Changquan Sun

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. doi request reprint Cocrystallization for successful drug delivery
    Changquan Calvin Sun
    University of Minnesota, College of Pharmacy, Department of Pharmaceutics, 9 127B Weaver Densford Hall, 308 Harvard Street S E, Minneapolis, MN 55455, USA
    Expert Opin Drug Deliv 10:201-13. 2013
  2. doi request reprint Improving powder flow properties of citric acid by crystal hydration
    Changquan Sun
    Amgen Inc, Materials Science Laboratory, Small Molecule Pharmaceutics, Thousand Oaks, California 91320, USA
    J Pharm Sci 98:1744-9. 2009
  3. doi request reprint Materials science tetrahedron--a useful tool for pharmaceutical research and development
    Changquan Calvin Sun
    Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9 127B Weaver Densford Hall, 308 Harvard Street S E, Minneapolis, Minnesota 55455, USA
    J Pharm Sci 98:1671-87. 2009
  4. doi request reprint Roles of granule size in over-granulation during high shear wet granulation
    Limin Shi
    Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Pharm Sci 99:3322-5. 2010
  5. doi request reprint Development of a high drug load tablet formulation based on assessment of powder manufacturability: moving towards quality by design
    Changquan Calvin Sun
    Amgen Inc, Materials Science Laboratory, Small Molecule Pharmaceutics, Thousand Oaks, California 91320, USA
    J Pharm Sci 98:239-47. 2009
  6. ncbi request reprint Improved tableting properties of p-hydroxybenzoic acid by water of crystallization: a molecular insight
    Changquan Sun
    Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Weaver Densford Hall, 308 Harvard Street S E, Minneapolis, MN 55455 0343, USA
    Pharm Res 21:382-6. 2004
  7. ncbi request reprint On the identification of slip planes in organic crystals based on attachment energy calculation
    Changquan Calvin Sun
    Preformulation, Small Molecule Pharmaceutics, Amgen, Inc, One Amgen Center Dr 21 2 A, Thousand Oaks, California 91320 1799, USA
    J Pharm Sci 97:3456-61. 2008
  8. ncbi request reprint Thermal expansion of organic crystals and precision of calculated crystal density: a survey of Cambridge Crystal Database
    Changquan Calvin Sun
    Amgen Inc, Materials Science Laboratory, Small Molecule Pharmaceutics, One Amgen Center Dr 21 2 A, Thousand Oaks, California 91320, USA
    J Pharm Sci 96:1043-52. 2007
  9. doi request reprint Quantifying effects of particulate properties on powder flow properties using a ring shear tester
    Hao Hou
    Materials Science Laboratory, Small Molecule Pharmaceutics, Amgen, Inc, One Amgen Center Dr 21 2 A, Thousand Oaks, California 91320 1799, USA
    J Pharm Sci 97:4030-9. 2008
  10. ncbi request reprint Mechanism of moisture induced variations in true density and compaction properties of microcrystalline cellulose
    Changquan Calvin Sun
    Materials Science Laboratory, Small Molecule Pharmaceutics, Amgen Inc, One Amgen Center Dr 21 2 A, Thousand Oaks, CA 91320, USA
    Int J Pharm 346:93-101. 2008

