JOHN SWEATT

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc An epigenetic hypothesis of aging-related cognitive dysfunction
    Marsha R Penner
    Arizona Research Laboratories Division of Neural Systems, Memory and Aging and Evelyn F McKnight Brain Institute, University of Arizona Tucson, AZ, USA
    Front Aging Neurosci 2:9. 2010
  2. pmc NADPH oxidase mediates beta-amyloid peptide-induced activation of ERK in hippocampal organotypic cultures
    Faridis Serrano
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA
    Mol Brain 2:31. 2009
  3. pmc Experience-dependent epigenetic modifications in the central nervous system
    J David Sweatt
    Department of Neurobiology and Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Biol Psychiatry 65:191-7. 2009
  4. ncbi request reprint An atomic switch for memory
    J David Sweatt
    Department of Neurobiology and McKnight Brain Institute, University of Alabama Birmingham, Birmingham, AL 35294, USA
    Cell 129:23-4. 2007
  5. pmc Regulation of chromatin structure in memory formation
    Tania L Roth
    Department of Neurobiology and Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Curr Opin Neurobiol 19:336-42. 2009
  6. pmc Histone methylation regulates memory formation
    Swati Gupta
    Evelyn F McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 30:3589-99. 2010
  7. pmc The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories
    Farah D Lubin
    The Evelyn F McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuron 55:942-57. 2007
  8. ncbi request reprint Covalent modification of DNA regulates memory formation
    Courtney A Miller
    Department of Neurobiology and the Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuron 53:857-69. 2007
  9. pmc Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances
    Abigail Polter
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Neuropsychopharmacology 35:1761-74. 2010
  10. pmc Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome
    Christopher J Yuskaitis
    Department of Psychiatry and Behavioral Neurobiology, 1720 7th Ave South, Sparks Center 1057, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Biochem Pharmacol 79:632-46. 2010

Research Grants

  1. Biochemical Mechanisms of Long-Term Potentiation
    John David Sweatt; Fiscal Year: 2010
  2. BIOCHEMICAL MECHANISMS FOR LONG TERM POTENTIATION
    JOHN SWEATT; Fiscal Year: 2004
  3. Biochemical Mechanisms of Long-Term Potentiation
    JOHN SWEATT; Fiscal Year: 2007
  4. TROPHIC INTERACTIONS OF NERVE AND MUSCLE
    JOHN SWEATT; Fiscal Year: 2007
  5. Molecular and Cellular Cognition Meeting
    JOHN SWEATT; Fiscal Year: 2007
  6. Biochemical Mechanisms of Long-Term Potentiation
    JOHN SWEATT; Fiscal Year: 2009
  7. TROPHIC INTERACTIONS OF NERVE AND MUSCLE
    JOHN SWEATT; Fiscal Year: 2009
  8. TROPHIC INTERACTIONS OF NERVE AND MUSCLE
    John David Sweatt; Fiscal Year: 2010
  9. TROPHIC INTERACTIONS OF NERVE AND MUSCLE
    JOHN SWEATT; Fiscal Year: 2009
  10. Biochemical Mechanisms of Long-Term Potentiation
    JOHN SWEATT; Fiscal Year: 2006

