Larry J Suva

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. pmc Bone metastasis: mechanisms and therapeutic opportunities
    Larry J Suva
    Department of Orthopedic Surgery, Center for Orthopedic Research, Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    Nat Rev Endocrinol 7:208-18. 2011
  2. pmc Mechanisms of bone metastases of breast cancer
    Larry J Suva
    Department of Orthopaedic Surgery, Barton Research Institute, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Endocr Relat Cancer 16:703-13. 2009
  3. ncbi request reprint Regulation of bone mass by mechanical loading: microarchitecture and genetics
    Larry J Suva
    Department of Orthopaedic Surgery, Physiology, and Biophysics, University of Arkansas for Medical Sciences, 4301 W Markham Street, Mail 644, Little Rock, AR 72205, USA
    Curr Osteoporos Rep 3:46-51. 2005
  4. pmc Rosiglitazone induces decreases in bone mass and strength that are reminiscent of aged bone
    Oxana P Lazarenko
    Department of Geriatrics, Reynolds Institute on Aging, 629 Jack Stephens Drive, Little Rock, AR 72205, USA
    Endocrinology 148:2669-80. 2007
  5. pmc Vitamin D supplementation protects against bone loss associated with chronic alcohol administration in female mice
    Kelly E Mercer
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Arkansas Children s Nutrition Center, 15 Children s Way, Little Rock, AR 72202, USA
    J Pharmacol Exp Ther 343:401-12. 2012
  6. pmc Tumor-derived syndecan-1 mediates distal cross-talk with bone that enhances osteoclastogenesis
    Thomas Kelly
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    J Bone Miner Res 25:1295-304. 2010
  7. pmc Inhibitor of DASH proteases affects expression of adhesion molecules in osteoclasts and reduces myeloma growth and bone disease
    Angela Pennisi
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Br J Haematol 145:775-87. 2009
  8. pmc Inhibin A enhances bone formation during distraction osteogenesis
    Daniel S Perrien
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Orthop Res 30:288-95. 2012
  9. pmc Bone turnover across the menopause transition : The role of gonadal inhibins
    Kristy M Nicks
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Ann N Y Acad Sci 1192:153-60. 2010
  10. ncbi request reprint Ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis: a role for the tumor necrosis factor signaling axis
    Elizabeth C Wahl
    Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, and Laboratory for Limb Regeneration Research, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72202, USA
    Alcohol Clin Exp Res 29:1466-72. 2005

Collaborators

Detail Information

Publications55

  1. pmc Bone metastasis: mechanisms and therapeutic opportunities
    Larry J Suva
    Department of Orthopedic Surgery, Center for Orthopedic Research, Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    Nat Rev Endocrinol 7:208-18. 2011
    ..The molecular mechanisms that underlie these painful and often incurable consequences of tumor metastasis to bone are beginning to be recognized, and they represent promising new molecular targets for therapy...
  2. pmc Mechanisms of bone metastases of breast cancer
    Larry J Suva
    Department of Orthopaedic Surgery, Barton Research Institute, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Endocr Relat Cancer 16:703-13. 2009
    ....
  3. ncbi request reprint Regulation of bone mass by mechanical loading: microarchitecture and genetics
    Larry J Suva
    Department of Orthopaedic Surgery, Physiology, and Biophysics, University of Arkansas for Medical Sciences, 4301 W Markham Street, Mail 644, Little Rock, AR 72205, USA
    Curr Osteoporos Rep 3:46-51. 2005
    ..It is the focus of this paper to evaluate the evidence underlying roles for genetics, osteocytes, and interstitial fluid flow in mediating disuse osteopenia...
  4. pmc Rosiglitazone induces decreases in bone mass and strength that are reminiscent of aged bone
    Oxana P Lazarenko
    Department of Geriatrics, Reynolds Institute on Aging, 629 Jack Stephens Drive, Little Rock, AR 72205, USA
    Endocrinology 148:2669-80. 2007
    ..In conclusion, rosiglitazone induces changes in bone reminiscent of aged bone and appears to induce bone loss by altering the phenotype of marrow mesenchymal stem cells...
