R A Sweet

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Genetic association between APOE*4 and neuropsychiatric symptoms in patients with probable Alzheimer's disease is dependent on the psychosis phenotype
    Drew Christie
    VISN 20 Mental Illness, Seattle, WA, USA
    Behav Brain Funct 8:62. 2012
  2. pmc Effect of Alzheimer's disease risk genes on trajectories of cognitive function in the Cardiovascular Health Study
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA
    Am J Psychiatry 169:954-62. 2012
  3. ncbi request reprint Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease
    R A Sweet
    Division of Geriatrics and Neuropsychiatry, Department of Psychiatry, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 10:1026-36. 2005
  4. ncbi request reprint Mapping auditory core, lateral belt, and parabelt cortices in the human superior temporal gyrus
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Comp Neurol 491:270-89. 2005
  5. ncbi request reprint Neuropathologic correlates of late-onset major depression
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2242-50. 2004
  6. ncbi request reprint Anatomical evidence of impaired feedforward auditory processing in schizophrenia
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 61:854-64. 2007
  7. pmc Reduced dendritic spine density in auditory cortex of subjects with schizophrenia
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213 2593, USA
    Neuropsychopharmacology 34:374-89. 2009
  8. pmc Assessment and familial aggregation of psychosis in Alzheimer's disease from the National Institute on Aging Late Onset Alzheimer's Disease Family Study
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Biomedical Science Tower, Rm W 1645, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Brain 133:1155-62. 2010
  9. ncbi request reprint The 5-HTTPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in Alzheimer disease
    R A Sweet
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    Int Psychogeriatr 13:401-9. 2001
  10. ncbi request reprint The 5-HTTPR*S/*L polymorphism and aggressive behavior in Alzheimer disease
    D L Sukonick
    Division of Geriatrics and Neuropsychiatry, Department of Psychiatry, University of Pittsburgh, PA, USA
    Arch Neurol 58:1425-8. 2001

Research Grants

Collaborators

Detail Information

Publications64

  1. pmc Genetic association between APOE*4 and neuropsychiatric symptoms in patients with probable Alzheimer's disease is dependent on the psychosis phenotype
    Drew Christie
    VISN 20 Mental Illness, Seattle, WA, USA
    Behav Brain Funct 8:62. 2012
    ..The E4 allele of the apolipoprotein E (APOE) gene is a well-documented risk factor for the development of AD. However, genetic association studies of the APOE 4 allele and BPS in AD have produced conflicting findings...
  2. pmc Effect of Alzheimer's disease risk genes on trajectories of cognitive function in the Cardiovascular Health Study
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA
    Am J Psychiatry 169:954-62. 2012
    ..Genetic variations in CLU, PICALM, and CR1 are associated with Alzheimer's disease, but it is unknown whether they exert their effects by altering cognitive trajectory in elderly individuals at risk for the disease...
  3. ncbi request reprint Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease
    R A Sweet
    Division of Geriatrics and Neuropsychiatry, Department of Psychiatry, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 10:1026-36. 2005
    ..Examination of variation at ERE6 in subjects with schizophrenia, and further examination of the independent and additive effects of variations in COMT on gene expression, is warranted...
  4. ncbi request reprint Mapping auditory core, lateral belt, and parabelt cortices in the human superior temporal gyrus
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Comp Neurol 491:270-89. 2005
    ..Variability of regional volume estimates was readily constrained using a multifaceted approach to reduce potential sources of variability in regional delineation...
  5. ncbi request reprint Neuropathologic correlates of late-onset major depression
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2242-50. 2004
    ..These preliminary findings suggest that AD is the predominant neuropathologic condition in LLMD subjects with dementia. Further assessment of the role of comorbid cerebrovascular disease and comorbid DLB is needed...
  6. ncbi request reprint Anatomical evidence of impaired feedforward auditory processing in schizophrenia
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 61:854-64. 2007
    ....
  7. pmc Reduced dendritic spine density in auditory cortex of subjects with schizophrenia
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213 2593, USA
    Neuropsychopharmacology 34:374-89. 2009
    ..This may contribute to impairments in auditory sensory processing that are present in subjects with schizophrenia...
