John Sullivan

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Genotypic and functional properties of early infant HIV-1 envelopes
    Michael Kishko
    Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, MA, USA
    Retrovirology 8:67. 2011
  2. pmc Characteristics and management of HIV-1-infected pregnant women enrolled in a randomised trial: differences between Europe and the USA
    Marie Louise Newell
    Centre of Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    BMC Infect Dis 7:60. 2007
  3. ncbi request reprint Prevention of mother-to-child transmission of HIV--what next?
    John L Sullivan
    Department of Pediatrics and Molecular Medicine, University Massachusetts Medical School, Worcester, MA 01655, USA
    J Acquir Immune Defic Syndr 34:S67-72. 2003
  4. ncbi request reprint The abnormal gene in X-linked lymphoproliferative syndrome
    J L Sullivan
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Biotech II, Suite 318, Worcester, MA 01605, USA
    Curr Opin Immunol 11:431-4. 1999
  5. ncbi request reprint Long-term nonprogressive infection with human immunodeficiency virus type 1 in a hemophilia cohort
    T C Greenough
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Infect Dis 180:1790-802. 1999
  6. pmc Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: control of viral replication and absence of persistent HIV-1-specific immune responses
    K Luzuriaga
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Virol 74:6984-91. 2000
  7. pmc Dynamics of human immunodeficiency virus type 1 replication in vertically infected infants
    K Luzuriaga
    Department of Pediatrics, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Boston, Massachusetts, USA
    J Virol 73:362-7. 1999
  8. ncbi request reprint Infrequent detection of HIV-1-specific, but not cytomegalovirus-specific, CD8(+) T cell responses in young HIV-1-infected infants
    Z A Scott
    Graduate Program in Immunology/Virology and Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 167:7134-40. 2001
  9. ncbi request reprint Viral and immunopathogenesis of vertical HIV-1 infection
    K Luzuriaga
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, USA
    Pediatr Clin North Am 47:65-78. 2000
  10. ncbi request reprint Nevirapine synergistically inhibits HIV-1 replication in combination with zidovudine, interferon or CD4 immunoadhesin
    R A Koup
    University of Massachusetts Medical School, Department of Pediatrics, Worcester
    AIDS 7:1181-4. 1993

Research Grants

  1. Quality Improvement through Electronic Enhancements
    John Sullivan; Fiscal Year: 2003
  2. EXPANSION AND CENTRALIZATION OF AQUATIC ANIMAL HOUSING
    John Sullivan; Fiscal Year: 2004
  3. Quality Improvement in Human Subjects Research
    John Sullivan; Fiscal Year: 2002
  4. IMMUNOREGULATORY DEFECTS IN HEMOPHILIA
    John Sullivan; Fiscal Year: 2001
  5. IMMUNOREGULATORY DEFECTS IN HEMOPHILIA
    John Sullivan; Fiscal Year: 1993
  6. UMMS Clinical and Translational Science
    John Sullivan; Fiscal Year: 2006

