K E Sullivan

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Primary immunodeficiency diseases consortium conference
    Kathleen Sullivan
    Children s Hospital of Philadelphia, Div Immunologic and Infectious Disease, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Clin Immunol 116:279-80. 2005
  2. ncbi request reprint DiGeorge syndrome/velocardiofacial syndrome: the chromosome 22q11.2 deletion syndrome
    Kathleen E Sullivan
    Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Adv Exp Med Biol 601:37-49. 2007
  3. ncbi request reprint DiGeorge syndrome/chromosome 22q11.2 deletion syndrome
    K E Sullivan
    Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Allergy Asthma Rep 1:438-44. 2001
  4. ncbi request reprint USIDNET: A Strategy to Build a Community of Clinical Immunologists
    Kathleen E Sullivan
    Department of Pediatrics, The Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA, 19104, USA
    J Clin Immunol 34:428-35. 2014
  5. pmc Global H4 acetylation analysis by ChIP-chip in systemic lupus erythematosus monocytes
    Z Zhang
    Center for Biomedical Informatics, Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Genes Immun 11:124-33. 2010
  6. pmc Cytokine-induced monocyte characteristics in SLE
    Zhe Zhang
    The Center for Bioinformatics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Biomed Biotechnol 2010:507475. 2010
  7. pmc Protecting pediatric oncology patients from influenza
    Leslie S Kersun
    Division of Oncology, Department of Pediatrics, The Children s Hospital of Philadelphia, Pennsylvania, USA
    Oncologist 18:204-11. 2013
  8. ncbi request reprint The clinical, immunological, and molecular spectrum of chromosome 22q11.2 deletion syndrome and DiGeorge syndrome
    Kathleen E Sullivan
    Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Allergy Clin Immunol 4:505-12. 2004
  9. pmc CD4(+) CD25(+) T-cell production in healthy humans and in patients with thymic hypoplasia
    Kathleen E Sullivan
    Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Clin Diagn Lab Immunol 9:1129-31. 2002
  10. ncbi request reprint Analysis of polymorphisms affecting immune complex handling in systemic lupus erythematosus
    K E Sullivan
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Rheumatology (Oxford) 42:446-52. 2003

Research Grants

  1. TNF Alpha In Inflammation
    Kathleen Sullivan; Fiscal Year: 2007
  2. ROLE OF TNF ALPHA IN SLE
    Kathleen Sullivan; Fiscal Year: 2000
  3. Epigenomics of SLE
    Kathleen Sullivan; Fiscal Year: 2009
  4. Immune Complex Stimulation of TNFalpha
    Kathleen Sullivan; Fiscal Year: 2007
  5. TNF Alpha In Inflammation
    Kathleen Sullivan; Fiscal Year: 2006
  6. Immune Complex Stimulation of TNFalpha
    Kathleen Sullivan; Fiscal Year: 2006
  7. TNF Alpha In Inflammation
    Kathleen Sullivan; Fiscal Year: 2005
  8. Immune Complex Stimulation of TNFalpha
    Kathleen Sullivan; Fiscal Year: 2005
  9. TNF Alpha In Inflammation
    Kathleen Sullivan; Fiscal Year: 2004
  10. Immune Complex Stimulation of TNFalpha
    Kathleen Sullivan; Fiscal Year: 2004

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Primary immunodeficiency diseases consortium conference
    Kathleen Sullivan
    Children s Hospital of Philadelphia, Div Immunologic and Infectious Disease, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Clin Immunol 116:279-80. 2005
  2. ncbi request reprint DiGeorge syndrome/velocardiofacial syndrome: the chromosome 22q11.2 deletion syndrome
    Kathleen E Sullivan
    Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Adv Exp Med Biol 601:37-49. 2007
    ..Patients will most often need interventions directed at maximizing function for many organ systems but can ultimately have a high level of functioning...
  3. ncbi request reprint DiGeorge syndrome/chromosome 22q11.2 deletion syndrome
    K E Sullivan
    Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Allergy Asthma Rep 1:438-44. 2001
    ..Fortunately, the majority of patients with either DiGeorge syndrome or chromosome 22q11.2 deletion syndrome have a mild to moderate immunodeficiency. These patients may develop recurrent infections or autoimmune disease...
