Mark A Supiano
Affiliation: University of Michigan
- A Web-based geriatrics portfolio to document medical students' learning outcomesMark A Supiano
Internal Medicine, University of Michigan Health System and VA Ann Arbor Healthcare System, 48105, USA
Acad Med 77:937-8. 2002..Students will demonstrate proficiency in these outcomes as a graduation requirement. We have developed an individualized, interactive, Web-based geriatrics portfolio to track the acquisition and mastery of these outcomes for students...
- Abdominal adiposity assessed by dual energy X-ray absorptiometry provides a sex-independent predictor of insulin sensitivity in older adultsCathy C Lee
Department of Internal Medicine, Division of Geriatrics, University of Michigan Health System, and the GRECC VA Ann Arbor Healthcare System, 48105, USA
J Gerontol A Biol Sci Med Sci 60:872-7. 2005..The objective of this cross-sectional study was to determine which measure of abdominal adiposity would provide the best sex-independent predictor of metabolic insulin sensitivity in older men and women...
- Serial changes in norepinephrine kinetics associated with feeding dogs a high-fat dietAlbert P Rocchini
Department of Pediatrics, Pediatric Cardiology Division, University of Michigan, Ann Arbor, MI 48109 5204, USA
J Clin Hypertens (Greenwich) 12:117-24. 2010..This study supports the hypothesis that activation of the SNS plays a pivotal role in the metabolic and hemodynamic changes that occur with weight gain induced by HFD...
- Development of a standardized patient instructor to teach functional assessment and communication skills to medical students and house officersBrent C Williams
Department of Internal Medicine, Divisions of Geriatric Medicine and General Medicine, Ann Arbor Veterans Affairs Healthcare System, Ann Arbor, Michigan, USA
J Am Geriatr Soc 54:1447-52. 2006..Unlike existing diagnosis-oriented SPs, the GSPI can be used to assess and teach geriatrics skills to physician learners across disciplines and levels of training...
- Limitation of the homeostasis model assessment to predict insulin resistance and beta-cell dysfunction in older peopleAnnette M Chang
University of Michigan, 5570 MSRB II, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0678, USA
J Clin Endocrinol Metab 91:629-34. 2006..Studies in older people have shown inconsistent agreement between homeostasis model assessment of insulin resistance (HOMA-IR) and dynamic measures of insulin action and have not evaluated HOMA beta-cell...
- Does increased arterial stiffness increase the risk for postural hypotension?David Sengstock
Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan Health System, and the Geriatric Research, Education, and Clinical Center, Veterans Affairs Health Care System, Ann Arbor, MI 48105, USA
Am J Geriatr Cardiol 14:224-9. 2005..45; p=0.001). This study does not support a relationship between arterial stiffness and a postural decrease in BP among healthy older adults; other age-related factors regulating BP homeostasis likely play a greater role...
- Renal norepinephrine spillover during infusion of nonesterified fatty acidsRoger J Grekin
Veterans Affairs Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI 48105, USA
Am J Hypertens 18:422-6. 2005..We have reported that infusion of nonesterified fatty acids increases blood pressure in animals through stimulation of the sympathetic nervous system...
- Arterial stiffness is related to insulin resistance in nondiabetic hypertensive older adultsDavid M Sengstock
Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan Health System and the Geriatric Research, Education and Clinical Center, Veterans Affairs Ann Arbor Health Care System, Ann Arbor, Michigan 48105, USA
J Clin Endocrinol Metab 90:2823-7. 2005..These results suggest that in hypertensive, nondiabetic, older adults, insulin resistance is associated with arterial stiffness independent of glucose tolerance status...
- Changes in systemic sympathetic nervous system activity after mitral valve surgery and their relationship to changes in left ventricular size and systolic performance in patients with mitral regurgitationRajendra H Mehta
University of Michigan and Veterans Affairs, Healthcare Systems, Ann Arbor, MI, USA
Am Heart J 147:729-35. 2004..We have shown that the systemic sympathetic nervous system (SNS) is activated in patients with chronic mitral regurgitation (MR). However, the fate of systemic SNS activity after surgical correction of MR is currently unknown...
- Relating medical students' knowledge, attitudes, and experience to an interest in geriatric medicineJames T Fitzgerald
Department of Medical Education, The University of Michigan Medical School, 1107 Towsley Center, Box 0201, Ann Arbor, MI 48109 0201, USA
Gerontologist 43:849-55. 2003..This study examined medical students' interest in geriatrics: Are knowledge, positive attitudes, and prior experience with older adults associated with an interest in geriatric medicine?..
- Differential effects of raloxifene and estrogen on insulin sensitivity in postmenopausal womenCathy C Lee
University of Michigan Health System, Ann Arbor, USA
J Am Geriatr Soc 51:683-8. 2003..To test the hypothesis that both raloxifene and estrogen would improve insulin sensitivity in postmenopausal women and that the magnitude of the effect would be similar for both drugs...
