Albert Y Sun

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. ncbi request reprint The "French Paradox" and beyond: neuroprotective effects of polyphenols
    Albert Y Sun
    Department of Pharmacology, University of Missouri, Columbia, MO 65212, USA
    Free Radic Biol Med 32:314-8. 2002
  2. pmc Resveratrol as a therapeutic agent for neurodegenerative diseases
    Albert Y Sun
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
    Mol Neurobiol 41:375-83. 2010
  3. pmc Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: role of NADPH oxidase-derived ROS
    Qun Wang
    Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Free Radic Biol Med 43:1048-60. 2007
  4. pmc Oral administration of grape polyphenol extract ameliorates cerebral ischemia/reperfusion-induced neuronal damage and behavioral deficits in gerbils: comparison of pre- and post-ischemic administration
    Qun Wang
    Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
    J Nutr Biochem 20:369-77. 2009
  5. pmc Targeting NADPH oxidase and phospholipases A2 in Alzheimer's disease
    Agnes Simonyi
    Biochemistry Department, University of Missouri, 117 Schweitzer Hall, Columbia, MO, USA
    Mol Neurobiol 41:73-86. 2010
  6. ncbi request reprint Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus
    Qun Wang
    Department of Biochemistry, M743 Medical Sciences Building, University of Missouri Columbia, Columbia, MO 65212, USA
    Brain Res 1090:182-9. 2006
  7. ncbi request reprint Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits
    Qun Wang
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
    J Neurosci Res 82:138-48. 2005
  8. pmc Phospholipases A2 and inflammatory responses in the central nervous system
    Grace Y Sun
    Department of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, MO 65211, USA
    Neuromolecular Med 12:133-48. 2010
  9. pmc Neuroprotective effects of a nanocrystal formulation of sPLA(2) inhibitor PX-18 in cerebral ischemia/reperfusion in gerbils
    Qun Wang
    Department of Biochemistry, University of Missouri School of Medicine, Columbia, MO 65211, USA
    Brain Res 1285:188-95. 2009
  10. doi request reprint Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons
    Phullara B Shelat
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    J Neurochem 106:45-55. 2008