  4. ncbi request reprint USIDNET: A Strategy to Build a Community of Clinical Immunologists
    Kathleen E Sullivan
    Department of Pediatrics, The Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA, 19104, USA
    J Clin Immunol 34:428-35. 2014
    ..This study describes the construction and use of a registry for patients with primary immune deficiencies and other efforts to improve knowledge and care for affected patients and their families...
  5. pmc Global H4 acetylation analysis by ChIP-chip in systemic lupus erythematosus monocytes
    Z Zhang
    Center for Biomedical Informatics, Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Genes Immun 11:124-33. 2010
    ....
  6. pmc Cytokine-induced monocyte characteristics in SLE
    Zhe Zhang
    The Center for Bioinformatics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Biomed Biotechnol 2010:507475. 2010
    ..Therefore, there are significant clusters of aberrantly expressed genes in SLE which are strongly associated with altered H4ac, suggesting that these cells have experienced durable changes to their epigenome...
  7. pmc Protecting pediatric oncology patients from influenza
    Leslie S Kersun
    Division of Oncology, Department of Pediatrics, The Children s Hospital of Philadelphia, Pennsylvania, USA
    Oncologist 18:204-11. 2013
    ..These strategies can also protect patients from prolonged hospitalizations and morbidity related to influenza...
  8. ncbi request reprint The clinical, immunological, and molecular spectrum of chromosome 22q11.2 deletion syndrome and DiGeorge syndrome
    Kathleen E Sullivan
    Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Allergy Clin Immunol 4:505-12. 2004
    ..2 deletion syndrome will be reviewed. Immunologists and primary care providers often are in a position to coordinate the complex care needs of these patients and an awareness of the clinical features is essential...
  9. pmc CD4(+) CD25(+) T-cell production in healthy humans and in patients with thymic hypoplasia
    Kathleen E Sullivan
    Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Clin Diagn Lab Immunol 9:1129-31. 2002
    ..Absolute numbers of CD4(+) CD25(+) T cells were markedly higher in healthy infants than in infants with chromosome 22q11.2 deletion syndrome...
  10. ncbi request reprint Analysis of polymorphisms affecting immune complex handling in systemic lupus erythematosus
    K E Sullivan
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Rheumatology (Oxford) 42:446-52. 2003
    ..This is consistent with the classic finding of immune complex deposition in affected end organs. We wished to examine combinatorial effects of polymorphic variants of genes involved in immune complex clearance in susceptibility to lupus...
  11. ncbi request reprint Regulation of inflammation
    Kathleen E Sullivan
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Immunol Res 27:529-38. 2003
    ..Its pleomorphic effects require complex regulatory strategies. Our work has focused on the role of TNFalpha in autoimmune diseases and the regulation of its expression by transcription factors and chromatin remodeling...
  12. doi request reprint Chromosome 22q11.2 deletion syndrome: DiGeorge syndrome/velocardiofacial Syndrome
    Kathleen E Sullivan
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104 4399, USA
    Immunol Allergy Clin North Am 28:353-66. 2008
    ..Later, speech and school issues dominate the picture. Allergies and autoimmune disorders also may be troubling for some school-age children...
  13. pmc Epigenetic regulation of tumor necrosis factor alpha
    K E Sullivan
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, 34th St and Civic Ctr Blvd, Philadelphia, PA 19104, USA
    Mol Cell Biol 27:5147-60. 2007
    ..These studies demonstrate the importance of epigenetic regulation in the control of TNF-alpha expression. These findings may have relevance for inflammatory disorders in which TNF-alpha is overproduced...
  14. pmc The TNFalpha locus is altered in monocytes from patients with systemic lupus erythematosus
    Kathleen E Sullivan
    Allergy Immunology, The Children s Hospital of Philadelphia, 34th Street and Civic Ctr Boulevard, Philadelphia, PA 19104, USA
    Clin Immunol 123:74-81. 2007
    ..Histone acetylation, associated with increased transcriptional competence of TNFalpha, may play a role in certain inflammatory aspects of the disease...
  15. ncbi request reprint Inflammation in juvenile idiopathic arthritis
    Kathleen E Sullivan
    University of Pennsylvania School of Medicine, Division of Allergy and Immunology, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatr Clin North Am 52:335-57, v. 2005
    ..Recent advances in the understanding of these processes have led to dramatic improvements in treatment...
