MICHELE SOMES SWANSON

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection
    Ari B Molofsky
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 203:1093-104. 2006
  2. pmc Nutrient salvaging and metabolism by the intracellular pathogen Legionella pneumophila
    Maris V Fonseca
    Science and Mathematics Division, Monroe County Community College Monroe, MI, USA
    Front Cell Infect Microbiol 4:12. 2014
  3. pmc Inflammasome components coordinate autophagy and pyroptosis as macrophage responses to infection
    Brenda G Byrne
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    MBio 4:e00620-12. 2013
  4. pmc Secrets of a successful pathogen: legionella resistance to progression along the autophagic pathway
    Amrita D Joshi
    Department of Microbiology and Immunology, University of Michigan Medical School Ann Arbor, MI, USA
    Front Microbiol 2:138. 2011
  5. ncbi request reprint Autophagy: eating for good health
    Michele S Swanson
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 177:4945-51. 2006
  6. pmc Autophagy and inflammatory cell death, partners of innate immunity
    Michele S Swanson
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Autophagy 1:174-6. 2005
  7. ncbi request reprint Legionella pneumophila pathogesesis: a fateful journey from amoebae to macrophages
    M S Swanson
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Annu Rev Microbiol 54:567-613. 2000
  8. ncbi request reprint A microbial strategy to multiply in macrophages: the pregnant pause
    Michele S Swanson
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    Traffic 3:170-7. 2002
  9. pmc Efficient generation of unmarked deletions in Legionella pneumophila
    Andrew Bryan
    Department of Microbiology and Immunology, University of Michigan Medical School, 5641 Medical Sciences Building II, 1150 West Medical Center Dr, Ann Arbor, MI 48109 5620, USA
    Appl Environ Microbiol 77:2545-8. 2011
  10. ncbi request reprint Early recruitment of neutrophils determines subsequent T1/T2 host responses in a murine model of Legionella pneumophila pneumonia
    K Tateda
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 166:3355-61. 2001

Research Grants

  1. Analysis of L. Pneumophilia Virulence Regulation
    MICHELE SWANSON; Fiscal Year: 2006
  2. Analysis of L. Pneumophilia Virulence Regulation
    MICHELE SOMES SWANSON; Fiscal Year: 2010
  3. Analysis of L. Pneumophilia Virulence Regulation
    MICHELE SWANSON; Fiscal Year: 2009
  4. Evasion of Macrophage Lysosomes by L pneumophilia
    MICHELE SWANSON; Fiscal Year: 2007
  5. Evasion of Macrophage Lysosomes by L pneumophilia
    MICHELE SWANSON; Fiscal Year: 2006
  6. Evasion of Macrophage Lysosomes by L pneumophilia
    MICHELE SWANSON; Fiscal Year: 2003
  7. Analysis of L. Pneumophilia Virulence Regulation
    MICHELE SWANSON; Fiscal Year: 2007
  8. Analysis of L. Pneumophilia Virulence Regulation
    MICHELE SWANSON; Fiscal Year: 2009

