Grace Y Sun

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. ncbi request reprint Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus
    Qun Wang
    Department of Biochemistry, M743 Medical Sciences Building, University of Missouri Columbia, Columbia, MO 65212, USA
    Brain Res 1090:182-9. 2006
  2. pmc Integrating cytosolic phospholipase A₂ with oxidative/nitrosative signaling pathways in neurons: a novel therapeutic strategy for AD
    Grace Y Sun
    Department of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, MO 65211, USA
    Mol Neurobiol 46:85-95. 2012
  3. ncbi request reprint The roles of NADPH oxidase and phospholipases A2 in oxidative and inflammatory responses in neurodegenerative diseases
    Grace Y Sun
    Department of Biochemistry, University of Missouri, Columbia, Missouri, USA
    J Neurochem 103:1-16. 2007
  4. pmc Phospholipases A2 and inflammatory responses in the central nervous system
    Grace Y Sun
    Department of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, MO 65211, USA
    Neuromolecular Med 12:133-48. 2010
  5. pmc Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: role of NADPH oxidase-derived ROS
    Qun Wang
    Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Free Radic Biol Med 43:1048-60. 2007
  6. doi request reprint Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons
    Phullara B Shelat
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    J Neurochem 106:45-55. 2008
  7. ncbi request reprint Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits
    Qun Wang
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
    J Neurosci Res 82:138-48. 2005
  8. pmc Targeting NADPH oxidase and phospholipases A2 in Alzheimer's disease
    Agnes Simonyi
    Biochemistry Department, University of Missouri, 117 Schweitzer Hall, Columbia, MO, USA
    Mol Neurobiol 41:73-86. 2010
  9. pmc Oral administration of grape polyphenol extract ameliorates cerebral ischemia/reperfusion-induced neuronal damage and behavioral deficits in gerbils: comparison of pre- and post-ischemic administration
    Qun Wang
    Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
    J Nutr Biochem 20:369-77. 2009
  10. pmc Prolonged exposure of cortical neurons to oligomeric amyloid-β impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate
    Yan He
    Department of Biochemistry, University of Missouri, Columbia, MO, USA
    ASN Neuro 3:e00050. 2011

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus
    Qun Wang
    Department of Biochemistry, M743 Medical Sciences Building, University of Missouri Columbia, Columbia, MO 65212, USA
    Brain Res 1090:182-9. 2006
    ....
  2. pmc Integrating cytosolic phospholipase A₂ with oxidative/nitrosative signaling pathways in neurons: a novel therapeutic strategy for AD
    Grace Y Sun
    Department of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, MO 65211, USA
    Mol Neurobiol 46:85-95. 2012
    ..Therefore, understanding mechanisms for cPLA(2) in the oxidative and nitrosative pathways in neurons will allow the development of novel therapeutic targets to mitigate the detrimental effects of AD...
  3. ncbi request reprint The roles of NADPH oxidase and phospholipases A2 in oxidative and inflammatory responses in neurodegenerative diseases
    Grace Y Sun
    Department of Biochemistry, University of Missouri, Columbia, Missouri, USA
    J Neurochem 103:1-16. 2007
    ....
  4. pmc Phospholipases A2 and inflammatory responses in the central nervous system
    Grace Y Sun
    Department of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, MO 65211, USA
    Neuromolecular Med 12:133-48. 2010
    ....
  5. pmc Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: role of NADPH oxidase-derived ROS
    Qun Wang
    Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Free Radic Biol Med 43:1048-60. 2007
    ..Our results further suggest the possibility that preconditioning with other pharmacological agents that induce a mild oxidative stress may have similar therapeutic value for suppressing stroke-mediated damage in brain...
  6. doi request reprint Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons
    Phullara B Shelat
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    J Neurochem 106:45-55. 2008
    ..This novel mechanism may contribute to the oxidative stress hypothesis and synaptic failure that underline the pathogenesis of Alzheimer's disease...
  7. ncbi request reprint Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits
    Qun Wang
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
    J Neurosci Res 82:138-48. 2005
    ..Together, these findings attribute the neuroprotective effect of curcumin against I/R-induced neuronal damage to its antioxidant capacity in reducing oxidative stress and the signaling cascade leading to apoptotic cell death...
