J M Swanson

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Efficacy of two once-daily methylphenidate formulations compared across dose levels at different times of the day: preliminary indications from a secondary analysis of the COMACS study data
    Edmund J S Sonuga-Barke
    The Developmental Brain Behaviour Unit, University of Southampton, Southampton, SO17 1BJ UK
    BMC Psychiatry 4:28. 2004
  2. pmc Assessing the molecular genetics of attention networks
    John Fossella
    Sackler Institute of Developmental Psychobiology, Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    BMC Neurosci 3:14. 2002
  3. ncbi request reprint Compliance with stimulants for attention-deficit/hyperactivity disorder: issues and approaches for improvement
    James Swanson
    University of California Irvine, Irvine, California 92612, USA
    CNS Drugs 17:117-31. 2003
  4. pmc Developmental origins of health and disease: environmental exposures
    James M Swanson
    Department of Pediatrics, University of California, Irvine, School of Medicine, 19722 MacArthur Boulevard, Irvine, CA 92612 4480, USA
    Semin Reprod Med 27:391-402. 2009
  5. ncbi request reprint The use of a laboratory school protocol to evaluate concepts about efficacy and side effects of new formulations of stimulant medications
    J M Swanson
    Child Development Center, University of California, Department of Pediatrics, Irvine 92697 4480, USA
    J Atten Disord 6:S73-88. 2002
  6. pmc Using long-acting stimulants: does it change ADHD treatment outcome?
    James M Swanson
    Professor of Pediatrics, UCI Child Development Center, Centerpointe Plaza, 19722 MacArthur Blvd, University of California at Irvine, Irvine, California 92612, 949 824 1822 Phone, 949 824 1811 Fax, Email
    Can Child Adolesc Psychiatr Rev 14:2-3. 2005
  7. doi request reprint Evidence, interpretation, and qualification from multiple reports of long-term outcomes in the Multimodal Treatment Study of children with ADHD (MTA): Part II: supporting details
    James Swanson
    UCI Child Development Center, University of California, Irvine, Irvine, CA 92612, USA
    J Atten Disord 12:15-43. 2008
  8. doi request reprint Evidence, interpretation, and qualification from multiple reports of long-term outcomes in the Multimodal Treatment study of Children With ADHD (MTA): part I: executive summary
    James Swanson
    UCI Child Development Center, University of California, Irvine, Irvine, CA 92612, USA
    J Atten Disord 12:4-14. 2008
  9. ncbi request reprint Serum and brain concentrations of methylphenidate: implications for use and abuse
    J M Swanson
    UCI Child Development Center, University of California, 19722 MacArthur Boulevard, Irvine, CA 92612 4480, USA
    Neurosci Biobehav Rev 27:615-21. 2003
  10. ncbi request reprint Role of executive function in ADHD
    James M Swanson
    Department of Pediatrics, University of California, Irvine, CA 92612, USA
    J Clin Psychiatry 64:35-9. 2003

Research Grants

  1. UCI-CFC Projects on School Readiness
    James Swanson; Fiscal Year: 2002
  2. Genetics of Attention Deficit-Hyperactivity Disorder
    James Swanson; Fiscal Year: 2006

Collaborators

Detail Information

Publications87

  1. pmc Efficacy of two once-daily methylphenidate formulations compared across dose levels at different times of the day: preliminary indications from a secondary analysis of the COMACS study data
    Edmund J S Sonuga-Barke
    The Developmental Brain Behaviour Unit, University of Southampton, Southampton, SO17 1BJ UK
    BMC Psychiatry 4:28. 2004
    ..The current paper presents a secondary analysis that provides a statistical test of these observations...
  2. pmc Assessing the molecular genetics of attention networks
    John Fossella
    Sackler Institute of Developmental Psychobiology, Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    BMC Neurosci 3:14. 2002
    ..g. attention) have been shown to be related to several anatomical networks. Recently, we have developed an Attention Network Test (ANT) that provides a separate measure for each of three anatomically defined attention networks...
  3. ncbi request reprint Compliance with stimulants for attention-deficit/hyperactivity disorder: issues and approaches for improvement
    James Swanson
    University of California Irvine, Irvine, California 92612, USA
    CNS Drugs 17:117-31. 2003
    ..Together, these strategies should improve treatment compliance for individuals with ADHD...
