John Sweeney

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi request reprint Eye movements in neurodevelopmental disorders
    John A Sweeney
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612 7327, USA
    Curr Opin Neurol 17:37-42. 2004
  2. pmc fMRI studies of eye movement control: investigating the interaction of cognitive and sensorimotor brain systems
    John A Sweeney
    Center for Cognitive Medicine, University of Illinois at Chicago, 912 S Wood Street MC 913, Chicago, IL 60612 7327, USA
    Neuroimage 36:T54-60. 2007
  3. ncbi request reprint Commentary: eye movement research with clinical populations
    John A Sweeney
    Center for Cognitive Medicine, Departments of Psychiatry, Neurology and Psychology, University of Illinois at Chicago, MC 913, 912 S Wood St, Neuropsychiatric Institute, Chicago, IL 60612, USA
    Prog Brain Res 140:507-22. 2002
  4. pmc Differential engagement of cognitive and affective neural systems in pediatric bipolar disorder and attention deficit hyperactivity disorder
    Alessandra M Passarotti
    Center for Cognitive Medicine, University of Illinois Medical Center at Chicago, Chicago, IL 60612, USA
    J Int Neuropsychol Soc 16:106-17. 2010
  5. ncbi request reprint Oculomotor studies of cerebellar function in autism
    Caralynn V Nowinski
    Department of Psychiatry, MC 913, University of Illinois at Chicago, 912 S Wood St, Suite 235, Chicago, IL 60612 7327, USA
    Psychiatry Res 137:11-9. 2005
  6. pmc Sensorimotor transformation deficits for smooth pursuit in first-episode affective psychoses and schizophrenia
    Rebekka Lencer
    Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Biol Psychiatry 67:217-23. 2010
  7. pmc Atypical involvement of frontostriatal systems during sensorimotor control in autism
    Yukari Takarae
    Department of Psychiatry MC 913, University of Illinois at Chicago, 912 S Wood St, Suite 235, Chicago, IL 60612 7327, USA
    Psychiatry Res 156:117-27. 2007
  8. pmc Response suppression deficits in treatment-naïve first-episode patients with schizophrenia, psychotic bipolar disorder and psychotic major depression
    Margret S H Harris
    Department of Psychiatry, University of Illinois, Chicago, IL, USA
    Psychiatry Res 170:150-6. 2009
  9. ncbi request reprint Adverse effects of risperidone on spatial working memory in first-episode schizophrenia
    James L Reilly
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, IL 60612, USA
    Arch Gen Psychiatry 63:1189-97. 2006
  10. ncbi request reprint Functional magnetic resonance imaging studies of eye movements in first episode schizophrenia: smooth pursuit, visually guided saccades and the oculomotor delayed response task
    Sarah K Keedy
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, 912 S Wood Street MC 913, Chicago, IL 60612 7327, USA
    Psychiatry Res 146:199-211. 2006

Detail Information

Publications84

  1. ncbi request reprint Eye movements in neurodevelopmental disorders
    John A Sweeney
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612 7327, USA
    Curr Opin Neurol 17:37-42. 2004
    ..It thus provides a promising methodology for characterizing and documenting maturational abnormalities in brain systems associated with neurodevelopmental disorders...
  2. pmc fMRI studies of eye movement control: investigating the interaction of cognitive and sensorimotor brain systems
    John A Sweeney
    Center for Cognitive Medicine, University of Illinois at Chicago, 912 S Wood Street MC 913, Chicago, IL 60612 7327, USA
    Neuroimage 36:T54-60. 2007
    ....
  3. ncbi request reprint Commentary: eye movement research with clinical populations
    John A Sweeney
    Center for Cognitive Medicine, Departments of Psychiatry, Neurology and Psychology, University of Illinois at Chicago, MC 913, 912 S Wood St, Neuropsychiatric Institute, Chicago, IL 60612, USA
    Prog Brain Res 140:507-22. 2002
    ....
  4. pmc Differential engagement of cognitive and affective neural systems in pediatric bipolar disorder and attention deficit hyperactivity disorder
    Alessandra M Passarotti
    Center for Cognitive Medicine, University of Illinois Medical Center at Chicago, Chicago, IL 60612, USA
    J Int Neuropsychol Soc 16:106-17. 2010
    ..During cognitive control of emotion processing, PBD patients deployed the VLPFC to a greater extent than HC. The ADHD patients showed decreased VLPFC engagement relative to both HC and PBD patients...