  8. pmc Targeting NADPH oxidase and phospholipases A2 in Alzheimer's disease
    Agnes Simonyi
    Biochemistry Department, University of Missouri, 117 Schweitzer Hall, Columbia, MO, USA
    Mol Neurobiol 41:73-86. 2010
    ..This information should provide new therapeutic approaches for prevention of this debilitating disease...
  9. pmc Oral administration of grape polyphenol extract ameliorates cerebral ischemia/reperfusion-induced neuronal damage and behavioral deficits in gerbils: comparison of pre- and post-ischemic administration
    Qun Wang
    Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
    J Nutr Biochem 20:369-77. 2009
    ..These findings indicate that oral GPE intake may confer protection against I/R injury and emphasize that early intervention may be an effective therapeutic measure for ameliorating brain injury in stroke...
  10. pmc Prolonged exposure of cortical neurons to oligomeric amyloid-β impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate
    Yan He
    Department of Biochemistry, University of Missouri, Columbia, MO, USA
    ASN Neuro 3:e00050. 2011
    ....
  11. pmc Neuroprotective effects of a nanocrystal formulation of sPLA(2) inhibitor PX-18 in cerebral ischemia/reperfusion in gerbils
    Qun Wang
    Department of Biochemistry, University of Missouri School of Medicine, Columbia, MO 65211, USA
    Brain Res 1285:188-95. 2009
    ..The results also suggest that nanocrystals hold promise as an effective strategy for the delivery of compounds with poor solubility that would otherwise be precluded from preclinical development...
  12. doi request reprint Oxidative and inflammatory pathways in Parkinson's disease
    Rebecca L Miller
    Department of Medical Pharmacology and Physiology, University of Missouri Columbia, Columbia, MO, 65212, USA
    Neurochem Res 34:55-65. 2009
    ..This review describes pathological effects of neurotoxins on cells and signaling pathways for production of reactive oxygen species (ROS) that underline the pathophysiology of PD...
  13. ncbi request reprint Oxidant-mediated AA release from astrocytes involves cPLA(2) and iPLA(2)
    Jianfeng Xu
    Department of Biochemistry, University of Missouri, Columbia, MO 65212, USA
    Free Radic Biol Med 34:1531-43. 2003
    ....
  14. pmc Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells
    Dennis Y Chuang
    Interdisciplinary Neuroscience Program, University of Missouri, Columbia, MO, USA
    J Neuroinflammation 10:15. 2013
    ..We also attempt to elucidate the mechanism and signaling pathways involved in cytokine-induced production of reactive oxygen species (ROS) in microglial cells...
  15. pmc Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA₂-IIA expression in astrocytes and microglia
    Wenwen Sheng
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    J Neuroinflammation 8:121. 2011
    ....
  16. pmc Resveratrol as a therapeutic agent for neurodegenerative diseases
    Albert Y Sun
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
    Mol Neurobiol 41:375-83. 2010
    ..The goal here is to provide a better understanding of the mode of action of resveratrol and its possible use as a potential therapeutic agent to ameliorate stroke damage as well as other age-related neurodegenerative disorders...
  17. ncbi request reprint Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases
    Grace Y Sun
    Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
    J Lipid Res 45:205-13. 2004
    ..Information from these studies has provided clear evidence for the important role of PLA2 in regulating physiological and pathological functions in the CNS...
  18. ncbi request reprint Distinct signaling pathways for induction of type II NOS by IFNgamma and LPS in BV-2 microglial cells
    Siming Shen
    Department of Nutritional Sciences, University of Missouri, Columbia, MO 65212, USA
    Neurochem Int 47:298-307. 2005
    ..These results demonstrated distinct signaling pathways for induction of iNOS by IFNgamma and LPS in BV-2 microglial cells...
  19. ncbi request reprint Phospholipase A2 in astrocytes: responses to oxidative stress, inflammation, and G protein-coupled receptor agonists
    Grace Y Sun
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO, USA
    Mol Neurobiol 31:27-41. 2005
    ..This review focuses on describing the effects of oxidative stress, inflammation, and activation of G protein-coupled receptors on PLA2 activation, arachidonic acid (AA) release, and production of prostanoids in astrocytes...