  16. ncbi request reprint The role of bone marrow transplantation in pediatric rheumatic diseases
    K E Sullivan
    Division of Immunologic and Infectious Diseases, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    J Rheumatol Suppl 58:49-52. 2000
    ..I describe some of the theories underlying its use and review the current data supporting its use...
  17. ncbi request reprint 3' polymorphisms of ETS1 are associated with different clinical phenotypes in SLE
    K E Sullivan
    Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, PA 19104, USA
    Hum Mutat 16:49-53. 2000
    ..These data suggest that ETS1 may be involved in the phenotypic expression of systemic lupus erythematosus...
  18. pmc Measurement of cytokine secretion, intracellular protein expression, and mRNA in resting and stimulated peripheral blood mononuclear cells
    K E Sullivan
    Division of Immunologic and Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Clin Diagn Lab Immunol 7:920-4. 2000
    ..All three methodologies detected significant stimulation of cytokine production. The combination of phytohemagglutinin and phorbol myristate acetate was overall the most-potent stimulus...
  19. ncbi request reprint A TNFR2 3' flanking region polymorphism in systemic lupus erythematosus
    K E Sullivan
    Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, 34th St and Civic Ctr Blvd, Philadelphia, PA 19104, USA
    Genes Immun 1:225-7. 2000
    ..No difference in the gene frequency of the two base-pair polymorphism in SLE patients compared to controls was found, nor was there any association with any particular clinical phenotype...
  20. pmc Longitudinal analysis of lymphocyte function and numbers in the first year of life in chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome)
    K E Sullivan
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Clin Diagn Lab Immunol 6:906-11. 1999
    ..Therefore, improvement in peripheral blood T-cell counts is variable in chromosome 22q11.2 deletion syndrome. The patients with the lowest T-cell counts improved the most in the first year of life...
  21. ncbi request reprint Cytokine and chemokine dysregulation in hyper-IgE syndrome
    J Chehimi
    The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Clin Immunol 100:49-56. 2001
    ..Underexpression of a set of chemokines could explain a number of features of hyper-IgE syndrome and may offer a new paradigm for the understanding of this disorder...
  22. ncbi request reprint An osteopontin (SPP1) polymorphism is associated with systemic lupus erythematosus
    A C Forton
    The University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Hum Mutat 19:459. 2002
    ..Additional associations with renal disease and opportunisitic infections were suggested. This is the first phenotypic association with a polymorphic variant of osteopontin...
  23. pmc Monocyte polarization: the relationship of genome-wide changes in H4 acetylation with polarization
    Z Zhang
    Center for Bioinformatics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Genes Immun 12:445-56. 2011
    ..Therefore, some changes in monocyte gene expression were sustained over a 3-day period. These durably altered gene sets were enriched for changes in H4ac and were associated with potential MAP kinase effects...
  24. ncbi request reprint Interferon-gamma polymorphisms in systemic lupus erythematosus
    J Y Lee
    The Division of Immunologic and Infectious Diseases, The Children s Hospital of Philadelphia The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Genes Immun 2:254-7. 2001
    ..Allele 2 appeared to be protective for arthritis. This suggests that genetic variation in interferon-gamma expression might influence the disease course...
  25. ncbi request reprint Immunologic features of chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome)
    A F Jawad
    Division of Biostatistics and Epidemiology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr 139:715-23. 2001
    ..To characterize immunologic function and clinical characteristics in patients with chromosome 22q11.2 deletion syndrome and determine whether there was significant change over time...
  26. ncbi request reprint C4A deficiency due to a 2 bp insertion is increased in patients with systemic lupus erythematosus
    K E Sullivan
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA
    J Rheumatol 26:2144-7. 1999
    ..We investigated whether a specific genetic cause of C4A deficiency, not associated with A1, B8, DR3, is found with increased frequency in SLE compared to controls...
  27. doi request reprint Aberrant regulation of the integrin very late antigen-4 in systemic lupus erythematosus
    H Rahimi
    Department of Pediatrics, The Children s Hospital of Philadelphia, PA, USA
    Lupus 22:297-306. 2013
    ..Stimulation of SLE monocytes with a VLA4 ligand induced significant TNF╬▒ expression, confirming a functional effect. This behavior may contribute to increased atherosclerosis and monocyte infiltrates in end organs...