  5. ncbi request reprint Oculomotor studies of cerebellar function in autism
    Caralynn V Nowinski
    Department of Psychiatry, MC 913, University of Illinois at Chicago, 912 S Wood St, Suite 235, Chicago, IL 60612 7327, USA
    Psychiatry Res 137:11-9. 2005
    ..The atypical metrics of intrusive saccades that were observed may be attributable to faulty functional connectivity in cortico-cerebellar networks...
  6. pmc Sensorimotor transformation deficits for smooth pursuit in first-episode affective psychoses and schizophrenia
    Rebekka Lencer
    Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Biol Psychiatry 67:217-23. 2010
    ..Which of these components are the primary causes of smooth pursuit impairments and whether they are impaired similarly across psychotic disorders remain to be established...
  7. pmc Atypical involvement of frontostriatal systems during sensorimotor control in autism
    Yukari Takarae
    Department of Psychiatry MC 913, University of Illinois at Chicago, 912 S Wood St, Suite 235, Chicago, IL 60612 7327, USA
    Psychiatry Res 156:117-27. 2007
    ..These findings document that neurodevelopmental disturbances in autism affect widely distributed brain systems beyond those mediating language and social cognition...
  8. pmc Response suppression deficits in treatment-naïve first-episode patients with schizophrenia, psychotic bipolar disorder and psychotic major depression
    Margret S H Harris
    Department of Psychiatry, University of Illinois, Chicago, IL, USA
    Psychiatry Res 170:150-6. 2009
    ..However, the distinct pattern of dysfunction in schizophrenia across oculomotor paradigms suggests possible unique causes of their observed oculomotor performance deficits...
  9. ncbi request reprint Adverse effects of risperidone on spatial working memory in first-episode schizophrenia
    James L Reilly
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, IL 60612, USA
    Arch Gen Psychiatry 63:1189-97. 2006
    ..The oculomotor delayed response task is a translational spatial working memory paradigm used to characterize the neurophysiologic and neurochemical aspects of working memory in the primate brain...
  10. ncbi request reprint Functional magnetic resonance imaging studies of eye movements in first episode schizophrenia: smooth pursuit, visually guided saccades and the oculomotor delayed response task
    Sarah K Keedy
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, 912 S Wood Street MC 913, Chicago, IL 60612 7327, USA
    Psychiatry Res 146:199-211. 2006
    ....
  11. ncbi request reprint Abnormalities in visually guided saccades suggest corticofugal dysregulation in never-treated schizophrenia
    James L Reilly
    Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Biol Psychiatry 57:145-54. 2005
    ..Previous studies have reported intact visually guided saccades in schizophrenia, but these are limited by potential acute and long-term pharmacological treatment effects, small sample sizes, and a failure to follow patients over time...
  12. ncbi request reprint Maturation of executive function in autism
    Beatriz Luna
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 61:474-81. 2007
    ..Executive dysfunction has been reported at different ages in autism. It is not clear however, when this impairment emerges or how its expression is affected by development...
  13. doi request reprint Alteration in functional brain systems after electrical injury
    Alona Ramati
    University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Neurotrauma 26:1815-22. 2009
    ..This is the first study to document task-dependent, system-level cortical and subcortical dysfunction in individuals who had experienced an electrical shock trauma...
  14. pmc Effects of risperidone on procedural learning in antipsychotic-naive first-episode schizophrenia
    Margret S H Harris
    Department of Psychiatry, Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 34:468-76. 2009
    ....
  15. ncbi request reprint Prolonged untreated illness duration from prodromal onset predicts outcome in first episode psychoses
    Matcheri S Keshavan
    University of Pittsburgh School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Schizophr Bull 29:757-69. 2003
    ..The latter, if true, would strongly support therapeutic intervention efforts in the prodromal and early psychotic phases of schizophrenia...
  16. ncbi request reprint Diagnostic specificity and neuroanatomical validity of neurological abnormalities in first-episode psychoses
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic and University of Pittsburgh School of Medicine, Pittsburg, PA 15213, USA
    Am J Psychiatry 160:1298-304. 2003
    ..quot; This study examined the neuroanatomical correlates and diagnostic specificity of abnormal findings on the neurological examination in first-episode schizophrenia and other psychotic disorders...
