Research Topics
Genomes and Genes | Larry J SuvaSummaryAffiliation: University of Arkansas for Medical Sciences Country: USA Publications
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Publications
Bone metastasis: mechanisms and therapeutic opportunitiesLarry J Suva
Department of Orthopedic Surgery, Center for Orthopedic Research, Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
Nat Rev Endocrinol 7:208-18. 2011..The molecular mechanisms that underlie these painful and often incurable consequences of tumor metastasis to bone are beginning to be recognized, and they represent promising new molecular targets for therapy...- Identification of PTHrP(12-48) as a Plasma Biomarker Associated with Breast Cancer Bone MetastasisCharity L Washam
Corresponding Author Larry J Suva, Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 644, Little Rock, AR 72205
Cancer Epidemiol Biomarkers Prev 22:972-83. 2013..Breast cancer bone metastasis is a complication that significantly compromises patient survival due, in part, to the lack of disease-specific biomarkers that allow early and accurate diagnosis... - Mechanisms of bone metastases of breast cancerLarry J Suva
Department of Orthopaedic Surgery, Barton Research Institute, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Endocr Relat Cancer 16:703-13. 2009.... 
Regulation of bone mass by mechanical loading: microarchitecture and geneticsLarry J Suva
Department of Orthopaedic Surgery, Physiology, and Biophysics, University of Arkansas for Medical Sciences, 4301 W Markham Street, Mail 644, Little Rock, AR 72205, USA
Curr Osteoporos Rep 3:46-51. 2005..It is the focus of this paper to evaluate the evidence underlying roles for genetics, osteocytes, and interstitial fluid flow in mediating disuse osteopenia...- Rosiglitazone induces decreases in bone mass and strength that are reminiscent of aged boneOxana P Lazarenko
Department of Geriatrics, Reynolds Institute on Aging, 629 Jack Stephens Drive, Little Rock, AR 72205, USA
Endocrinology 148:2669-80. 2007..In conclusion, rosiglitazone induces changes in bone reminiscent of aged bone and appears to induce bone loss by altering the phenotype of marrow mesenchymal stem cells... - Vitamin D supplementation protects against bone loss associated with chronic alcohol administration in female miceKelly E Mercer
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Arkansas Children s Nutrition Center, 15 Children s Way, Little Rock, AR 72202, USA
J Pharmacol Exp Ther 343:401-12. 2012..These findings suggest dietary VitD supplementation may prevent skeletal toxicity in chronic drinkers by normalizing calcium homeostasis, preventing apoptosis, and suppressing EtOH-induced increases in bone resorption... - Tumor-derived syndecan-1 mediates distal cross-talk with bone that enhances osteoclastogenesisThomas Kelly
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
J Bone Miner Res 25:1295-304. 2010..05). Together these data suggest that syndecan-1 shed by tumor cells exerts biologic effects distal to the primary tumor and that it participates in driving osteoclastogenesis and the resulting bone destruction... - Inhibitor of DASH proteases affects expression of adhesion molecules in osteoclasts and reduces myeloma growth and bone diseaseAngela Pennisi
Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Br J Haematol 145:775-87. 2009..These data demonstrated that DASH proteases are involved in myeloma bone disease and tumour growth... 