  28. pmc Gamma interferon and lipopolysaccharide interact at the level of transcription to induce tumor necrosis factor alpha expression
    J Y Lee
    Division of Immunologic and Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Infect Immun 69:2847-52. 2001
    ..The modulatory effect of IFN-gamma may be mediated by Jak2...
  29. ncbi request reprint Abnormal apoptosis in chronic granulomatous disease and autoantibody production characteristic of lupus
    A N Sanford
    Immunology, CHOP, 34th St and Civic Ctr Blvd, Philadelphia, PA 19104, USA
    Rheumatology (Oxford) 45:178-81. 2006
    ..This disorder is a neutrophil defect in intracellular killing. Abnormal apoptosis has been described. We hypothesized that abnormal apoptosis occurring in neutrophils of patients made them more immunogenic...
  30. ncbi request reprint Loss of endothelial surface expression of E-selectin in a patient with recurrent infections
    H M DeLisser
    Pulmonary and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Blood 94:884-94. 1999
    ....
  31. doi request reprint Poor immunogenicity of the H1N1 2009 vaccine in well controlled HIV-infected individuals
    Pablo Tebas
    University of Pennsylvania School of Medicine, Philadelphia, USA
    AIDS 24:2187-92. 2010
    ..To evaluate the safety and immunogenicity of the H1N1 2009 vaccine in HIV-positive individuals...
  32. ncbi request reprint Decreased natural killer (NK) cell function in chronic NK cell lymphocytosis associated with decreased surface expression of CD11b
    J S Orange
    Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Clin Immunol 99:53-64. 2001
    ..These observed differences may explain the relatively benign phenotype of this disorder...
  33. ncbi request reprint Burden of copy number variation in common variable immunodeficiency
    M Keller
    The Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, PA, USA Division of Allergy and Immunology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Clin Exp Immunol 177:269-71. 2014
    ..These findings suggest that the increased CNV burden is static and intrinsic to CVID as a disease. ..
  34. doi request reprint Dyskeratosis congenita: a combined immunodeficiency with broad clinical spectrum--a single-center pediatric experience
    S Jyonouchi
    Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Allergy Immunol 22:313-9. 2011
    ..The immunologic features of DKC remain under diagnosed and under treated despite the fact that immunodeficiency is a major cause of premature mortality in DKC...
  35. ncbi request reprint Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome
    K E Sullivan
    Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Clin Immunol Immunopathol 82:43-8. 1997
    ..Therefore, cells from patients with Nijmegen breakage syndrome have an abnormal response to radiation exposure similar to that seen in ataxia-telangiectasia...
  36. ncbi request reprint Safety of live viral vaccines in patients with chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome)
    Elena E Perez
    Division of Allergy and Immunology at Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 112:e325. 2003
    ..2 deletion with live viral vaccines does not carry a significantly higher risk of adverse reactions compared with the general population, provided that they have no evidence of severe immunocompromise...
  37. ncbi request reprint Polarization of primary human monocytes by IFN-gamma induces chromatin changes and recruits RNA Pol II to the TNF-alpha promoter
    Stacey Garrett
    Division of Allergy Immunology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 180:5257-66. 2008
    ..These studies provide an important perspective on monocyte polarization. Polarization by IFN-gamma has a durable effect on TNF-alpha expression, and histone acetylation may provide a mechanism for persistence of the effect...
  38. ncbi request reprint T-cell homeostasis in humans with thymic hypoplasia due to chromosome 22q11.2 deletion syndrome
    Lisa M Piliero
    Division of Allergy and Immunology, ARC 1208, CHOP, 34th St and Civic Ctr Blvd, Philadelphia, PA 10104, USA
    Blood 103:1020-5. 2004
    ..These data are consistent with homeostatic proliferation of T cells in patients with limited T-cell production due to thymic hypoplasia...
  39. ncbi request reprint A potential screening tool for IPEX syndrome
    Meredith Lee Heltzer
    Division of Allergy and Immunology, Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Dev Pathol 10:98-105. 2007
    ..This screening test provides a valuable tool for diagnosing IPEX syndrome in extremely ill patients who may not tolerate a delay in therapeutic intervention...
