P F Sullivan

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Evaluating the comparability of gene expression in blood and brain
    Patrick F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7264, USA
    Am J Med Genet B Neuropsychiatr Genet 141:261-8. 2006
  2. pmc Genome-wide association analysis identifies 13 new risk loci for schizophrenia
    Stephan Ripke
    1 Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA 3
    Nat Genet 45:1150-9. 2013
  3. pmc MethylPCA: a toolkit to control for confounders in methylome-wide association studies
    Wenan Chen
    Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
    BMC Bioinformatics 14:74. 2013
  4. pmc Genome-wide association studies in psychiatry: what have we learned?
    Ann L Collins
    Department of Genetics, CB 7264, 5097 Genomic Medicine Building, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Br J Psychiatry 202:1-4. 2013
  5. pmc Family history of schizophrenia and bipolar disorder as risk factors for autism
    Patrick F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, USA
    Arch Gen Psychiatry 69:1099-1103. 2012
  6. pmc Genetic architectures of psychiatric disorders: the emerging picture and its implications
    Patrick F Sullivan
    Departments of Genetics and Psychiatry, CB 7264, 5097 Genomic Medicine, University of North Carolina at Chapel Hill, North Carolina 27599 27264, USA
    Nat Rev Genet 13:537-51. 2012
  7. pmc The public health utility of genome-wide association study results for smoking behavior
    Helena Furberg
    Department of Psychiatry and Behavioral Science, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave, New York, NY 10022, USA
    Genome Med 2:26. 2010
  8. pmc MAOA haplotypes associated with thrombocyte-MAO activity
    Marten Jansson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    BMC Genet 6:46. 2005
  9. pmc The genetics of schizophrenia
    Patrick F Sullivan
    Department of Genetics, Psychiatry, and Epidemiology, University of North Carolina, Chapel Hill, USA
    PLoS Med 2:e212. 2005
  10. ncbi request reprint Chronic fatigue in a population sample: definitions and heterogeneity
    Patrick F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, NC 27599 7264, USA
    Psychol Med 35:1337-48. 2005

Collaborators

Detail Information

Publications85

  1. ncbi request reprint Evaluating the comparability of gene expression in blood and brain
    Patrick F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7264, USA
    Am J Med Genet B Neuropsychiatr Genet 141:261-8. 2006
    ..This suggests that the cautious and thoughtful use of peripheral gene expression may be a useful surrogate for gene expression in the CNS when it has been determined that the relevant gene is expressed in both...
  2. pmc Genome-wide association analysis identifies 13 new risk loci for schizophrenia
    Stephan Ripke
    1 Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA 3
    Nat Genet 45:1150-9. 2013
    ..Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder. ..
  3. pmc MethylPCA: a toolkit to control for confounders in methylome-wide association studies
    Wenan Chen
    Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
    BMC Bioinformatics 14:74. 2013
    ..This approach is, however, computationally very challenging due to the extremely large number of methylation sites in the human genome...
  4. pmc Genome-wide association studies in psychiatry: what have we learned?
    Ann L Collins
    Department of Genetics, CB 7264, 5097 Genomic Medicine Building, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Br J Psychiatry 202:1-4. 2013
    ..There is a now a clear path to increased knowledge of the 'parts lists' for these disorders...
  5. pmc Family history of schizophrenia and bipolar disorder as risk factors for autism
    Patrick F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, USA
    Arch Gen Psychiatry 69:1099-1103. 2012
    ..The degree to which these disorders share a basis in etiology has important implications for clinicians, researchers, and those affected by the disorders...
  6. pmc Genetic architectures of psychiatric disorders: the emerging picture and its implications
    Patrick F Sullivan
    Departments of Genetics and Psychiatry, CB 7264, 5097 Genomic Medicine, University of North Carolina at Chapel Hill, North Carolina 27599 27264, USA
    Nat Rev Genet 13:537-51. 2012
    ..Further study using a balanced portfolio of methods to assess multiple forms of genetic variation is likely to yield many additional new findings...