  4. pmc Developmental origins of health and disease: environmental exposures
    James M Swanson
    Department of Pediatrics, University of California, Irvine, School of Medicine, 19722 MacArthur Boulevard, Irvine, CA 92612 4480, USA
    Semin Reprod Med 27:391-402. 2009
    ....
  5. ncbi request reprint The use of a laboratory school protocol to evaluate concepts about efficacy and side effects of new formulations of stimulant medications
    J M Swanson
    Child Development Center, University of California, Department of Pediatrics, Irvine 92697 4480, USA
    J Atten Disord 6:S73-88. 2002
    ..In addition to efficacy, applications of the LSP to measure common side effects related to eating and sleeping were described and discussed...
  6. pmc Using long-acting stimulants: does it change ADHD treatment outcome?
    James M Swanson
    Professor of Pediatrics, UCI Child Development Center, Centerpointe Plaza, 19722 MacArthur Blvd, University of California at Irvine, Irvine, California 92612, 949 824 1822 Phone, 949 824 1811 Fax, Email
    Can Child Adolesc Psychiatr Rev 14:2-3. 2005
    ..Over 30% of children with ADHD treated with a rigorous multimodal intervention in the MTA study did not reach full functional remission. New long-acting drugs have been developed with this treatment goal in mind...
  7. doi request reprint Evidence, interpretation, and qualification from multiple reports of long-term outcomes in the Multimodal Treatment Study of children with ADHD (MTA): Part II: supporting details
    James Swanson
    UCI Child Development Center, University of California, Irvine, Irvine, CA 92612, USA
    J Atten Disord 12:15-43. 2008
    ..To review and provide details about the primary and secondary findings from the Multimodal Treatment study of ADHD (MTA) published during the past decade as three sets of articles...
  8. doi request reprint Evidence, interpretation, and qualification from multiple reports of long-term outcomes in the Multimodal Treatment study of Children With ADHD (MTA): part I: executive summary
    James Swanson
    UCI Child Development Center, University of California, Irvine, Irvine, CA 92612, USA
    J Atten Disord 12:4-14. 2008
    ..To review the primary and secondary findings from the Multimodal Treatment study of ADHD (MTA) published over the past decade as three sets of articles...
  9. ncbi request reprint Serum and brain concentrations of methylphenidate: implications for use and abuse
    J M Swanson
    UCI Child Development Center, University of California, 19722 MacArthur Boulevard, Irvine, CA 92612 4480, USA
    Neurosci Biobehav Rev 27:615-21. 2003
    ....
  10. ncbi request reprint Role of executive function in ADHD
    James M Swanson
    Department of Pediatrics, University of California, Irvine, CA 92612, USA
    J Clin Psychiatry 64:35-9. 2003
    ..However, further placebo-controlled and flexible-dose studies are needed to determine the efficacy of modafinil in treating the symptoms of ADHD in children and adults...
  11. ncbi request reprint A comparison of once-daily extended-release methylphenidate formulations in children with attention-deficit/hyperactivity disorder in the laboratory school (the Comacs Study)
    James M Swanson
    University of California at Irvine Child Development Center, Irvine, California 92612, USA
    Pediatrics 113:e206-16. 2004
    ..According to this PK/PD model, clinical superiority is expected at any point in time for the formulation with the highest MPH plasma concentration...
  12. ncbi request reprint Effects of source of DNA on genotyping success rates and allele percentages in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    James M Swanson
    Child Development Center, University of California Irvine, 19722 MacArthur Boulevard, Irvine, CA 92612, USA
    J Child Adolesc Psychopharmacol 17:635-46. 2007
    ....
  13. ncbi request reprint Etiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the dopamine hypothesis
    James M Swanson
    Department of Pediatrics, University of California, Irvine, CA 92612, USA
    Neuropsychol Rev 17:39-59. 2007
    ....
  14. pmc Contrast of medical and nonmedical use of stimulant drugs, basis for the distinction, and risk of addiction: comment on Smith and Farah (2011)
    James M Swanson
    Department of Psychiatry, Florida International University
    Psychol Bull 137:742-8. 2011
    ..g., the likelihood of addiction to stimulant drugs in a small minority of the population) rather than just the potential benefits of cognitive enhancement...