  17. ncbi request reprint Maturation of cognitive processes from late childhood to adulthood
    Beatriz Luna
    Laboratory of Neurocognitive Development, Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Child Dev 75:1357-72. 2004
    ..How brain maturation specific to adolescence may support cognitive maturation is discussed...
  18. ncbi request reprint Spatial working memory deficits in autism
    Shelly D Steele
    Department of Psychology, University of Illinois at Chicago, Chicago, IL 60612 7327, USA
    J Autism Dev Disord 37:605-12. 2007
    ..Overall, these results demonstrate reduced spatial working memory abilities in autism, and extend previous findings by demonstrating that these deficits are significant when tasks impose heavier demands on working memory...
  19. pmc Neurobehavioral abnormalities in first-degree relatives of individuals with autism
    Matthew W Mosconi
    Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Arch Gen Psychiatry 67:830-40. 2010
    ..Studying sensorimotor and neurocognitive impairments in unaffected family members of individuals with autism may help identify familial pathophysiological mechanisms associated with the disorder...
  20. ncbi request reprint A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parents
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Room 984, University of Pittsburgh School of Medicine, 3811 0 Hara Street, Pittsburgh, PA 15213, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:1143-9. 2002
    ..These abnormalities need to be prospectively investigated in nonpsychotic individuals at risk for schizophrenia in order to determine their predictive value for eventual emergence of schizophrenia or related disorders...
  21. pmc Longitudinal alterations of executive function in non-psychotic adolescents at familial risk for schizophrenia
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, Massachusetts, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:469-74. 2010
    ..Our results suggest an altered maturational trajectory of executive function during adolescence in individuals at familial risk for schizophrenia...
  22. ncbi request reprint Psychosis proneness and ADHD in young relatives of schizophrenia patients
    Matcheri S Keshavan
    Department of Psychiatry, UPMC Health System Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Room 984, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Schizophr Res 59:85-92. 2003
    ..Longitudinal studies can clarify whether an "ADHD subgroup" within HR subjects predict an increased risk for future emergence of schizophrenia...
  23. ncbi request reprint Cognitive processes in the development of TOL performance
    Miya R Asato
    Laboratory of Neurocognitive Development, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychologia 44:2259-69. 2006
    ....
  24. ncbi request reprint Failure of positive but not negative emotional valence to enhance memory in schizophrenia
    Ellen S Herbener
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Abnorm Psychol 116:43-55. 2007
    ....
  25. pmc Efficiency of the CATIE and BACS neuropsychological batteries in assessing cognitive effects of antipsychotic treatments in schizophrenia
    S Kristian Hill
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Int Neuropsychol Soc 14:209-21. 2008
    ....
  26. pmc Oculomotor and neuropsychological effects of antipsychotic treatment for schizophrenia
    S Kristian Hill
    Center for Cognitive Medicine, Department of Psychiatry M C 913, University of Illinois at Chicago, Chicago, IL 60612, USA
    Schizophr Bull 34:494-506. 2008
    ..These findings warrant further investigation regarding the utility of neurophysiological biomarkers for assessing cognitive outcomes of antipsychotic treatment in clinical trials and in early-phase drug development...
  27. ncbi request reprint Biological risk factors in pediatric bipolar disorder
    Mani N Pavuluri
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
    Biol Psychiatry 60:936-41. 2006
    ..The current study attempted to determine whether neurodevelopmental and acquired brain abnormalities are more common in pediatric bipolar disorder (PBD)...
  28. ncbi request reprint Affective neural circuitry during facial emotion processing in pediatric bipolar disorder
    Mani N Pavuluri
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Biol Psychiatry 62:158-67. 2007
    ..Identifying pathophysiology in affect processing circuitry that supports the ability to assess facial emotions might facilitate understanding of affect regulation in pediatric bipolar disorder...
  29. ncbi request reprint Sex difference in cognitive response to antipsychotic treatment in first episode schizophrenia
    Leah H Rubin
    Department of Psychiatry and Psychology, Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 33:290-7. 2008
    ..Future studies of the neurocognitive effects of antipsychotic treatment may need to take potential sex differences in cognitive response into account...