  20. pmc Involvement of oxidative pathways in cytokine-induced secretory phospholipase A2-IIA in astrocytes
    Michael D Jensen
    Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
    Neurochem Int 55:362-8. 2009
    ....
  21. pmc Up-regulation and activation of the P2Y(2) nucleotide receptor mediate neurite extension in IL-1β-treated mouse primary cortical neurons
    Troy S Peterson
    Interdisciplinary Neuroscience Program, University of Missouri, Columbia, Missouri 65211 7310, USA
    J Neurochem 125:885-96. 2013
    ....
  22. ncbi request reprint Dietary grape supplement ameliorates cerebral ischemia-induced neuronal death in gerbils
    Qun Wang
    Department of Biochemistry, University of Missouri, Columbia, MO, USA
    Mol Nutr Food Res 49:443-51. 2005
    ..The neuroprotective effects of GP supplement may have wide implication in the future for prevention/protection against other neurodegenerative damage...
  23. doi request reprint NAD(P)H oxidase-mediated reactive oxygen species production alters astrocyte membrane molecular order via phospholipase A2
    Donghui Zhu
    Department of Biological Engineering, University of Missouri, Columbia, MO 65211, USA
    Biochem J 421:201-10. 2009
    ....
  24. ncbi request reprint Hydrogen peroxide alters membrane and cytoskeleton properties and increases intercellular connections in astrocytes
    Donghui Zhu
    Department of Biological Engineering, University of Missouri Columbia, Columbia, MO 65211, USA
    J Cell Sci 118:3695-703. 2005
    ..These results suggest that H2O2 alters astrocyte membranes and the cytoskeleton through activation of the p38 MAPK pathway...
  25. ncbi request reprint P2X7 nucleotide receptor activation enhances IFN gamma-induced type II nitric oxide synthase activity in BV-2 microglial cells
    Fernand Pierre Gendron
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65212, USA
    J Neurochem 87:344-52. 2003
    ..These results suggest that activation of P2X7 receptors may contribute to inflammatory responses in microglial cells seen in neurodegenerative diseases...
  26. pmc Nucleotides released from Aβ₁₋₄₂ -treated microglial cells increase cell migration and Aβ₁₋₄₂ uptake through P2Y₂ receptor activation
    Hye Jung Kim
    Department of Biochemistry, University of Missouri, Columbia, Missouri, USA
    J Neurochem 121:228-38. 2012
    ..Taken together, our findings suggest that P2Y(2) Rs can activate microglial cells to enhance Aβ clearance and highlight the P2Y(2) R as a therapeutic target in Alzheimer's disease...
  27. pmc Botanical phenolics and brain health
    Albert Y Sun
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA
    Neuromolecular Med 10:259-74. 2008
    ..The main goal is to provide a better understanding of the mode of action of these compounds and assess their use as therapeutics to ameliorate age-related neurodegenerative diseases...
  28. pmc Amyloid-beta peptide induces temporal membrane biphasic changes in astrocytes through cytosolic phospholipase A2
    Jacob B Hicks
    Department of Biological Engineering, University of Missouri, Columbia, Missouri 65211, USA
    Biochim Biophys Acta 1778:2512-9. 2008
    ....
  29. ncbi request reprint Phospholipases A2 mediate amyloid-beta peptide-induced mitochondrial dysfunction
    Donghui Zhu
    Department of Biological Engineering, University of Missouri, Columbia, Missouri 65211, USA
    J Neurosci 26:11111-9. 2006
    ....
  30. pmc Secretory phospholipase A2 type III enhances alpha-secretase-dependent amyloid precursor protein processing through alterations in membrane fluidity
    Xiaoguang Yang
    Department of Biological Engineering, University of Missouri, Columbia, MO 65211, USA
    J Lipid Res 51:957-66. 2010
    ..Taken together, these results support the hypothesis that sPLA(2)-III enhances sAPP(alpha) secretion through its action to increase membrane fluidity and recruitment of APP at the cell surface...