  7. pmc The public health utility of genome-wide association study results for smoking behavior
    Helena Furberg
    Department of Psychiatry and Behavioral Science, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave, New York, NY 10022, USA
    Genome Med 2:26. 2010
    ..The coordinated effort of multidisciplinary research teams will help reveal the circumstances under which we can translate genetic insights into clinical practice in the hope of reducing the burden of smoking in society...
  8. pmc MAOA haplotypes associated with thrombocyte-MAO activity
    Marten Jansson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    BMC Genet 6:46. 2005
    ..3 - 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals)...
  9. pmc The genetics of schizophrenia
    Patrick F Sullivan
    Department of Genetics, Psychiatry, and Epidemiology, University of North Carolina, Chapel Hill, USA
    PLoS Med 2:e212. 2005
  10. ncbi request reprint Chronic fatigue in a population sample: definitions and heterogeneity
    Patrick F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, NC 27599 7264, USA
    Psychol Med 35:1337-48. 2005
    ..Numerous nosological decisions are made when moving from the common human symptom of unusual fatigue to the rare chronic fatigue syndrome (CFS). These decisions have infrequently been subjected to rigorous evaluation...
  11. ncbi request reprint NCAM1 and neurocognition in schizophrenia
    Patrick F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Biol Psychiatry 61:902-10. 2007
    ..Neural cell adhesion molecule 1 (NCAM1, aliases NCAM and CD56) may be a candidate gene for schizophrenia or for neurocognition in schizophrenia as supported by linkage and functional findings...
  12. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
    ..With the integrated replication effort, we present a specific hypothesis for further studies...
  13. ncbi request reprint Empirical evaluation of the genetic similarity of samples from twin registries in Australia and the Netherlands using 359 STRP markers
    Patrick F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, United States of America
    Twin Res Hum Genet 9:600-2. 2006
    ..30% between the Australian and the Netherlands cohorts, a smaller value than between many European groups. We conclude that it is reasonable to combine the Australian and the Netherlands samples for joint genetic analyses...
  14. ncbi request reprint Spurious genetic associations
    Patrick F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Biol Psychiatry 61:1121-6. 2007
    ..I explored the capacity of association studies to produce false positive findings and the impact of various definitions of replication...
  15. pmc An unbiased metagenomic search for infectious agents using monozygotic twins discordant for chronic fatigue
    Patrick F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    BMC Microbiol 11:2. 2011
    ..Controls were the unaffected monozygotic co-twins of cases, and serum samples were obtained at the same place and time...
  16. pmc Genomewide linkage survey of nicotine dependence phenotypes
    Patrick F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Drug Alcohol Depend 93:210-6. 2008
    ..We sought to identify genomic regions that might contain etiologically-relevant loci using genomewide univariate and bivariate linkage analyses...
  17. ncbi request reprint Evaluation of genetic substructure in the Irish Study of High-Density Schizophrenia Families
    Patrick F Sullivan
    University of North Carolina at Chapel Hill, Department of Genetics, 27599 7264, USA
    Psychiatr Genet 14:187-9. 2004
    ..We found no evidence for the presence of genetic substructure in this sample...
  18. ncbi request reprint Multipoint and single point non-parametric linkage analysis with imperfect data
    Patrick F Sullivan
    Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7264, USA
    Am J Med Genet B Neuropsychiatr Genet 121:89-94. 2003
    ..The absence of parental genotypes in the presence of 1% genotype error led to marked degradation of linkage signal, particularly for multipoint analyses...
  19. ncbi request reprint Twin analyses of chronic fatigue in a Swedish national sample
    Patrick F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, NC 27599 7264, USA
    Psychol Med 35:1327-36. 2005
    ..Chronic fatigue has infrequently been studied in twins. Data from twin studies can inform clinical and research approaches to the management and etiology of human complex traits...
  20. pmc Genomewide association for schizophrenia in the CATIE study: results of stage 1
    P F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 13:570-84. 2008
    ....
  21. pmc Schizophrenia genetics: the search for a hard lead
    Patrick F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, NC 27599 7264, USA
    Curr Opin Psychiatry 21:157-60. 2008
    ....