  8. pmc Assessment and familial aggregation of psychosis in Alzheimer's disease from the National Institute on Aging Late Onset Alzheimer's Disease Family Study
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Biomedical Science Tower, Rm W 1645, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Brain 133:1155-62. 2010
    ..Future studies should examine the linkage and association of psychosis with genetic variation within these families...
  9. ncbi request reprint The 5-HTTPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in Alzheimer disease
    R A Sweet
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    Int Psychogeriatr 13:401-9. 2001
    ..We recently found that AD subjects homozygous for long alleles (l) of an insertion/deletion polymorphism in the promoter region of the serotonin transporter (5-HTTPR) had elevated rates of aggressive behavior...
  10. ncbi request reprint The 5-HTTPR*S/*L polymorphism and aggressive behavior in Alzheimer disease
    D L Sukonick
    Division of Geriatrics and Neuropsychiatry, Department of Psychiatry, University of Pittsburgh, PA, USA
    Arch Neurol 58:1425-8. 2001
    ....
  11. pmc Genome-wide association analysis of age-at-onset in Alzheimer's disease
    M I Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Psychiatry 17:1340-6. 2012
    ..These findings need to be confirmed in additional well-powered samples...
  12. ncbi request reprint A double-blind randomized comparison of nortriptyline plus perphenazine versus nortriptyline plus placebo in the treatment of psychotic depression in late life
    B H Mulsant
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 62:597-604. 2001
    ..To conduct the first randomized study comparing the efficacy of an antidepressant alone versus an antidepressant plus a neuroleptic in the treatment of late-life psychotic depression...
  13. ncbi request reprint Pharmacologic profile of perphenazine's metabolites
    R A Sweet
    Geriatric Psychopharmacology, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Clin Psychopharmacol 20:181-7. 2000
    ..Further exploration of atypical properties of DAPZ should include de novo administration of this metabolite in animal models...
  14. ncbi request reprint Alterations of striatal dopamine receptor binding in Alzheimer disease are associated with Lewy body pathology and antemortem psychosis
    R A Sweet
    University of Pittsburgh, Division of Geriatrics and Neuropsychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Arch Neurol 58:466-72. 2001
    ..Lewy bodies (LB) are present in at least 20% to 30% of persons with Alzheimer disease (AD) and contribute to the risk of psychosis and to excess cognitive burden...
  15. ncbi request reprint A twelve-week, double-blind, randomized comparison of nortriptyline and paroxetine in older depressed inpatients and outpatients
    B H Mulsant
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 9:406-14. 2001
    ....
  16. ncbi request reprint Dopamine receptor genetic variation, psychosis, and aggression in Alzheimer disease
    R A Sweet
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Arch Neurol 55:1335-40. 1998
    ..To examine if selected polymorphisms in the dopamine receptor genes DRD1, DRD2, DRD3, and DRD4 are associated with the presence of psychosis or aggressive behavior in patients with Alzheimer disease (AD)...
  17. ncbi request reprint Methodological issues in characterizing treatment response in demented patients with behavioral disturbances
    B H Mulsant
    Department of Psychiatry, University of Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 12:537-47. 1997
    ....
  18. ncbi request reprint Determinants of spontaneous extrapyramidal symptoms in elderly psychiatric inpatients diagnosed with Alzheimer's disease, major depressive disorder, or psychotic disorders
    R A Sweet
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 10:68-77. 1998
    ..These findings suggest that rigidity is associated with DAT independently of any concurrent psychotic or depressive process, whereas bradykinesia does not appear to be specific to DAT among late-life neuropsychiatric illnesses...
  19. pmc Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study
    O L Lopez
    Department of Psychiatry and Neurology, University of Pittsburgh, PA, USA
    Neurology 70:1664-71. 2008
    ....
  20. ncbi request reprint The effects of perphenazine on the concentration of nortriptyline and its hydroxymetabolites in older patients
    B H Mulsant
    Geriatric Psychopharmacology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychopharmacol 17:318-21. 1997
    ....