Inhibin A enhances bone formation during distraction osteogenesisDaniel S Perrien
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
J Orthop Res 30:288-95. 2012..This mechanism is consistent with the effects of other agents and pathologies that modulate bone formation during DO, and demonstrates the potential of hInhA to enhance bone repair and regeneration...- Ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis: a role for the tumor necrosis factor signaling axisElizabeth C Wahl
Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, and Laboratory for Limb Regeneration Research, Arkansas Children's Hospital Research Institute, Little Rock, Arkansas 72202, USA
Alcohol Clin Exp Res 29:1466-72. 2005..CONCLUSIONS: These results suggest that the osteoinhibitory effects of chronic ethanol exposure are mediated in part by the TNF signaling axis... - Tumor-derived interleukin-8 stimulates osteolysis independent of the receptor activator of nuclear factor-kappaB ligand pathwayManali S Bendre
Department of Orthopaedic Surgery, Center for Orthopaedic Research, Barton Research Institute, University of Arkansas for Medical Sciences, Little Rock 72205, USA
Cancer Res 65:11001-9. 2005.... - Bone turnover across the menopause transition : The role of gonadal inhibinsKristy M Nicks
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Ann N Y Acad Sci 1192:153-60. 2010.... - Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastasesThomas Kelly
Department of Pathology, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7199, USA
Cancer Res 65:5778-84. 2005..This novel role for heparanase as a promoter of osteolysis before tumor metastasis suggests that therapies designed to block heparanase function may disrupt the early progression of bone-homing tumors... - Aging alters the skeletal response to disuse in the ratDaniel S Perrien
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 West Markham St, Slot 505, Little Rock, AR 72205, USA
Am J Physiol Regul Integr Comp Physiol 292:R988-96. 2007.... - Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand diseaseLarry J Suva
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Am J Pathol 172:430-9. 2008..These studies provide new insights into the relationship between the regulation of megakaryocytopoiesis and bone mass... - Interleukin-1 and tumor necrosis factor antagonists attenuate ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesisDaniel S Perrien
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
J Pharmacol Exp Ther 303:904-8. 2002.... - Inhibin A is an endocrine stimulator of bone mass and strengthDaniel S Perrien
Department of Physiology and Biophysics, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 505, Little Rock, Arkansas 72205, USA
Endocrinology 148:1654-65. 2007.... - Serum biomarker profile associated with high bone turnover and BMD in postmenopausal womenSudeepa Bhattacharyya
Department of Orthopaedic Surgery, Center for Orthopaedic Research, Barton Research Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
J Bone Miner Res 23:1106-17. 2008..In conjunction with the identification of the individual proteins, this protein fingerprint may provide a novel approach to evaluate high bone turnover states... - Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, Activin and InhibinKristy M Nicks
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Mol Cell Endocrinol 310:11-20. 2009..This fundamental action has the potential to de-repress locally stimulated changes in osteoblastogenesis and osteoclastogenesis, thereby altering bone metabolism... - Characterization of the glycosylation profile of the human breast cancer cell line, MDA-231, and a bone colonizing variantJaime Carcel-Trullols
Arkansas Cancer Research Center and Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Int J Oncol 28:1173-83. 2006..These data suggest that the glycomic phenotype of MDA-MET cells is associated with a select set of accumulated functions that collectively impact on the bone metastases and bone colonization capacity of breast cancer cells... - Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone diseaseManali S Bendre
Center for Orthopaedic Research, Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Bone 33:28-37. 2003..These results demonstrate a direct effect of IL-8 on osteoclast differentiation and activity. Together, these data implicate IL-8 in the osteolysis associated with metastatic breast cancer... - Repression of multiple myeloma growth and preservation of bone with combined radiotherapy and anti-angiogenic agentDan Jia
Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR72205, USA
Radiat Res 173:809-17. 2010..These results suggest that radiotherapy, when primed by anti-angiogenic agents, may be a potent therapy for focal multiple myeloma... - Rosiglitazone inhibits bone regeneration and causes significant accumulation of fat at sites of new bone formationLichu Liu
Arkansas Children s Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Calcif Tissue Int 91:139-48. 2012..These studies suggest that bone regeneration may be significantly compromised in T2DM patients on TZD therapy... - The promise of bone cancer proteomicsStephanie Byrum
Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Ann N Y Acad Sci 1192:222-9. 2010..As recent advances in proteomic technology have thrust the bone cancer field into the era of proteomics, a review of the current status of the proteome as it relates to the skeletal consequences of malignancy seems reasonable... - Proteomic analysis of bone cancer: a review of current and future developmentsSudeepa Bhattacharyya