  31. pmc Interleukin-1beta enhances nucleotide-induced and alpha-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y(2) receptor
    Qiongman Kong
    Interdisciplinary Neuroscience Program, University of Missouri, Columbia, Missouri, USA
    J Neurochem 109:1300-10. 2009
    ..These results demonstrate that elevated levels of pro-inflammatory cytokines associated with neurodegenerative diseases, such as IL-1beta, can enhance non-amyloidogenic APP processing through up-regulation of the P2Y(2)R in neurons...
  32. pmc P2Y2 nucleotide receptor-mediated responses in brain cells
    Troy S Peterson
    Department of Biochemistry, Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA
    Mol Neurobiol 41:356-66. 2010
    ..Thus, activation of pro-inflammatory P2Y(2)Rs in glial cells can promote neuroprotective responses, suggesting that P2Y(2)Rs represent a novel pharmacological target in neurodegenerative and other pro-inflammatory diseases...
  33. ncbi request reprint Polyphenols in cerebral ischemia: novel targets for neuroprotection
    Agnes Simonyi
    Department of Biochemistry and Pathology, University of Missouri Columbia, Columbia, MO, USA
    Mol Neurobiol 31:135-47. 2005
    ..This article reviews the neuroprotective effects of plant extracts and their constituents that have been used in animal models of cerebral ischemia. The use of polyphenols as therapeutic agents in stroke has been suggested...
  34. ncbi request reprint The neuroprotective effects of apocynin
    Agnes Simonyi
    Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
    Front Biosci (Elite Ed) 4:2183-93. 2012
    ..In this review, we aim to give an overview of current literature on the neuroprotective effects of apocynin in the prevention and treatment of neurodegenerative disorders. Particular attention is given to in vivo studies...
  35. ncbi request reprint Resveratrol protects against neurotoxicity induced by kainic acid
    Qun Wang
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
    Neurochem Res 29:2105-12. 2004
    ..Since increased oxidative stress is a key factor for KA-induced neurotoxicity, this study demonstrated the ability of resveratrol to act as free radical scavenger to protect against neuronal damage caused by excitotoxic insults...
  36. pmc Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase
    Rebecca L Miller
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA
    Brain Res 1167:129-39. 2007
    ..Taken together, this study demonstrates the involvement of ROS from NADPH oxidase in mediating paraquat cytotoxicity in BV-2 microglial cells and this process is mediated through PKCdelta- and ERK-dependent pathways...
  37. ncbi request reprint Kainic acid-mediated excitotoxicity as a model for neurodegeneration
    Qun Wang
    Department of Medical Pharmacology, University of Missouri School of Medicine, Columbia, MO, USA
    Mol Neurobiol 31:3-16. 2005
    ..The focus of this review is to summarize studies demonstrating KA-induced excitotoxicity in the central nervous system and possible intervention by anti-oxidants...
  38. pmc Phospholipases A2 and neural membrane dynamics: implications for Alzheimer's disease
    James C M Lee
    Biological Engineering Department, University of Missouri, Columbia, Missouri 65211, USA
    J Neurochem 116:813-9. 2011
    ....
  39. pmc P2X(7) nucleotide receptors mediate caspase-8/9/3-dependent apoptosis in rat primary cortical neurons
    Qiongman Kong
    Interdisciplinary Neuroscience Program, University of Missouri Columbia, Columbia, Missouri, USA
    Purinergic Signal 1:337-47. 2005
    ..Taken together, these data indicate that extracellular nucleotides mediate neuronal apoptosis through activation of P2X(7)Rs and their downstream signaling pathways involving JNK1, ERK and caspases 8/9/3...
  40. ncbi request reprint Resveratrol protects against global cerebral ischemic injury in gerbils
    Qun Wang
    Department of Pharmacology, School of Medicine, M526 Medical Science Bldg, 1 Hospital Drive, University of Missouri Columbia, Columbia, MO 65212, USA
    Brain Res 958:439-47. 2002
    ..This study demonstrated for the first time that resveratrol, a polyphenolic antioxidant, can cross the blood-brain barrier and exert protective effects against cerebral ischemic injury...