Collaborators

Detail Information

Publications35

  1. pmc Genotypic and functional properties of early infant HIV-1 envelopes
    Michael Kishko
    Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, MA, USA
    Retrovirology 8:67. 2011
    ..Following extensive genotypic and phylogenetic analyses, 35 representative clones were selected for functional studies...
  2. pmc Characteristics and management of HIV-1-infected pregnant women enrolled in a randomised trial: differences between Europe and the USA
    Marie Louise Newell
    Centre of Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    BMC Infect Dis 7:60. 2007
    ....
  3. ncbi request reprint Prevention of mother-to-child transmission of HIV--what next?
    John L Sullivan
    Department of Pediatrics and Molecular Medicine, University Massachusetts Medical School, Worcester, MA 01655, USA
    J Acquir Immune Defic Syndr 34:S67-72. 2003
    ..However, a number of issues remain to be resolved, particularly methods to reduce the transmission of the virus during breastfeeding and to deliver effective treatment for the mothers' own HIV infection...
  4. ncbi request reprint The abnormal gene in X-linked lymphoproliferative syndrome
    J L Sullivan
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Biotech II, Suite 318, Worcester, MA 01605, USA
    Curr Opin Immunol 11:431-4. 1999
    ....
  5. ncbi request reprint Long-term nonprogressive infection with human immunodeficiency virus type 1 in a hemophilia cohort
    T C Greenough
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Infect Dis 180:1790-802. 1999
    ..The presence of expanded, activated CD8 T cells with cytotoxic effector function in the peripheral blood suggests ongoing viral replication...
  6. pmc Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: control of viral replication and absence of persistent HIV-1-specific immune responses
    K Luzuriaga
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Virol 74:6984-91. 2000
    ..These results are consistent with the notion that early combination antiretroviral therapy of HIV-1-infected infants allows the long-term suppression of viral replication...
  7. pmc Dynamics of human immunodeficiency virus type 1 replication in vertically infected infants
    K Luzuriaga
    Department of Pediatrics, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Boston, Massachusetts, USA
    J Virol 73:362-7. 1999
    ..These data confirm the central role of HIV-1 replication in the pathogenesis of vertical HIV-1 infection and reinforce the importance of early, potent combination therapies for the long-term control of HIV-1 replication...
  8. ncbi request reprint Infrequent detection of HIV-1-specific, but not cytomegalovirus-specific, CD8(+) T cell responses in young HIV-1-infected infants
    Z A Scott
    Graduate Program in Immunology/Virology and Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 167:7134-40. 2001
    ..Therapeutic HIV-1 vaccine strategies in young infants may prolong the clinical benefit of ART by expanding the HIV-1-specific CD8(+) T cell pool...
  9. ncbi request reprint Viral and immunopathogenesis of vertical HIV-1 infection
    K Luzuriaga
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, USA
    Pediatr Clin North Am 47:65-78. 2000
    ....
  10. ncbi request reprint Nevirapine synergistically inhibits HIV-1 replication in combination with zidovudine, interferon or CD4 immunoadhesin
    R A Koup
    University of Massachusetts Medical School, Department of Pediatrics, Worcester
    AIDS 7:1181-4. 1993
    ..To determine whether synergistic inhibition of HIV-1 replication would result from the in vitro use of nevirapine in combination with zidovudine, interferon (IFN)-alpha 2C, and CD4 immunoadhesin...
  11. ncbi request reprint Antibody-dependent cell-mediated cytotoxicity directed by a human monoclonal antibody reactive with gp120 of HIV-1
    R A Koup
    Department of Pediatrics, University of Massachusetts Medical School, Worcester
    AIDS 5:1309-14. 1991
    ..15e defines an important epitope in the human immune response to HIV-1 infection. Antibodies with 15e-like activity may be useful in immunoprophylaxis or immunotherapy of HIV-1 infection...
  12. ncbi request reprint High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice
    R M Hesselton
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, USA
    J Infect Dis 172:974-82. 1995
    ..B-17-scid/scid mice. The NOD/LtSz-scid/scid mouse may provide a useful small animal model for studies of HIV-1...
  13. pmc Accuracy of the TRUGENE HIV-1 genotyping kit
    Robert M Grant
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94141, USA
    J Clin Microbiol 41:1586-93. 2003
    ..This integrated assay system for the detection of HIV-1 drug resistance mutations has a high degree of accuracy and reproducibility in several laboratories...
  14. ncbi request reprint Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice
    Thomas C Greenough
    Department of Pediatrics, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 02130, USA
    J Infect Dis 191:507-14. 2005
    ..Human monoclonal antibodies (MAbs) that neutralize SARS-associated coronavirus (SARS-CoV) could provide protection for exposed individuals...
  15. pmc Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2
    Wenhui Li
    Partners AIDS Research Center, 65 Landsdowne St, Cambridge, MA 02139, USA
    J Virol 78:11429-33. 2004
    ..These data imply that a mouse transgenically expressing human ACE2 may be a useful animal model of SARS...
  16. ncbi request reprint The impact of race/ethnicity on mother-to-child HIV transmission in the United States in Pediatric AIDS Clinical Trials Group Protocol 316
    Coleen K Cunningham
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    J Acquir Immune Defic Syndr 36:800-7. 2004
    ..Race/ethnicity is significant in predicting viral suppression at the time of delivery...
  17. ncbi request reprint A trial of three antiretroviral regimens in HIV-1-infected children
    Katherine Luzuriaga
    Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Mass 01605, USA
    N Engl J Med 350:2471-80. 2004
    ..Depletion of CD4 T-cell counts or progression of human immunodeficiency virus (HIV) disease occurs rapidly in children, but few data address the efficacy of aggressive therapy for HIV-infected children...
  18. pmc Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus
    Thomas C Greenough
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Am J Pathol 167:455-63. 2005
    ..These findings identify the common marmoset as a promising nonhuman primate to study SARS-CoV pathogenesis...
  19. ncbi request reprint Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamsters
    Anjeanette Roberts
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 193:685-92. 2006
    ....
  20. ncbi request reprint Pediatric HIV-1 infection: advances and remaining challenges
    Katherine Luzuriaga
    University of Massachusetts Medical School, Department of Pediatrics, Program in Molecular Medicine, 373 Plantation Street, Biotech II Suite 318, Worcester, MA 01605, USA
    AIDS Rev 4:21-6. 2002