Collaborators

Detail Information

Publications10

  1. doi request reprint Cocrystallization for successful drug delivery
    Changquan Calvin Sun
    University of Minnesota, College of Pharmacy, Department of Pharmaceutics, 9 127B Weaver Densford Hall, 308 Harvard Street S E, Minneapolis, MN 55455, USA
    Expert Opin Drug Deliv 10:201-13. 2013
    ..An updated review that systematically examines the cocrystal research in the context of drug delivery is timely and valuable...
  2. doi request reprint Improving powder flow properties of citric acid by crystal hydration
    Changquan Sun
    Amgen Inc, Materials Science Laboratory, Small Molecule Pharmaceutics, Thousand Oaks, California 91320, USA
    J Pharm Sci 98:1744-9. 2009
    ..Flow properties of the powders were tested using a ring shear cell. Results show the hydration can significantly improve flow properties of anhydrous citric acid...
  3. doi request reprint Materials science tetrahedron--a useful tool for pharmaceutical research and development
    Changquan Calvin Sun
    Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9 127B Weaver Densford Hall, 308 Harvard Street S E, Minneapolis, Minnesota 55455, USA
    J Pharm Sci 98:1671-87. 2009
    ..By following the principle of MST, integration of research among different laboratories can be attained. The pharmaceutical science community as a whole can conduct more efficient, collaborative, and coherent research...
  4. doi request reprint Roles of granule size in over-granulation during high shear wet granulation
    Limin Shi
    Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Pharm Sci 99:3322-5. 2010
    ..The tabletability of the finest fraction (45-90 microm) is nearly four times that of the largest fraction (300-425 microm). These results show that size reduction can be an effective strategy to address the problem of over-granulation...
  5. doi request reprint Development of a high drug load tablet formulation based on assessment of powder manufacturability: moving towards quality by design
    Changquan Calvin Sun
    Amgen Inc, Materials Science Laboratory, Small Molecule Pharmaceutics, Thousand Oaks, California 91320, USA
    J Pharm Sci 98:239-47. 2009
    ..Larger batches were subsequently manufactured to confirm predictions...
  6. ncbi request reprint Improved tableting properties of p-hydroxybenzoic acid by water of crystallization: a molecular insight
    Changquan Sun
    Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Weaver Densford Hall, 308 Harvard Street S E, Minneapolis, MN 55455 0343, USA
    Pharm Res 21:382-6. 2004
    ..To understand the influence of water in the crystal structure on the compaction properties of otherwise structurally similar crystals, p-hydroxybenzoic acid anhydrate (HA) and the monohydrate (HM) were used as model compounds...
  7. ncbi request reprint On the identification of slip planes in organic crystals based on attachment energy calculation
    Changquan Calvin Sun
    Preformulation, Small Molecule Pharmaceutics, Amgen, Inc, One Amgen Center Dr 21 2 A, Thousand Oaks, California 91320 1799, USA
    J Pharm Sci 97:3456-61. 2008
    ..Thus predicted slip/cleavage planes by attachment energy calculation may not be always accurate and should be treated with caution...
  8. ncbi request reprint Thermal expansion of organic crystals and precision of calculated crystal density: a survey of Cambridge Crystal Database
    Changquan Calvin Sun
    Amgen Inc, Materials Science Laboratory, Small Molecule Pharmaceutics, One Amgen Center Dr 21 2 A, Thousand Oaks, California 91320, USA
    J Pharm Sci 96:1043-52. 2007
    ..This likely contributes to the less than perfect prediction of relative stability of polymorphs at ambient temperature using the density rule...
  9. doi request reprint Quantifying effects of particulate properties on powder flow properties using a ring shear tester
    Hao Hou
    Materials Science Laboratory, Small Molecule Pharmaceutics, Amgen, Inc, One Amgen Center Dr 21 2 A, Thousand Oaks, California 91320 1799, USA
    J Pharm Sci 97:4030-9. 2008
    ..When corrected for density effect, higher particle density corresponded to better flow behavior. Surface silicification significantly improved flow properties of finer MCC, but did not improve those of coarser...
  10. ncbi request reprint Mechanism of moisture induced variations in true density and compaction properties of microcrystalline cellulose
    Changquan Calvin Sun
    Materials Science Laboratory, Small Molecule Pharmaceutics, Amgen Inc, One Amgen Center Dr 21 2 A, Thousand Oaks, CA 91320, USA
    Int J Pharm 346:93-101. 2008
    ..At above 3.3% water, increasing moisture content also reduced bonding strength. Due to the interplay among the plasticity, compaction pressure and bonding strength, tablet tensile strength peaked in the range of 3.3-5.6% moisture...