  21. ncbi request reprint Psychotic symptoms in Alzheimer's disease are not associated with more severe neuropathologic features
    R A Sweet
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Int Psychogeriatr 12:547-58. 2000
    ..The association of AD+P with a more rapidly progressive course of AD appears to be mediated by a neuropathologic process other than increased severity of plaque and tangle formation...
  22. pmc The relationship of excess cognitive impairment in MCI and early Alzheimer's disease to the subsequent emergence of psychosis
    Elise A Weamer
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA
    Int Psychogeriatr 21:78-85. 2009
    ..This study seeks to determine whether the degree of cognitive impairment and cognitive decline in early AD predicts subsequent AD + P onset...
  23. ncbi request reprint Linkage analysis of Alzheimer disease with psychosis
    S A Bacanu
    Department of Psychiatry, University of Pittsburgh, School of Medicine, PA, USA
    Neurology 59:118-20. 2002
    ..Linkage analysis of families with LOAD+P identified one significant and several suggestive novel linkage signals, which bolsters the conjecture of greater etiologic homogeneity...
  24. ncbi request reprint Increased familial risk of the psychotic phenotype of Alzheimer disease
    R A Sweet
    Division of Geriatrics and Neuropsychiatry, School of Medicine, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Neurology 58:907-11. 2002
    ..Psychotic symptoms in patients with AD (AD with psychosis [AD+P]) define a phenotype characterized by more rapid cognitive and functional decline and a liability to aggressive behaviors...
  25. ncbi request reprint Alzheimer disease subjects with psychosis have increased schizotypal symptoms before dementia onset
    Elise A Eror
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 58:325-30. 2005
    ..One prediction of this model would be that AD+P subjects would have evidence of increased degrees of subsyndromal psychosis before AD onset...
  26. ncbi request reprint Alzheimer disease with psychosis: excess cognitive impairment is restricted to the misidentification subtype
    Gina Perez-Madriñan
    Dept of Psychiatry, Univ of Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 12:449-56. 2004
    ..We hypothesized that these two groups differed in their patterns of cognitive impairment, compared with AD subjects without psychosis...
  27. ncbi request reprint Prediction of psychosis onset in Alzheimer disease: The role of cognitive impairment, depressive symptoms, and further evidence for psychosis subtypes
    Patricia A Wilkosz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 14:352-60. 2006
    ..Most prior studies of the clinical correlates of AD+P have been limited, however, by the inclusion of prevalent cases...
  28. pmc Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease
    O L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 80:600-7. 2009
    ..There are no long-term studies of the effects of memantine in combination with ChEIs use in Alzheimer disease (AD). This study was conducted to examine the effects of ChEIs and memantine on time to death and time to NH admission...
  29. ncbi request reprint Psychotic symptoms in Alzheimer disease: evidence for a distinct phenotype
    R A Sweet
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15231, USA
    Mol Psychiatry 8:383-92. 2003
    ..We discuss possible genetic models of psychotic symptoms in AD, and suggest strategies for further investigation. Identification of such genetic factors may facilitate gene-mapping studies for both AD and idiopathic psychoses...
  30. ncbi request reprint Apolipoprotein E and alpha-1-antichymotrypsin genotypes do not predict time to psychosis in Alzheimer's disease
    Robert A Sweet
    Department of Psychiatry, School of Medicine, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA
    J Geriatr Psychiatry Neurol 15:24-30. 2002
    ..The findings support the hypothesis that these two genetic determinants of AD risk do not contribute to the risk of development of psychotic symptoms in AD...
  31. ncbi request reprint Lewy bodies in the amygdala increase risk for major depression in subjects with Alzheimer disease
    O L Lopez
    Alzheimer s Disease Research Center, Department of Neurology, University of Pittsburgh School of Medicine, PA, USA
    Neurology 67:660-5. 2006
    ..To determine the relationship between major depression and the presence of Lewy bodies (LBs) in patients with Alzheimer disease (AD)...
  32. ncbi request reprint Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression
    B G Pollock
    Intervention Research Center for Late Life Mood Disorders and the Geriatric Psychopharmacology Program, Graduate School of Public Health, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 23:587-90. 2000
    ..Onset of response to nortriptyline was not affected. Allelic variation of 5-HTTLPR may contribute to the variable initial response of patients treated with a selective serotonin reuptake inhibitor...