University of Arkansas for Medical Sciences, Department of Orthopaedic Surgery, Center for Orthopaedic Research, Barton Research Institute, Little Rock, AR 72205, USA
Expert Rev Proteomics 4:371-8. 2007.... - Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumor growth and metastasisRalph D Sanderson
Department of Pathology and Arkansas Cancer Research Center, University of Arkansas, for Medical Sciences, Little Rock, AR, USA
Matrix Biol 23:341-52. 2004..Understanding the role of heparan sulfate and heparanase in the regulation of tumor behavior may lead to new therapeutic approaches for treating cancer... - Bone turnover across the menopause transition: correlations with inhibins and follicle-stimulating hormoneDaniel S Perrien
Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
J Clin Endocrinol Metab 91:1848-54. 2006..CONCLUSIONS: Decreases in inhibin levels across the menopause transition are associated with increasing bone turnover, regardless of changes in sex steroids or FSH... - Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatmentTristan W Fowler
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
PLoS ONE 7:e42967. 2012..These studies provide novel insight into the cause of the profound bone fragility in DS and identify PTH as a potential anabolic agent in the adult low bone mass DS population... - Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11 gene expression in forming surface P-selectin ligands in aggressive breast cancer cellsCraig A Cooney
Department of Biochemistry and Molecular Biology, The University of Arkansas for Medical Sciences, Little Rock, 72205, USA
Breast Cancer Res 13:R58. 2011.... - Rapid loss of bone mass and strength in mice after abdominal irradiationDan Jia
Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Radiat Res 176:624-35. 2011..These effects are bone type- and region-specific but are independent of radiation fractionation. The radiation-induced abscopal damage to the skeleton is manifested by the deterioration of biomechanical properties of the affected bone... - Genomics and proteomics of bone cancerAaron G Marguiles
Department of Orthopaedic Surgery, Center for Orthopaedic Research, Barton Research Institute, Little Rock, Arkansas 72205, USA
Clin Cancer Res 12:6217s-6221s. 2006..Future studies will identify the mechanisms that participate in the formation of secondary tumor growths of cancers in bone... - Proteomic technologies for the study of osteosarcomaStephanie D Byrum
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
Sarcoma 2012:169416. 2012..The current signaling markers/pathways associated with primary and metastatic osteosarcoma that have been identified by early-stage proteomic technologies thus far are also described... - Biomarkers that discriminate multiple myeloma patients with or without skeletal involvement detected using SELDI-TOF mass spectrometry and statistical and machine learning toolsSudeepa Bhattacharyya
Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Dis Markers 22:245-55. 2006.... - Expression of interleukin 8 and not parathyroid hormone-related protein by human breast cancer cells correlates with bone metastasis in vivoManali S Bendre
Center for Orthopaedic Research, Department of Orthopaedic Surgery, Barton Research Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Cancer Res 62:5571-9. 2002..These experiments suggest that the elevated expression of IL-8 (and not PTHrP) by MDA-MET cells is a phenotypic change that may be related to their enhanced ability to metastasize to the skeleton... - Microcomputed tomography assessment of glenoid component cementation techniques in total shoulder arthroplastySyed Ashfaq Hasan
Department of Orthopaedic Surgery, Center for Orthopaedic Research, Barton Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Orthop Res 28:559-64. 2010..Both WH and MWH techniques increase cement mantle volume around individual pegs and decrease the amount of glenoid face cement compared to conventional SP... - Heparanase promotes the spontaneous metastasis of myeloma cells to boneYang Yang
Department of Pathology, Myeloma Institute for Research and Therapy, Center for Orthopaedic Research, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Blood 105:1303-9. 2005..These studies describe a novel experimental animal model for examining the spontaneous metastasis of bone-homing tumors and indicate that heparanase is a critical determinant of myeloma dissemination and growth in vivo... - Comparison of biomechanical properties of alloderm and enduragen as static facial sling biomaterialsEmre Vural
Section of Otolaryngology Head and Neck Surgery, Department of Surgery, John McClellan VA Hospital, Little Rock, Arkansas 72205, USA
Laryngoscope 116:394-6. 2006..However, no data currently exist regarding its biomechanical properties and potential use as an alternative implant to Alloderm in static facial sling procedures... - Concurrent septic arthritis and osteomyelitis in childrenCorey O Montgomery
Departments of Orthopaedics Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas Medical Sciences, Little Rock, AR
J Pediatr Orthop 33:464-7. 2013..This study aims to identify factors that may help to diagnosis concurrent infections (CI) earlier... - The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesityGwen V Childs
Professor and Chair, Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Endocrinology 152:69-81. 2011..The specific ablation of the Lepr exon 17 gene in somatotropes resulted in GH deficiency with a consequential reduction in lipolytic activity normally maintained by GH and increased adiposity... - Relationship of bicipital groove rotation with humeral head retroversion: a three-dimensional computed tomographic analysisJeff W Johnson