  30. pmc Neurocognitive function in pediatric bipolar disorder: 3-year follow-up shows cognitive development lagging behind healthy youths
    Mani N Pavuluri
    Department of Psychiatry, University of Illinois at Chicago, Institute for Juvenile Research and Center for Cognitive Medicine, 912 South Wood Street M C 913, Chicago, IL 60612, USA
    J Am Acad Child Adolesc Psychiatry 48:299-307. 2009
    ..Longitudinal follow-up of neurocognitive functioning in people with pediatric bipolar disorder (PBD) was conducted to characterize the developmental trajectory of cognitive disabilities in this disorder...
  31. pmc Neural correlates of incidental and directed facial emotion processing in adolescents and adults
    Alessandra M Passarotti
    Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, 912 South Wood Street M C 913, Chicago, IL 60612, USA
    Soc Cogn Affect Neurosci 4:387-98. 2009
    ..These results indicate that the neural circuitries for affect regulation are still developing in adolescence and have not yet reached the adult level...
  32. pmc Effect of second-generation antipsychotics on cognition: current issues and future challenges
    S Kristian Hill
    Center for Cognitive Medicine M C 913, University of Illinois at Chicago, 912 South Wood Street, Suite 235, Chicago, IL 60612, USA
    Expert Rev Neurother 10:43-57. 2010
    ....
  33. pmc Peripheral oxytocin is associated with reduced symptom severity in schizophrenia
    Leah H Rubin
    Department of Psychiatry, Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Schizophr Res 124:13-21. 2010
    ..We investigated the effects of menstrual cycle phase and related fluctuations in peripheral hormone levels on clinical symptoms in women with chronic schizophrenia...
  34. pmc Neural correlates of response inhibition in pediatric bipolar disorder and attention deficit hyperactivity disorder
    Alessandra M Passarotti
    Center for Cognitive Medicine, University of Illinois Medical Center at Chicago, Chicago, IL 60612, USA
    Psychiatry Res 181:36-43. 2010
    ..Prefrontal dysfunction was observed in both the ADHD and PBD groups relative to HC, although it was more extensive and accompanied by subcortical overactivity in ADHD...
  35. pmc A comparison of neuropsychological dysfunction in first-episode psychosis patients with unipolar depression, bipolar disorder, and schizophrenia
    S Kristian Hill
    Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Schizophr Res 113:167-75. 2009
    ..To the extent that these findings are generalizable, neuropsychological deficits in psychotic affective disorders, like schizophrenia, may be trait-like deficits with persistent functional implications...
  36. ncbi request reprint Neuropsychological dysfunction in antipsychotic-naive first-episode unipolar psychotic depression
    S Kristian Hill
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Psychiatry 161:996-1003. 2004
    ....
  37. ncbi request reprint Estimation and classification of fMRI hemodynamic response patterns
    Robert D Gibbons
    Center for Health Statistics, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuroimage 22:804-14. 2004
    ..The procedure is demonstrated on real data from an event-related design experiment of visually guided saccades and shown to be an effective alternative to existing methods...
  38. ncbi request reprint Insight and prefrontal cortex in first-episode Schizophrenia
    Mujeeb U Shad
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuroimage 22:1315-20. 2004
    ....
  39. pmc Lateralized response timing deficits in autism
    Anna Maria D'Cruz
    Center for Cognitive Medicine, University of Illinois at Chicago, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 66:393-7. 2009
    ..Evaluating performance on procedural learning tasks can provide unique information about neurodevelopmental disorders in which frontostriatal disturbances have been reported, such as autism...
  40. ncbi request reprint Functional neuroanatomy of anticipatory behavior: dissociation between sensory-driven and memory-driven systems
    Lucia S Simo
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois, Chicago, IL 60611, USA
    Cereb Cortex 15:1982-91. 2005
    ..Anticipatory behavior induced by the PRED task required less sensory-related processing activity and was subserved by a distributed cortico-subcortical memory system including prefronto-striatal circuitry...
  41. pmc Effectiveness of lamotrigine in maintaining symptom control in pediatric bipolar disorder
    Mani N Pavuluri
    University of Illinois at Chicago, Chicago, Illinois, USA
    J Child Adolesc Psychopharmacol 19:75-82. 2009
    ..The aim of this study was to test the effectiveness and safety of lamotrigine in maintenance of manic and depressive symptom control in pediatric bipolar disorder (PBD)...
