C M Surawicz
Affiliation: University of Washington
- Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile diseaseLynne V McFarland
Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, USA
Am J Gastroenterol 97:1769-75. 2002..The persistence of C. difficile spores suggests that additional strategies to restore the normal colonic microflora may also be beneficial...
- Treatment of recurrent Clostridium difficile-associated diseaseChristina M Surawicz
University of Washington School of Medicine and Harborview Medical Center, Seattle, WA 98104, USA
Nat Clin Pract Gastroenterol Hepatol 1:32-8. 2004..In addition, there are numerous new treatment approaches that are under development, including a vaccine, which promise to aid the future treatment of RCDAD as well as prevention of initial CDAD...
- Pseudomembranous colitis: causes and curesC M Surawicz
University of Washington, Seattle, Wash, USA
Digestion 60:91-100. 1999..The yeast Saccharomyces boulardii has been proven in controlled trials to reduce recurrences when given as an adjunct to antibiotic therapy. Careful hand washing and environmental decontamination are necessary to prevent epidemics...
- [The microbiota and infectious diarrhea]C M Surawicz
University of Washington School of Medicine, 325 9th Avenue, Seattle, WA 98104, USA
Gastroenterol Clin Biol 34:S29-36. 2010..It is likely that we will learn even more in the future about the beneficial effect of our microbiota...
- Mechanisms of diarrheaChristina M Surawicz
Division of Gastroenterology, Department of Medicine, School of Medicine, Harborview Medical Center, University of Washington School of Medicine, 325 Ninth Avenue, Box 359773, Seattle, WA 98104, USA
Curr Gastroenterol Rep 12:236-41. 2010..Understanding such basic mechanisms may lead to better and novel therapies for treatment of diarrhea...
- Role of probiotics in antibiotic-associated diarrhea, Clostridium difficile-associated diarrhea, and recurrent Clostridium difficile-associated diarrheaChristina M Surawicz
University of Washington SOM, Seattle, WA 98104, USA
J Clin Gastroenterol 42:S64-70. 2008..difficile diarrhea is reviewed. Various probiotics have variable efficacy. More studies are needed to define further their efficacies, roles, and indications...
- Treatment of refractory and recurrent Clostridium difficile infectionChristina M Surawicz
Division of Gastroenterology, Department of Medicine, University of Washington School of Medicine, 325 Ninth Avenue, Box 359773, Seattle, WA 98104, USA
Nat Rev Gastroenterol Hepatol 8:330-9. 2011..Treatments include antibiotics, adjunct probiotics, fecal microbiota transplant and immune approaches. This Review discusses the various therapeutic approaches used for the treatment of refractory and recurrent CDI...
- Antibiotic-associated diarrhea and pseudomembranous colitis: are they less common with poorly absorbed antimicrobials?Christina M Surawicz
Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA
Chemotherapy 51:81-9. 2005..Controlled trials would prove this but are not yet available. Probiotics may be a good adjunct to poorly absorbed antibiotics to minimize the risk of diarrhea associated with antibiotics...
- Probiotics, antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in humansChristina M Surawicz
Department of Medicine, University of Washington School of Medicine, Seattle, USA
Best Pract Res Clin Gastroenterol 17:775-83. 2003..Additional controlled trials and safety studies are needed before there can be a widespread endorsement of probiotics for these two conditions...
- The search for a better treatment for recurrent Clostridium difficile disease: use of high-dose vancomycin combined with Saccharomyces boulardiiC M Surawicz
Division of Gastroenterology, Department of Medicine, University of Washoington, Seattle, WA USA
Clin Infect Dis 31:1012-7. 2000..Comparison of data from this trial with data from previous studies indicates that recurrent CDD may respond to a short course of high-dose vancomycin or to longer courses of low-dose vancomycin when either is combined with S. boulardii...