  15. ncbi request reprint Secondary evaluations of MTA 36-month outcomes: propensity score and growth mixture model analyses
    James M Swanson
    UCI Child Development Center, 19722 MacArthur Blvd, Irvine, CA 92612, USA
    J Am Acad Child Adolesc Psychiatry 46:1003-14. 2007
    ....
  16. ncbi request reprint Stimulant-related reductions of growth rates in the PATS
    James Swanson
    Child Development Center, University of California, Irvine 92612, USA
    J Am Acad Child Adolesc Psychiatry 45:1304-13. 2006
    ..2 mg/day) administered three times daily, 7 days/week for asymptotically equal to1 year...
  17. ncbi request reprint Response to commentary on the multimodal treatment study of ADHD (MTA): mining the meaning of the MTA
    James M Swanson
    Department of Pediatrics, University of California, Irvine 92612, USA
    J Abnorm Child Psychol 30:327-32. 2002
    ..Finally, we invite others to use the large and rich data set that will soon be available in the public domain, to perform secondary analyses to mine the meaning of the MTA and to evaluate theories of ADHD and response to treatments...
  18. ncbi request reprint Effects of stimulant medication on growth rates across 3 years in the MTA follow-up
    James M Swanson
    UCI Child Development Center, 19722 MacArthur Blvd, Irvine, CA 92612, USA
    J Am Acad Child Adolesc Psychiatry 46:1015-27. 2007
    ..To evaluate the hypothesis of stimulant medication effect on physical growth in the follow-up phase of the Multimodal Treatment Study of Children With ADHD...
  19. ncbi request reprint Clinical relevance of the primary findings of the MTA: success rates based on severity of ADHD and ODD symptoms at the end of treatment
    J M Swanson
    University of California at Irvine, Child Development Center, 19722 MacArthur Blvd, Irvine, CA 92612, USA
    J Am Acad Child Adolesc Psychiatry 40:168-79. 2001
    ....
  20. ncbi request reprint Pharmacokinetic and pharmacodynamic properties of stimulants: implications for the design of new treatments for ADHD
    J M Swanson
    Department of Pediatrics, University of California at Irvine, 19722 MacArthur Boulevard, Irvine, CA 92697 4480, USA
    Behav Brain Res 130:73-8. 2002
    ..We will review these two topics and use this new information to evaluate the mechanisms of action of MPH...
  21. ncbi request reprint Dopamine genes and ADHD
    J M Swanson
    Child Development Center, University of California at Irvine, 92715, USA
    Neurosci Biobehav Rev 24:21-5. 2000
    ..These and other variants of the dopamine hypothesis of ADHD will be discussed...
  22. ncbi request reprint Analog classroom assessment of Adderall in children with ADHD
    J M Swanson
    Child Development Center, University of California, Irvine 92612, USA
    J Am Acad Child Adolesc Psychiatry 37:519-26. 1998
    ....
  23. ncbi request reprint The Texas Children's Medication Algorithm Project: Report of the Texas Consensus Conference Panel on Medication Treatment of Childhood Attention-Deficit/Hyperactivity Disorder. Part II: Tactics. Attention-Deficit/Hyperactivity Disorder
    S R Pliszka
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, USA
    J Am Acad Child Adolesc Psychiatry 39:920-7. 2000
    ..Specific tactical recommendations were developed with regard to medication dosage, assessment of drug response, management of side effects, and long-term medication management...
  24. pmc The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus
    E Wang
    Department of Biological Chemistry, University of California at Irvine, Irvine, CA 92697, USA
    Am J Hum Genet 74:931-44. 2004
    ..We propose a model for selection at the DRD4 locus consistent with these observed LD patterns and with the known biochemical and physiological differences between receptor variants...
  25. ncbi request reprint Impairment and deportment responses to different methylphenidate doses in children with ADHD: the MTA titration trial
    L L Greenhill
    Clinical Psychiatry, Department of Psychiatry, Columbia University, New York, USA
    J Am Acad Child Adolesc Psychiatry 40:180-7. 2001
    ....
  26. ncbi request reprint Sequence variants of the DRD4 gene in autism: further evidence that rare DRD4 7R haplotypes are ADHD specific
    D L Grady
    Department of Biological Chemistry, College of Medicine, University of California at Irvine, 92697, USA
    Am J Med Genet B Neuropsychiatr Genet 136:33-5. 2005
    ..These results suggest strongly that the high prevalence of rare DRD4 alleles in ADHD probands is due to ascertainment of the sample by diagnosis of ADHD...