  41. ncbi request reprint Ischemia-induced increase in RGS7 mRNA expression in gerbil hippocampus
    Phullara B Shelat
    Department of Biochemistry, M743 Medical Sciences Bldg, University of Missouri Columbia, 65212, USA
    Neurosci Lett 403:157-61. 2006
    ..Our results show a subtype-, time-, and subregion-specific regulation in mRNA expression of RGS proteins after cerebral ischemia in gerbil hippocampus...
  42. ncbi request reprint Mechanisms of P2X7 receptor-mediated ERK1/2 phosphorylation in human astrocytoma cells
    Fernand Pierre Gendron
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65212, USA
    Am J Physiol Cell Physiol 284:C571-81. 2003
    ..These results support the hypothesis that the P2X(7) receptor and its signaling pathways play a role in astrocyte-mediated inflammation and neurodegenerative disease...
  43. pmc Bioavailability of apocynin through its conversion to glycoconjugate but not to diapocynin
    Qun Wang
    Department of Biochemistry, M743 Medical Sciences Building, University of Missouri, M743 Medical Sciences Building, Columbia, MO 65212, USA
    Phytomedicine 15:496-503. 2008
    ..No diapocynin was detected in any samples. These results indicate rapid glycosylation of apocynin and its transport to blood and other organs but no apparent conversion to diapocynin in vivo...
  44. pmc Effects of fatty acid unsaturation numbers on membrane fluidity and α-secretase-dependent amyloid precursor protein processing
    Xiaoguang Yang
    Department of Biological Engineering, University of Missouri, Columbia, MO 65211, USA
    Neurochem Int 58:321-9. 2011
    ..This study provides insights into dietary strategies for the prevention of AD...
  45. pmc Altered microglial copper homeostasis in a mouse model of Alzheimer's disease
    Zhiqiang Zheng
    Department of Nutritional Sciences and Exercise Physiology, University of Missouri, Columbia, Missouri 65211 7310, USA
    J Neurochem 114:1630-8. 2010
    ..It is concluded that copper sequestration by microglia may provide a neuroprotective mechanism in AD...
  46. ncbi request reprint Grape polyphenols inhibit chronic ethanol-induced COX-2 mRNA expression in rat brain
    Agnes Simonyi
    Department of Biochemistry, University of Missouri, M121 Medical Sciences Building, Columbia, MO 65212, USA
    Alcohol Clin Exp Res 26:352-7. 2002
    ..This study was aimed at examining the effects of GP on mRNA expression of ERK1/2, cytosolic PLA2 (cPLA2), and COX-2 in different brain regions after chronic ethanol treatment...
  47. ncbi request reprint Role of PKC and MAPK in cytosolic PLA2 phosphorylation and arachadonic acid release in primary murine astrocytes
    Jianfeng Xu
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri, USA
    J Neurochem 83:259-70. 2002
    ..Together, our results provided evidence for an important role of PKC in mediating cPLA2 phosphorylation and AA release in astrocytes through both ERK1/2-dependent and ERK1/2-independent pathways...
  48. ncbi request reprint Molecular determinants of P2Y2 nucleotide receptor function: implications for proliferative and inflammatory pathways in astrocytes
    Gary A Weisman
    Department of Biochemistry and Neuroscience Program, University of Missouri Columbia, Columbia, MO, USA
    Mol Neurobiol 31:169-83. 2005
    ..Thus, P2Y2 receptors present novel targets to control reactive astrogliosis in neurodegenerative diseases...
  49. ncbi request reprint Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging
    Agnes Simonyi
    Department of Biochemistry, University of Missouri, Columbia, MO 65212, USA
    Brain Res 1043:95-106. 2005
    ..These results demonstrate region- and subtype-specific, including splice variant specific changes in the expression of mGlu receptors in the brain with increasing age...
  50. pmc Amyloid-β peptide on sialyl-Lewis(X)-selectin-mediated membrane tether mechanics at the cerebral endothelial cell surface
    Sholpan Askarova
    Department of Biological Engineering, University of Missouri, Columbia, Missouri, USA
    PLoS ONE 8:e60972. 2013
    ....