  22. ncbi request reprint Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies
    Patrick F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, 27599, USA
    Arch Gen Psychiatry 60:1187-92. 2003
    ....
  23. pmc Snus use and other correlates of smoking cessation in the Swedish Twin Registry
    H Furberg
    Department of Genetics, University of North Carolina at Chapel Hill, NC 27599 7264, USA
    Psychol Med 38:1299-308. 2008
    ..We investigated 12 variables and their interactions as correlates of smoking cessation among regular smokers in the population-based Swedish Twin Registry (STR)...
  24. pmc Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results
    A L Collins
    Department of Genetics, University of North Carolina at Chapel Hill, NC 27599 7264, USA
    Psychol Med 42:607-16. 2012
    ..The hypothesis-driven candidate gene literature can be appraised by comparison with the results of genome-wide association studies (GWAS)...
  25. pmc The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognition
    James J Crowley
    Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599 7264, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1298-300. 2008
    ..We were unable to replicate previous associations of rs6994992 with schizophrenia and, moreover, did not find significant associations with age of onset, an estimate of pre-morbid IQ, or neurocognition...
  26. ncbi request reprint AKT1 and neurocognition in schizophrenia
    Andrea Poyastro Pinheiro
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC, USA
    Aust N Z J Psychiatry 41:169-77. 2007
    ..Therefore, the association of genetic variation in AKT1 with neurocognition was investigated in patients with schizophrenia...
  27. ncbi request reprint Simulating association studies: a data-based resampling method for candidate regions or whole genome scans
    Fred A Wright
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA
    Bioinformatics 23:2581-8. 2007
    ..Improvements in study design and analytic techniques will require the simulation of datasets with realistic patterns of linkage disequilibrium and allele frequencies for typed SNPs...
  28. ncbi request reprint [Genetics in eating disorders: extending the boundaries of research]
    Andrea Poyastro Pinheiro
    Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA
    Rev Bras Psiquiatr 28:218-25. 2006
    ..To review the recent literature relevant to genetic research in eating disorders and to discuss unique issues which are crucial for the development of a genetic research project in eating disorders in Brazil...
  29. pmc Cigarettes and oral snuff use in Sweden: Prevalence and transitions
    Helena Furberg
    Department of Genetics, University of North Carolina at Chapel Hill, NC 27599 7264, USA
    Addiction 101:1509-15. 2006
    ..To investigate the prevalence and patterns of transitions between cigarette and snus use...
  30. pmc Genetic variation in Transaldolase 1 and risk of squamous cell carcinoma of the head and neck
    Patricia V Basta
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7435, USA
    Cancer Detect Prev 32:200-8. 2008
    ..Here we present data examining the association of genetic variation in one of the key enzymes of the PPP, Transaldolase 1 (TALDO1) with squamous cell carcinoma of the head and neck (SCCHN)...
  31. pmc Current developments in the genetics of autism: from phenome to genome
    Molly Losh
    Department of Allied Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7190, USA
    J Neuropathol Exp Neurol 67:829-37. 2008
    ....
  32. ncbi request reprint The genetics of anorexia nervosa
    Cynthia M Bulik
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599, USA
    Annu Rev Nutr 27:263-75. 2007
    ..With these bodies of literature as a starting point, we evaluate critically the current state of research on molecular genetic studies of anorexia nervosa and provide guidance for future research...
  33. ncbi request reprint The types of regular cigarette smokers: a latent class analysis
    Helena Furberg
    Department of Genetics, University of North Carolina at Chapel Hill, School of Medicine 27599 7264, USA
    Nicotine Tob Res 7:351-60. 2005
    ....
  34. ncbi request reprint Prevalence, heritability, and prospective risk factors for anorexia nervosa
    Cynthia M Bulik
    Department of Psychiatry, School of Public Health, University of North Carolina at Chapel Hill, 27599, USA
    Arch Gen Psychiatry 63:305-12. 2006
    ..Anorexia nervosa (AN) is a serious mental illness with marked morbidity and mortality...