- Cardiac-specific norepinephrine mass transport and its relationship to left ventricular size and systolic performanceP Michael Grossman
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA
Am J Physiol Heart Circ Physiol 287:H878-88. 2004..These data support the concept that this new model of organ-specific NE kinetics has physiological relevance...
- A vertically integrated geriatric curriculum improves medical student knowledge and clinical skillsMark A Supiano
Department of Internal Medicine, Geriatrics Division, Center on Aging, University of Utah, Salt Lake City, Utah 84132, USA
J Am Geriatr Soc 55:1650-5. 2007....
- Regional differences in glucose clearance: effects of insulin and resistance training on arm and leg glucose clearance in older hypertensive individualsThomas H Reynolds
Dept of Internal Medicine, University of Michigan, Ann Arbor, USA
J Appl Physiol (1985) 102:985-91. 2007..In conclusion, the greater GC in the arm than in the leg at baseline is primarily due to enhanced arm BF. Furthermore, whole body RT appears to increase GC in the leg but not in the arm...
- Exercise-induced changes in insulin action are associated with ACE gene polymorphisms in older adultsDonald R Dengel
School of Kinesiology, University of Minnesota, Minneapolis 55455, USA
Physiol Genomics 11:73-80. 2002..4 +/- 6.2 and -3.6 +/- 2.5 mU/ml) ACE genotypes. In conclusion, we demonstrated that those older hypertensives with the ACE II genotype have the greatest improvement in insulin action following AEX...
- Effect of aerobic exercise training on renal responses to sodium in hypertensivesDonald R Dengel
School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
Med Sci Sports Exerc 38:217-22. 2006..The exact mechanism(s) by which aerobic exercise training elicits these changes are unknown; however, it is possible that changes in renal hemodynamics may play a role...
- Aerobic exercise training improves insulin sensitivity independent of plasma tumor necrosis factor-alpha levels in older female hypertensivesThomas H Reynolds
Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan and GRECC, Ann Arbor Veterans Affairs Healthcare System, Ann Arbor, MI, USA
Metabolism 51:1402-6. 2002..In conclusion, in this population of older hypertensive females, AEX improved insulin sensitivity and lowered blood pressure without a reduction in plasma TNF-alpha levels...
- Compared with control subjects, the systemic sympathetic nervous system is activated in patients with mitral regurgitationRajendra H Mehta
TOP University of Michigan and Veterans Affairs Healthcare Systems, Ann Arbor, USA
Am Heart J 145:1078-85. 2003....
- Resistance training enhances insulin-mediated glucose disposal with minimal effect on the tumor necrosis factor-alpha system in older hypertensivesThomas H Reynolds
Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan, Ann Arbor, MI, USA
Metabolism 53:397-402. 2004..168). In conclusion, a 4-month RT program significantly increased insulin-mediated glucose disposal and LBM without a significant reduction in plasma levels of TNF-alpha, sTNF R1, and sTNF R2 in older hypertensive subjects...
- Androgenicity and obesity are independently associated with insulin sensitivity in postmenopausal womenCathy C Lee
Department of Pediatrics, Division of Geriatrics, University of Michigan Health System, Ann Arbor, MI, USA
Metabolism 53:507-12. 2004..Interventions to decrease androgenicity may therefore be useful in improving insulin sensitivity in postmenopausal women...
- Validity and reliability of dual-energy X-ray absorptiometry for the assessment of abdominal adiposityScott G Glickman
Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan, USA
J Appl Physiol 97:509-14. 2004..94, 0.97, and 0.89, respectively). In conclusion, the DXA L1-L4 region of interest compared with CT proved to be both reliable and accurate method to determine abdominal obesity...
- Sympathetic activity and the heterogenous blood pressure response to exercise training in hypertensivesMichael D Brown
Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan Health System and Geriatric Research, Education, and Clinical Center, Ann Arbor Veterans Affairs Health System, Ann Arbor, Michigan 48105, USA
J Appl Physiol (1985) 92:1434-42. 2002..Thus suppression of SNS activity may play a role in the reduction in MABP and account for a portion of the heterogeneity of the MABP response to aerobic exercise training in older hypertensive subjects...
- Screening for common clinical conditions in older womenSonal Sonia Thakur
Division of Geriatrics, University of Utah School of Medicine, VA Salt Lake City Geriatric Research Education and Clinical Center, University of Utah Center on Aging, Salt Lake City, Utah 84132, USA
Clin Obstet Gynecol 50:767-75. 2007..Effective treatments for these conditions are available to prevent cardiovascular disease morbidity and mortality. An overview of current screening guidelines for these common conditions is presented...