  42. pmc Enhanced working and verbal memory after lamotrigine treatment in pediatric bipolar disorder
    Mani N Pavuluri
    Center for Cognitive Medicine, University of Illinois Medical Center at Chicago, Chicago, IL 60612, USA
    Bipolar Disord 12:213-20. 2010
    ..To examine the treatment impact of lamotrigine on the neurocognitive profile of patients with pediatric bipolar disorder (PBD)...
  43. pmc Pharmacological treatment effects on eye movement control
    James L Reilly
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Brain Cogn 68:415-35. 2008
    ....
  44. pmc Diffusion tensor imaging study of white matter fiber tracts in pediatric bipolar disorder and attention-deficit/hyperactivity disorder
    Mani N Pavuluri
    Center for Cognitive Medicine, University of Illinois Medical Center at Chicago, 912 S Wood Street, Chicago, IL 60612 7327, USA
    Biol Psychiatry 65:586-93. 2009
    ..To investigate microstructure of white matter fiber tracts in pediatric bipolar disorder (PBD) and attention-deficit/hyperactivity disorder (ADHD)...
  45. pmc Reduced attentional engagement contributes to deficits in prefrontal inhibitory control in schizophrenia
    James L Reilly
    Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Biol Psychiatry 63:776-83. 2008
    ..This suggests that dysregulation of automatic attentional processes may contribute to disturbances in prefrontally mediated control of voluntary behavior...
  46. pmc An fMRI study of visual attention and sensorimotor function before and after antipsychotic treatment in first-episode schizophrenia
    Sarah K Keedy
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, United States
    Psychiatry Res 172:16-23. 2009
    ....
  47. pmc Enhanced prefrontal function with pharmacotherapy on a response inhibition task in adolescent bipolar disorder
    Mani N Pavuluri
    Institute for Juvenile Research and Center for Cognitive Medicine, University of Illinois at Chicago, 912 South Wood St M C 913, Chicago, IL 60612, USA
    J Clin Psychiatry 71:1526-34. 2010
    ..The aim of the current study is to determine whether pharmacotherapy normalizes cognitive circuitry function supporting voluntary behavioral inhibition in adolescent bipolar disorder...
  48. pmc An fMRI study of the interface between affective and cognitive neural circuitry in pediatric bipolar disorder
    Mani N Pavuluri
    Center for Cognitive Medicine at the University of Illinois at Chicago UIC, Chicago, IL 60612, USA
    Psychiatry Res 162:244-55. 2008
    ..This pattern of functional alteration in affective and cognitive circuitry may contribute to the reduced capacity for affect regulation and behavioral self-control in pediatric bipolar disorder...
  49. pmc Neurocognitive allied phenotypes for schizophrenia and bipolar disorder
    S Kristian Hill
    Center for Cognitive Medicine, Department of Psychiatry M C 913, University of Illinois at Chicago, 912 South Wood Street, Suite 235, Chicago, IL 60612, USA
    Schizophr Bull 34:743-59. 2008
    ..However, very few studies have evaluated neurocognitive dimensions in bipolar probands or their unaffected relatives, and much work in this area is needed...
  50. pmc An fMRI study of the neural correlates of incidental versus directed emotion processing in pediatric bipolar disorder
    Mani N Pavuluri
    Department of Psychiatry, University of Illinois at Chicago, Institute for Juvenile Research and Center for Cognitive Medicine, 912 South Wood Street M C 913, Chicago, IL 60612, USA
    J Am Acad Child Adolesc Psychiatry 48:308-19. 2009
    ..To use functional neuroimaging to probe the affective circuitry dysfunctions underlying disturbances in emotion processing and emotional reactivity in pediatric bipolar disorder (PBD)...
  51. pmc Integrating functional brain neuroimaging and developmental cognitive neuroscience in child psychiatry research
    Mani N Pavuluri
    Center for Cognitive Medicine at the University of Illinois at Chicago, Chicago, IL 60612, USA
    J Am Acad Child Adolesc Psychiatry 47:1273-88. 2008
    ..To provide an overview of clinical research aiming to develop a mechanistic understanding of brain dysfunction in child psychiatric disorders...