Collaborators

Detail Information

Publications24

  1. pmc An epigenetic hypothesis of aging-related cognitive dysfunction
    Marsha R Penner
    Arizona Research Laboratories Division of Neural Systems, Memory and Aging and Evelyn F McKnight Brain Institute, University of Arizona Tucson, AZ, USA
    Front Aging Neurosci 2:9. 2010
    ..Finally, several open questions will be discussed that we believe will fuel experimental discovery...
  2. pmc NADPH oxidase mediates beta-amyloid peptide-induced activation of ERK in hippocampal organotypic cultures
    Faridis Serrano
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA
    Mol Brain 2:31. 2009
    ..In this study we sought to characterize the cellular localization of phosphorylated, active ERK in organotypic hippocampal cultures after acute exposure to either Abeta (1-42) or nicotine...
  3. pmc Experience-dependent epigenetic modifications in the central nervous system
    J David Sweatt
    Department of Neurobiology and Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Biol Psychiatry 65:191-7. 2009
    ..Taken together, these eclectic findings suggest a new perspective on experience-dependent dynamic regulation of epigenetic mechanisms in the adult nervous system and their relevance to biological psychiatry...
  4. ncbi request reprint An atomic switch for memory
    J David Sweatt
    Department of Neurobiology and McKnight Brain Institute, University of Alabama Birmingham, Birmingham, AL 35294, USA
    Cell 129:23-4. 2007
    ..An excellent example of this is provided in this issue of Cell by Costa-Mattioli et al. (2007), whose results implicate a single protein dephosphorylation event in the control of long-term memory formation in mice...
  5. pmc Regulation of chromatin structure in memory formation
    Tania L Roth
    Department of Neurobiology and Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Curr Opin Neurobiol 19:336-42. 2009
    ..As an understanding of these novel mechanisms of transcriptional regulation promises to invigorate many areas of investigation, we end by speculating upon some of the open questions ripe for discovery...
  6. pmc Histone methylation regulates memory formation
    Swati Gupta
    Evelyn F McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 30:3589-99. 2010
    ..Zif268 DNA methylation levels returned to baseline at 24 h. Together, these data demonstrate that histone methylation is actively regulated in the hippocampus and facilitates long-term memory formation...
  7. pmc The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories
    Farah D Lubin
    The Evelyn F McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuron 55:942-57. 2007
    ..These data provide insights into IKK-regulated transcriptional mechanisms in hippocampus that are necessary for memory reconsolidation...
  8. ncbi request reprint Covalent modification of DNA regulates memory formation
    Courtney A Miller
    Department of Neurobiology and the Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuron 53:857-69. 2007
    ..These results demonstrate that DNA methylation is dynamically regulated in the adult nervous system and that this cellular mechanism is a crucial step in memory formation...
  9. pmc Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances
    Abigail Polter
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Neuropsychopharmacology 35:1761-74. 2010
    ....
  10. pmc Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome
    Christopher J Yuskaitis
    Department of Psychiatry and Behavioral Neurobiology, 1720 7th Ave South, Sparks Center 1057, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Biochem Pharmacol 79:632-46. 2010
    ..These findings support the hypothesis that impaired inhibition of GSK3 contributes to the pathogenesis of FXS and support GSK3 as a potential therapeutic target...
  11. pmc Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory
    Farah D Lubin
    Department of Neurobiology, The Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 28:10576-86. 2008
    ..These results suggest epigenetic modification of the bdnf gene as a mechanism for isoform-specific gene readout during memory consolidation...
  12. doi request reprint Rhythms of memory
    Tania L Roth
    Department of Neurobiology and McKnight Brain Institute, University of Alabama Birmingham, 1825 University Blvd, SHEL 1010, Birmingham, Alabama 35294 2182, USA
    Nat Neurosci 11:993-4. 2008
    ..Mitogen-activated Protein Kinases (MAPKs) are critical for the formation of stable long-term memories. New work shows that circadian MAPK activity cycling is important in the formation of new hippocampus-dependent memories...
