Affiliation: University of Texas Medical Branch
Liang Y, Yi P, Yuan D, Jie Z, Kwota Z, Soong L, et al
. IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis. Cell Mol Immunol. 2019;16:126-137 pubmed publisher
..Collectively, our findings shed new light on the mechanisms associated with IL-33-triggered neutrophils in the liver and suggest potential targets for therapeutic investigation in viral hepatitis. ..
Sun J, Alison Stalls M, Thompson K, Fisher Van Houten N. Cell cycle block in anergic T cells during tolerance induction. Cell Immunol. 2003;225:33-41 pubmed
..Our results indicate either that tolerance is a default pathway and a secondary stimulus is required at day 3 to progress to sensitization, or that elements that limit cell cycle progression are provided for tolerance induction. ..
Sun J, Tumurbaatar B, Jia J, Diao H, Bodola F, Lemon S, et al
. Parenchymal expression of CD86/B7.2 contributes to hepatitis C virus-related liver injury. J Virol. 2005;79:10730-9 pubmed
..This study provides an additional rationale for exploring immunomodulation-based therapies that could reduce disease progression in individuals with chronic HCV infection. ..
Hou L, Wang T, Sun J. Î³Î´ T cells in infection and autoimmunity. Int Immunopharmacol. 2015;28:887-91 pubmed publisher
..This review will summarize the characteristics of IFN-Î³(+) (Î³Î´ T-IFN-Î³) and IL-17(+) Î³Î´ T cells (Î³Î´T17) and discuss their distinct pathogenic functions in different disease models. ..
Jie Z, Liang Y, Yi P, Tang H, Soong L, Cong Y, et al
. Retinoic Acid Regulates Immune Responses by Promoting IL-22 and Modulating S100 Proteins in Viral Hepatitis. J Immunol. 2017;198:3448-3460 pubmed publisher
..Our study has demonstrated a crucial role for RA in promoting IL-22 production and tempering DC function through downregulating S100 family proteins during viral hepatitis. ..
Yi P, Liang Y, Yuan D, Jie Z, Kwota Z, Chen Y, et al
. A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection. Sci Rep. 2017;7:3857 pubmed publisher
Chen J, Liang Y, Yi P, Xu L, Hawkins H, Rossi S, et al
. Outcomes of Congenital Zika Disease Depend on Timing of Infection and Maternal-Fetal Interferon Action. Cell Rep. 2017;21:1588-1599 pubmed publisher
..Our data highlight IFN-?1 as a potential therapeutic useful for women at risk for congenital Zika disease. ..