Collaborators

Detail Information

Publications32

  1. ncbi request reprint The "French Paradox" and beyond: neuroprotective effects of polyphenols
    Albert Y Sun
    Department of Pharmacology, University of Missouri, Columbia, MO 65212, USA
    Free Radic Biol Med 32:314-8. 2002
    ..These studies demonstrate an urgent need to extend research beyond the "French Paradox" towards better understanding molecular mechanisms of action of polyphenolic compounds and their application to human health...
  2. pmc Resveratrol as a therapeutic agent for neurodegenerative diseases
    Albert Y Sun
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
    Mol Neurobiol 41:375-83. 2010
    ..The goal here is to provide a better understanding of the mode of action of resveratrol and its possible use as a potential therapeutic agent to ameliorate stroke damage as well as other age-related neurodegenerative disorders...
  3. pmc Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: role of NADPH oxidase-derived ROS
    Qun Wang
    Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Free Radic Biol Med 43:1048-60. 2007
    ..Our results further suggest the possibility that preconditioning with other pharmacological agents that induce a mild oxidative stress may have similar therapeutic value for suppressing stroke-mediated damage in brain...
  4. pmc Oral administration of grape polyphenol extract ameliorates cerebral ischemia/reperfusion-induced neuronal damage and behavioral deficits in gerbils: comparison of pre- and post-ischemic administration
    Qun Wang
    Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
    J Nutr Biochem 20:369-77. 2009
    ..These findings indicate that oral GPE intake may confer protection against I/R injury and emphasize that early intervention may be an effective therapeutic measure for ameliorating brain injury in stroke...
  5. pmc Targeting NADPH oxidase and phospholipases A2 in Alzheimer's disease
    Agnes Simonyi
    Biochemistry Department, University of Missouri, 117 Schweitzer Hall, Columbia, MO, USA
    Mol Neurobiol 41:73-86. 2010
    ..This information should provide new therapeutic approaches for prevention of this debilitating disease...
  6. ncbi request reprint Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus
    Qun Wang
    Department of Biochemistry, M743 Medical Sciences Building, University of Missouri Columbia, Columbia, MO 65212, USA
    Brain Res 1090:182-9. 2006
    ....
  7. ncbi request reprint Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits
    Qun Wang
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
    J Neurosci Res 82:138-48. 2005
    ..Together, these findings attribute the neuroprotective effect of curcumin against I/R-induced neuronal damage to its antioxidant capacity in reducing oxidative stress and the signaling cascade leading to apoptotic cell death...
  8. pmc Phospholipases A2 and inflammatory responses in the central nervous system
    Grace Y Sun
    Department of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, MO 65211, USA
    Neuromolecular Med 12:133-48. 2010
    ....
  9. pmc Neuroprotective effects of a nanocrystal formulation of sPLA(2) inhibitor PX-18 in cerebral ischemia/reperfusion in gerbils
    Qun Wang
    Department of Biochemistry, University of Missouri School of Medicine, Columbia, MO 65211, USA
    Brain Res 1285:188-95. 2009
    ..The results also suggest that nanocrystals hold promise as an effective strategy for the delivery of compounds with poor solubility that would otherwise be precluded from preclinical development...
  10. doi request reprint Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons
    Phullara B Shelat
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    J Neurochem 106:45-55. 2008
    ..This novel mechanism may contribute to the oxidative stress hypothesis and synaptic failure that underline the pathogenesis of Alzheimer's disease...
  11. doi request reprint Oxidative and inflammatory pathways in Parkinson's disease
    Rebecca L Miller
    Department of Medical Pharmacology and Physiology, University of Missouri Columbia, Columbia, MO, 65212, USA
    Neurochem Res 34:55-65. 2009
    ..This review describes pathological effects of neurotoxins on cells and signaling pathways for production of reactive oxygen species (ROS) that underline the pathophysiology of PD...
  12. ncbi request reprint Dietary grape supplement ameliorates cerebral ischemia-induced neuronal death in gerbils
    Qun Wang
    Department of Biochemistry, University of Missouri, Columbia, MO, USA
    Mol Nutr Food Res 49:443-51. 2005
    ..The neuroprotective effects of GP supplement may have wide implication in the future for prevention/protection against other neurodegenerative damage...
  13. pmc Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA₂-IIA expression in astrocytes and microglia
    Wenwen Sheng
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    J Neuroinflammation 8:121. 2011
    ....
  14. doi request reprint NAD(P)H oxidase-mediated reactive oxygen species production alters astrocyte membrane molecular order via phospholipase A2
    Donghui Zhu
    Department of Biological Engineering, University of Missouri, Columbia, MO 65211, USA
    Biochem J 421:201-10. 2009
    ....
  15. pmc Involvement of oxidative pathways in cytokine-induced secretory phospholipase A2-IIA in astrocytes
    Michael D Jensen
    Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
    Neurochem Int 55:362-8. 2009
    ....
  16. pmc Botanical phenolics and brain health
    Albert Y Sun
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA
    Neuromolecular Med 10:259-74. 2008
    ..The main goal is to provide a better understanding of the mode of action of these compounds and assess their use as therapeutics to ameliorate age-related neurodegenerative diseases...
  17. pmc Prolonged exposure of cortical neurons to oligomeric amyloid-β impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate
    Yan He
    Department of Biochemistry, University of Missouri, Columbia, MO, USA
    ASN Neuro 3:e00050. 2011
    ....
  18. pmc Integrating cytosolic phospholipase A₂ with oxidative/nitrosative signaling pathways in neurons: a novel therapeutic strategy for AD
