Miao Sun

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Gene expression profiles in acute myeloid leukemia with common translocations using SAGE
    Sanggyu Lee
    Department of Medicine, University of Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 103:1030-5. 2006
  2. pmc SAGE is far more sensitive than EST for detecting low-abundance transcripts
    Miao Sun
    Department of Medicine, University of Chicago, 5841 S, Maryland Avenue, MC2115, Chicago, Illinois 60637, USA
    BMC Genomics 5:1. 2004
  3. pmc Distinct microRNA expression profiles in acute myeloid leukemia with common translocations
    Zejuan Li
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 105:15535-40. 2008
  4. pmc Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias
    Zejuan Li
    Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Cancer Res 69:1109-16. 2009
  5. ncbi request reprint Genome-wide analysis of coordinate expression and evolution of human cis-encoded sense-antisense transcripts
    Jianjun Chen
    Department of Medicine, University of Chicago, 5841 S Maryland Avenue, MC2115, Chicago, IL 60637, USA
    Trends Genet 21:326-9. 2005
  6. pmc Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia
    Shuangli Mi
    Department of Medicine and Committee on Genetics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 107:3710-5. 2010
  7. pmc Evidence for a preferential targeting of 3'-UTRs by cis-encoded natural antisense transcripts
    Miao Sun
    Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Avenue, MC2115, Chicago, IL 60637, USA
    Nucleic Acids Res 33:5533-43. 2005
  8. pmc Identifying novel transcripts and novel genes in the human genome by using novel SAGE tags
    Jianjun Chen
    Department of Medicine, University of Chicago, 5841 South Maryland, MC2115, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 99:12257-62. 2002
  9. pmc HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis
    Miao Sun
    Ben May Department for Cancer Research, Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 110:9920-5. 2013
  10. pmc Over 20% of human transcripts might form sense-antisense pairs
    Jianjun Chen
    Department of Medicine, University of Chicago, 5841 S Maryland Avenue, MC2115, Chicago, IL 60637, USA
    Nucleic Acids Res 32:4812-20. 2004

Collaborators

Detail Information

Publications18

  1. pmc Gene expression profiles in acute myeloid leukemia with common translocations using SAGE
    Sanggyu Lee
    Department of Medicine, University of Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 103:1030-5. 2006
    ....
  2. pmc SAGE is far more sensitive than EST for detecting low-abundance transcripts
    Miao Sun
    Department of Medicine, University of Chicago, 5841 S, Maryland Avenue, MC2115, Chicago, Illinois 60637, USA
    BMC Genomics 5:1. 2004
    ..We compared the EST method and the SAGE method to determine which one is more sensitive and to what extent the sensitivity is great for the detection of low-abundance transcripts...
  3. pmc Distinct microRNA expression profiles in acute myeloid leukemia with common translocations
    Zejuan Li
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 105:15535-40. 2008
    ....
  4. pmc Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias
    Zejuan Li
    Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Cancer Res 69:1109-16. 2009
    ..The identification and validation of consistent changes of gene expression in human and murine MLL rearrangement leukemias provide important insights into the genetic base for MLL-associated leukemogenesis...
  5. ncbi request reprint Genome-wide analysis of coordinate expression and evolution of human cis-encoded sense-antisense transcripts
    Jianjun Chen
    Department of Medicine, University of Chicago, 5841 S Maryland Avenue, MC2115, Chicago, IL 60637, USA
    Trends Genet 21:326-9. 2005
    ..Moreover, co-expressed and inversely expressed SA pairs exhibit a striking pattern of evolutionary conservation. These findings suggest that antisense regulation is a common and important mechanism of gene regulation in the human genome...
  6. pmc Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia
    Shuangli Mi
    Department of Medicine and Committee on Genetics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 107:3710-5. 2010
    ....
  7. pmc Evidence for a preferential targeting of 3'-UTRs by cis-encoded natural antisense transcripts
    Miao Sun
    Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Avenue, MC2115, Chicago, IL 60637, USA
    Nucleic Acids Res 33:5533-43. 2005
    ..These findings underscore the preference for, and conservation of, 3'-UTR-targeted antisense regulation, and the importance of 3'-UTRs in gene regulation...
  8. pmc Identifying novel transcripts and novel genes in the human genome by using novel SAGE tags
    Jianjun Chen
    Department of Medicine, University of Chicago, 5841 South Maryland, MC2115, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 99:12257-62. 2002
    ..Our study indicates that by using novel SAGE tags as probes, we should be able to identify efficiently many novel transcripts/novel genes in the human genome that are difficult to identify by conventional methods...
  9. pmc HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis
    Miao Sun
    Ben May Department for Cancer Research, Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 110:9920-5. 2013
    ..These results implicate the HMGA2-TET1-HOX signaling pathway in the epigenetic regulation of human breast cancer and highlight the importance of targeting methylation in specific subpopulations as a potential therapeutic strategy...
  10. pmc Over 20% of human transcripts might form sense-antisense pairs
    Jianjun Chen
    Department of Medicine, University of Chicago, 5841 S Maryland Avenue, MC2115, Chicago, IL 60637, USA
    Nucleic Acids Res 32:4812-20. 2004
    ....
  11. pmc TET1 plays an essential oncogenic role in MLL-rearranged leukemia
    Hao Huang
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 110:11994-9. 2013
    ..Collectively, our data delineate an MLL-fusion/Tet1/Hoxa9/Meis1/Pbx3 signaling axis in MLL-rearranged leukemia and highlight TET1 as a potential therapeutic target in treating this presently therapy-resistant disease. ..
  12. pmc Evidence for variation in abundance of antisense transcripts between multicellular animals but no relationship between antisense transcriptionand organismic complexity
    Miao Sun
    Section of Hematology Oncology, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Genome Res 16:922-33. 2006
    ..Instead, our results suggest that antisense transcription might be prevalent in almost all metazoan genomes, nematodes being an unexplained exception...
  13. pmc Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study
    Zejuan Li
    University of Chicago, Chicago, IL 60637, USA
    J Clin Oncol 31:1172-81. 2013
    ..To identify a robust prognostic gene expression signature as an independent predictor of survival of patients with acute myeloid leukemia (AML) and use it to improve established risk classification...
  14. ncbi request reprint MicroRNA and cancer: Current status and prospective
    Wei Wu
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Int J Cancer 120:953-60. 2007
    ..MiRNAs may provide useful diagnostic and prognostic markers for cancer diagnosis and treatment, as well as serving as potential therapeutic targets or tools...
  15. pmc MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia
    Shuangli Mi
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 104:19971-6. 2007
    ....
  16. ncbi request reprint Human antisense genes have unusually short introns: evidence for selection for rapid transcription
    Jianjun Chen
    Department of Medicine, University of Chicago, 5841 S Maryland Avenue, MC2115, Chicago, IL 60637, USA
    Trends Genet 21:203-7. 2005
    ....
  17. pmc The small introns of antisense genes are better explained by selection for rapid transcription than by "genomic design"
    Jianjun Chen
    Genetics 171:2151-5. 2005
    ..We show that the effects are not specific to noncoding RNAs and that the predictions of the "genomic design" model for the most part are not upheld...
  18. ncbi request reprint [A de nono I462S mutation in the KRT6A gene is associated with pachyonychia congenita type I]
    Xiao Jing Kang
    Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
    Zhonghua Yi Xue Za Zhi 84:1344-7. 2004
    ..To analyze the KRT6A gene mutation and mutating patterns in a sporadic Chinese patient with Pachyonychia congenita (PC)-1 so as to provide a basis for gene diagnosis and genetic counseling of this disorder...