  52. ncbi request reprint White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study
    Marilyn F Kraus
    Department of Psychiatry, University of Illinois at Chicago Medical Center, Chicago, IL, USA
    Brain 130:2508-19. 2007
    ..The more severe injuries impact both. DTI provides an objective means for determining the relationship of cognitive deficits to TBI, even in cases where the injury was sustained years prior to the evaluation...
  53. ncbi request reprint Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic-naïve patients with schizophrenia
    S Kristian Hill
    Center for Cognitive Medicine, Department of Psychiatry M C 913, University of Illinois at Chicago, 912 South Wood Street, Suite 235, Chicago, IL 60612, USA
    Schizophr Res 68:49-63. 2004
    ..Relatively static and generalized neuropsychological dysfunction, evident from illness onset, is consistent with neurodevelopmental rather than neurodegenerative models of schizophrenia...
  54. ncbi request reprint Impact of neurocognitive function on academic difficulties in pediatric bipolar disorder: A clinical translation
    Mani N Pavuluri
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
    Biol Psychiatry 60:951-6. 2006
    ..Investigation of the degree to which neuropsychological deficits might contribute to those academic problems is needed to aid in the recognition and intervention for school achievement difficulties in PBD...
  55. ncbi request reprint Longitudinal studies of antisaccades in antipsychotic-naive first-episode schizophrenia
    Margret S H Harris
    Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Psychol Med 36:485-94. 2006
    ..Some data suggest that treatment with antipsychotic medications may ameliorate these deficits...
  56. ncbi request reprint Oculomotor function in chronic traumatic brain injury
    Marilyn F Kraus
    Center for Cognitive Medicine and Department of Psychiatry, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Cogn Behav Neurol 20:170-8. 2007
    ..To characterize oculomotor function using visually guided saccade and antisaccade (AS) tasks in chronic traumatic brain injury (TBI) and assess the relationship to neuropsychologic testing...
  57. ncbi request reprint Psychotic symptoms in pediatric bipolar disorder
    Mani N Pavuluri
    Center for Cognitive Medicine, University of Illinois at Chicago, USA
    J Affect Disord 80:19-28. 2004
    ..There is under-recognition or misdiagnosis of pediatric bipolar disorder with psychotic features. It is of major public health importance to recognize psychosis in bipolar disorder...
  58. ncbi request reprint Neurocognitive function in unmedicated manic and medicated euthymic pediatric bipolar patients
    Mani N Pavuluri
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, 912 South Wood St M C 913, Chicago, IL 60612, USA
    Am J Psychiatry 163:286-93. 2006
    ....
  59. ncbi request reprint Antipsychotic drugs exacerbate impairment on a working memory task in first-episode schizophrenia
    James L Reilly
    Center for Cognitive Medicine, University of Illinois at Chicago, Illinois 60612, USA
    Biol Psychiatry 62:818-21. 2007
    ....
  60. ncbi request reprint Effects of antipsychotic treatment on emotion perception deficits in first-episode schizophrenia
    Ellen S Herbener
    Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, 912 S Wood St, Chicago, IL 60612, USA
    Am J Psychiatry 162:1746-8. 2005
    ..The authors evaluated emotion perception in acutely ill patients experiencing a first episode of schizophrenia. They also investigated the effects of antipsychotic medication on emotion perception...
  61. ncbi request reprint Facial emotion processing in acutely ill and euthymic patients with pediatric bipolar disorder
    Lindsay S Schenkel
    Department of Psychiatry, University of Illinois at Chicago, USA
    J Am Acad Child Adolesc Psychiatry 46:1070-9. 2007
    ..However, the extent to which these deficits represent state- and trait-related factors is unclear. We investigated facial affect processing in acutely ill and clinically stabilized children with PBD and matched healthy subjects...
  62. pmc What aspects of emotional functioning are impaired in schizophrenia?
    Ellen S Herbener
    Center for Cognitive Medicine, University of Illinois at Chicago, 912 S Wood Street M C 913, Chicago, IL 60612, USA
    Schizophr Res 98:239-46. 2008
    ....