    ..Continued efforts to understand MTCT and pediatric HIV-1 pathogenesis and to refine preventive and therapeutic strategies are of high priority...
  21. ncbi request reprint Predose infant nevirapine concentration with the two-dose intrapartum neonatal nevirapine regimen: association with timing of maternal intrapartum nevirapine dose
    Mark Mirochnick
    Boston University School of Medicine, Boston Medical Center, 91 Concord Street, 6th Floor, Boston, MA 02118, USA
    J Acquir Immune Defic Syndr 33:153-6. 2003
    ..To evaluate cord blood and predose nevirapine concentrations in infants exposed to the two-dose intrapartum neonatal nevirapine regimen...
  22. pmc Multicenter evaluation of use of dried blood and plasma spot specimens in quantitative assays for human immunodeficiency virus RNA: measurement, precision, and RNA stability
    Don Brambilla
    New England Research Center, Waltham, Massachusetts, USA
    J Clin Microbiol 41:1888-93. 2003
    ..Dried blood and dried plasma spots can be used as an easy and inexpensive means for the collection and storage of specimens under field conditions for the diagnosis of HIV infection and the monitoring of antiretroviral therapy...
  23. ncbi request reprint Enhanced culture method for detection of replication-competent virus in peripheral blood mononuclear cells of HIV type 1-infected individuals
    John P Haran
    Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605
    AIDS Res Hum Retroviruses 18:577-83. 2002
    ..This will be a useful technique by which to study viral latency and HIV-1 pathogenesis in adult and pediatric populations...
  24. ncbi request reprint A multicenter randomized controlled trial of nevirapine versus a combination of zidovudine and lamivudine to reduce intrapartum and early postpartum mother-to-child transmission of human immunodeficiency virus type 1
    Dhayendre Moodley
    Department of Obstetrics and Gynaecology, Paediatrics and Child Health, Nelson R Mandela School of Medicine, University of Natal, KwaZulu Natal, Congella 4013, South Africa
    J Infect Dis 187:725-35. 2003
    ..3%; Zdv/3TC group, 26.3%) and respiratory for infants (Nvp group, 16.1%; Zdv/3TC group, 17.0%). This study further confirms the efficacy and safety of short-course ARV regimens in reducing MTCT rates in developing countries...
  25. ncbi request reprint Vaccines to prevent transmission of HIV-1 via breastmilk: scientific and logistical priorities
    Katherine Luzuriaga
    University of Massachusetts Medical School, Program in Molecular Medicine, 373 Plantation Street, Suite 318, Worcester, MA 01605, USA
    Lancet 368:511-21. 2006
    ..Here, we discuss the scientific and logistical challenges for the development of paediatric HIV vaccines; available vaccines and completed or planned paediatric vaccine trials are also discussed...
  26. ncbi request reprint Development of resistance mutations in women receiving standard antiretroviral therapy who received intrapartum nevirapine to prevent perinatal human immunodeficiency virus type 1 transmission: a substudy of pediatric AIDS clinical trials group protocol 3
    Coleen K Cunningham
    Department of Pediatrics, State University of New York Upstate Medical University, Syracuse, Syracuse, NY 13210, USA
    J Infect Dis 186:181-8. 2002
    ..The risk of nevirapine resistance should be considered when determining the risks or benefits of intrapartum nevirapine in women receiving antepartum antiretroviral therapy...
  27. ncbi request reprint Two-dose intrapartum/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission: a randomized trial
    Alejandro Dorenbaum
    Department of Pediatrics, University of California, San Francisco, USA
    JAMA 288:189-98. 2002
    ..However, it is unknown whether the addition of the 2-dose nevirapine regimen to standard ART would further reduce perinatal HIV transmission...
  28. ncbi request reprint Prevention of mother-to-child transmission of HIV infection
    Katherine Luzuriaga
    Clin Infect Dis 40:466-7. 2005
  29. ncbi request reprint Nuclear localization of HIV type 1 Vif isolated from a long-term asymptomatic individual and potential role in virus attenuation
    Melissa A Farrow
    Program in Molecular Medicine and Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    AIDS Res Hum Retroviruses 21:565-74. 2005
    ..Our data highlight the importance of Vif in HIV-1 pathogenesis and also provide a unique tool to investigate the interaction of Vif and Apobec3G...
  30. pmc Acute infection with Epstein-Barr virus targets and overwhelms the peripheral memory B-cell compartment with resting, latently infected cells
    Donna Hochberg
    Department of Pathology, Jaharis Building, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA
    J Virol 78:5194-204. 2004
    ..This phase is followed by a slower decline that, even by 1 year, had not reached a steady state. Therefore, EBV may approach but never reach a stable equilibrium...
  31. ncbi request reprint Alterations in HIV-1 LTR promoter activity during AIDS progression
    Kirsten Hiebenthal-Millow
    Institute for Clinical and Molecular Virology, University of Erlangen Nurnberg, Schlossgarten 4, 91054 Erlangen, Germany
    Virology 317:109-18. 2003
    ..Our findings show that in a subset of HIV-1-infected individuals enhanced LTR transcription contributes to the increased replicative potential of late stage virus isolates and might accelerate disease progression...
  32. ncbi request reprint Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
    Wenhui Li
    Partners AIDS Research Center, Brigham and Women s Hospital, Department of Medicine Microbiology and Molecular Genetics, Boston, Massachusetts 02115, USA
    Nature 426:450-4. 2003
    ..Finally, anti-ACE2 but not anti-ACE1 antibody blocked viral replication on Vero E6 cells. Together our data indicate that ACE2 is a functional receptor for SARS-CoV...
  33. ncbi request reprint Differential kinetics and specificity of EBV-specific CD4+ and CD8+ T cells during primary infection
    Melissa L Precopio
    Graduate Program in Immunology Virology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 170:2590-8. 2003
    ..Peripheral blood EBV load directly correlated with the frequency of EBV-specific CD4(+) T cell responses at presentation and over time, suggesting that EBV-specific CD4(+) T cell responses are Ag-driven...
  34. ncbi request reprint Concentrations of protease inhibitors in cord blood after in utero exposure
    Mark Mirochnick
    Boston University School of Medicine, and Statistical and Data Analysis Center Harvard School of Public Health, Boston, MA, USA
    Pediatr Infect Dis J 21:835-8. 2002
    ..To determine the concentrations of protease inhibitors in cord blood after prenatal protease inhibitor use by pregnant women...
  35. pmc Evidence for a cytopathogenicity determinant in HIV-1 Vpr
    Mohan Somasundaran
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 99:9503-8. 2002
    ..This study suggests the presence of a determinant of in vivo cytopathogenicity within HIV-1 Vpr and further indicates that viral replication can be uncoupled from cytopathicity in vitro and in vivo...