  35. pmc Association study of 182 candidate genes in anorexia nervosa
    Andrea Poyastro Pinheiro
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7160, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1070-80. 2010
    ....
  36. pmc The STAGE cohort: a prospective study of tobacco use among Swedish twins
    Helena Furberg
    Department of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA
    Nicotine Tob Res 10:1727-35. 2008
    ..Patterns of tobacco use may be changing in Sweden; snus use appears to be increasing, while daily smoking appears to be decreasing in popularity among the younger Swedish twins...
  37. pmc Gene expression in peripheral blood leukocytes in monozygotic twins discordant for chronic fatigue: no evidence of a biomarker
    Andrea Byrnes
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e5805. 2009
    ..Chronic fatiguing illness remains a poorly understood syndrome of unknown pathogenesis. We attempted to identify biomarkers for chronic fatiguing illness using microarrays to query the transcriptome in peripheral blood leukocytes...
  38. pmc Meta-analysis of genome-wide association studies with overlapping subjects
    Dan Yu Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Hum Genet 85:862-72. 2009
    ..The advantages of the new approach are illustrated with empirical data from two sets of genome-wide association studies...
  39. pmc The prevalence of self-reported chronic fatigue in a U.S. twin registry
    Helena Furberg
    Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
    J Psychosom Res 59:283-90. 2005
    ..To investigate the prevalence and correlates of various definitions of self-reported lifetime fatiguing illness in a U.S. twin registry...
  40. pmc Is Swedish snus associated with smoking initiation or smoking cessation?
    H Furberg
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Tob Control 14:422-4. 2005
    ..Evaluation of the efficacy of snus for smoking cessation should be evaluated in randomised clinical trials...
  41. pmc No association of the serotonin transporter polymorphisms 5-HTTLPR and RS25531 with schizophrenia or neurocognition
    Thomas I Konneker
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7264, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1115-7. 2010
    ..67 and negative symptoms P = 0.46). We were unable to identify association of the triallelic 5-HTTLPR with schizophrenia, neurocognition, or core psychotic symptoms even at levels of significance unadjusted for multiple comparisons...
  42. ncbi request reprint TAMAL: an integrated approach to choosing SNPs for genetic studies of human complex traits
    Bradley M Hemminger
    School of Information and Library Science, University of North Carolina at Chapel Hill, NC, USA
    Bioinformatics 22:626-7. 2006
    ..g. haplotype tagging SNPs or SNP predicted to lead to amino acid changes) from current versions of online resources (i.e. HapMap, Perlegen, Affymetrix, dbSNP and the UCSC genome browser)...
  43. pmc A searchable database of genetic evidence for psychiatric disorders
    Thomas Konneker
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7264, USA
    Am J Med Genet B Neuropsychiatr Genet 147:671-5. 2008
    ..Findings can be save to disk or viewed via a genome browser...
  44. pmc Transcriptional targets of the schizophrenia risk gene MIR137
    A L Collins
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Transl Psychiatry 4:e404. 2014
    ..Critically, differentially expressed genes at 48 h were enriched for smaller association P-values in the largest published schizophrenia GWAS. This work provides empirical support for a role of miR-137 in the etiology of schizophrenia...
  45. ncbi request reprint Genotyping accuracy for whole-genome amplification of DNA from buccal epithelial cells
    Keren Leviel
    Department of Genetics, University of North Carolina at Chapel Hill, 27599 7264, USA
    Twin Res 7:482-4. 2004
    ..If used with caution, these data suggest that rolling-circle whole-genome amplification can be used to increase the DNA mass available for large-scale genotyping projects based on DNA from buccal cells...
  46. ncbi request reprint An empirical study of the typology of bulimic symptoms in young Portuguese women
    Andrea Poyastro Pinheiro
    Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina, USA
    Int J Eat Disord 41:251-8. 2008
    ..To investigate whether clusters of bulimic symptoms exist in a community sample of young Portuguese women...
  47. pmc Schizophrenia genetics: where next?
    Yunjung Kim
    Department of Genetics, University of North Carolina, Chapel Hill, NC 2Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Schizophr Bull 37:456-63. 2011
    ....
