Daekyu Sun

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Binding of G-quadruplex-interactive agents to distinct G-quadruplexes induces different biological effects in MiaPaCa cells
    Weijun Liu
    College of Pharmacy, The University of Arizona, Tucson, Arizona 85724, USA
    Nucleosides Nucleotides Nucleic Acids 24:1801-15. 2005
  2. pmc Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene
    Kexiao Guo
    Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, USA
    J Am Chem Soc 129:10220-8. 2007
  3. pmc Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene
    Kexiao Guo
    Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721, USA
    Nucleic Acids Res 36:4598-608. 2008
  4. pmc The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents
    Daekyu Sun
    BIO5 Institute, Room 102, 1657 East Helen Street, Tucson, AZ 85721, USA
    Mol Cancer Ther 7:880-9. 2008
  5. ncbi request reprint Induction of DNA ligase I by 1-beta-D-arabinosylcytosine and aphidicolin in MiaPaCa human pancreatic cancer cells
    Daekyu Sun
    Institute for Drug Development, Cancer Therapy and Research Center, San Antonio, Texas 78245, USA
    Exp Cell Res 280:90-6. 2002
  6. ncbi request reprint Effects of cisplatin on expression of DNA ligases in MiaPaCa human pancreatic cancer cells
    Daekyu Sun
    Institute for Drug Development, Cancer Therapy and Research Center, 14960 Omicron Drive, San Antonio, TX 78245, USA
    Biochem Biophys Res Commun 298:537-44. 2002
  7. ncbi request reprint Development of non-electrophoretic assay method for DNA ligases and its application to screening of chemical inhibitors of DNA ligase I
    Daekyu Sun
    Institute for Drug Development, Cancer Therapy and Research Center, 14960 Omicron Drive, San Antonio, TX 78245 3217, USA
    J Biochem Biophys Methods 59:49-59. 2004
  8. pmc Evidence of the formation of G-quadruplex structures in the promoter region of the human vascular endothelial growth factor gene
    Daekyu Sun
    College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
    Nucleic Acids Res 39:1256-65. 2011
  9. pmc The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression
    Daekyu Sun
    College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA
    J Med Chem 52:2863-74. 2009
  10. pmc Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents
    Daekyu Sun
    College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
    Nucleic Acids Res 33:6070-80. 2005