  13. doi request reprint Striatal histone modifications in models of levodopa-induced dyskinesia
    Anthony P Nicholas
    Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, AL 35294 0017, USA
    J Neurochem 106:486-94. 2008
    ..However, both models exhibit marked deacetylation of histone H4, suggesting that inhibitors of H4 deacetylation may be useful in preventing or reversing LDID...
  14. pmc DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity
    Courtney A Miller
    Department of Neurobiology, Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, 1074 Shelby Building, 1825 University Boulevard, Birmingham, AL, USA
    Neurobiol Learn Mem 89:599-603. 2008
    ....
  15. pmc Increased c-fos expression in the central nucleus of the amygdala and enhancement of cued fear memory in Dyt1 DeltaGAG knock-in mice
    Fumiaki Yokoi
    Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neurosci Res 65:228-35. 2009
    ..These results suggest that the Dyt1 DeltaGAG mutation increased the activity of the CE and enhanced the acquisition of the cued fear memory...
  16. doi request reprint Epigenetic regulation of genes in learning and memory
    Tania L Roth
    Department of Neurobiology and Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Essays Biochem 48:263-74. 2010
    ..In this chapter, we discuss data regarding epigenetic marking of genes in adult learning and memory formation and impairment thereof, as well as data showcasing the promise for manipulating the epigenome in restoring memory capacity...
  17. pmc Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease
    Mark Kilgore
    Department of Neurobiology, Evelyn F McKnight Brain Institute, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
    Neuropsychopharmacology 35:870-80. 2010
    ..These preclinical results indicate that targeted inhibition of class I HDAC isoforms is a promising avenue for treating the cognitive deficits associated with early stage AD...
  18. pmc Lasting epigenetic influence of early-life adversity on the BDNF gene
    Tania L Roth
    Department of Neurobiology and the Evelyn F McKnight Brain Institute, University of Alabama Birmingham, Birmingham, Alabama 35294, USA
    Biol Psychiatry 65:760-9. 2009
    ..With a rat model of infant maltreatment by a caregiver, we investigated whether early-life adversity leaves lasting epigenetic marks at the brain-derived neurotrophic factor (BDNF) gene in the central nervous system...
  19. pmc Cortical DNA methylation maintains remote memory
    Courtney A Miller
    Department of Neurobiology and Evelyn F McKnight Brain Institute, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA
    Nat Neurosci 13:664-6. 2010
    ..We propose that the adult brain utilizes DNA methylation to preserve long-lasting memories...
  20. pmc DNA methylation and memory formation
    Jeremy J Day
    Department of Neurobiology and Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nat Neurosci 13:1319-23. 2010
    ....
  21. pmc Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of Schizophrenia
    Xiaochuan Guo
    Department of Neurobiology and Evelyn F McKnight Brain Institute, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuropsychopharmacology 34:1659-72. 2009
    ..Taken together, these data support the idea that schizophrenia may arise from abnormal signaling pathways that are mediated by NMDA receptors...
  22. ncbi request reprint Amnesia or retrieval deficit? Implications of a molecular approach to the question of reconsolidation
    Courtney A Miller
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Learn Mem 13:498-505. 2006
    ....
  23. pmc Altered phosphorylation and localization of the A-type channel, Kv4.2 in status epilepticus
    Joaquin N Lugo
    The Cain Foundation Laboratories, Department of Pediatrics, Houston, Texas, USA
    J Neurochem 106:1929-40. 2008
    ..The finding of decreased Kv4.2 levels in hippocampal synaptosomes and surface membranes suggest additional mechanisms for decreasing the dendritic A-current, which could lead to altered intrinsic membrane excitability during SE...
  24. ncbi request reprint PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex
    Laura A Schrader
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 22:10123-33. 2002
    ..2-encoded A channels by PKA. Overall, our studies indicate that PKA must of necessity act on a supramolecular complex of pore-forming alpha-subunits plus ancillary subunits to alter channel properties...