  48. pmc A candidate gene study of Tardive dyskinesia in the CATIE schizophrenia trial
    Huei Ting Tsai
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Med Genet B Neuropsychiatr Genet 153:336-40. 2010
    ..No single marker or haplotype association reached statistical significance after adjustment for multiple comparisons. Thus, we found no support for either novel or prior associations from the literature...
  49. ncbi request reprint Model-based gene selection shows engrailed 1 is associated with antipsychotic response
    Bradley Todd Webb
    Center for Biomarker Research and Personalized Medicine, Department of Pharmacy, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Pharmacogenet Genomics 18:751-9. 2008
    ..We sought to find genes that may influence treatment response in a less biased manner, after integrating heterogeneous data sources related to schizophrenia...
  50. pmc Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample
    Po Hsiu Kuo
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
    Alcohol Clin Exp Res 32:785-95. 2008
    ..The present study examined evidence for the association of alcohol metabolism genes with AD in the Irish Affected Sib Pair Study of alcohol dependence...
  51. pmc Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands
    Naomi R Wray
    Department of Genetic Epidemiology, Queensland Institute of Medical Research, 300 Herston Rd, Brisbane, Australia 4029
    Arch Gen Psychiatry 65:649-58. 2008
    ..Studying this personality dimension can give insights into the etiology of these important psychiatric disorders...
  52. ncbi request reprint A genome scan of neuroticism in nicotine dependent smokers
    Benjamin M Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 132:65-9. 2005
    ..52 and 1.97 (P-value of 0.003 and 0.0108) respectively, and have some evidence for a novel finding on chromosome 12 with a LOD of 2.85 (P-value of 0.0014)...
  53. pmc Association of RGS2 and RGS5 variants with schizophrenia symptom severity
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Schizophr Res 101:67-75. 2008
    ..3-1q31. Due to overlapping cellular functions and chromosomal proximity, we hypothesized that multiple RGS genes may contribute to schizophrenia severity and treatment responsiveness...
  54. pmc Comment on a simple and improved correction for population stratification
    Seunggeun Lee
    Am J Hum Genet 82:524-6; author reply 526-8. 2008
  55. ncbi request reprint Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings
    Christel M Middeldorp
    Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
    Twin Res Hum Genet 8:609-15. 2005
    ..Furthermore, different genetic risk factors appear to contribute to the vulnerability for panic disorder and/or agoraphobia in men and women. No other sex differences were found...
  56. ncbi request reprint Epidemiology of cancer-related fatigue in the Swedish twin registry
    Michael J Forlenza
    Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
    Cancer 104:2022-31. 2005
    ..However, most studies examining the prevalence of CRF have been hospital-based or clinic-based studies, which often are subject to bias...
  57. ncbi request reprint The subtypes of major depression in a twin registry
    Patrick F Sullivan
    Virginia Commonwealth University, Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, P O Box 980126, Richmond VA 23298 0126, USA
    J Affect Disord 68:273-84. 2002
    ..The subtypes of major depression (MD) remain incompletely understood. While there is consensus about the existence of MD with 'typical' vegetative features, further data are required to evaluate the existence of MD with atypical features...
  58. ncbi request reprint The epidemiology of chronic fatigue in the Swedish Twin Registry
    Birgitta Evengard
    Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    Psychol Med 35:1317-26. 2005
    ..Chronic fatigue syndrome (CFS) remains an idiopathic and controversial entity...
  59. ncbi request reprint Mania in the Swedish Twin Registry: criterion validity and prevalence
    Federico Soldani
    Department of Psychiatry, Harvard University, Boston, MA, USA
    Aust N Z J Psychiatry 39:235-43. 2005
    ..We examined the criterion validity and prevalence of lifetime mania in a survey of Swedish twins conducted with interview methodology usually applied in psychiatric epidemiology...
  60. ncbi request reprint The Irish Affected Sib Pair Study of Alcohol Dependence: study methodology and validation of diagnosis by interview and family history
    Carol A Prescott
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Alcohol Clin Exp Res 29:417-29. 2005
    ....