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Binding of G-quadruplex-interactive agents to distinct G-quadruplexes induces different biological effects in MiaPaCa cells
    Weijun Liu
    College of Pharmacy, The University of Arizona, Tucson, Arizona 85724, USA
    Nucleosides Nucleotides Nucleic Acids 24:1801-15. 2005
    ..Our data suggest that binding of G-quadruplex-interactive agents to distinct G-quadruplexes could induce different biological effects in human cancer cells...
  2. pmc Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene
    Kexiao Guo
    Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, USA
    J Am Chem Soc 129:10220-8. 2007
    ....
  3. pmc Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene
    Kexiao Guo
    Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721, USA
    Nucleic Acids Res 36:4598-608. 2008
    ....
  4. pmc The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents
    Daekyu Sun
    BIO5 Institute, Room 102, 1657 East Helen Street, Tucson, AZ 85721, USA
    Mol Cancer Ther 7:880-9. 2008
    ..Our results also provide further support for the idea that G-quadruplex structures may play structural roles in vivo and therefore might provide insight into novel methodologies for rational drug design...
  5. ncbi request reprint Induction of DNA ligase I by 1-beta-D-arabinosylcytosine and aphidicolin in MiaPaCa human pancreatic cancer cells
    Daekyu Sun
    Institute for Drug Development, Cancer Therapy and Research Center, San Antonio, Texas 78245, USA
    Exp Cell Res 280:90-6. 2002
    ..We propose that ara-C and aphidicolin induce damage to the DNA strand by arresting DNA replication forks and subsequently increase DNA ligase I levels to facilitate repair of DNA damage...
  6. ncbi request reprint Effects of cisplatin on expression of DNA ligases in MiaPaCa human pancreatic cancer cells
    Daekyu Sun
    Institute for Drug Development, Cancer Therapy and Research Center, 14960 Omicron Drive, San Antonio, TX 78245, USA
    Biochem Biophys Res Commun 298:537-44. 2002
    ..We propose that the increase of DNA ligase I expression after exposure to cisplatin might be required for aiding the cells to recover from the damage by facilitating the repair process...
  7. ncbi request reprint Development of non-electrophoretic assay method for DNA ligases and its application to screening of chemical inhibitors of DNA ligase I
    Daekyu Sun
    Institute for Drug Development, Cancer Therapy and Research Center, 14960 Omicron Drive, San Antonio, TX 78245 3217, USA
    J Biochem Biophys Methods 59:49-59. 2004
    ..The method described here is anticipated to be very useful for screening DNA ligase inhibitors from chemical libraries...
  8. pmc Evidence of the formation of G-quadruplex structures in the promoter region of the human vascular endothelial growth factor gene
    Daekyu Sun
    College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
    Nucleic Acids Res 39:1256-65. 2011
    ....
  9. pmc The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression
    Daekyu Sun
    College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA
    J Med Chem 52:2863-74. 2009
    ....
  10. pmc Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents
    Daekyu Sun
    College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
    Nucleic Acids Res 33:6070-80. 2005
    ....
  11. pmc In vitro footprinting of promoter regions within supercoiled plasmid DNA
    Daekyu Sun
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, BIO5 Institute, Tucson, AZ, USA
    Methods Mol Biol 613:223-33. 2010
    ..This is demonstrated with the proximal promoter region of the human vascular endothelial growth factor (VEGF) gene, which also contains multiple binding sites for Sp1 and Egr-1 transcription factors...
  12. ncbi request reprint Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure
    Jeyaprakashnarayanan Seenisamy
    College of Pharmacy, The University of Arizona, 1703 East Mabel, Tucson, Arizona 85721, USA
    J Am Chem Soc 127:2944-59. 2005
    ..From this study, we have identified an expanded porphyrin that selectively binds with the c-MYC G-quadruplex in the presence of duplex DNA and other G-quadruplexes...
  13. pmc DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences
    Velliyur Viswesh
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, BIO5 Institute, Room 102, 1657 E Helen Street, Tucson, AZ 85721, USA
    Bioorg Med Chem 20:4413-21. 2012
    ..Collectively, our findings suggest that both NER and BER pathways play an important role in the repair of DNA damage caused by leinamycin...
  14. pmc Heterogeneous nuclear ribonucleoprotein K and nucleolin as transcriptional activators of the vascular endothelial growth factor promoter through interaction with secondary DNA structures
    Diana J Uribe
    Pharmacology and Toxicology Department, University of Arizona, Tucson, Arizona 85721, USA
    Biochemistry 50:3796-806. 2011
    ..Taken together, the identification of transcription factors that can recognize and bind to atypical DNA structures within the pPu/pPy tract will provide new insight into mechanisms of transcriptional regulation of the VEGF gene...
  15. pmc Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4
    Yong Qin
    College of Pharmacy, 1703 E Mabel, University of Arizona, Tucson, Arizona 85721, USA
    Nucleic Acids Res 35:7698-713. 2007
    ..On the basis of these results, we have established that ligand-mediated stabilization of G-quadruplex structures within the PDGF-A NHE can silence PDGF-A expression...
  16. ncbi request reprint Cellular response and molecular mechanism of antitumor activity by leinamycin in MiaPaCa human pancreatic cancer cells
    Stephen Bassett
    Department of Pharmacology and Toxicology, University of Arizona, Tucson 85724, USA
    Anticancer Drugs 15:689-96. 2004
    ....
  17. pmc Characterization of DNA damage induced by a natural product antitumor antibiotic leinamycin in human cancer cells
    Velliyur Viswesh
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA
    Chem Res Toxicol 23:99-107. 2010
    ....
  18. pmc Biochemical techniques for the characterization of G-quadruplex structures: EMSA, DMS footprinting, and DNA polymerase stop assay
    Daekyu Sun
    Department of Pharmacology, College of Pharmacy, University of Arizona, Tucson, AZ, USA
    Methods Mol Biol 608:65-79. 2010
    ....
  19. ncbi request reprint Enhancement of DNA ligase I level by gemcitabine in human cancer cells
    Daekyu Sun
    Institute for Drug Development, Cancer Therapy and Research Center, San Antonio, Texas 78245, USA
    Clin Cancer Res 8:1189-95. 2002
    ....
  20. ncbi request reprint Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter
    Richard De Armond
    Arizona Cancer Center, University of Arizona, 1515 North Campbell Avenue, Tucson, Arizona 85724 5024, USA
    Biochemistry 44:16341-50. 2005
    ..These data suggest that a quadruplex structure may form in a region of the HIF-1alpha promoter that regulates basal HIF-1alpha expression...
  21. pmc Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein
    Veronica Gonzalez
    College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA
    J Biol Chem 284:23622-35. 2009
    ..Finally, we show that nucleolin binds to the c-myc promoter in HeLa cells, which indicates that this interaction occurs in vivo. In summary, nucleolin may induce c-myc G4 formation in vivo...
  22. pmc Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter
    Thomas S Dexheimer
    College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA
    J Am Chem Soc 128:5404-15. 2006
    ....
  23. ncbi request reprint Biotinylated primer for detecting telomerase activity without amplification
    Daekyu Sun
    Department of Translational Research, Institute for Drug Development, Cancer Therapy and Research Center, San Antonio, TX, USA
    Methods Mol Biol 191:165-71. 2002
  24. doi request reprint Synthesis and antiproliferating activity of iron chelators of hydroxyamino-1,3,5-triazine family
    Daekyu Sun
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, United States
    Bioorg Med Chem Lett 20:458-60. 2010
    ..The antiproliferative activity of new chelators was found to correlate with iron(III) chelation ability and some of analogs showed substantially higher antiproliferative activity than DFX...
  25. pmc NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1)
    Thomas S Dexheimer
    College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA
    Mol Cancer Ther 8:1363-77. 2009
    ..Furthermore, this model provides a rationale for how the stabilization of the G-quadruplex or i-motif structures formed within the c-myc gene promoter region can inhibit NM23-H2 from activating c-myc gene expression...

Research Grants9

  1. Targeting Tumor Angiogenesis with G-Quadruplex Binders
    Daekyu Sun; Fiscal Year: 2010
    ..abstract_text> ..
  2. DNA LIGASE I AS A POTENTIAL TARGET FOR ANTICANCER DRUGS
    Daekyu Sun; Fiscal Year: 2002
    ..3) Test whether DNA ligase I inhibition produces antitumor activity using antisense strategy in preclinical in vitro and in vivo evaluation systems. 4) Develop a sensitive and reproducible assay for DNA ligase I. ..
  3. Targeting Tumor Angiogenesis with G-Quadruplex Binders
    Daekyu Sun; Fiscal Year: 2007
    ....