  33. ncbi request reprint Regional specificity of chandelier neuron axon terminal alterations in schizophrenia
    G T Konopaske
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Neuroscience 138:189-96. 2006
    ..The goal of this study was to determine if reductions in the density of GABA membrane transporter-1-immunoreactive cartridges in schizophrenia are restricted to the prefrontal cortex...
  34. ncbi request reprint Antipsychotic radioreceptor assay: a modification identifying selective receptor effects
    R A Sweet
    Geriatric Psychopharmacology Program, Division of Geriatrics and Neuropsychiatry, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Ther Drug Monit 23:421-6. 2001
    ..Valid receptor-selective antipsychotic assays can be established and may have utility for dissecting the in vivo activity of atypical antipsychotics in relation to specific outcomes in clinical trials...
  35. ncbi request reprint Incidence of dementia in mild cognitive impairment in the cardiovascular health study cognition study
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, 3501 Forbes Ave, Suite 830, Oxford Bldg, Pittsburgh, PA 15213 3323, USA
    Arch Neurol 64:416-20. 2007
    ..To examine the incidence of dementia in subjects with mild cognitive impairment (MCI) in the Cardiovascular Health Study Cognition Study...
  36. pmc Prediction of psychosis onset in Alzheimer disease: the role of depression symptom severity and the HTR2A T102C polymorphism
    Patricia A Wilkosz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 144:1054-62. 2007
    ..This did not result from an interaction of HTR2A genotype with antidepressant use. Psychosis onset in AD is strongly associated with severity of depressive symptoms, an association that may be modified by HTR2A genotype...
  37. pmc Depressed mood is not a risk factor for incident dementia in a community-based cohort
    James T Becker
    Department of Psychiatry, School of Medicine, Graduate School of Public Health, University of Pittsburgh, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:653-63. 2009
    ..To determine the relationship between depressed mood and the development of Alzheimer disease in cognitively normal individuals...
  38. pmc Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapies
    David A Lewis
    University of Pittsburgh, Department of Psychiatry, W1651 Biomedical Science Tower, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
    J Clin Invest 119:706-16. 2009
    ..The identification of molecular alterations in these circuits is providing critical insights for the rational development of new therapeutic interventions...
  39. pmc An automated segmentation methodology for quantifying immunoreactive puncta number and fluorescence intensity in tissue sections
    Kenneth N Fish
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Brain Res 1240:62-72. 2008
    ..g., average fluorescence intensity of proteins of interest). Importantly, the segmentation method presented can be easily adapted for use with most existing microscopy analysis packages...
  40. ncbi request reprint Cognitive and behavioral correlates of low vitamin B12 levels in elderly patients with progressive dementia
    Ellen M Whyte
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 10:321-7. 2002
    ..In AD, the prevalence of low vitamin B12 serum levels is consistent with that found in community-dwelling elderly persons in general but is associated with greater overall cognitive impairment...
  41. ncbi request reprint Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients
    Bruce G Pollock
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 159:460-5. 2002
    ....
  42. ncbi request reprint Effect of nortriptyline and paroxetine on CYP2D6 activity in depressed elderly patients
    LalithKumar K Solai
    Mental Health Intervention Research Center for the Study of Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Clin Psychopharmacol 22:481-6. 2002
    ..CYP2D6 inhibition by paroxetine, which effectively converted 59% of patients to phenotypic PMs, may be especially relevant for elderly patients given their generally higher concentration of paroxetine...
  43. ncbi request reprint Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's disease
    Oscar L Lopez
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 15:346-53. 2003
    ..Education and race were independently associated with psychosis. However, while education was associated with psychosis in mild/moderate stages, race was associated with psychosis in moderate/severe stages...
  44. ncbi request reprint APOE is associated with age-of-onset, but not cognitive functioning, in late-life depression
    Meryl A Butters
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 18:1075-81. 2003
    ..We also predicted that APOE4 allele frequency would be increased among subjects with LLD...
  45. ncbi request reprint Altered cortical glutamate neurotransmission in schizophrenia: evidence from morphological studies of pyramidal neurons
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
    Ann N Y Acad Sci 1003:102-12. 2003
    ....