Departments of Orthopaedic Surgery J W J and L J S and Biostatistics J D T, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 531, Little Rock, AR 72205
J Bone Joint Surg Am 95:719-24. 2013..We hypothesized that variability in groove rotation is directly related to variability in humeral head retroversion and that by defining the degree of groove rotation, humeral head retroversion can be predicted... - Two-incision versus one-incision repair for distal biceps tendon rupture: a cadaveric studyS Ashfaq Hasan
Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA
J Shoulder Elbow Surg 21:935-41. 2012.... - Netoglitazone is a PPAR-gamma ligand with selective effects on bone and fatOxana P Lazarenko
Department of Geriatrics, University of Arkansas for Medical Sciences, 629 Jack Stephens Dr, Little Rock, AR 72205, USA
Bone 38:74-84. 2006..In conclusion, netoglitazone is a member of a new class of PPAR-gamma ligands with distinct anti-diabetic, anti-osteoblastic, and pro-adipocytic activities in vivo... - Skeletal toxicity associated with chronic ethanol exposure in a rat model using total enteral nutritionElizabeth C Brown
Laboratory for Limb Regeneration Research, Arkansas Children's Hospital Research Institute, 1120 Marshall Street, Little Rock, AR 72202, USA
J Pharmacol Exp Ther 301:1132-8. 2002..Also, the DO studies demonstrate, for the first time, that chronic ethanol inhibits rapid bone formation during limb lengthening... - Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) for determining prognosis in advanced stage hormone relapsing prostate cancerManish Kohli
Division of Hematology Oncology Department of Medicine, University of Arkansas for Medical Sciences UAMS, 4301 West Markham Street, Little Rock, AR 72211, USA
Cancer Biomark 2:249-58. 2006..In summary, SELDI-TOF MS captured a specific biomarker profile associated with biochemical relapse and provided additional prognostic information regarding long-term survival, independent of clinical PSA status... - Early detection of bone infection and differentiation from post-surgical inflammation using 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography (FDG-PET) in an animal modelLaurie Jones-Jackson
Department of Radiology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
J Orthop Res 23:1484-9. 2005..Visual analysis of FDG-PET scans revealed a significant difference (p<0.01) between the infected and uninfected groups as early as day 8. This was due in part to the ability to visualize regional lymph nodes by FDG-PET... - Diagnosis of pancreatic cancer using serum proteomic profilingSudeepa Bhattacharyya
Center for Orthopaedic Research, Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Neoplasia 6:674-86. 2004..These results suggest that high-throughput proteomics profiling has the capacity to provide new biomarkers for the early detection and diagnosis of PCa... - The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapyYang Yang
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Blood 110:2041-8. 2007.... - Investigation of the regulation of bone mass by mechanical loading: from quantitative cytochemistry to gene arrayTim M Skerry
Veterinary Basic Sciences, Royal Veterinary College, London, UK
Cell Biochem Funct 21:223-9. 2003..Without Joe Chayen's involvement in this area, which now impacts on almost all bone biological science either directly or indirectly, our understanding of the pathophysiology of osteoporosis would have been very different... - Modeling the interactions between osteoblast and osteoclast activities in bone remodelingVincent Lemaire
Scientific Computing and Mathematical Modeling, GlaxoSmithKline, King of Prussia, PA, USA
J Theor Biol 229:293-309. 2004..This model was conceived as the first step in a bone turnover modeling platform. These initial modeling results are extremely encouraging and lead us to proceed with additional explorations into bone turnover and skeletal remodeling... - Regulation of osteoblastogenesis and bone mass by Wnt10bChristina N Bennett
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109 0622, USA
Proc Natl Acad Sci U S A 102:3324-9. 2005..Finally, Wnt10b-/- mice have decreased trabecular bone and serum osteocalcin, confirming that Wnt10b is an endogenous regulator of bone formation... - Osteoprotegrin and the bone homing and colonization potential of breast cancer cellsPreeti Kapoor
Division of Musculoskeletal Sciences, Department of Orthopedics and Rehabilitation, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Cell Biochem 103:30-41. 2008.... - Response to continuous and pulsatile PTH dosing: a mathematical model for parathyroid hormone receptor kineticsLaura K Potter
Scientific Computing and Mathematical Modeling, GlaxoSmithKline, Research Triangle Park, NC, USA
Bone 37:159-69. 2005..Moreover, this model provides a unique starting point from which to design experiments investigating PTH receptor biology... - Advances in treating metastatic bone cancer: summary statement for the First Cambridge ConferenceAllan Lipton
Milton S Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA, and Department of Oncology, Norwegian Radium Hospital, Oslo, Norway
Clin Cancer Res 12:6209s-6212s. 2006..The conclusions reached during the 2-day meeting are summarized in this article and presented in more detail in the individual articles and accompanying discussion sessions that comprise the conference proceedings...