  61. ncbi request reprint A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependence
    Hermine H Maes
    Departments of Human Genetics and Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
    Psychol Med 34:1251-61. 2004
    ..As the development of ND requires regular tobacco use (RTU) which in turn requires TI, a conditional approach is necessary...
  62. ncbi request reprint Psychiatric and medical symptoms in binge eating in the absence of compensatory behaviors
    Ted Reichborn-Kjennerud
    Division of Epidemiology, The Norwegian Institute of Public Health, P O Box 4404 Nydalen, N 0403 Oslo, Norway
    Obes Res 12:1445-54. 2004
    ..To explore the extent to which binge eating in the absence of compensatory behaviors (BE) is associated with psychiatric and medical symptoms in men and women and to control for the independent effects of BMI...
  63. ncbi request reprint Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics
    Patrick F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, VA, USA
    Am J Med Genet B Neuropsychiatr Genet 126:23-36. 2004
    ..Although the hypotheses resulting from these linkage and bioinformatic analyses are plausible and intriguing, their ultimate worth depends on replication in additional linkage samples and in future experimental studies...
  64. ncbi request reprint A framework for controlling false discovery rates and minimizing the amount of genotyping in the search for disease mutations
    Edwin J C G van den Oord
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, PO Box 980126, Richmond, VA 23298 0126, USA
    Hum Hered 56:188-99. 2003
    ..To develop a method for designing studies to find disease mutations that can achieve a set of goals with respect to proportions of false and true discoveries with the minimum amount of genotyping...
  65. ncbi request reprint Causes and recovery in anorexia nervosa: the patient's perspective
    Federica Tozzi
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Int J Eat Disord 33:143-54. 2003
    ..We explored anorexic patients' subjective accounts of the causes of their anorexia and of the factors that fostered recovery. Subjective accounts could assist in understanding this complicated and often intractable disorder...
  66. ncbi request reprint The relation between eating disorders and components of perfectionism
    Cynthia M Bulik
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, USA
    Am J Psychiatry 160:366-8. 2003
    ..The authors' goal was to explore the relation between perfectionism and psychopathology, including eating disorders...
  67. ncbi request reprint Combined linkage and association analyses of the 124-bp allele of marker D2S2944 with anxiety, depression, neuroticism and major depression
    A Leo Beem
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Behav Genet 36:127-36. 2006
    ..However, the association occurred in the absence of evidence for linkage in this region on chromosome 2...
  68. ncbi request reprint Genetic, developmental and personality correlates of self-mutilation in depressed patients
    Peter R Joyce
    Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, New Zealand
    Aust N Z J Psychiatry 40:225-9. 2006
    ..To examine whether the T allele of G protein beta3 (GNbeta3) is associated with self-mutilation in depressed patients...
  69. ncbi request reprint A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients
    Peter R Joyce
    Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Psychol Med 36:807-13. 2006
    ..We were interested in differences in genetic and developmental risk factors between depressed patients with or without a co-morbid BPD...
  70. pmc Twin analyses of fatigue
    Ellen Schur
    1 Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Twin Res Hum Genet 10:729-33. 2007
    ..About half the variance for both prolonged and chronic fatigue in males was due to genetic effects, and half due to individual-specific environmental effects. For females, most variance was due to individual environmental effects...
  71. ncbi request reprint Genetic and phenotypic stability of measures of neuroticism over 22 years
    Naomi R Wray
    Genetic Epidermology, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 10:695-702. 2007
    ..33 for a single measure to .43 for mean score because of the reduction in the estimate of the environmental variance, and this will increase power in genetic linkage or association studies of neuroticism...
  72. ncbi request reprint Irritable bowel syndrome: a co-twin control analysis
    Mary K Wojczynski
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Gastroenterol 102:2220-9. 2007
    ..Therefore, we aimed to examine if there is a genetic component to the co-occurrence of MDD and IBS in participants from the population-based Swedish Twin Registry...
  73. pmc Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biol Psychiatry 63:32-41. 2008
    ..The central role of RGS4 in regulating signaling via Gi/o coupled neurotransmitter receptors led us to hypothesize that there may be RGS4 genotypes predictive of specific disease phenotypes and antipsychotic treatment responses...