  46. pmc Pyramidal neuron number in layer 3 of primary auditory cortex of subjects with schizophrenia
    Karl Anton Dorph-Petersen
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Brain Res 1285:42-57. 2009
    ..Our approach represents a powerful new method for stereologic estimation of features of interest within individual layers of cerebral cortex, with applications beyond the current study...
  47. ncbi request reprint Alteration of a clinically meaningful outcome in the natural history of Alzheimer's disease by cholinesterase inhibition
    Oscar L Lopez
    Alzheimer s Disease Research Center and Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 53:83-7. 2005
    ..To describe the effect of cholinesterase inhibitors (CEIs) on the natural course of Alzheimer's disease (AD) using clinically meaningful outcomes...
  48. ncbi request reprint Non-cognitive symptoms in mild cognitive impairment subjects
    Oscar L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurocase 11:65-71. 2005
    ....
  49. ncbi request reprint Psychosis in Alzheimer disease: postmortem magnetic resonance spectroscopy evidence of excess neuronal and membrane phospholipid pathology
    Robert A Sweet
    Department of Psychiatry, Division of Geriatrics, Neuropsychiatry, University of Pittsburgh School of Medicine, PA, USA
    Neurobiol Aging 23:547-53. 2002
    ..Although AD+P has been inconsistently associated with more severe neuropathology, no prior studies have examined measures of neuronal and synaptic integrity...
  50. ncbi request reprint Patterns of change in the treatment of psychiatric symptoms in patients with probable Alzheimer's disease from 1983 to 2000
    Oscar L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 15:67-73. 2003
    ..g., aggression, agitation) and sleep disorders in AD. Although the use of SHA has a proven deleterious effect on patients with AD, their use has increased over the past two decades...
  51. pmc Genome-wide association study of Alzheimer's disease
    M I Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Transl Psychiatry 2:e117. 2012
    ..43. This is a potential candidate gene for AD as this is expressed in the brain and is involved in lipid metabolism. These findings need to be confirmed in additional samples...
  52. ncbi request reprint Test-retest variability of serotonin 5-HT2A receptor binding measured with positron emission tomography and [18F]altanserin in the human brain
    G S Smith
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Synapse 30:380-92. 1998
    ..These findings support the usefulness of [18F]altanserin as a radioligand for PET studies of 5-HT2A receptors...
  53. pmc Genetics of psychosis in Alzheimer's disease: a review
    Mary Ann DeMichele-Sweet
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    J Alzheimers Dis 19:761-80. 2010
    ..Specific attention is given to familial aggregation and heritability, linkage to chromosomal loci, and associations of candidate genes of APOE and the monoamine neurotransmitter system...
  54. ncbi request reprint Research evaluation and prospective diagnosis of dementia with Lewy bodies
    Oscar L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh, PA, USA
    Arch Neurol 59:43-6. 2002
    ..To evaluate the relative merits of recently developed criteria for dementia with Lewy bodies (DLBs) in a longitudinal study of dementia...
  55. pmc Trajectories of cognitive decline in Alzheimer's disease
    Patricia A Wilkosz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Int Psychogeriatr 22:281-90. 2010
    ..We therefore used latent class modeling to characterize trajectories of cognitive and behavioral decline in a cohort of AD subjects...
  56. ncbi request reprint Managing antipsychotic-induced parkinsonism
    D C Mamo
    Department of Psychiatry, University of Pittsburgh School of Medicine, Philadelphia, USA
    Drug Saf 20:269-75. 1999
    ..An individualised risk-benefit assessment is necessary for the younger patient in whom prophylactic use of anticholinergic drugs is considered...
  57. ncbi request reprint Pyramidal cell size reduction in schizophrenia: evidence for involvement of auditory feedforward circuits
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 55:1128-37. 2004
    ..To discriminate between involvement of feedforward and feedback circuit components, we examined pyramidal cell somal volume in layer 3 of primary auditory cortex (feedforward) and layer 5 of auditory association cortex (feedback)...
  58. ncbi request reprint Reduced pyramidal cell somal volume in auditory association cortex of subjects with schizophrenia
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 28:599-609. 2003
    ..This reduction may contribute to impairment in auditory function. The correlated reductions of somal volume in BA42 and BA9 suggest that a common factor may affect deep layer 3 pyramidal cells in both regions...