  5. pmc Vitamin D supplementation protects against bone loss associated with chronic alcohol administration in female mice
    Kelly E Mercer
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Arkansas Children s Nutrition Center, 15 Children s Way, Little Rock, AR 72202, USA
    J Pharmacol Exp Ther 343:401-12. 2012
    ..These findings suggest dietary VitD supplementation may prevent skeletal toxicity in chronic drinkers by normalizing calcium homeostasis, preventing apoptosis, and suppressing EtOH-induced increases in bone resorption...
  6. pmc Tumor-derived syndecan-1 mediates distal cross-talk with bone that enhances osteoclastogenesis
    Thomas Kelly
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    J Bone Miner Res 25:1295-304. 2010
    ..05). Together these data suggest that syndecan-1 shed by tumor cells exerts biologic effects distal to the primary tumor and that it participates in driving osteoclastogenesis and the resulting bone destruction...
  7. pmc Inhibitor of DASH proteases affects expression of adhesion molecules in osteoclasts and reduces myeloma growth and bone disease
    Angela Pennisi
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Br J Haematol 145:775-87. 2009
    ..These data demonstrated that DASH proteases are involved in myeloma bone disease and tumour growth...
  8. pmc Inhibin A enhances bone formation during distraction osteogenesis
    Daniel S Perrien
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Orthop Res 30:288-95. 2012
    ..This mechanism is consistent with the effects of other agents and pathologies that modulate bone formation during DO, and demonstrates the potential of hInhA to enhance bone repair and regeneration...
  9. pmc Bone turnover across the menopause transition : The role of gonadal inhibins
    Kristy M Nicks
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Ann N Y Acad Sci 1192:153-60. 2010
    ....
  10. ncbi request reprint Ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis: a role for the tumor necrosis factor signaling axis
    Elizabeth C Wahl
    Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, and Laboratory for Limb Regeneration Research, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72202, USA
    Alcohol Clin Exp Res 29:1466-72. 2005
    ....
  11. ncbi request reprint Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases
    Thomas Kelly
    Department of Pathology, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7199, USA
    Cancer Res 65:5778-84. 2005
    ..This novel role for heparanase as a promoter of osteolysis before tumor metastasis suggests that therapies designed to block heparanase function may disrupt the early progression of bone-homing tumors...
  12. pmc Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment
    Tristan W Fowler
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    PLoS ONE 7:e42967. 2012
    ..These studies provide novel insight into the cause of the profound bone fragility in DS and identify PTH as a potential anabolic agent in the adult low bone mass DS population...
  13. pmc Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease
    Larry J Suva
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Am J Pathol 172:430-9. 2008
    ..These studies provide new insights into the relationship between the regulation of megakaryocytopoiesis and bone mass...
  14. ncbi request reprint Interleukin-1 and tumor necrosis factor antagonists attenuate ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis
    Daniel S Perrien
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Pharmacol Exp Ther 303:904-8. 2002
    ....
  15. ncbi request reprint Aging alters the skeletal response to disuse in the rat
    Daniel S Perrien
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 West Markham St, Slot 505, Little Rock, AR 72205, USA
    Am J Physiol Regul Integr Comp Physiol 292:R988-96. 2007
    ....
  16. ncbi request reprint Tumor-derived interleukin-8 stimulates osteolysis independent of the receptor activator of nuclear factor-kappaB ligand pathway
    Manali S Bendre
    Department of Orthopaedic Surgery, Center for Orthopaedic Research, Barton Research Institute, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Cancer Res 65:11001-9. 2005
    ....
  17. pmc Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, Activin and Inhibin
    Kristy M Nicks
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Mol Cell Endocrinol 310:11-20. 2009
    ..This fundamental action has the potential to de-repress locally stimulated changes in osteoblastogenesis and osteoclastogenesis, thereby altering bone metabolism...
  18. pmc Serum biomarker profile associated with high bone turnover and BMD in postmenopausal women
    Sudeepa Bhattacharyya
    Department of Orthopaedic Surgery, Center for Orthopaedic Research, Barton Research Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Bone Miner Res 23:1106-17. 2008
    ..In conjunction with the identification of the individual proteins, this protein fingerprint may provide a novel approach to evaluate high bone turnover states...
  19. ncbi request reprint Inhibin A is an endocrine stimulator of bone mass and strength
    Daniel S Perrien
    Department of Physiology and Biophysics, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 505, Little Rock, Arkansas 72205, USA
    Endocrinology 148:1654-65. 2007
    ....
