Tatyana Svitkina

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Functions of nonmuscle myosin II in assembly of the cellular contractile system
    Maria Shutova
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e40814. 2012
  2. pmc Coordination of membrane and actin cytoskeleton dynamics during filopodia protrusion
    Changsong Yang
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 4:e5678. 2009
  3. pmc Ultrastructure of protrusive actin filament arrays
    Tatyana M Svitkina
    Department of Biology, University of Pennsylvania, 415 S University Avenue, Philadelphia, PA 19104, USA
    Curr Opin Cell Biol 25:574-81. 2013
  4. pmc Septin-driven coordination of actin and microtubule remodeling regulates the collateral branching of axons
    Jianli Hu
    Department of Biology, Drexel University, Philadelphia, PA 19104, USA
    Curr Biol 22:1109-15. 2012
  5. pmc Exo70 generates membrane curvature for morphogenesis and cell migration
    Yuting Zhao
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 26:266-78. 2013
  6. pmc CARMIL leading edge localization depends on a non-canonical PH domain and dimerization
    Adam Zwolak
    Department of Physiology, Perelman School of Medicine, University of Pennsylvania, 728 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Commun 4:2523. 2013
  7. pmc Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors
    David J Kast
    Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Struct Mol Biol 21:413-22. 2014
  8. pmc Axon initial segment cytoskeleton comprises a multiprotein submembranous coat containing sparse actin filaments
    Steven L Jones
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104
    J Cell Biol 205:67-81. 2014
  9. pmc Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders
    Tatyana Svitkina
    Department of Biology, The University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 30:14937-42. 2010
  10. pmc Mechanism of actin filament bundling by fascin
    Silvia Jansen
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 286:30087-96. 2011