  27. ncbi request reprint Family processes and treatment outcome in the MTA: negative/ineffective parenting practices in relation to multimodal treatment
    S P Hinshaw
    Department of Psychology, University of California, Berkeley 94720 1650, USA
    J Abnorm Child Psychol 28:555-68. 2000
    ....
  28. ncbi request reprint Anxiety as a predictor and outcome variable in the multimodal treatment study of children with ADHD (MTA)
    J S March
    Department of Psychiatry, DUMC, Durham, NC 27710, USA
    J Abnorm Child Psychol 28:527-41. 2000
    ..When treating ADHD, it is important to search for comorbid anxiety and negative affectivity and to adjust treatment strategies accordingly...
  29. ncbi request reprint High prevalence of rare dopamine receptor D4 alleles in children diagnosed with attention-deficit hyperactivity disorder
    D L Grady
    Department of Biological Chemistry, College of Medicine, University of California, Irvine, CA 92697, USA
    Mol Psychiatry 8:536-45. 2003
    ..0001. These results suggest that allelic heterogeneity at the DRD4 locus may also contribute to the observed association with ADHD...
  30. ncbi request reprint The Texas Children's Medication Algorithm Project: Report of the Texas Consensus Conference Panel on Medication Treatment of Childhood Attention-Deficit/Hyperactivity Disorder. Part I. Attention-Deficit/Hyperactivity Disorder
    S R Pliszka
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, USA
    J Am Acad Child Adolesc Psychiatry 39:908-19. 2000
    ....
  31. ncbi request reprint Symptom profiles in children with ADHD: effects of comorbidity and gender
    J H Newcorn
    Department of Psychiatry, Mount Sinai School of Medicine, USA
    J Am Acad Child Adolesc Psychiatry 40:137-46. 2001
    ....
  32. ncbi request reprint Asymmetrical hemispheric control of visual-spatial attention in adults with attention deficit hyperactivity disorder
    J N Epstein
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuropsychology 11:467-73. 1997
    ..This specific pattern of dysfunction was interpreted as a difficulty with maintaining attention possibly associated with anterior attention mechanisms in the right hemisphere...
  33. ncbi request reprint Efficacy of a new pattern of delivery of methylphenidate for the treatment of ADHD: effects on activity level in the classroom and on the playground
    James M Swanson
    Child Development Center, University of California, Irvine, CA, USA
    J Am Acad Child Adolesc Psychiatry 41:1306-14. 2002
    ....
  34. ncbi request reprint How a regression artifact makes ICFs/MR look ineffective
    F M Crinella
    Ment Retard 36:219-25; discussion 225-6. 1998
    ..We discussed the methodological logic involved in matching and the broader policy issues raised by this evaluation...
  35. pmc Developmental origins of health and disease: brief history of the approach and current focus on epigenetic mechanisms
    Pathik D Wadhwa
    Department of Pediatrics, University of California, Irvine, School of Medicine, 3117 GillespieNeuroscience Research Facility, Irvine, CA 92697 4260, USA
    Semin Reprod Med 27:358-68. 2009
    ..Next, we discuss the relevance of the DOHaD approach to reproductive medicine. Finally, we consider the next steps that might be taken to apply, evaluate, and extend the DOHaD approach...
  36. ncbi request reprint A double-blind, placebo-controlled trial of dexmethylphenidate hydrochloride and d,l-threo-methylphenidate hydrochloride in children with attention-deficit/hyperactivity disorder
    Sharon Wigal
    Irvine Child Development Center, University of California, Irvine, CA 92612, USA
    J Am Acad Child Adolesc Psychiatry 43:1406-14. 2004
    ....
  37. ncbi request reprint Modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder: results of a randomized, double-blind, placebo-controlled, fixed-dose study followed by abrupt discontinuation
    James M Swanson
    University of California at Irvine Child Development Center, 19722 MacArthur Boulevard, Irvine, CA 92627 4480, USA
    J Clin Psychiatry 67:137-47. 2006
    ..In addition, the effect of abrupt discontinuation of modafinil was evaluated in a 2-week observation period...
  38. ncbi request reprint Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder
    G J LaHoste
    Department of Physical Medicine and Rehabilitation, University of California, Irvine 92717 4550, USA
    Mol Psychiatry 1:121-4. 1996
    ....