Research Grants27

  1. Biochemical Mechanisms of Long-Term Potentiation
    John David Sweatt; Fiscal Year: 2010
    ..One Aim of the Project specifically involves preclinical studies to evaluate a potential new type of treatment for learning and memory disorders. ..
  2. BIOCHEMICAL MECHANISMS FOR LONG TERM POTENTIATION
    JOHN SWEATT; Fiscal Year: 2004
    ..These studies will provide insight into mechanisms involved in long-lasting changes in neuronal function in the mammalian CNS and should increase our understanding of the molecular basis of neuropsychiatric disorders. ..
  3. Biochemical Mechanisms of Long-Term Potentiation
    JOHN SWEATT; Fiscal Year: 2007
    ..These studies will give us insights into key functional loci in the hippocampal ERK MAP Kinase cascade, a new signal transduction pathway involved in transcriptional regulation, synaptic plasticity, and memory formation. ..
  4. TROPHIC INTERACTIONS OF NERVE AND MUSCLE
    JOHN SWEATT; Fiscal Year: 2007
    ....
  5. Molecular and Cellular Cognition Meeting
    JOHN SWEATT; Fiscal Year: 2007
    ....
  6. Biochemical Mechanisms of Long-Term Potentiation
    JOHN SWEATT; Fiscal Year: 2009
    ..These studies will give us insights into key functional loci in the hippocampal ERK MAP Kinase cascade, a new signal transduction pathway involved in transcriptional regulation, synaptic plasticity, and memory formation. ..
  7. TROPHIC INTERACTIONS OF NERVE AND MUSCLE
    JOHN SWEATT; Fiscal Year: 2009
    ....
  8. TROPHIC INTERACTIONS OF NERVE AND MUSCLE
    John David Sweatt; Fiscal Year: 2010
    ....
  9. TROPHIC INTERACTIONS OF NERVE AND MUSCLE
    JOHN SWEATT; Fiscal Year: 2009
    ....
  10. Biochemical Mechanisms of Long-Term Potentiation
    JOHN SWEATT; Fiscal Year: 2006
    ..These studies will give us insights into key functional loci in the hippocampal ERK MAP Kinase cascade, a new signal transduction pathway involved in transcriptional regulation, synaptic plasticity, and memory formation. ..
  11. TROPHIC INTERACTION OF NERVE AND MUSCLE
    JOHN SWEATT; Fiscal Year: 2004
    ....
  12. TROPHIC INTERACTION OF NERVE AND MUSCLE
    JOHN SWEATT; Fiscal Year: 2005
    ....
  13. BIOCHEMICAL MECHANISMS FOR LONG TERM POTENTIATION
    JOHN SWEATT; Fiscal Year: 2000
    ..These studies will provide insight into mechanisms involved in long-lasting changes in neuronal function in the mammalian CNS and should increase our understanding of the molecular basis of neuropsychiatric disorders. ..
  14. BIOCHEMICAL MECHANISMS FOR LONG TERM POTENTIATION
    JOHN SWEATT; Fiscal Year: 2001
    ..These studies will provide insight into mechanisms involved in long-lasting changes in neuronal function in the mammalian CNS and should increase our understanding of the molecular basis of neuropsychiatric disorders. ..
  15. BIOCHEMICAL MECHANISMS FOR LONG TERM POTENTIATION
    JOHN SWEATT; Fiscal Year: 2002
    ..These studies will provide insight into mechanisms involved in long-lasting changes in neuronal function in the mammalian CNS and should increase our understanding of the molecular basis of neuropsychiatric disorders. ..
  16. BIOCHEMICAL MECHANISMS FOR LONG TERM POTENTIATION
    JOHN SWEATT; Fiscal Year: 2002
    ..These studies will provide insight into mechanisms involved in long-lasting changes in neuronal function in the mammalian CNS and should increase our understanding of the molecular basis of neuropsychiatric disorders. ..
  17. TROPHIC INTERACTION OF NERVE AND MUSCLE
    JOHN SWEATT; Fiscal Year: 2003
    ....
  18. BIOCHEMICAL MECHANISMS FOR LONG TERM POTENTIATION
    JOHN SWEATT; Fiscal Year: 2003
    ..These studies will provide insight into mechanisms involved in long-lasting changes in neuronal function in the mammalian CNS and should increase our understanding of the molecular basis of neuropsychiatric disorders. ..
  19. TROPHIC INTERACTION OF NERVE AND MUSCLE
    JOHN SWEATT; Fiscal Year: 2004
    ....
  20. Biochemical Mechanisms of Long-Term Potentiation
    JOHN SWEATT; Fiscal Year: 2005
    ..These studies will give us insights into key functional loci in the hippocampal ERK MAP Kinase cascade, a new signal transduction pathway involved in transcriptional regulation, synaptic plasticity, and memory formation. ..