Research Grants

Collaborators

Detail Information

Publications22

  1. pmc Functions of nonmuscle myosin II in assembly of the cellular contractile system
    Maria Shutova
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e40814. 2012
    ..Subsequently, the mechanical resistance of focal complexes activates a load-dependent mechanism of NMII polymerization in association with attached bundles, leading to assembly of stress fibers and maturation of focal adhesions...
  2. pmc Coordination of membrane and actin cytoskeleton dynamics during filopodia protrusion
    Changsong Yang
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 4:e5678. 2009
    ..Together, our data suggest that actin filaments may not directly drive the protrusion, but only stabilize the space generated by the membrane deformation; yet, such stabilization is necessary for efficient protrusion...
  3. pmc Ultrastructure of protrusive actin filament arrays
    Tatyana M Svitkina
    Department of Biology, University of Pennsylvania, 415 S University Avenue, Philadelphia, PA 19104, USA
    Curr Opin Cell Biol 25:574-81. 2013
    ..This review summarizes our current knowledge of the structural organization of these two actin filament arrays. ..
  4. pmc Septin-driven coordination of actin and microtubule remodeling regulates the collateral branching of axons
    Jianli Hu
    Department of Biology, Drexel University, Philadelphia, PA 19104, USA
    Curr Biol 22:1109-15. 2012
    ..Surprisingly, septins provide a novel mechanism for the collateral branching of axons by coordinating the remodeling of the actin and microtubule cytoskeleton...
  5. pmc Exo70 generates membrane curvature for morphogenesis and cell migration
    Yuting Zhao
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 26:266-78. 2013
    ..Exo70 thus represents a membrane-bending protein that may couple actin dynamics and plasma membrane remodeling for morphogenesis...
  6. pmc CARMIL leading edge localization depends on a non-canonical PH domain and dimerization
    Adam Zwolak
    Department of Physiology, Perelman School of Medicine, University of Pennsylvania, 728 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Commun 4:2523. 2013
    ..In cells, deletion of the PH domain impairs leading edge localization. The results support a direct membrane-binding mechanism for CARMIL localization at the leading edge, where it regulates cytoskeletal effectors and motility. ..
  7. pmc Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors
    David J Kast
    Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Struct Mol Biol 21:413-22. 2014
    ..Structure-inspired mutations disrupt autoinhibition and Cdc42 binding in vitro and decouple Cdc42- and IRSp53-dependent filopodia formation in cells. The data support a combinatorial mechanism of IRSp53 activation. ..
  8. pmc Axon initial segment cytoskeleton comprises a multiprotein submembranous coat containing sparse actin filaments
    Steven L Jones
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104
    J Cell Biol 205:67-81. 2014
    ..We propose that stable actin filaments play a structural role for formation of the AIS diffusion barrier, whereas dynamic actin may promote AIS coat remodeling. ..
  9. pmc Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders
    Tatyana Svitkina
    Department of Biology, The University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 30:14937-42. 2010
    ..It will also highlight evolving studies into how disruptions to these pathways might be functionally coupled to congenital disorders such as mental retardation...
  10. pmc Mechanism of actin filament bundling by fascin
    Silvia Jansen
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 286:30087-96. 2011
    ..These molecules could guide the rational design of new anticancer fascin inhibitors...
  11. pmc Arginylation regulates intracellular actin polymer level by modulating actin properties and binding of capping and severing proteins
    Sougata Saha
    Department of Animal Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Biol Cell 21:1350-61. 2010
    ..This regulation is achieved through interconnected mechanisms that involve actin polymerization per se and through binding of actin-associated proteins...
  12. pmc The cytoskeletal mechanisms of cell-cell junction formation in endothelial cells
    Matthew K Hoelzle
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Biol Cell 23:310-23. 2012
    ..Moreover, a novel lamellipodia-to-filopodia transition is used in this context...
  13. pmc Molecular architecture of synaptic actin cytoskeleton in hippocampal neurons reveals a mechanism of dendritic spine morphogenesis
    Farida Korobova
    Department of Biology, The University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Biol Cell 21:165-76. 2010
    ....
  14. pmc Exo70 stimulates the Arp2/3 complex for lamellipodia formation and directional cell migration
    Jianglan Liu
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Biol 22:1510-5. 2012
    ..Our findings provide a novel mechanism for regulating actin polymerization and branching for effective membrane protrusion during cell morphogenesis and migration...
  15. pmc The actin nucleating Arp2/3 complex contributes to the formation of axonal filopodia and branches through the regulation of actin patch precursors to filopodia
    Mirela Spillane
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    Dev Neurobiol 71:747-58. 2011
    ..Collectively, these data reveal that the Arp2/3 complex contributes to the formation of axon collateral branches through its involvement in the formation of actin patches leading to the emergence of axonal filopodia...
  16. pmc Structural organization of the actin cytoskeleton at sites of clathrin-mediated endocytosis
    Agnieszka Collins
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Biol 21:1167-75. 2011
    ..However, its exact functions remain uncertain as a result of a lack of high-resolution structural information regarding actin architecture at endocytic sites...
  17. pmc Imaging cytoskeleton components by electron microscopy
    Tatyana Svitkina
    Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
    Methods Mol Biol 586:187-206. 2009
    ..g., expressed fluorescent proteins, with high resolution structural organization of the cytoskeleton in the same cell...
  18. pmc Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse
    Gregory D Rak
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Biol 9:e1001151. 2011
    ....
  19. ncbi request reprint N-WASP generates a buzz at membranes on the move
    Tatyana Svitkina
    Department of Biology, University of Pennsylvania, 415 S University Avenue, Philadelphia, PA 19104, USA
    Cell 128:828-30. 2007
    ..Co et al. (2007) now show that the neural Wiskott-Aldrich syndrome protein (N-WASP) mediates dynamic attachment between membranes and the growing ends of actin filaments to sustain membrane movement...
  20. pmc Mechanisms of plasma membrane targeting of formin mDia2 through its amino terminal domains
    Roman Gorelik
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Biol Cell 22:189-201. 2011
    ..These results suggest that the entire N terminus of mDia2 serves as a coincidence detection module, directing mDia2 to the plasma membrane through interactions with phospholipids and activated Rif...
  21. pmc Arp2/3 complex is important for filopodia formation, growth cone motility, and neuritogenesis in neuronal cells
    Farida Korobova
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Biol Cell 19:1561-74. 2008
    ..Consistent with this phenotype, RhoA activity was increased in Arp2/3 complex-depleted cells, indicating that besides nucleating actin filaments, Arp2/3 complex may influence cell motility by altering Rho GTPase signaling...
  22. pmc Divalent cation-induced cluster formation by polyphosphoinositides in model membranes
    Yu Hsiu Wang
    Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Chem Soc 134:3387-95. 2012
    ..These results suggest that divalent metal ions have substantial effects on PIP2 lateral organization at physiological concentrations, and local fluxes in their cytoplasmic levels can contribute to regulating protein-PIP2 interactions...

Research Grants8

  1. Molecular Design of Filopodia, Cell's Sensory Organelles
    Tatyana Svitkina; Fiscal Year: 2004
    ....
  2. Molecular Design of Filopodia, Cell's Sensory Organelles
    Tatyana Svitkina; Fiscal Year: 2005
    ....
  3. Molecular Design of Filopodia, Cell's Sensory Organelles
    Tatyana Svitkina; Fiscal Year: 2006
    ....
  4. TRANSMISSION ELECTRON MICROSCOPE
    Tatyana Svitkina; Fiscal Year: 2007
    ..Such structural information paves a road toward understanding of complex biological processes, without which it is not possible to fight a disease. ..
  5. Molecular Design of Filopodia, Cell's Sensory Organelles
    Tatyana Svitkina; Fiscal Year: 2007
    ....
  6. Molecular Design of Filopodia, Cell's Sensory Organelles
    Tatyana Svitkina; Fiscal Year: 2009
    ..This information will help to design drugs, treatments and diagnostic tools. ..
  7. MOLECULAR DESIGN OF FILOPODIA, CELL'S SENSORY ORGANELLES
    Tatyana Svitkina; Fiscal Year: 2010
    ..This information will help to design drugs, treatments and diagnostic tools. ..