  74. ncbi request reprint Anxiety and comorbid measures associated with PLXNA2
    Naomi R Wray
    Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, QLD 4029, Australia
    Arch Gen Psychiatry 64:318-26. 2007
    ..Common genetic liabilities have been reported between psychiatric and psychological measures, but few examples exist of common genetic variants...
  75. ncbi request reprint The Swedish Twin Registry in the third millennium: an update
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Twin Res Hum Genet 9:875-82. 2006
    ..In particular, we describe recent efforts to screen all twins born between 1959 and 1985, and young twin pairs when they turn 9 and 12 years of age. For these studies, we present initial frequencies of common conditions and exposures...
  76. ncbi request reprint A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Alcohol Clin Exp Res 30:1972-7. 2006
    ..Are the susceptibility genes underlying this peak specific for AD or do they increase risk for externalizing disorders more generally? Can we, in the IASPSAD, replicate prior evidence for linkage to conduct disorder (CD)?..
  77. ncbi request reprint Premorbid predictors of chronic fatigue
    Kenji Kato
    Department of Medical Epidemiology and Biostatistics, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Arch Gen Psychiatry 63:1267-72. 2006
    ..Moreover, subjects with chronic fatiguing illness may have distinctive personality traits, although this finding could reflect confounding by other mechanisms...
  78. ncbi request reprint Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Alcohol Clin Exp Res 30:1807-16. 2006
    ..The goal of this study was to identify genomic regions containing susceptibility loci for alcohol-related traits...
  79. ncbi request reprint Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia
    Xiangning Chen
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richimond, VA 23298, USA
    Hum Mol Genet 15:3329-42. 2006
    ..However, due to the extended high LD in this region, we were unable to distinguish whether the association signals came from one or more of these genes...
  80. ncbi request reprint Recurrence risks for schizophrenia in a Swedish national cohort
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Psychol Med 36:1417-25. 2006
    ..Widely cited estimates are from small/older samples. If these estimates are biased upwards, then the rationale for molecular genetic studies of schizophrenia may not be as solid...
  81. ncbi request reprint Evaluation of analyses of univariate discrete twin data
    Patrick F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Richmond, 23298 0126, USA
    Behav Genet 32:221-7. 2002
    ..These results suggest that the use of AIC to guide twin modeling for univariate discrete traits should either be abandoned or used with great caution...
  82. ncbi request reprint False discoveries and models for gene discovery
    Edwin J C G van den Oord
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Trends Genet 19:537-42. 2003
    ..This raises the question of whether current models for gene discovery are shaped excessively by a fear of false discoveries...
  83. ncbi request reprint Genetic and environmental contributions to obesity and binge eating
    Cynthia M Bulik
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, PO Box 980126, Richmond, VA 23298 0126, USA
    Int J Eat Disord 33:293-8. 2003
    ..The purpose of this article was to determine the extent of overlap between genetic and environmental factors that contribute to the liability to obesity and binge eating...

Research Grants22

  1. DETECTING SUSCEPTIBILITY LOCI FOR RECURRENT DEPRESSION
    Patrick Sullivan; Fiscal Year: 2000
    ..abstract_text> ..
  2. Replication of Schizophrenia Associations in CATIE
    Patrick Sullivan; Fiscal Year: 2007
    ..We believe that the results of our study will be highly informative and are essential to the field at this critical juncture in the hunt for genes mediating liability to schizophrenia. [unreadable] [unreadable]..
  3. A Large-Scale Schizophrenia Association Study in Sweden
    Patrick Sullivan; Fiscal Year: 2007
    ..For the long-term, establishment of this sample will provide an accessible resource for the psychiatric research community. Future projects could include whole genome association and nested case-control studies. ..
  4. Major Depression: Stage 1 Genomewide Association in Population-Based Samples
    Patrick Sullivan; Fiscal Year: 2007
    ..This is arguably the best and most comprehensive sample collection for MDD in the world. [unreadable] [unreadable] [unreadable]..