  39. pmc Evidence of positive selection acting at the human dopamine receptor D4 gene locus
    Yuan Chun Ding
    Department of Biological Chemistry, College of Medicine, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 99:309-14. 2002
    ....
  40. ncbi request reprint Gender differences for the predictors of depression in young adults with genital herpes
    S L Dibble
    Institute for Health and Aging, School of Nursing, University of California, San Francisco, California 94143 0646, USA
    Public Health Nurs 17:187-94. 2000
    ..Gender-specific interventions need to be developed in order to assist young adults who are living with genital herpes...
  41. ncbi request reprint Personal, cognitive, behavioral, and demographic predictors of HIV testing and STDs in homeless women
    A M Nyamathi
    School of Nursing, University of California, Los Angeles 90095 1702, USA
    J Behav Med 23:123-47. 2000
    ..Indirect effects on the outcomes mediated through coping styles are also reported. Theoretical and practical implications of results for community outreach are discussed...
  42. ncbi request reprint Which treatment for whom for ADHD? Moderators of treatment response in the MTA
    Elizabeth B Owens
    Institute of Human Development, University of California, Berkeley 94720 1690, USA
    J Consult Clin Psychol 71:540-52. 2003
    ..No predictors or moderators emerged for behavioral and community comparison treatments. The authors discuss conceptual and clinical implications of research on treatment moderators...
  43. ncbi request reprint Catecholamine response to exercise in children with attention deficit hyperactivity disorder
    Sharon B Wigal
    Child Development Center, University of California, Irvine 92612, USA
    Pediatr Res 53:756-61. 2003
    ..005). Our data suggest that CA excretion after exercise challenges in children with ADHD is deficient. This deficiency can be detected using a minimally invasive, nonpharmacologic challenge...
  44. pmc Parent-reported homework problems in the MTA study: evidence for sustained improvement with behavioral treatment
    Joshua M Langberg
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Division of Behavioral Medicine and Clinical Psychology, 3333 Burnet Avenue, MLC 10006, Cincinnati, OH 45229 3039, USA
    J Clin Child Adolesc Psychol 39:220-33. 2010
    ..37, .40, respectively). Parent ratings of initial ADHD symptom severity was the only variable found to moderate these effects...
  45. pmc DSM-V and the future diagnosis of attention-deficit/hyperactivity disorder
    James M Swanson
    Department of Pediatrics, University of California, Irvine, 19722 MacArthur Boulevard, Irvine, CA 92612 4480, USA
    Curr Psychiatry Rep 11:399-406. 2009
    ....
  46. ncbi request reprint 3-year follow-up of the NIMH MTA study
    Peter S Jensen
    Center for the Advancement of Children s Mental Health, Unit 78, Columbia University NYSPI, 1051 Riverside Drive, New York, NY 10027, USA
    J Am Acad Child Adolesc Psychiatry 46:989-1002. 2007
    ..This report examines 36-month outcomes, 2 years after treatment by the study ended...
  47. pmc Treatment for ADHD: is more complex treatment cost-effective for more complex cases?
    E Michael Foster
    Department of Maternal and Child Health, The University of North Carolina, School of Public Health, 407 C Rosenau Hall, CB 7445, Chapel Hill, NC 27599, USA
    Health Serv Res 42:165-82. 2007
    ..Data for the study were distilled from administrative data and from interviews with parents, including estimates of the child's functional impairment. These analyses focus on changes in functional impairment over 14 months...
  48. ncbi request reprint Child and parent predictors of perceptions of parent--child relationship quality
    Alyson C Gerdes
    Marquette University, USA
    J Atten Disord 11:37-48. 2007
    ..The findings resolve a previous contradiction in the literature regarding the relationship between child depressive symptoms and parental perceptions of parent-child relationship quality...
  49. ncbi request reprint Sex differences in the response of children with ADHD to once-daily formulations of methylphenidate
    Edmund J S Sonuga-Barke
    Developmental Brain Behaviour Unit, University of Southampton, Southampton, UK
    J Am Acad Child Adolesc Psychiatry 46:701-10. 2007
    ..This paper reports an examination of sex differences based on further analysis of data from a comparison of two once-daily methylphenidate formulations (the COMACS study), which addresses these shortcomings...