  63. ncbi request reprint Impairment of verbal memory and learning in antipsychotic-naïve patients with first-episode schizophrenia
    S Kristian Hill
    Center for Cognitive Medicine, University of Illinois at Chicago, 912 South Wood Street, Suite 235, Chicago, IL 60612, USA
    Schizophr Res 68:127-36. 2004
    ..The goal of this study was to characterize the nature of verbal memory impairments in antipsychotic-naïve schizophrenic patients early in the course of illness...
  64. ncbi request reprint The emergence of collaborative brain function: FMRI studies of the development of response inhibition
    Beatriz Luna
    Laboratory of Neurocognitive Development, University of Pittsburgh Medical Center, 3501 Forbes Avenue, 743, Pittsburgh, PA 15213, USA
    Ann N Y Acad Sci 1021:296-309. 2004
    ..We also propose a model for brain-behavior maturation that allows for the qualitative changes in cognitive processes that occur during adolescence...
  65. ncbi request reprint Risperidone in first-episode psychosis: a longitudinal, exploratory voxel-based morphometric study
    Ragy R Girgis
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Schizophr Res 82:89-94. 2006
    ..No areas of change were found in controls. The results of this exploratory investigation support the possibility that risperidone has short-term effects on brain parenchyma in individuals with first-episode psychosis...
  66. ncbi request reprint Abnormalities in MRI-measured signal intensity in the corpus callosum in schizophrenia
    Vaibhav A Diwadkar
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Schizophr Res 67:277-82. 2004
    ....
  67. ncbi request reprint Frequency and metrics of square-wave jerks: influences of task-demand characteristics
    Dennis M Shaffer
    Social and Behavioral Sciences Program, Arizona State University West, Phoenix, Arizona, USA
    Invest Ophthalmol Vis Sci 44:1082-7. 2003
    ..Square-wave jerks (SWJs) during visual fixation and pursuit tracking of targets of varying speed and predictability were investigated in the present study...
  68. ncbi request reprint Combining brains: a survey of methods for statistical pooling of information
    Nicole A Lazar
    Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Neuroimage 16:538-50. 2002
    ..Given a combination of brain images, the researcher needs to interpret the result and decide on areas of activation; the question of thresholding is critical here and is also explored...
  69. ncbi request reprint Negative symptom resolution and improvements in specific cognitive deficits after acute treatment in first-episode schizophrenia
    Daniel Schuepbach
    Neurobehavioral Studies Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Schizophr Res 53:249-61. 2002
    ..Reduction in positive symptoms was not associated with change in cognitive abilities. These findings suggest a linkage between early, treatment-induced improvements in negative symptoms and reductions in distinct cognitive deficits...
  70. ncbi request reprint Pursuit eye movement deficits in autism
    Yukari Takarae
    University of Illinois at Chicago, Chicago, Illinois and 2 University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Brain 127:2584-94. 2004
    ....
  71. ncbi request reprint Relationships between cognitive and neurological performance in neuroleptic-naïve psychosis
    Richard D Sanders
    Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 16:480-7. 2004
    ..Customarily, frontal neuropsychological tasks also relate more strongly to CogPer than to RepMot. Approximately one-half of the variability in these cognitive and neurological assessments is shared...
  72. ncbi request reprint Effects of olanzapine, quetiapine, and risperidone on neurocognitive function in early psychosis: a randomized, double-blind 52-week comparison
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Psychiatry 164:1061-71. 2007
    ..The authors sought to compare the effects of olanzapine, quetiapine, and risperidone on neurocognitive function in patients with early psychosis...
  73. ncbi request reprint When does the brain inform the eyes whether and where to move? An EEG study in humans
    Brett A Clementz
    Department of Psychology and Neuroscience, Bio Imaging Research Center, University of Georgia, Athens, GA 30602, USA
    Cereb Cortex 17:2634-43. 2007
    ..These data highlight how a distributed neural architecture supports the evaluation of stimuli and response choices...
  74. pmc Psychopathology among offspring of parents with schizophrenia: relationship to premorbid impairments
    Matcheri Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201, St Antoine Blvd, Detroit, MI 48201, USA
    Schizophr Res 103:114-20. 2008
    ..We examined the prevalence and correlates of psychopathology in an ongoing study of offspring genetically at risk for schizophrenia...
