteric changes in Hb across a broad range of oxyHb saturation. Cross-linking of Hb does not limit its pulmonary vasoconstrictor effects...
Pulmonary extravascular fluid accumulation in climbersPeter Bartsch
Lancet 360:571; author reply 571-2. 2002
Membrane inlet for mass spectrometric measurement of nitric oxideChingkuang Tu
Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610, USA
Free Radic Biol Med 43:1453-7. 2007..0 nM. This apparatus was used to measure the generation of NO from solutions of nitrite, NONOates, and nitroprusside. The usefulness of such an inlet in measuring NO in physiological systems is discussed...
Therapeutic hypercapnia: are we in "stasis" or moving forward?David A Kregenow
Crit Care Med 36:2473-4. 2008
High-altitude pulmonary edema getting worse after descent? An unlikely eventAndrew M Luks
Wilderness Environ Med 18:71-2; author reply 72. 2007
What do dead-space measurements tell us about the lung with acute respiratory distress syndrome?H Thomas Robertson
Respir Care 49:1006-7. 2004
Hypoxic lung whiteout: further clearing but more questions from on highErik R Swenson
Ann Intern Med 145:550-2. 2006
Therapeutic hypercapnic acidosis: pushing the envelopeErik R Swenson
Am J Respir Crit Care Med 169:8-9. 2004
ACE inhibitors and high altitudeErik R Swenson
High Alt Med Biol 5:92-4. 2004
Carbonic anhydrase in mammalian vascular smooth muscleJohn T Berg
Department of Pharmacology, University of Hawaii, Honolulu, HI, USA
J Histochem Cytochem 52:1101-6. 2004..These data establish the activity, inhibition, and isozyme pattern of carbonic anhydrase expression in mammalian vascular smooth muscle...
Comet tails in high-altitude pulmonary edema: diagnostic portent or streak in the sky?Andrew M Luks
Chest 131:951-3. 2007