  20. pmc Repression of multiple myeloma growth and preservation of bone with combined radiotherapy and anti-angiogenic agent
    Dan Jia
    Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR72205, USA
    Radiat Res 173:809-17. 2010
    ..These results suggest that radiotherapy, when primed by anti-angiogenic agents, may be a potent therapy for focal multiple myeloma...
  21. ncbi request reprint Characterization of the glycosylation profile of the human breast cancer cell line, MDA-231, and a bone colonizing variant
    Jaime Carcel-Trullols
    Arkansas Cancer Research Center and Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Int J Oncol 28:1173-83. 2006
    ..These data suggest that the glycomic phenotype of MDA-MET cells is associated with a select set of accumulated functions that collectively impact on the bone metastases and bone colonization capacity of breast cancer cells...
  22. ncbi request reprint Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease
    Manali S Bendre
    Center for Orthopaedic Research, Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Bone 33:28-37. 2003
    ..These results demonstrate a direct effect of IL-8 on osteoclast differentiation and activity. Together, these data implicate IL-8 in the osteolysis associated with metastatic breast cancer...
  23. ncbi request reprint Bone turnover across the menopause transition: correlations with inhibins and follicle-stimulating hormone
    Daniel S Perrien
    Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 91:1848-54. 2006
    ....
  24. pmc Identification of PTHrP(12-48) as a plasma biomarker associated with breast cancer bone metastasis
    Charity L Washam
    Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Cancer Epidemiol Biomarkers Prev 22:972-83. 2013
    ..Breast cancer bone metastasis is a complication that significantly compromises patient survival due, in part, to the lack of disease-specific biomarkers that allow early and accurate diagnosis...
  25. pmc Rosiglitazone inhibits bone regeneration and causes significant accumulation of fat at sites of new bone formation
    Lichu Liu
    Arkansas Children s Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Calcif Tissue Int 91:139-48. 2012
    ..These studies suggest that bone regeneration may be significantly compromised in T2DM patients on TZD therapy...
  26. ncbi request reprint Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumor growth and metastasis
    Ralph D Sanderson
    Department of Pathology and Arkansas Cancer Research Center, University of Arkansas, for Medical Sciences, Little Rock, AR, USA
    Matrix Biol 23:341-52. 2004
    ..Understanding the role of heparan sulfate and heparanase in the regulation of tumor behavior may lead to new therapeutic approaches for treating cancer...
  27. doi request reprint The promise of bone cancer proteomics
    Stephanie Byrum
    Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Ann N Y Acad Sci 1192:222-9. 2010
    ..As recent advances in proteomic technology have thrust the bone cancer field into the era of proteomics, a review of the current status of the proteome as it relates to the skeletal consequences of malignancy seems reasonable...
  28. ncbi request reprint Proteomic analysis of bone cancer: a review of current and future developments
    Sudeepa Bhattacharyya
    University of Arkansas for Medical Sciences, Department of Orthopaedic Surgery, Center for Orthopaedic Research, Barton Research Institute, Little Rock, AR 72205, USA
    Expert Rev Proteomics 4:371-8. 2007
    ....
  29. ncbi request reprint Genomics and proteomics of bone cancer
    Aaron G Marguiles
    Department of Orthopaedic Surgery, Center for Orthopaedic Research, Barton Research Institute, Little Rock, Arkansas 72205, USA
    Clin Cancer Res 12:6217s-6221s. 2006
    ..Future studies will identify the mechanisms that participate in the formation of secondary tumor growths of cancers in bone...
  30. doi request reprint Cisplatin inhibits bone healing during distraction osteogenesis
    Kimo C Stine
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas
    J Orthop Res 32:464-70. 2014
    ..2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:464-470, 2014. ..
  31. pmc Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11 gene expression in forming surface P-selectin ligands in aggressive breast cancer cells
    Craig A Cooney
    Department of Biochemistry and Molecular Biology, The University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Breast Cancer Res 13:R58. 2011
    ....
  32. pmc Rapid loss of bone mass and strength in mice after abdominal irradiation
    Dan Jia
    Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Radiat Res 176:624-35. 2011
    ..These effects are bone type- and region-specific but are independent of radiation fractionation. The radiation-induced abscopal damage to the skeleton is manifested by the deterioration of biomechanical properties of the affected bone...