  75. ncbi request reprint Brain basis of developmental change in visuospatial working memory
    K Suzanne Scherf
    University of Pittsburgh, PA 15213, USA
    J Cogn Neurosci 18:1045-58. 2006
    ..These results suggest that the maturation of adult-level cognition involves a combination of increasing localization within necessary regions and their integration with performance-enhancing regions...
  76. ncbi request reprint Genetically predisposed offspring with schizotypal features: an ultra high-risk group for schizophrenia?
    Vaibhav A Diwadkar
    Depatment of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Prog Neuropsychopharmacol Biol Psychiatry 30:230-8. 2006
    ..We propose that schizotypy may define a hyper vulnerable sub-sample among individuals genetically predisposed to schizophrenia and that future studies that attempt to assess risk may benefit from such a convergent approach...
  77. ncbi request reprint Premorbid indicators and risk for schizophrenia: a selective review and update
    Matcheri S Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201 St Antoine, Suite 9B, Detroit, MI 48201, USA
    Schizophr Res 79:45-57. 2005
    ..Collectively, such data may help us to predict the eventual emergence of schizophrenia, and schizophrenia spectrum or non-spectrum psychopathology...
  78. ncbi request reprint Early treatment-induced improvement of negative symptoms predicts cognitive functioning in treatment-naive first episode schizophrenia: a 2-year followup
    Daniel Schuepbach
    Psychiatric University Hospital Zurich, PO Box 68, CH 8029 Zurich, Switzerland
    Schizophr Bull 30:837-48. 2004
    ..These findings suggest an important relationship between treatment efficacy of antipsychotic medication and the longer term course of cognitive deficits in schizophrenia...
  79. pmc Effects of second-generation antipsychotic medication on smooth pursuit performance in antipsychotic-naive schizophrenia
    Rebekka Lencer
    Department of Psychiatry, University of Lubeck, Lubeck, Germany
    Arch Gen Psychiatry 65:1146-54. 2008
    ..Although pursuit eye tracking deficits have been widely reported in schizophrenia, the integrity of discrete components of pursuit responses and the effect of second-generation antipsychotic medication on them are not well established...
  80. pmc Reduced N-acetyl-aspartate levels in schizophrenia patients with a younger onset age: a single-voxel 1H spectroscopy study
    Jeffrey A Stanley
    Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, United States
    Schizophr Res 93:23-32. 2007
    ....
  81. ncbi request reprint Development of the corpus callosum in childhood, adolescence and early adulthood
    Matcheri S Keshavan
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Life Sci 70:1909-22. 2002
    ..CC maturational changes appeared synchronous across sub-regions suggesting parallel maturation of diverse brain regions during childhood and adolescence...
  82. ncbi request reprint Mechanisms underlying spatial representation revealed through studies of hemispatial neglect
    Marlene Behrmann
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    J Cogn Neurosci 14:272-90. 2002
    ..The findings dovetail well with results from existing neurophysiological studies and shed further light on the spatial representations mediated by the human parietal cortex...
  83. ncbi request reprint Pursuit and saccadic eye movement subregions in human frontal eye field: a high-resolution fMRI investigation
    Caterina Rosano
    Neurobehavioral Studies Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Cereb Cortex 12:107-15. 2002
    ..These findings localize distinct pursuit and saccadic subregions of FEF in humans and demonstrate a high degree of homology in the organization of these FEF subregions in the human and the macaque monkey...
  84. ncbi request reprint Abnormal brain lateralization in high-functioning autism
    Paul R Escalante-Mead
    University of Illinois at Chicago, Chicago, IL 60612, USA
    J Autism Dev Disord 33:539-43. 2003
    ..The data indicated maturational disturbances in establishing lateral preference rather than increased rates of left handedness. Atypical establishment of cerebral dominance may be one cause of disordered language development in autism...

Research Grants9

  1. OCULOMOTOR & SPATIAL COGNITION DEFICITS IN SCHIZOPHRENIA
    John Sweeney; Fiscal Year: 2004
    ..Findings will also clarify the diagnostic specificity of regional brain disturbances causing these abnormalities, and the impact of known effective treatments upon them. ..
  2. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    John Sweeney; Fiscal Year: 2007
    ....
  3. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    John Sweeney; Fiscal Year: 2009
    ....
  4. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    John A Sweeney; Fiscal Year: 2010
    ....