  50. ncbi request reprint Methylphenidate effects on functional outcomes in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Howard B Abikoff
    New York University Child Study Center, 215 Lexington Avenue, New York, NY 10016, USA
    J Child Adolesc Psychopharmacol 17:581-92. 2007
    ....
  51. ncbi request reprint Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:932-40. 2007
    ..There is considerable evidence that brain dopamine is involved in ADHD, but it is unclear whether dopamine activity is enhanced or depressed...
  52. pmc Increasing use of stimulants warns of potential abuse
    James M Swanson
    Nature 453:586. 2008
  53. pmc Does childhood treatment of ADHD with stimulant medication affect substance abuse in adulthood?
    Nora D Volkow
    Am J Psychiatry 165:553-5. 2008
  54. pmc Methylphenidate decreased the amount of glucose needed by the brain to perform a cognitive task
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland, United States of America
    PLoS ONE 3:e2017. 2008
    ..This would explain why methylphenidate has beneficial effects in some individuals and contexts and detrimental effects in others...
  55. ncbi request reprint Heterogeneity in the pharmacodynamics of two long-acting methylphenidate formulations for children with attention deficit/hyperactivity disorder. A growth mixture modelling analysis
    Edmund J S Sonuga-Barke
    School of Psychology, Institute for Disorders of Impulse and Attention, University of Southampton, Southampton, UK
    Eur Child Adolesc Psychiatry 17:245-54. 2008
    ....
  56. ncbi request reprint Parent versus teacher ratings of attention-deficit/hyperactivity disorder symptoms in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Desiree W Murray
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    J Child Adolesc Psychopharmacol 17:605-20. 2007
    ..To assess parent-teacher concordance on ratings of DSM-IV symptoms of attention-deficit/hyperactivity disorder (ADHD) in a sample of preschool children referred for an ADHD treatment study...
  57. ncbi request reprint Effectiveness of methylphenidate in the 10-month continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Benedetto Vitiello
    Child and Adolescent Treatment and Preventive Intervention Research Branch, National Institute of Mental Health, 6001 Executive Boulevard, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 17:593-604. 2007
    ..The aim of this study was to examine immediate-release methylphenidate effectiveness during the 10-month open-label continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder (ADHD) Treatment Study (PATS)...
  58. ncbi request reprint Comorbidity moderates response to methylphenidate in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Jaswinder K Ghuman
    University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    J Child Adolesc Psychopharmacol 17:563-80. 2007
    ..The aim of this study was to examine whether demographic or pretreatment clinical and social characteristics influenced the response to methylphenidate (MPH) in the Preschoolers with ADHD Treatment Study (PATS)...
  59. ncbi request reprint Clinical presentation of attention-deficit/hyperactivity disorder in preschool children: the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Kelly Posner
    New York State Psychiatric Institute Columbia University, 1041 Riverside Drive, New York, NY 10032, USA
    J Child Adolesc Psychopharmacol 17:547-62. 2007
    ..The diagnosis and evaluation process will also be described...
  60. ncbi request reprint Delinquent behavior and emerging substance use in the MTA at 36 months: prevalence, course, and treatment effects
    Brooke S G Molina
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 46:1028-40. 2007
    ....
  61. ncbi request reprint Reducing hyperactivity with a feedback actigraph: initial findings
    Warren W Tryon
    Department of Psychology, Fordham University, Bronx, NY 10458 993, USA
    Clin Child Psychol Psychiatry 11:607-17. 2006
    ..These changes were statistically significant and constitute a large effect...
  62. ncbi request reprint Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain
    Nora D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
    Am J Psychiatry 161:1173-80. 2004
    ..The objective of this study was to assess if methylphenidate, by increasing dopamine (neurotransmitter involved in motivation) in brain, would enhance the saliency of an academic task, making it more interesting...
  63. ncbi request reprint Nine months of multicomponent behavioral treatment for ADHD and effectiveness of MTA fading procedures
    L Eugene Arnold
    The Ohio State University, Columbus, Ohio, USA
    J Abnorm Child Psychol 32:39-51. 2004
    ....
  64. ncbi request reprint Expectation enhances the regional brain metabolic and the reinforcing effects of stimulants in cocaine abusers
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 23:11461-8. 2003
    ..The enhanced cerebellar activation with expectation may reflect conditioned responses that are not linked to conscious responses...