    Grace Y Sun
    Department of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, MO 65211, USA
    Mol Neurobiol 46:85-95. 2012
    ..Therefore, understanding mechanisms for cPLA(2) in the oxidative and nitrosative pathways in neurons will allow the development of novel therapeutic targets to mitigate the detrimental effects of AD...
  19. ncbi request reprint The neuroprotective effects of apocynin
    Agnes Simonyi
    Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
    Front Biosci (Elite Ed) 4:2183-93. 2012
    ..In this review, we aim to give an overview of current literature on the neuroprotective effects of apocynin in the prevention and treatment of neurodegenerative disorders. Particular attention is given to in vivo studies...
  20. ncbi request reprint Hydrogen peroxide alters membrane and cytoskeleton properties and increases intercellular connections in astrocytes
    Donghui Zhu
    Department of Biological Engineering, University of Missouri Columbia, Columbia, MO 65211, USA
    J Cell Sci 118:3695-703. 2005
    ..These results suggest that H2O2 alters astrocyte membranes and the cytoskeleton through activation of the p38 MAPK pathway...
  21. ncbi request reprint Resveratrol protects against neurotoxicity induced by kainic acid
    Qun Wang
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
    Neurochem Res 29:2105-12. 2004
    ..Since increased oxidative stress is a key factor for KA-induced neurotoxicity, this study demonstrated the ability of resveratrol to act as free radical scavenger to protect against neuronal damage caused by excitotoxic insults...
  22. ncbi request reprint Polyphenols in cerebral ischemia: novel targets for neuroprotection
    Agnes Simonyi
    Department of Biochemistry and Pathology, University of Missouri Columbia, Columbia, MO, USA
    Mol Neurobiol 31:135-47. 2005
    ..This article reviews the neuroprotective effects of plant extracts and their constituents that have been used in animal models of cerebral ischemia. The use of polyphenols as therapeutic agents in stroke has been suggested...
  23. ncbi request reprint Phospholipase A2 in astrocytes: responses to oxidative stress, inflammation, and G protein-coupled receptor agonists
    Grace Y Sun
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO, USA
    Mol Neurobiol 31:27-41. 2005
    ..This review focuses on describing the effects of oxidative stress, inflammation, and activation of G protein-coupled receptors on PLA2 activation, arachidonic acid (AA) release, and production of prostanoids in astrocytes...
  24. pmc Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase
    Rebecca L Miller
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA
    Brain Res 1167:129-39. 2007
    ..Taken together, this study demonstrates the involvement of ROS from NADPH oxidase in mediating paraquat cytotoxicity in BV-2 microglial cells and this process is mediated through PKCdelta- and ERK-dependent pathways...
  25. ncbi request reprint Kainic acid-mediated excitotoxicity as a model for neurodegeneration
    Qun Wang
    Department of Medical Pharmacology, University of Missouri School of Medicine, Columbia, MO, USA
    Mol Neurobiol 31:3-16. 2005
    ..The focus of this review is to summarize studies demonstrating KA-induced excitotoxicity in the central nervous system and possible intervention by anti-oxidants...
  26. pmc Phospholipases A2 and neural membrane dynamics: implications for Alzheimer's disease
    James C M Lee
    Biological Engineering Department, University of Missouri, Columbia, Missouri 65211, USA
    J Neurochem 116:813-9. 2011
    ....
  27. ncbi request reprint Resveratrol protects against global cerebral ischemic injury in gerbils
    Qun Wang
    Department of Pharmacology, School of Medicine, M526 Medical Science Bldg, 1 Hospital Drive, University of Missouri Columbia, Columbia, MO 65212, USA
    Brain Res 958:439-47. 2002
    ..This study demonstrated for the first time that resveratrol, a polyphenolic antioxidant, can cross the blood-brain barrier and exert protective effects against cerebral ischemic injury...
  28. pmc Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells
    Dennis Y Chuang
    Interdisciplinary Neuroscience Program, University of Missouri, Columbia, MO, USA
    J Neuroinflammation 10:15. 2013
    ..We also attempt to elucidate the mechanism and signaling pathways involved in cytokine-induced production of reactive oxygen species (ROS) in microglial cells...
  29. pmc Bioavailability of apocynin through its conversion to glycoconjugate but not to diapocynin
    Qun Wang
    Department of Biochemistry, M743 Medical Sciences Building, University of Missouri, M743 Medical Sciences Building, Columbia, MO 65212, USA
    Phytomedicine 15:496-503. 2008
    ..No diapocynin was detected in any samples. These results indicate rapid glycosylation of apocynin and its transport to blood and other organs but no apparent conversion to diapocynin in vivo...
  30. ncbi request reprint Grape polyphenols inhibit chronic ethanol-induced COX-2 mRNA expression in rat brain
    Agnes Simonyi
    Department of Biochemistry, University of Missouri, M121 Medical Sciences Building, Columbia, MO 65212, USA
    Alcohol Clin Exp Res 26:352-7. 2002
    ..This study was aimed at examining the effects of GP on mRNA expression of ERK1/2, cytosolic PLA2 (cPLA2), and COX-2 in different brain regions after chronic ethanol treatment...
  31. ncbi request reprint Chronic ethanol-induced subtype- and subregion-specific decrease in the mRNA expression of metabotropic glutamate receptors in rat hippocampus
    Agnes Simonyi
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
    Alcohol Clin Exp Res 28:1419-23. 2004
    ..This study was aimed to determine whether chronic ethanol treatment could change the messenger RNA (mRNA) expression of mGlu receptors in the hippocampus...
  32. ncbi request reprint Oxidant-mediated AA release from astrocytes involves cPLA(2) and iPLA(2)
    Jianfeng Xu
    Department of Biochemistry, University of Missouri, Columbia, MO 65212, USA
    Free Radic Biol Med 34:1531-43. 2003
    ....