E Suh

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Clusterin gene transcription is activated by caudal-related homeobox genes in intestinal epithelium
    E Suh
    Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Gastrointest Liver Physiol 280:G149-56. 2001
  2. ncbi request reprint DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines
    Eun Ran Suh
    Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:35795-800. 2002
  3. ncbi request reprint Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene
    Francois Boudreau
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:31909-17. 2002
  4. pmc A novel colonic repressor element regulates intestinal gene expression by interacting with Cux/CDP
    Francois Boudreau
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Cell Biol 22:5467-78. 2002
  5. pmc The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestine
    Mary Ann S Crissey
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, 600 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 USA
    Neoplasia 10:8-19. 2008
  6. ncbi request reprint The role of Cdx proteins in intestinal development and cancer
    Rong Jun Guo
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Biol Ther 3:593-601. 2004
  7. ncbi request reprint Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia
    Francois Boudreau
    Département d Anatomie et de Biologie Cellulaire, Faculte de Medecine et des Sciences de la Sante, 3001 12e Ave Nord, Fleurimont, QC, Canada, J1H 5N4
    FASEB J 21:3853-65. 2007

Collaborators

  • Z Wang
  • Minoru Toyota
  • P G Traber
  • Hong Li
  • John P Lynch
  • F Fogt
  • Debra Silberg
  • Francois Boudreau
  • Rong Jun Guo
  • Mary Ann S Crissey
  • Edmond H H M Rings
  • Gary P Swain
  • Jonathan P Katz
  • Nathalie Rivard
  • Sébastien Mongrain
  • Julie L Drouin
  • Carine R Lussier
  • Mathieu Darsigny
  • Geneviève Doyon
  • Nathalie Perreault
  • Jean Francois Beaulieu
  • Stephen D Krasinski
  • Richard K Kim
  • Richard J Grand
  • Jennifer Moffett
  • Herbert M van Wering
  • Angus M Sinclair
  • Richard H Scheuermann

Detail Information

Publications7

  1. ncbi request reprint Clusterin gene transcription is activated by caudal-related homeobox genes in intestinal epithelium
    E Suh
    Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Gastrointest Liver Physiol 280:G149-56. 2001
    ..Together, these data suggest that clusterin is a direct target gene for Cdx homeobox proteins, and the pattern of clusterin protein expression suggests that it is associated with the differentiated state in the intestinal epithelium...
  2. ncbi request reprint DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines
    Eun Ran Suh
    Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:35795-800. 2002
    ..These results indicate that aberrant methylation of the CpG island in the CDX1 promoter is one of the mechanisms that mediate CDX1 down-regulation in colorectal cancer cell lines...
  3. ncbi request reprint Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene
    Francois Boudreau
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:31909-17. 2002
    ..These findings imply a combinatory role of HNF-1 alpha, Cdx2, and GATA-4 for the time- and position-dependent regulation of SI transcription during development...
  4. pmc A novel colonic repressor element regulates intestinal gene expression by interacting with Cux/CDP
    Francois Boudreau
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Cell Biol 22:5467-78. 2002
    ..Our results demonstrate that an intestinal gene can be repressed in the distal gut and identify Cux/CDP as a regulator of this repression during development...
  5. pmc The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestine
    Mary Ann S Crissey
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, 600 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 USA
    Neoplasia 10:8-19. 2008
    ..Our results therefore suggest that Cdx1 is not an oncogene in normal intestinal epithelium...
  6. ncbi request reprint The role of Cdx proteins in intestinal development and cancer
    Rong Jun Guo
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Biol Ther 3:593-601. 2004
    ..This review will explore our current understanding of the roles of the caudal homologues Cdx1 and Cdx2 in intestinal development and carcinogenesis...
  7. ncbi request reprint Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia
    Francois Boudreau
    Département d Anatomie et de Biologie Cellulaire, Faculte de Medecine et des Sciences de la Sante, 3001 12e Ave Nord, Fleurimont, QC, Canada, J1H 5N4
    FASEB J 21:3853-65. 2007
    ....

Research Grants8

  1. REGULATION OF CDX GENE EXPRESSION IN COLON CANCER
    Eunran Suh; Fiscal Year: 1999
    ..This will provide the basis for understanding the network of cellular pathways that control these important cell specific transcription factors and how they are altered in neoplasia. ..
  2. REGULATION OF CDX GENE EXPRESSION IN COLON CANCER
    Eunran Suh; Fiscal Year: 2000
    ..This will provide the basis for understanding the network of cellular pathways that control these important cell specific transcription factors and how they are altered in neoplasia. ..
  3. REGULATION OF CDX GENE EXPRESSION IN COLON CANCER
    Eunran Suh; Fiscal Year: 2001
    ..This will provide the basis for understanding the network of cellular pathways that control these important cell specific transcription factors and how they are altered in neoplasia. ..
  4. REGULATION OF CDX GENE EXPRESSION IN COLON CANCER
    Eunran Suh; Fiscal Year: 2002
    ..This will provide the basis for understanding the network of cellular pathways that control these important cell specific transcription factors and how they are altered in neoplasia. ..
  5. REGULATION OF INTESTINE-SPECIFIC GENE TRANSCRIPTION
    Eunran Suh; Fiscal Year: 2003
    ..abstract_text> ..
  6. REGULATION OF INTESTINE-SPECIFIC GENE TRANSCRIPTION
    Eunran Suh; Fiscal Year: 2004
    ..abstract_text> ..
  7. REGULATION OF INTESTINE-SPECIFIC GENE TRANSCRIPTION
    Eunran Suh; Fiscal Year: 2005
    ..abstract_text> ..
  8. REGULATION OF INTESTINE-SPECIFIC GENE TRANSCRIPTION
    Eunran Suh; Fiscal Year: 2006
    ..abstract_text> ..