  65. ncbi request reprint A pharmacokinetic/pharmacodynamic study comparing a single morning dose of adderall to twice-daily dosing in children with ADHD
    Laurence L Greenhill
    Attention Deficit Disorder Research Program, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    J Am Acad Child Adolesc Psychiatry 42:1234-41. 2003
    ..To determine the pharmacokinetic and pharmacodynamic properties of once-daily versus twice-daily doses of Adderall...
  66. ncbi request reprint Effects of ethnicity on treatment attendance, stimulant response/dose, and 14-month outcome in ADHD
    L Eugene Arnold
    Department of Psychiatry, Ohio State University, USA
    J Consult Clin Psychol 71:713-27. 2003
    ..Treatment for lower socioeconomic status minority children, especially if comorbid, should combine medication and behavioral treatment...
  67. ncbi request reprint Pharmacokinetics of SLI381 (ADDERALL XR), an extended-release formulation of Adderall
    James J McGough
    Department of Psychiatry and Biobehavioral Sciences, Division of Child and Adolescent Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, USA
    J Am Acad Child Adolesc Psychiatry 42:684-91. 2003
    ..To assess the pharmacokinetic (PK) properties of a single daily dose of Adderall (mixed amphetamine salts) and the extended-release formulation, SLI381 (ADDERALL XR), in pediatric attention-deficit/hyperactivity disorder (ADHD)...
  68. ncbi request reprint Analog classroom assessment of a once-daily mixed amphetamine formulation, SLI381 (Adderall XR), in children with ADHD
    James T McCracken
    Department of Psychiatry and Biobehavioral Sciences, Division of Child andAdolescent Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, CA 90024 1759, USA
    J Am Acad Child Adolesc Psychiatry 42:673-83. 2003
    ..Secondary objectives included examination of the time course, pharmacokinetic, and pharmacodynamic properties of SLI381...
  69. ncbi request reprint Response to methylphenidate in children with attention deficit hyperactivity disorder and manic symptoms in the multimodal treatment study of children with attention deficit hyperactivity disorder titration trial
    Cathryn A Galanter
    Columbia University New York State Psychiatric Institute, New York, New York 10032, USA
    J Child Adolesc Psychopharmacol 13:123-36. 2003
    ..Recent reports raise concern that children with attention deficit hyperactivity disorder (ADHD) and some manic symptoms may worsen with stimulant treatment. This study examines the response to methylphenidate in such children...
  70. ncbi request reprint Cardiovascular effects of methylphenidate in humans are associated with increases of dopamine in brain and of epinephrine in plasma
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychopharmacology (Berl) 166:264-70. 2003
    ..However, there is some evidence that dopaminergic effects are involved in the cardiovascular actions of these drugs. Here, we evaluated this association in humans...
  71. ncbi request reprint Emergency/Adjunct services and attrition prevention for randomized clinical trials in children: the MTA manual-based solution
    Howard Abikoff
    Child and Adolescent Psychiatry, NYU Child Study Center, NYU School of Medicine, NY 10016, USA
    J Am Acad Child Adolesc Psychiatry 41:498-504. 2002
    ..Although the manual-based guidelines are especially applicable to multisite RCTs, many of the procedures in the ASAP Manual can apply to any treatment study in children...
  72. ncbi request reprint A double-blind, placebo-controlled study of modified-release methylphenidate in children with attention-deficit/hyperactivity disorder
    Laurence L Greenhill
    New York State Psychiatric Institute, New York, New York 10032, USA
    Pediatrics 109:E39. 2002
    ..To compare the efficacy, safety, and tolerability of once-daily administration of modified-release methylphenidate (MPH MR) with placebo in children with attention-deficit/hyperactivity disorder (ADHD)...
  73. ncbi request reprint Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: therapeutic implications
    Nora D Volkow
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 43:181-7. 2002
    ....
  74. ncbi request reprint Weekend holidays during methylphenidate use in ADHD children: a randomized clinical trial
    Silvia Martins
    ADHD Outpatient Clinic, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil 90035 003
    J Child Adolesc Psychopharmacol 14:195-206. 2004
    ....
  75. pmc Functional connectivity of frontal cortex in healthy and ADHD children reflected in EEG coherence
    Michael Murias
    Autism Center, Center on Human Development and Disability, University of Washington, Seattle, WA, USA
    Cereb Cortex 17:1788-99. 2007
    ..The findings suggest a static state of deficient connectivity in ADHD and a stimulus-induced state of overconnectivity within and between frontal hemispheres...