  40. doi request reprint Use of sirolimus in IPEX and IPEX-like children
    Pierre L Yong
    Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    J Clin Immunol 28:581-7. 2008
    ..Data on optimal therapy are limited...
  41. ncbi request reprint Histone acetylation and chromatin conformation are regulated separately at the TNF-alpha promoter in monocytes and macrophages
    Julia Y Lee
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, PA 19104, USA
    J Leukoc Biol 73:862-71. 2003
    ..These data suggest that there is a hierarchy of controls regulating expression of TNF-alpha. Acetylation of histones is a prerequisite but is insufficient on its own for TNF-alpha production...
  42. ncbi request reprint Mannose binding lectin (MBL) polymorphisms associated with low MBL production in patients with dermatomyositis
    Victoria P Werth
    Philadelphia V A Medical Center Department of Dermatology Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, PA 19104, USA
    J Invest Dermatol 119:1394-9. 2002
    ..Our model is that genetic polymorphisms leading to overproduction of apoptotic keratinocytes and then impaired clearance of these cells contribute to the pathogenesis of adult dermatomyositis, a photoinduced autoimmune skin disease...
  43. ncbi request reprint Chromosome 22q11.2 deletion syndrome (DiGeorge and velocardiofacial syndromes)
    Elena Perez
    The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Curr Opin Pediatr 14:678-83. 2002
    ..We describe recent advances in understanding the genetic basis for the syndrome, the clinical manifestations of the syndrome, and new information on autoimmune diseases in this syndrome...
  44. pmc GCF2/LRRFIP1 represses tumor necrosis factor alpha expression
    April R Suriano
    University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 25:9073-81. 2005
    ..Thus, dynamic changes on the TNF-alpha promoter, particularly at the -308 site, accompany the transition from repressed to active transcription. GCF2/LRRFIP1 is the first TNF-alpha repressor identified...
  45. ncbi request reprint Associations of tumor necrosis factor alpha and HLA polymorphisms with adult dermatomyositis: implications for a unique pathogenesis
    Victoria P Werth
    Philadelphia V A Medical Center, Department of Dermatology, University of Pennsylvania, USA
    J Invest Dermatol 119:617-20. 2002
    ..The differences in linkage with HLA-DR3, as well as several divergent clinical features, indicate that there are also fundamental mechanistic differences between dermatomyositis and subacute cutaneous lupus erythematosus...
  46. ncbi request reprint Ultraviolet-B recruits mannose-binding lectin into skin from non-cutaneous sources
    Michele L Lokitz
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Invest Dermatol 125:166-73. 2005
    ..We hypothesize that MBL may facilitate non-inflammatory clearance of apoptotic debris in patients with photosensitive forms of DM...
  47. ncbi request reprint A role for PKC-delta and PI 3-kinase in TNF-alpha-mediated antiapoptotic signaling in the human neutrophil
    Laurie E Kilpatrick
    Department of Pediatrics, University of Pennsylvania School of Medicine and the Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Cell Physiol 283:C48-57. 2002
    ..Thus both PKC-delta and PI 3-kinase have essential roles in TNF-alpha-mediated antiapoptotic signaling in adherent neutrophils...
  48. ncbi request reprint Thrombocytopenia in patients with chromosome 22q11.2 deletion syndrome
    Scott Lawrence
    Division of Allergy and Immunology, Division of Clinical Genetics, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Pediatr 143:277-8. 2003
    ..2 deletion syndrome (n=112) were analyzed along with 57 age-matched controls. Even after the exclusion of patients with idiopathic thrombocytopenia purpura, the mean platelet count was approximately 70% of the control population...
  49. ncbi request reprint TNFalpha inhibition in MRL/lpr mice ameliorates pulmonary but not renal disease
    Nahmah Kim
    Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Autoimmun 19:215-22. 2002
    ..This has important implications for designing therapeutics for SLE...
  50. ncbi request reprint LPS and poly I:C induce chromatin modifications at a novel upstream region of the IL-23 p19 promoter
    Stacey Garrett
    The Division of Allergy and Immunology, The Children s Hospital of Philadelphia, ARC 1216, 34th St and Civic Ctr Blvd, Philadelphia, PA 19104, USA
    Inflammation 31:235-46. 2008
    ..Our data suggest that one of the mechanisms regulating IL-23 expression is the regulation of histone modifications at this distal upstream region of the promoter...