Collaborators

Detail Information

Publications31

  1. pmc Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection
    Ari B Molofsky
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 203:1093-104. 2006
    ..Accordingly, macrophages respond to cytosolic flagellin by a mechanism that requires Naip5 and caspase 1 to restrict bacterial replication and release proinflammatory cytokines that control L. pneumophila infection...
  2. pmc Nutrient salvaging and metabolism by the intracellular pathogen Legionella pneumophila
    Maris V Fonseca
    Science and Mathematics Division, Monroe County Community College Monroe, MI, USA
    Front Cell Infect Microbiol 4:12. 2014
    ..Specifically, we highlight the metabolic cues that are coupled to bacterial differentiation, nutrient acquisition systems, and the strategies utilized by L. pneumophila to exploit host metabolites for intracellular replication. ..
  3. pmc Inflammasome components coordinate autophagy and pyroptosis as macrophage responses to infection
    Brenda G Byrne
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    MBio 4:e00620-12. 2013
    ....
  4. pmc Secrets of a successful pathogen: legionella resistance to progression along the autophagic pathway
    Amrita D Joshi
    Department of Microbiology and Immunology, University of Michigan Medical School Ann Arbor, MI, USA
    Front Microbiol 2:138. 2011
    ..Accordingly, L. pneumophila can be exploited as a genetic tool to analyze the recruitment and function of the macrophage autophagy pathway...
  5. ncbi request reprint Autophagy: eating for good health
    Michele S Swanson
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 177:4945-51. 2006
    ....
  6. pmc Autophagy and inflammatory cell death, partners of innate immunity
    Michele S Swanson
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Autophagy 1:174-6. 2005
    ....
  7. ncbi request reprint Legionella pneumophila pathogesesis: a fateful journey from amoebae to macrophages
    M S Swanson
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Annu Rev Microbiol 54:567-613. 2000
    ..Knowledge of L. pneumophila ecology may also inform efforts to combat the emergence of new opportunistic macrophage pathogens...
  8. ncbi request reprint A microbial strategy to multiply in macrophages: the pregnant pause
    Michele S Swanson
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    Traffic 3:170-7. 2002
    ..In the transmissible state, Leishmania spp., Coxiella burnetii, and Legionella pneumophila block phagosome maturation; after a pregnant pause, replicative forms emerge and thrive in lysosomes...
  9. pmc Efficient generation of unmarked deletions in Legionella pneumophila
    Andrew Bryan
    Department of Microbiology and Immunology, University of Michigan Medical School, 5641 Medical Sciences Building II, 1150 West Medical Center Dr, Ann Arbor, MI 48109 5620, USA
    Appl Environ Microbiol 77:2545-8. 2011
    ..pneumophila by natural transformation. Resistance cassettes were then efficiently excised using the Flp site-specific recombinase encoded on a plasmid that is readily lost...
  10. ncbi request reprint Early recruitment of neutrophils determines subsequent T1/T2 host responses in a murine model of Legionella pneumophila pneumonia
    K Tateda
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 166:3355-61. 2001
    ..pneumophila infection, not via direct killing but more immunomodulatory effects. Our results suggest that the early recruitment of neutrophils may contribute to T1 polarization in a murine model of L. pneumophila pneumonia...
  11. ncbi request reprint Evidence that Dot-dependent and -independent factors isolate the Legionella pneumophila phagosome from the endocytic network in mouse macrophages
    A D Joshi
    Department of Microbiology and Immunology, The University of Michigan Medical School, Ann Arbor 48109, USA
    Cell Microbiol 3:99-114. 2001
    ..pneumophila phagosome from a LAMP-1-containing compartment, and a formalin-resistant Dot-independent activity inhibits vacuolar accumulation of endocytosed material and delivery to the degradative lysosomes...
  12. ncbi request reprint RpoS co-operates with other factors to induce Legionella pneumophila virulence in the stationary phase
    M A Bachman
    Department of Microbiology and Immunology, The University of Michigan Medical School, 6734 Medical Sciences II, Ann Arbor, MI 48109, USA
    Mol Microbiol 40:1201-14. 2001
    ..Together, the data support a model in which RpoS co-operates with other regulators to induce L. pneumophila virulence in the PE phase...
  13. pmc Mouse macrophages are permissive to motile Legionella species that fail to trigger pyroptosis
    Natalie N Whitfield
    Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Infect Immun 78:423-32. 2010
    ..These results point to the complexity of disease, a product of the pathogenic potential of the microbe, as defined in the laboratory, and the capacity of the host to mount a measured defense...
  14. pmc ppGpp conjures bacterial virulence
    Zachary D Dalebroux
    Department of Microbiology and Immunology, University of Michigan Medical School, 6733 Medical Science Building II, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5620, USA
    Microbiol Mol Biol Rev 74:171-99. 2010
    ..Here we discuss how components of the stringent response contribute to the virulence of a wide variety of pathogenic bacteria...
  15. pmc The Legionella pneumophila LetA/LetS two-component system exhibits rheostat-like behavior
    Rachel L Edwards
    University of Michigan Medical School, Ann Arbor, Michigan, USA
    Infect Immun 78:2571-83. 2010
    ..Thus, as first described for BvgA/BvgS, rather than acting as on/off switches, this family of two-component systems exhibit rheostat activity that likely confers versatility as microbes adapt to fluctuating environments...
  16. pmc Mouse infection by Legionella, a model to analyze autophagy
    Jean Francois Dubuisson
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0620, USA
    Autophagy 2:179-82. 2006
    ..Here we discuss the mouse macrophage response to L. pneumophila, the facultative intracellular bacterium responsible for an acute form of pneumonia, Legionnaire's disease...
