Fayyaz S Sutterwala

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. doi request reprint The tiny conductor: immune regulation via commensal organisms
    SUZANNE L CASSEL
    Division of Allergy and Immunology, University of Iowa, Iowa City, IA 52242, USA
    Cell Host Microbe 3:340-1. 2008
  2. pmc NLRC4/IPAF: a CARD carrying member of the NLR family
    Fayyaz S Sutterwala
    Inflammation Program, Department of Internal Medicine, University of Iowa, Iowa City, IA 52241, USA
    Clin Immunol 130:2-6. 2009
  3. pmc Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation
    Tyler K Ulland
    Inflammation Program, University of Iowa, Iowa City, Iowa, USA
    Infect Immun 81:201-8. 2013
  4. pmc Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans
    Sophie Joly
    Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Immunol 189:4713-7. 2012
  5. pmc Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation
    Shankar S Iyer
    Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Immunity 39:311-23. 2013
  6. pmc Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome
    Shankar S Iyer
    Division of Infectious Diseases, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 106:20388-93. 2009
  7. pmc Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome
    Sophie Joly
    Division of Infectious Diseases, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 183:3578-81. 2009
  8. doi request reprint Fungal pathogen recognition by the NLRP3 inflammasome
    Sophie Joly
    Inflammation Program, University of Iowa, Iowa City, IA, USA
    Virulence 1:276-80. 2010
  9. pmc The Nalp3 inflammasome is essential for the development of silicosis
    SUZANNE L CASSEL
    Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 105:9035-40. 2008
  10. ncbi request reprint ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection
    Joao H F Pedra
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 179:4783-91. 2007

Research Grants

Collaborators

Detail Information

Publications16

  1. doi request reprint The tiny conductor: immune regulation via commensal organisms
    SUZANNE L CASSEL
    Division of Allergy and Immunology, University of Iowa, Iowa City, IA 52242, USA
    Cell Host Microbe 3:340-1. 2008
    ..In a recent study in Nature, Mazmanian et al. (2008) reveal the ability of specific moieties on the surface of Bacteroides fragilis to direct the host's immune response...
  2. pmc NLRC4/IPAF: a CARD carrying member of the NLR family
    Fayyaz S Sutterwala
    Inflammation Program, Department of Internal Medicine, University of Iowa, Iowa City, IA 52241, USA
    Clin Immunol 130:2-6. 2009
    ..This review will discuss these findings as well as the role of bacterial type III and type IV secretion systems and flagellin in NLRC4-mediated caspase-1 activation...
  3. pmc Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation
    Tyler K Ulland
    Inflammation Program, University of Iowa, Iowa City, Iowa, USA
    Infect Immun 81:201-8. 2013
    ..These findings further illustrate that F. tularensis LVS possesses numerous genes that influence its ability to activate the inflammasome, which is a key host strategy to control infection with this pathogen in vivo...
  4. pmc Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans
    Sophie Joly
    Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Immunol 189:4713-7. 2012
    ..albicans. However, Nlrp10-deficient mice displayed a profound defect in Candida-specific Th1 and Th17 responses. These results demonstrate a novel role for Nlrp10 in the generation of adaptive immune responses to fungal infection...
  5. pmc Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation
    Shankar S Iyer
    Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Immunity 39:311-23. 2013
    ..Together these data suggest that mitochondria play a critical role in the activation of the Nlrp3 inflammasome through the direct binding of Nlrp3 to cardiolipin. ..
  6. pmc Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome
    Shankar S Iyer
    Division of Infectious Diseases, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 106:20388-93. 2009
    ..These findings suggest that the inhibition of Nlrp3 inflammasome activity can diminish the acute inflammation and damage associated with tissue injury...
  7. pmc Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome
    Sophie Joly
    Division of Infectious Diseases, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 183:3578-81. 2009
    ..Nlrp3-deficient mice also demonstrated increased susceptibility to infection with C. albicans, which is consistent with a key role for Nlrp3 in innate immune responses to the pathogen C. albicans...
  8. doi request reprint Fungal pathogen recognition by the NLRP3 inflammasome
    Sophie Joly
    Inflammation Program, University of Iowa, Iowa City, IA, USA
    Virulence 1:276-80. 2010
    ..Here we will review these findings and discuss the role of the NLRP3 inflammasome in initiating an innate immune response to invasive C. albicans...
  9. pmc The Nalp3 inflammasome is essential for the development of silicosis
    SUZANNE L CASSEL
    Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 105:9035-40. 2008
    ..This study demonstrates a key role for the Nalp3 inflammasome in the pathogenesis of pneumoconiosis...
  10. ncbi request reprint ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection
    Joao H F Pedra
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 179:4783-91. 2007
    ..phagocytophilum. Taken together, our data demonstrate that ASC and caspase-1 are critical for IFN-gamma-mediated control of A. phagocytophilum infection...
  11. pmc Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence
    Tyler K Ulland
    Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 185:2670-4. 2010
    ..This study demonstrates that mviN limits F. tularensis-induced absent in melanoma 2 inflammasome activation, which is critical for its virulence in vivo...
  12. pmc Sterile inflammatory responses mediated by the NLRP3 inflammasome
    SUZANNE L CASSEL
    Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA, USA
    Eur J Immunol 40:607-11. 2010
    ..Here we discuss the role of the NLRP3 inflammasome in the recognition of cellular damage and the initiation of sterile inflammatory responses...
  13. doi request reprint Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice
    SUZANNE L CASSEL
    Inflammation Program, Department of Internal Medicine, Graduate Program in Immunology, Department of Pediatrics, Department of Pathology, Department of Orthopedics, Dows Institute for Dental Research and Department of Periodontics, College of Dentistry, and Department of Epidemiology, University of Iowa, Iowa City, IA 52242
    Proc Natl Acad Sci U S A 111:1072-7. 2014
    ..These data provide a rationale for directly targeting IL-1RI or IL-1β as a therapeutic strategy in CRMO. ..
  14. pmc Damage control: management of cellular stress by the NLRP3 inflammasome
    Stefanie Haasken
    Inflammation Program, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Eur J Immunol 43:2003-5. 2013
    ....
  15. pmc The NLRP3 inflammasome: a sensor of immune danger signals
    SUZANNE L CASSEL
    Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Semin Immunol 21:194-8. 2009
    ..One of the best-studied members of the NLR family is NLRP3 for which a number of divergent activators have recently been described. These and other studies examining the NLRP3 inflammasome will be discussed in this review...
  16. pmc Control of innate and adaptive immunity by the inflammasome
    Ceren Ciraci
    Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Microbes Infect 14:1263-70. 2012
    ..This review examines recent advances in inflammasome biology with an emphasis on its roles in sterile inflammation and triggering of adaptive immune responses...

Research Grants2

  1. Nlrp3 inflammasome signaling in immune responses to Candida albicans
    Fayyaz S Sutterwala; Fiscal Year: 2010
    ..In addition the information gained from the proposed studies will also shed light on the pathogenesis of other fungal organisms. ..