  51. ncbi request reprint Systemic conditions associated with periodontitis in childhood and adolescence. A review of diagnostic possibilities
    Thomas P Sollecito
    Oral Medicine, University of Pennsylvania, USA
    Med Oral Patol Oral Cir Bucal 10:142-50. 2005
    ..In this review we will discuss the most important systemic diseases that should be considered in a differential diagnosis when evaluating a pediatric patient presenting with periodontitis...
  52. ncbi request reprint Diminished T cell numbers in patients with chronic granulomatous disease
    Meredith Heltzer
    St Christopher s Hospital For Children, Philadelphia, Pennsylvania 19134, USA
    Clin Immunol 105:273-8. 2002
    ..The difference increased with age. It is not known whether diminished T cell numbers influence the susceptibility to infections in these patients, but T cell effects could represent a significant cofactor for infection...
  53. ncbi request reprint Prevalence of chronic granulomatous disease in pediatric patients diagnosed with Crohn's disease
    Steven Liu
    Inflamm Bowel Dis 14:727-8. 2008
  54. ncbi request reprint Velocardiofacial syndrome, DiGeorge syndrome: the chromosome 22q11.2 deletion syndromes
    Lisa J Kobrynski
    Department of Pediatrics, Allergy and Immunology Section, Emory University School of Medicine, Atlanta, GA, USA
    Lancet 370:1443-52. 2007
    ..Patients with chromosome 22q11.2 deletion syndrome might have high level of functioning, but most often need interventions to improve the function of many organ systems...
  55. ncbi request reprint Contiguous X-chromosome deletion syndrome encompassing the BTK, TIMM8A, TAF7L, and DRP2 genes
    Anna Sediva
    Institute of Immunology, University Hospital Motol, V Uvalu 84, 150 06, Prague 5, Czech Republic
    J Clin Immunol 27:640-6. 2007
    ..The severity of symptoms, however, did not correlate with the extent of the deletion...
  56. ncbi request reprint Allergies in patients with chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome) and patients with chronic granulomatous disease
    Lauren Staple
    The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Allergy Immunol 16:226-30. 2005
    ..2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome) was found to be significantly associated with both eczema and asthma but not allergic rhinitis. CGD was not found to be significantly associated with atopic diseases...
  57. ncbi request reprint Uncommon conundrum in common variable immunodeficiency
    Charlotte Cunningham-Rundles
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Clin Immunol 116:208-10. 2005
  58. ncbi request reprint Live viral vaccines in patients with DiGeorge syndrome
    Kathleen E Sullivan
    Clin Immunol 113:3. 2004
  59. ncbi request reprint Primary care and primary immunodeficiencies
    Kathleen E Sullivan
    Am Fam Physician 68:1919, 1923, 1926. 2003
  60. ncbi request reprint Strange symptoms in Sneddon's syndrome
    Johannes Wohlrab
    Martin Luther Universitat Halle Wittenberg, Germany
    Clin Immunol 119:13-5. 2006
  61. ncbi request reprint X-linked lymphoproliferative syndrome: an X-cellent question
    Alexandra Filipovich
    Cincinnati Children s Hospital Medical Center, OH, USA
    Clin Immunol 119:241-4. 2006
  62. pmc Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)
    David T Teachey
    Divisions of Oncology and Hematology, Children s Hospital of Philadelphia, ARC 902, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Blood 108:1965-71. 2006
    ..We conclude that rapamycin is an effective treatment for murine ALPS and should be explored as treatment for affected humans...
  63. ncbi request reprint ATM stabilizes DNA double-strand-break complexes during V(D)J recombination
    Andrea L Bredemeyer
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 442:466-70. 2006
    ....
  64. ncbi request reprint Chronic arthritis without uveitis in velocardiofacial syndrome
    Randy Q Cron
    J Pediatr 149:281. 2006
  65. ncbi request reprint Failure of physiologic doses of pure UVA or UVB to induce lesions in photosensitive cutaneous lupus erythematosus: implications for phototesting
    Michele L Lokitz
    The University of Pennsylvania, Philadelphia, PA, USA
    Photodermatol Photoimmunol Photomed 22:290-6. 2006
    ..Phototesting studies in cutaneous lupus erythematosus have yielded variable results, with most trials reporting photo-induction of lesions by both UVA and UVB in substantial numbers of patients...