  59. pmc Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys
    Glenn T Konopaske
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 63:759-65. 2008
    ..Consequently, in this study we sought to determine whether the lower glial cell number was due to fewer oligodendrocytes as opposed to lower numbers of astrocytes...
  60. ncbi request reprint Psychotic symptoms in Alzheimer disease: evidence for subtypes
    Sarah E Cook
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 11:406-13. 2003
    ..Psychotic symptoms in Alzheimer disease (AD) identify a phenotype with distinct neurobiology and genetic architecture. The authors investigated whether AD with psychosis is homogeneous or is a composite of subtypes...
  61. ncbi request reprint Heritability of psychosis in Alzheimer disease
    Silviu Alin Bacanu
    Dept of Psychiatry, Univ of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:624-7. 2005
    ..The authors have previously demonstrated familial clustering of psychotic symptoms in late-onset Alzheimer disease (LOAD+P) and sought to estimate and explore the nature of the heritability of LOAD+P...
  62. ncbi request reprint Risperidone and 9-hydroxyrisperidone concentrations are not dependent on age or creatinine clearance among elderly subjects
    Rae Ann Maxwell
    Pharmacy Department, Western Psychiatric Institute and Clinic, VA Pittsburgh Health System, Pennsylvania, USA
    J Geriatr Psychiatry Neurol 15:77-81. 2002
    ..These results were unchanged when concentrations were corrected for total daily risperidone dose. Among elderly subjects, risperidone and 9-OH clearance do not decline with increasing age or declining CrCl...
  63. ncbi request reprint The effect of age on the pharmacological management of ambulatory patients treated with depot neuroleptic medications for schizophrenia and related psychotic disorders
    David C Mamo
    Centre for Addiction and Mental Health, Toronto, Canada
    Int J Geriatr Psychiatry 17:1012-7. 2002
    ..It has been suggested, therefore, that older patients with schizophrenia could be maintained on reduced doses of conventional neuroleptics...
  64. ncbi request reprint Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychoses
    Rodney C P Go
    University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Med Genet B Neuropsychiatr Genet 139:28-32. 2005
    ..Our results suggest that NRG1 plays a role in increasing the genetic risk to positive symptoms of psychosis in a proportion of LOAD families...

Research Grants12

  1. Auditory Cortex: Regional Pathology In Schizophrenia
    Robert Sweet; Fiscal Year: 2003
    ..abstract_text> ..
  2. Plasticity of Auditory Cortical Circuits in Schizophrenia
    Robert A Sweet; Fiscal Year: 2010
    ..The proposed studies may provide a basis for future interventions to improve sound processing in individuals with this illness, and to prevent loss of sound circuit components during the early stages of disease. ..
  3. Plasticity of Auditory Cortical Circuits in Schizophrenia
    Robert Sweet; Fiscal Year: 2009
    ..The proposed studies may provide a basis for future interventions to improve sound processing in individuals with this illness, and to prevent loss of sound circuit components during the early stages of disease. ..
  4. Prediction of Psychosis in Alzheimer Disease
    Robert Sweet; Fiscal Year: 2009
    ..These findings may guide the development of interventions for the prediction, treatment, and/or prevention of psychosis and excess cognitive morbidity in AD. ..
  5. Prediction of Psychosis in Alzheimer Disease
    Robert Sweet; Fiscal Year: 2007
    ..These findings may guide the development of interventions for the prediction, treatment, and/or prevention of psychosis and excess cognitive morbidity in AD. ..
  6. Auditory corticocortical circuits in schizophrenia
    Robert Sweet; Fiscal Year: 2007
    ..This knowledge will guide the design of future investigations of auditory cortex pathology, and inform the interpretation of psychophysiology investigations and neural modeling of auditory processing in schizophrenia. ..
  7. Prediction of Psychosis in Alzheimer Disease
    Robert A Sweet; Fiscal Year: 2010
    ..These findings may guide the development of interventions for the prediction, treatment, and/or prevention of psychosis and excess cognitive morbidity in AD. ..