  51. pmc Exercise and diet induced weight loss improves measures of oxidative stress and insulin sensitivity in adults with characteristics of the metabolic syndrome
    R Scott Rector
    Department of Nutritional Sciences, University of Missouri Columbia, 65211, USA
    Am J Physiol Endocrinol Metab 293:E500-6. 2007
    ..Diet- and exercise-induced weight loss ( approximately 10%) improves measures of insulin sensitivity and beneficially alters biomarkers of oxidative status...
  52. ncbi request reprint Chronic ethanol-induced subtype- and subregion-specific decrease in the mRNA expression of metabotropic glutamate receptors in rat hippocampus
    Agnes Simonyi
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
    Alcohol Clin Exp Res 28:1419-23. 2004
    ..This study was aimed to determine whether chronic ethanol treatment could change the messenger RNA (mRNA) expression of mGlu receptors in the hippocampus...
  53. ncbi request reprint The "French Paradox" and beyond: neuroprotective effects of polyphenols
    Albert Y Sun
    Department of Pharmacology, University of Missouri, Columbia, MO 65212, USA
    Free Radic Biol Med 32:314-8. 2002
    ..These studies demonstrate an urgent need to extend research beyond the "French Paradox" towards better understanding molecular mechanisms of action of polyphenolic compounds and their application to human health...
  54. ncbi request reprint Increased atherosclerosis in diabetic dyslipidemic swine: protection by atorvastatin involves decreased VLDL triglycerides but minimal effects on the lipoprotein profile
    Joseph L Dixon
    Dalton Cardiovascular Research Center, University of Missouri, Research Park, Columbia, MO, USA
    J Lipid Res 43:1618-29. 2002
    ..Lack of major effects on other lipid parameters, including the LDL/HDL ratio, suggests that atorvastatin may have yet other anti-atherogenic effects, possibly directly in the vessel wall...
  55. doi request reprint Repeated resveratrol treatment attenuates methamphetamine-induced hyperactivity and [3H]dopamine overflow in rodents
    Dennis K Miller
    Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, USA Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA Electronic address
    Neurosci Lett 554:53-8. 2013
    ..These data encourage future research to further investigate the relationship between polyphenolics and psychostimulant abuse and dependence. ..
  56. ncbi request reprint Short-term lifestyle modification alters circulating biomarkers of endothelial health in sedentary, overweight adults
    R Scott Rector
    Department of Nutritional Sciences, University of Missouri, Columbia, MO 65211 USA
    Appl Physiol Nutr Metab 31:512-7. 2006
    ....
  57. ncbi request reprint Extracellular signal-regulated kinase 2 mRNA expression in the rat brain during aging
    Agnes Simonyi
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
    Neurochem Res 28:1375-8. 2003
    ..These results suggest that the impairment in ERK1/2 activity observed during aging is probably not regulated at the gene expression level...
  58. doi request reprint Nanoparticle-emitted light attenuates amyloid-β-induced superoxide and inflammation in astrocytes
    Brittani L Bungart
    Department of Biological Engineering, University of Missouri, Columbia, MO
    Nanomedicine 10:15-7. 2014
    ..Our results show that BRET-Qdot-emitted NIR suppresses Aβ-induced oxidative stress and inflammatory responses in primary rat astrocytes. These data provide a proof of concept for a nanomedicine platform for LLLT...
  59. pmc Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia
    Jiankun Cui
    Department of Pathology and Anatomical Sciences, Center for Translational Neuroscience, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    Mol Neurodegener 7:21. 2012
    ..We previously reported that the thiirane inhibitor SB-3CT, which is selective for gelatinases (MMP-2 and -9), could antagonize neuronal apoptosis after transient focal cerebral ischemia...
  60. ncbi request reprint Cholesterol distribution in the Golgi complex of DITNC1 astrocytes is differentially altered by fresh and aged amyloid beta-peptide-(1-42)
    Urule Igbavboa
    Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Columbia, Missouri 65211, USA
    J Biol Chem 278:17150-7. 2003
    ..Extracellular Abeta-(1-42) targets the Golgi complex and disrupts cell cholesterol homeostasis, and this action of Abeta-(1-42) could alter cell functions requiring optimal levels of cholesterol...