  66. pmc Infections in patients with inherited defects in phagocytic function
    Timothy Andrews
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Clin Microbiol Rev 16:597-621. 2003
    ..Conversely, understanding the role of the neutrophil and macrophage in infection has benefited not just the patients described in this review but also other patients with similar disease processes...
  67. ncbi request reprint Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS)
    David T Teachey
    Division of Oncology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, ARC 902, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Blood 105:2443-8. 2005
    ..Our data further suggest that a number of patients with ES may have ALPS, a novel finding with important therapeutic implications...
  68. ncbi request reprint Progressive neurodegeneration in patients with primary immunodeficiency disease on IVIG treatment
    Ulrike H M Ziegner
    Department of Pediatrics, UCLA School of Medicine, Los Angeles, California, USA
    Clin Immunol 102:19-24. 2002
    ..To help determine the etiology of this rare complication, an international surveillance system for primary immunodeficiency patients who develop progressive neurodegeneration of unknown cause is recommended...

Research Grants15

  1. TNF Alpha In Inflammation
    Kathleen Sullivan; Fiscal Year: 2007
    ..Overall, this proposal will define the mechanisms underlying repression of the TNF alpha locus. ..
  2. ROLE OF TNF ALPHA IN SLE
    Kathleen Sullivan; Fiscal Year: 2000
    ..This mechanistic approach will define the role of the macrophage-specific complex in the transcriptional regulation of TNF-alpha. These studies may ultimately enable rational interventions directed at TNF-alpha. ..
  3. Epigenomics of SLE
    Kathleen Sullivan; Fiscal Year: 2009
    ..These studies have broad implications for how our immune system could be molded by prior experiences and could lead to novel therapies for SLE. ..
  4. Immune Complex Stimulation of TNFalpha
    Kathleen Sullivan; Fiscal Year: 2007
    ..In the third aim, we will define the role of chromatin in the regulation of responses to immune complexes. ..
  5. TNF Alpha In Inflammation
    Kathleen Sullivan; Fiscal Year: 2006
    ..Overall, this proposal will define the mechanisms underlying repression of the TNF alpha locus. ..
  6. Immune Complex Stimulation of TNFalpha
    Kathleen Sullivan; Fiscal Year: 2006
    ..In the third aim, we will define the role of chromatin in the regulation of responses to immune complexes. ..
  7. TNF Alpha In Inflammation
    Kathleen Sullivan; Fiscal Year: 2005
    ..Overall, this proposal will define the mechanisms underlying repression of the TNF alpha locus. ..
  8. Immune Complex Stimulation of TNFalpha
    Kathleen Sullivan; Fiscal Year: 2005
    ..In the third aim, we will define the role of chromatin in the regulation of responses to immune complexes. ..
  9. TNF Alpha In Inflammation
    Kathleen Sullivan; Fiscal Year: 2004
    ..Overall, this proposal will define the mechanisms underlying repression of the TNF alpha locus. ..
  10. Immune Complex Stimulation of TNFalpha
    Kathleen Sullivan; Fiscal Year: 2004
    ..In the third aim, we will define the role of chromatin in the regulation of responses to immune complexes. ..
  11. Immune Complex Stimulation of TNFalpha
    Kathleen Sullivan; Fiscal Year: 2003
    ..In the third aim, we will define the role of chromatin in the regulation of responses to immune complexes. ..
  12. ROLE OF TNF ALPHA IN SLE
    Kathleen Sullivan; Fiscal Year: 2002
    ..This mechanistic approach will define the role of the macrophage-specific complex in the transcriptional regulation of TNF-alpha. These studies may ultimately enable rational interventions directed at TNF-alpha. ..
  13. ROLE OF TNF ALPHA IN SLE
    Kathleen Sullivan; Fiscal Year: 2001
    ..This mechanistic approach will define the role of the macrophage-specific complex in the transcriptional regulation of TNF-alpha. These studies may ultimately enable rational interventions directed at TNF-alpha. ..
  14. Epigenomics of SLE
    Kathleen E Sullivan; Fiscal Year: 2010
    ..These studies have broad implications for how our immune system could be molded by prior experiences and could lead to novel therapies for SLE. ..