  33. ncbi request reprint Heparanase promotes the spontaneous metastasis of myeloma cells to bone
    Yang Yang
    Department of Pathology, Myeloma Institute for Research and Therapy, Center for Orthopaedic Research, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 105:1303-9. 2005
    ..These studies describe a novel experimental animal model for examining the spontaneous metastasis of bone-homing tumors and indicate that heparanase is a critical determinant of myeloma dissemination and growth in vivo...
  34. doi request reprint Concurrent septic arthritis and osteomyelitis in children
    Corey O Montgomery
    Department of Orthopaedics, Center for Orthopaedic Research, University of Arkansas Medical Sciences, Little Rock, AR 72205, USA
    J Pediatr Orthop 33:464-7. 2013
    ..This study aims to identify factors that may help to diagnosis concurrent infections (CI) earlier...
  35. ncbi request reprint Expression of interleukin 8 and not parathyroid hormone-related protein by human breast cancer cells correlates with bone metastasis in vivo
    Manali S Bendre
    Center for Orthopaedic Research, Department of Orthopaedic Surgery, Barton Research Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Cancer Res 62:5571-9. 2002
    ..These experiments suggest that the elevated expression of IL-8 (and not PTHrP) by MDA-MET cells is a phenotypic change that may be related to their enhanced ability to metastasize to the skeleton...
  36. pmc Biomarkers that discriminate multiple myeloma patients with or without skeletal involvement detected using SELDI-TOF mass spectrometry and statistical and machine learning tools
    Sudeepa Bhattacharyya
    Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Dis Markers 22:245-55. 2006
    ....
  37. doi request reprint Microcomputed tomography assessment of glenoid component cementation techniques in total shoulder arthroplasty
    Syed Ashfaq Hasan
    Department of Orthopaedic Surgery, Center for Orthopaedic Research, Barton Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Orthop Res 28:559-64. 2010
    ..Both WH and MWH techniques increase cement mantle volume around individual pegs and decrease the amount of glenoid face cement compared to conventional SP...
  38. ncbi request reprint Comparison of biomechanical properties of alloderm and enduragen as static facial sling biomaterials
    Emre Vural
    Section of Otolaryngology Head and Neck Surgery, Department of Surgery, John McClellan VA Hospital, Little Rock, Arkansas 72205, USA
    Laryngoscope 116:394-6. 2006
    ..However, no data currently exist regarding its biomechanical properties and potential use as an alternative implant to Alloderm in static facial sling procedures...
  39. doi request reprint Oral glutamine reduces radiation morbidity in breast conservation surgery
    Isabel Rubio
    Department of Surgery Breast Surgical Oncology, Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    JPEN J Parenter Enteral Nutr 37:623-30. 2013
    ..These results suggest that Gln is an effective way to reduce radiation morbidity to breast cancer and is associated with the increased expression of a novel serum protein biomarker. ..
  40. ncbi request reprint Early detection of bone infection and differentiation from post-surgical inflammation using 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography (FDG-PET) in an animal model
    Laurie Jones-Jackson
    Department of Radiology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    J Orthop Res 23:1484-9. 2005
    ..Visual analysis of FDG-PET scans revealed a significant difference (p<0.01) between the infected and uninfected groups as early as day 8. This was due in part to the ability to visualize regional lymph nodes by FDG-PET...
  41. doi request reprint Relationship of bicipital groove rotation with humeral head retroversion: a three-dimensional computed tomographic analysis
    Jeff W Johnson
    Departments of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Bone Joint Surg Am 95:719-24. 2013
    ..We hypothesized that variability in groove rotation is directly related to variability in humeral head retroversion and that by defining the degree of groove rotation, humeral head retroversion can be predicted...
  42. pmc The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity
    Gwen V Childs
    Professor and Chair, Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Endocrinology 152:69-81. 2011
    ..The specific ablation of the Lepr exon 17 gene in somatotropes resulted in GH deficiency with a consequential reduction in lipolytic activity normally maintained by GH and increased adiposity...
  43. pmc Proteomic technologies for the study of osteosarcoma
    Stephanie D Byrum
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
    Sarcoma 2012:169416. 2012
    ..The current signaling markers/pathways associated with primary and metastatic osteosarcoma that have been identified by early-stage proteomic technologies thus far are also described...
  44. doi request reprint Two-incision versus one-incision repair for distal biceps tendon rupture: a cadaveric study
    S Ashfaq Hasan
    Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    J Shoulder Elbow Surg 21:935-41. 2012
    ....