  17. pmc Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    Daniel J Klionsky
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Autophagy 4:151-75. 2008
    ..In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response...
  18. pmc Legionella pneumophila catalase-peroxidases are required for proper trafficking and growth in primary macrophages
    Purnima Bandyopadhyay
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 71:4526-35. 2003
    ..We also observed that wild-type JR32, unlike Lp02, shows minimal contact-dependent cytotoxicity, suggesting that cytotoxicity of JR32 is not a prerequisite for formation of replication-competent Legionella phagosomes in macrophages...
  19. ncbi request reprint A phagosome of one's own: a microbial guide to life in the macrophage
    Amal O Amer
    University of Michigan Medical School, 6734 Medical Sciences Building II, Ann Arbor, MI 48109 0620, USA
    Curr Opin Microbiol 5:56-61. 2002
    ..Recent studies support a new paradigm in which pathogens evade lysosomal degradation by entering macrophages within specialized lipid microdomains of the plasma membrane...
  20. pmc Macrophages rapidly transfer pathogens from lipid raft vacuoles to autophagosomes
    Amal O Amer
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Autophagy 1:53-8. 2005
    ..A model in which macrophages exploit autophagy to capture pathogens within the lipid raft pathway for antigen presentation prior to disposal in lysosomes is discussed...
  21. pmc The LetE protein enhances expression of multiple LetA/LetS-dependent transmission traits by Legionella pneumophila
    Michael A Bachman
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0620, USA
    Infect Immun 72:3284-93. 2004
    ..We also discuss how the LetE protein may interact with LetA/LetS and CsrA to enhance L. pneumophila differentiation to a transmissible form...
  22. pmc Autophagy is an immediate macrophage response to Legionella pneumophila
    Amal O Amer
    Department of Microbiology and Immunology, University of Michigan Medical School, 6734 Medical Science Building II, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0620, USA
    Cell Microbiol 7:765-78. 2005
    ..Accordingly, we discuss a model in which macrophages elevate autophagy as a barrier to infection, a decision influenced by regulatory interactions between Naip proteins and caspases...
  23. pmc The phagosomal transporter A couples threonine acquisition to differentiation and replication of Legionella pneumophila in macrophages
    John Demian Sauer
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    Proc Natl Acad Sci U S A 102:9924-9. 2005
    ..Accordingly, we propose that the Pht transporter family equips transmissive L. pneumophila, C. burnetii, and F. tularensis to assess their phagosomal nutrient supply before committing to reenter the cell cycle...
  24. pmc Specificity of Legionella pneumophila and Coxiella burnetii vacuoles and versatility of Legionella pneumophila revealed by coinfection
    John Demian Sauer
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 S 4th St, Hamilton, MT 59840, USA
    Infect Immun 73:4494-504. 2005
    ..pneumophila replication vacuole. Moreover, L. pneumophila can replicate efficiently in either lysosomal vacuoles of A/J mouse cells or in nonlysosomal vacuoles of primate cells...
  25. pmc Membrane vesicles shed by Legionella pneumophila inhibit fusion of phagosomes with lysosomes
    Esteban Fernandez-Moreira
    Department of Microbiology and Immunology, University of Michigan Medical School, 6734 Medical Sciences Building II, Ann Arbor, MI 48109 0620, USA
    Infect Immun 74:3285-95. 2006
    ..pneumophila developmentally regulates its surface composition and releases vesicles into phagosomes that inhibit their fusion with lysosomes...
  26. pmc Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death
    A B Molofsky
    Department of Microbiology and Immunology, University of Michigan Medical School, 6734 Medical Sciences Building II, Ann Arbor, MI 48109 0620, USA
    Infect Immun 73:5720-34. 2005
    ..Thus, the flagellar regulon equips the aquatic pathogen L. pneumophila to coordinate motility with multiple traits vital to virulence...
  27. doi request reprint The phagosomal nutrient transporter (Pht) family
    Derek E Chen
    Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093 0116, USA
    Microbiology 154:42-53. 2008
    ..This work serves to characterize two novel families within the MFS and provides compelling evidence for horizontal transfer of some of the family members...
  28. ncbi request reprint A two-component regulator induces the transmission phenotype of stationary-phase Legionella pneumophila
    Brian K Hammer
    Department of Microbiology and Immunology, University of Michigan Medical School, 6734 Medical Sciences Building II, Ann Arbor, MI 48109 0620, USA
    Mol Microbiol 44:107-18. 2002
    ..Together, the data indicate that, as the nutrient supply wanes, ppGpp triggers a regulatory cascade mediated by LetA/ LetS, RpoS, FliA and letE that coordinates differentiation of replicating L. pneumophila to a transmissible form...
  29. ncbi request reprint Differentiate to thrive: lessons from the Legionella pneumophila life cycle
    Ari B Molofsky
    Department of Microbiology and Immunology, University of Michigan Medical School, 6734 Medical Sciences Building II, Ann Arbor, MI 48109 0620, USA
    Mol Microbiol 53:29-40. 2004
    ....
  30. pmc Genetic evidence that Legionella pneumophila RpoS modulates expression of the transmission phenotype in both the exponential phase and the stationary phase
    Michael A Bachman
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0620, USA
    Infect Immun 72:2468-76. 2004
    ..By coupling transcriptional and posttranscriptional control pathways, intracellular L. pneumophila could respond to stress by rapidly differentiating to a transmissible form...
  31. ncbi request reprint Legionella pneumophila CsrA is a pivotal repressor of transmission traits and activator of replication
    Ari B Molofsky
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    Mol Microbiol 50:445-61. 2003
    ..The reciprocal regulation of replication and transmission exemplified by CsrA likely enhances the fitness of microbes faced with fluctuating environments...