- Behaviour of Saccharomyces boulardii in recurrent Clostridium difficile disease patientsG W Elmer
Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle 98195, USA
Aliment Pharmacol Ther 13:1663-8. 1999..The present study reports the stool concentrations of Saccharomyces boulardii in a patient population with Clostridium difficile disease (CDD) and correlates stool concentrations with efficacy...
- Treatment strategies for C. difficile associated diarrheaCrenguta Stepan
University of Washington, Seattle, USA
Acta Gastroenterol Latinoam 37:183-91. 2007..Prevention is also very important in controlling this disease: first by limiting the use of broad spectrum antibiotics and secondly by controlling the environmental spreading through gloves, handwashing and disposable thermometers...
- Probiotics in the prevention and treatment of gastrointestinal infectionsElizabeth S Huebner
Division of Gastroenterology, University of Washington School of Medicine, Box 356424, 1959 NE Pacific Street, Seattle, WA 98195-6424, USA
Gastroenterol Clin North Am 35:355-65. 2006..Additional clinical trials are indicated to define the role of probiotics further before wide-spread use can be recommended...
- Evolving concepts in Clostridium difficile colitisNaomi G Diggs
Department of Medicine, Division of Gastroenterology, University of Washington School of Medicine, Harborview Medical Center, Seattle, WA 98104, USA
Curr Gastroenterol Rep 11:400-5. 2009..With increasing incidence and severity of disease, the need for improved diagnostic, treatment, and infection control strategies cannot be overstated...
- Treatment strategies for recurrent and refractory Clostridium difficile-associated diarrheaCrenguta Stepan
University of Washington, Gastroenterology, Harborview Medical Center, 325 9th Avenue, Box 359773 Seattle, WA 98104, USA
Expert Rev Gastroenterol Hepatol 1:295-305. 2007..Treatment of refractory and recurrent CDAD remain therapeutic challenges. Improved treatments are needed; several new drugs are currently in trials...
- Probiotics and prebiotics in clinical practiceElizabeth K Broussard
Division of Gastroenterology, University of Washington School of Medicine, Seattle, Washington 98104, USA
Nutr Clin Care 7:104-13. 2004..Rather than introducing exogenous bacteria into the intestinal millieu, prebiotics stimulate certain indigenous bacteria already resident in the gut...
- Clinical correlation of toxin and common antigen enzyme immunoassay testing in patients with Clostridium difficile diseaseScott D Lee
Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Am J Gastroenterol 98:1569-72. 2003..When both common antigen and toxin A are positive, the likelihood of C. difficile diarrhea is high; conversely, when both results are negative, the likelihood of C. difficile diarrhea is low...
- Maintenance infliximab infusions forever?Scott D Lee
University of Washington, Seattle, USA
Am J Gastroenterol 97:2917-8. 2002
- Emerging infections of the gastrointestinal tractChristine Schlenker
Division of Gastroenterology, Department of Medicine, University of Washington, School of Medicine, Seattle, WA 98104, USA
Best Pract Res Clin Gastroenterol 23:89-99. 2009..Helicobacteria are reviewed, as well as the role of gastric acid suppression in predisposing to enteric infections...
- Chronic diarrheaPeggy D Headstrom
Department of Gastroenterology, University of Washington, Seattle, Washington, USA
Clin Gastroenterol Hepatol 3:734-7. 2005
- The changing face of Clostridium difficile: what treatment options remain?Edie P Shen
Am J Gastroenterol 102:2789-92. 2007..difficile-associated diarrhea (CDAD). This editorial explores these, particularly in complicated cases and high-risk populations...
- Antibiotics and Clostridium difficile: cause and cureChristina M Surawicz
J Clin Gastroenterol 41:1-2. 2007
- Clostridium difficile infectionErnst J Kuipers
Departments of Gastroenterology and Hepatology, and Internal Medicine, Erasmus MC University Medical Center, 3000 CA Rotterdam, Netherlands
Lancet 371:1486-8. 2008
- Antibiotic-associated diarrhea in children: how many dirty diapers?Christina M Surawicz
J Pediatr Gastroenterol Nutr 37:2-3. 2003