  76. ncbi request reprint A comparison of once-daily and divided doses of modafinil in children with attention-deficit/hyperactivity disorder: a randomized, double-blind, and placebo-controlled study
    Joseph Biederman
    Department of Pediatric Psychopharmacology, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 67:727-35. 2006
    ....
  77. ncbi request reprint Effects of expectation on the brain metabolic responses to methylphenidate and to its placebo in non-drug abusing subjects
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, MD 20892, USA
    Neuroimage 32:1782-92. 2006
    ..Thus, the state of expectation needs to be considered as a variable modulating the reinforcing and therapeutic effects of drugs even in subjects who have no prior experience with the drug...
  78. ncbi request reprint Assessing medication effects in the MTA study using neuropsychological outcomes
    Jeffery N Epstein
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Child Psychol Psychiatry 47:446-56. 2006
    ....
  79. ncbi request reprint A randomized, double-blind, placebo-controlled study of modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder
    Laurence L Greenhill
    New York State Psychiatric Institute, NY 10032, USA
    J Am Acad Child Adolesc Psychiatry 45:503-11. 2006
    ..To evaluate the efficacy and tolerability of modafinil in children and adolescents, ages 7 to 17, with attention-deficit/hyperactivity disorder (ADHD)...
  80. ncbi request reprint Efficacy and safety of modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder: results of a randomized, double-blind, placebo-controlled, flexible-dose study
    Joseph Biederman
    Department of Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
    Pediatrics 116:e777-84. 2005
    ..This study evaluated a new formulation of modafinil (modafinil film-coated tablets) in children and adolescents with ADHD...
  81. ncbi request reprint Comments on 'Cytogenetic effects in children treated with methylphenidate' by El-Zein et al
    R Julian Preston
    Cancer Lett 230:292-4. 2005
  82. ncbi request reprint Activation of orbital and medial prefrontal cortex by methylphenidate in cocaine-addicted subjects but not in controls: relevance to addiction
    Nora D Volkow
    National Institute of Drug Abuse, Rockville, Maryland 20857, USA
    J Neurosci 25:3932-9. 2005
    ..It also suggests that the mesothalamic DA pathway may contribute to these processes...
  83. ncbi request reprint Peer-assessed outcomes in the multimodal treatment study of children with attention deficit hyperactivity disorder
    Betsy Hoza
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907 2081, USA
    J Clin Child Adolesc Psychol 34:74-86. 2005
    ..Results indicated that children from all groups remained significantly impaired in their peer relationships...
  84. ncbi request reprint Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD
    Nora D Volkow
    National Institute on Drug Abuse NIH, 6001 Executive Boulevard, Room 5274 MSC 9581, Bethesda, MD 20892, USA
    Am J Psychiatry 160:1909-18. 2003
    ..The authors evaluated variables that distinguish these two properties...
  85. ncbi request reprint The Texas Children's Medication Algorithm Project: revision of the algorithm for pharmacotherapy of attention-deficit/hyperactivity disorder
    Steven R Pliszka
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    J Am Acad Child Adolesc Psychiatry 45:642-57. 2006
    ..Advances in the psychopharmacology of ADHD and results of a feasibility study of algorithm use in community mental health centers caused the algorithm to be modified and updated...
  86. ncbi request reprint Dopamine in drug abuse and addiction: results of imaging studies and treatment implications
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274 MSC 9581, Bethesda, MD 20892, USA
    Arch Neurol 64:1575-9. 2007
    ....
  87. ncbi request reprint Self-perceptions of competence in children with ADHD and comparison children
    Betsy Hoza
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907 2081, USA
    J Consult Clin Psychol 72:382-91. 2004
    ..Examination by comorbidity subgroups revealed that children with ADHD inflated their self-perceptions the most in domains of greatest deficit. Gender effects also are reported...

Research Grants5

  1. UCI-CFC Projects on School Readiness
    James Swanson; Fiscal Year: 2002
    ....
  2. Genetics of Attention Deficit-Hyperactivity Disorder
    James Swanson; Fiscal Year: 2006
    ..Genomic haplotypes", meaning haplo-specific genotypes at more than one locus, will be defined and tested for possible interactive roles among the genes. ..