  45. ncbi request reprint Skeletal toxicity associated with chronic ethanol exposure in a rat model using total enteral nutrition
    Elizabeth C Brown
    Laboratory for Limb Regeneration Research, Arkansas Children s Hospital Research Institute, 1120 Marshall Street, Little Rock, AR 72202, USA
    J Pharmacol Exp Ther 301:1132-8. 2002
    ..Also, the DO studies demonstrate, for the first time, that chronic ethanol inhibits rapid bone formation during limb lengthening...
  46. pmc Netoglitazone is a PPAR-gamma ligand with selective effects on bone and fat
    Oxana P Lazarenko
    Department of Geriatrics, University of Arkansas for Medical Sciences, 629 Jack Stephens Dr, Little Rock, AR 72205, USA
    Bone 38:74-84. 2006
    ..In conclusion, netoglitazone is a member of a new class of PPAR-gamma ligands with distinct anti-diabetic, anti-osteoblastic, and pro-adipocytic activities in vivo...
  47. ncbi request reprint Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) for determining prognosis in advanced stage hormone relapsing prostate cancer
    Manish Kohli
    Division of Hematology Oncology Department of Medicine, University of Arkansas for Medical Sciences UAMS, 4301 West Markham Street, Little Rock, AR 72211, USA
    Cancer Biomark 2:249-58. 2006
    ..In summary, SELDI-TOF MS captured a specific biomarker profile associated with biochemical relapse and provided additional prognostic information regarding long-term survival, independent of clinical PSA status...
  48. pmc Diagnosis of pancreatic cancer using serum proteomic profiling
    Sudeepa Bhattacharyya
    Center for Orthopaedic Research, Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Neoplasia 6:674-86. 2004
    ..These results suggest that high-throughput proteomics profiling has the capacity to provide new biomarkers for the early detection and diagnosis of PCa...
  49. ncbi request reprint Investigation of the regulation of bone mass by mechanical loading: from quantitative cytochemistry to gene array
    Tim M Skerry
    Veterinary Basic Sciences, Royal Veterinary College, London, UK
    Cell Biochem Funct 21:223-9. 2003
    ..Without Joe Chayen's involvement in this area, which now impacts on almost all bone biological science either directly or indirectly, our understanding of the pathophysiology of osteoporosis would have been very different...
  50. pmc The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy
    Yang Yang
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Blood 110:2041-8. 2007
    ....
  51. ncbi request reprint Modeling the interactions between osteoblast and osteoclast activities in bone remodeling
    Vincent Lemaire
    Scientific Computing and Mathematical Modeling, GlaxoSmithKline, King of Prussia, PA, USA
    J Theor Biol 229:293-309. 2004
    ..This model was conceived as the first step in a bone turnover modeling platform. These initial modeling results are extremely encouraging and lead us to proceed with additional explorations into bone turnover and skeletal remodeling...
  52. ncbi request reprint Response to continuous and pulsatile PTH dosing: a mathematical model for parathyroid hormone receptor kinetics
    Laura K Potter
    Scientific Computing and Mathematical Modeling, GlaxoSmithKline, Research Triangle Park, NC, USA
    Bone 37:159-69. 2005
    ..Moreover, this model provides a unique starting point from which to design experiments investigating PTH receptor biology...
  53. pmc Advances in treating metastatic bone cancer: summary statement for the First Cambridge Conference
    Allan Lipton
    Milton S Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA, and Department of Oncology, Norwegian Radium Hospital, Oslo, Norway
    Clin Cancer Res 12:6209s-6212s. 2006
    ..The conclusions reached during the 2-day meeting are summarized in this article and presented in more detail in the individual articles and accompanying discussion sessions that comprise the conference proceedings...
  54. ncbi request reprint Osteoprotegrin and the bone homing and colonization potential of breast cancer cells
    Preeti Kapoor
    Division of Musculoskeletal Sciences, Department of Orthopedics and Rehabilitation, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Cell Biochem 103:30-41. 2008
    ....
  55. pmc Regulation of osteoblastogenesis and bone mass by Wnt10b
    Christina N Bennett
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109 0622, USA
    Proc Natl Acad Sci U S A 102:3324-9. 2005
    ..Finally, Wnt10b-/- mice have decreased trabecular bone and serum osteocalcin, confirming that Wnt10b is an endogenous regulator of bone formation...