  61. ncbi request reprint Exercise training does not reduce hyperlipidemia in pigs fed a high-fat diet
    Tom R Thomas
    Department of Nutritional Sciences, Veterinary Biomedical Sciences, University of Missouri Columbia, Columbia, MO, USA
    Metabolism 51:1587-95. 2002
    ..Furthermore, under the conditions of this study, exercise training does not moderate the effects of an atherogenic diet on lipoproteins...
  62. ncbi request reprint Induction of secretory phospholipase A2 in reactive astrocytes in response to transient focal cerebral ischemia in the rat brain
    Teng Nan Lin
    Neuroscience Program, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    J Neurochem 90:637-45. 2004
    ..Taken together, these results demonstrate for the first time an up-regulation of the inflammatory sPLA2-IIA in reactive astrocytes in response to cerebral ischemia-reperfusion...
  63. ncbi request reprint P2Y receptors activate neuroprotective mechanisms in astrocytic cells
    Nataliya E Chorna
    Department of Chemistry, Rio Piedras Campus, University of Puerto Rico, San Juan, Puerto Rico
    J Neurochem 91:119-32. 2004
    ..Taken together, our results suggest an important novel role for the P2Y2 receptor in survival and neuroprotective mechanisms under pathological conditions...
  64. ncbi request reprint Inhibition of N-methyl-D-aspartic acid-nitric oxide synthase in rat hippocampal slices by ethanol. Evidence for the involvement of tetrahydrobiopterin but not lipid peroxidation
    Grzegorz A Czapski
    Department of Cellular Signalling, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    J Biomed Sci 9:3-9. 2002
    ..Taken together, these results provide evidence for the role of BH4 but not oxidative stress in the inhibitory effect of ethanol on NMDA-NOS activity in rat hippocampal slices...
  65. ncbi request reprint A new role for apolipoprotein E: modulating transport of polyunsaturated phospholipid molecular species in synaptic plasma membranes
    Urule Igbavboa
    VA Medical Center and Department of Pharmacology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55417, USA
    J Neurochem 80:255-61. 2002
    ..Since polyunsaturated fatty acids in neurons are mainly supplied by astrocytes, these results revealed a new role for apoE in regulating polyunsaturated phospholipid molecular species in neuronal membranes...
  66. ncbi request reprint Effect of exercise on postprandial lipemia following a higher calorie meal in Yucatan miniature swine
    R Scott Rector
    Department of Nutritional Sciences, University of Missouri Columbia, 65211, USA
    Metabolism 53:1021-6. 2004
    ....
  67. ncbi request reprint Changes in LPLa and reverse cholesterol transport variables during 24-h postexercise period
    John Q Zhang
    Department of Health and Kinesiology, University of Texas at San Antonio, San Antonio, Texas 78249, USA
    Am J Physiol Endocrinol Metab 283:E267-74. 2002
    ..Furthermore, in the sedentary population with or without HTG, the variables related to RCT do not change during the 24-h period after exercise...
  68. ncbi request reprint Mechanisms for inhibition of P2 receptors signaling in neural cells
    Fernando A Gonzalez
    Department of Chemistry, University of Puerto Rico, Rio Piedras Campus, Puerto Rico
    Mol Neurobiol 31:65-79. 2005
    ..Understanding selective mechanisms for regulating P2Y2 receptor signaling could provide novel targets for therapeutic strategies in the management of brain injury, synaptogenesis, and neurological disorders...
  69. pmc Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity
    Linda A Kotilinek
    Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    Brain 131:651-64. 2008
    ..The results lead us to propose a third possible mechanism by which NSAIDs may protect against Alzheimer's disease, involving the blockade of a COX-2-mediated PGE2 response at synapses...
  70. ncbi request reprint Exercise plus n-3 fatty acids: additive effect on postprandial lipemia
    Bryan K Smith
    Center for Physical Activity and Weight Management, Schiefelbusch Life Span Institute, University of Kansas, Lawrence, USA
    Metabolism 53:1365-71. 2004
    ..These results suggest that the combination of exercise and n-3FA supplementation reduce PPL to a greater degree in recreationally active males when compared with the individual treatments...