Research Grants16

  1. Analysis of L. Pneumophilia Virulence Regulation
    MICHELE SWANSON; Fiscal Year: 2006
    ..Thus, concepts and pathways identified here can also guide studies and management of less tractable intracellular pathogens such as the Mycobacteria, Chlamydia, Francisella, and Coxiella species. ..
  2. Analysis of L. Pneumophilia Virulence Regulation
    MICHELE SOMES SWANSON; Fiscal Year: 2010
    ..Thus, concepts and pathways identified here can also guide studies and management of less tractable intracellular pathogens such as the Mycobacteria, Chlamydia, Francisella, and Coxiella species. ..
  3. Analysis of L. Pneumophilia Virulence Regulation
    MICHELE SWANSON; Fiscal Year: 2009
    ..Thus, concepts and pathways identified here can also guide studies and management of less tractable intracellular pathogens such as the Mycobacteria, Chlamydia, Francisella, and Coxiella species. ..
  4. Evasion of Macrophage Lysosomes by L pneumophilia
    MICHELE SWANSON; Fiscal Year: 2007
    ..abstract_text> ..
  5. Evasion of Macrophage Lysosomes by L pneumophilia
    MICHELE SWANSON; Fiscal Year: 2006
    ..abstract_text> ..
  6. Evasion of Macrophage Lysosomes by L pneumophilia
    MICHELE SWANSON; Fiscal Year: 2003
    ..abstract_text> ..
  7. Analysis of L. Pneumophilia Virulence Regulation
    MICHELE SWANSON; Fiscal Year: 2007
    ..Thus, concepts and pathways identified here can also guide studies and management of less tractable intracellular pathogens such as the Mycobacteria, Chlamydia, Francisella, and Coxiella species. ..
  8. Analysis of L. Pneumophilia Virulence Regulation
    MICHELE SWANSON; Fiscal Year: 2009
    ..Thus, concepts and pathways identified here can also guide studies and management of less tractable intracellular pathogens such as the Mycobacteria, Chlamydia, Francisella, and Coxiella species. ..