  5. 2/2 A genome-wide association study to detect genetic variation for schizophrenia
    Patrick Sullivan; Fiscal Year: 2008
    ..Case-finding efforts could be greatly improved and we could learn far more about how this devastating disease develops. ..
  6. A Large-Scale Schizophrenia Association Study in Sweden
    Patrick Sullivan; Fiscal Year: 2008
    ..For the long-term, establishment of this sample will provide an accessible resource for the psychiatric research community. Future projects could include whole genome association and nested case-control studies. ..
  7. 2/2 A genome-wide association study to detect genetic variation for schizophrenia
    Patrick Sullivan; Fiscal Year: 2009
    ..Case-finding efforts could be greatly improved and we could learn far more about how this devastating disease develops. ..
  8. 1/5-The Psychiatric GWAS Consortium: Integrated & Coordinated GWAS Meta-Analyses
    Patrick Sullivan; Fiscal Year: 2008
    ..Finally, the PGC proposes to abide as fully as possible with the NIH's GWAS data sharing policies and we provide a detailed data sharing plan and timetable. [unreadable] [unreadable] [unreadable]..
  9. A Large-Scale Schizophrenia Association Study in Sweden
    Patrick Sullivan; Fiscal Year: 2009
    ..For the long-term, establishment of this sample will provide an accessible resource for the psychiatric research community. Future projects could include whole genome association and nested case-control studies. ..
  10. 2/2 A genome-wide association study to detect genetic variation for schizophrenia
    Patrick F Sullivan; Fiscal Year: 2010
    ..Case-finding efforts could be greatly improved and we could learn far more about how this devastating disease develops. ..
  11. GENETIC & ENVIRONMENT DETERMINANTS OF SMOKING CESSATION
    Patrick Sullivan; Fiscal Year: 2006
    ....
  12. Replication of Schizophrenia Associations in CATIE
    Patrick Sullivan; Fiscal Year: 2006
    ..We believe that the results of our study will be highly informative and are essential to the field at this critical juncture in the hunt for genes mediating liability to schizophrenia. [unreadable] [unreadable]..
  13. GENETIC & ENVIRONMENT DETERMINANTS OF SMOKING CESSATION
    Patrick Sullivan; Fiscal Year: 2001
    ....
  14. DETECTING SUSCEPTIBILITY LOCI FOR RECURRENT DEPRESSION
    Patrick Sullivan; Fiscal Year: 2001
    ..abstract_text> ..
  15. GENETIC & ENVIRONMENT DETERMINANTS OF SMOKING CESSATION
    Patrick Sullivan; Fiscal Year: 2002
    ....
  16. GENETIC & ENVIRONMENT DETERMINANTS OF SMOKING CESSATION
    Patrick Sullivan; Fiscal Year: 2003
    ....
  17. GENETIC & ENVIRONMENT DETERMINANTS OF SMOKING CESSATION
    Patrick Sullivan; Fiscal Year: 2004
    ....
  18. DETECTING SUSCEPTIBILITY LOCI FOR RECURRENT DEPRESSION
    Patrick Sullivan; Fiscal Year: 2002
    ..abstract_text> ..
  19. Microarrays & Proteomics in MZ Twins Discordant for CFS
    Patrick Sullivan; Fiscal Year: 2004
    ..If successful, this work could lead to profound changes in the understanding of CFS and resolution of some attendant controversies. ..
  20. Microarrays & Proteomics in MZ Twins Discordant for CFS
    Patrick Sullivan; Fiscal Year: 2005
    ..If successful, this work could lead to profound changes in the understanding of CFS and resolution of some attendant controversies. ..
  21. Microarrays & Proteomics in MZ Twins Discordant for CFS
    Patrick Sullivan; Fiscal Year: 2006
    ..If successful, this work could lead to profound changes in the understanding of CFS and resolution of some attendant controversies. ..
  22. 2/2 A genome-wide association study to detect genetic variation for schizophrenia
    Patrick F Sullivan; Fiscal Year: 2010
    ..Case-finding efforts could be greatly improved and we could learn far more about how this devastating disease develops. ..