Research Grants19

  1. Quality Improvement through Electronic Enhancements
    John Sullivan; Fiscal Year: 2003
    ..abstract_text> ..
  2. EXPANSION AND CENTRALIZATION OF AQUATIC ANIMAL HOUSING
    John Sullivan; Fiscal Year: 2004
    ..The requested basic research equipment will be used by both zebrafish and Xenopus users and will significantly augment UMMS aquatic animal research. ..
  3. Quality Improvement in Human Subjects Research
    John Sullivan; Fiscal Year: 2002
    ..Acknowledging that UMMS is dedicated to expanding our capacity for human subjects protection, there is a strong institutional commitment to continue these efforts beyond this one-year IRB enhancement funding. ..
  4. IMMUNOREGULATORY DEFECTS IN HEMOPHILIA
    John Sullivan; Fiscal Year: 2001
    ..These studies should further our understanding of HIV-1 specific cell-mediated immunity and provide new information which will be useful in the development of an effective vaccine for the prevention of HIV-1 infection. ..
  5. IMMUNOREGULATORY DEFECTS IN HEMOPHILIA
    John Sullivan; Fiscal Year: 1993
    ..They will also contribute important information as to the clinical significance of the immune deficits and the effect on the immune system of alternative forms of factor replacement in classic hemophilia...
  6. UMMS Clinical and Translational Science
    John Sullivan; Fiscal Year: 2006
    ....