Thomas C Sudhof

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Synaptotagmins: why so many?
    Thomas C Sudhof
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 277:7629-32. 2002
  2. ncbi request reprint C-terminal ECFP fusion impairs synaptotagmin 1 function: crowding out synaptotagmin 1
    Weiping Han
    Center for Basic Neuroscience, The Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 280:5089-100. 2005
  3. pmc Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior
    Jacqueline Blundell
    Departments of Neurology and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390 8813, USA
    J Neurosci 30:2115-29. 2010
  4. ncbi request reprint A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins
    Antony A Boucard
    Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard NA4 118, Dallas, Texas 75390, USA
    Neuron 48:229-36. 2005
  5. ncbi request reprint Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family
    Angela Ho
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 26:13089-101. 2006
  6. ncbi request reprint Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation
    Xinwei Cao
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 279:24601-11. 2004
  7. pmc Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming
    Ferenc Deak
    Howard Hughes Medical Institute, Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 184:751-64. 2009
  8. pmc Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease
    Angela Ho
    Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 28:14392-400. 2008
  9. pmc RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning
    Pascal S Kaeser
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:14680-5. 2008
  10. pmc Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins
    Irina Dulubova
    Department of Biochemistry, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas 75390, USA
    Proc Natl Acad Sci U S A 100:32-7. 2003

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Synaptotagmins: why so many?
    Thomas C Sudhof
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 277:7629-32. 2002
  2. ncbi request reprint C-terminal ECFP fusion impairs synaptotagmin 1 function: crowding out synaptotagmin 1
    Weiping Han
    Center for Basic Neuroscience, The Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 280:5089-100. 2005
    ..In addition, the data demonstrate that synaptotagmin 1 function requires a free C terminus, possibly because of spatial constraints at the release sites...
  3. pmc Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior
    Jacqueline Blundell
    Departments of Neurology and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390 8813, USA
    J Neurosci 30:2115-29. 2010
    ....
  4. ncbi request reprint A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins
    Antony A Boucard
    Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard NA4 118, Dallas, Texas 75390, USA
    Neuron 48:229-36. 2005
    ....
  5. ncbi request reprint Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family
    Angela Ho
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 26:13089-101. 2006
    ..Our studies thus indicate that Mints are important regulators of presynaptic neurotransmitter release that are essential for mouse survival...
  6. ncbi request reprint Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation
    Xinwei Cao
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 279:24601-11. 2004
    ..Our data suggest that transcriptional transactivation by APP and Notch may involve distinct mechanisms; whereas the Notch intracellular domain directly functions in the nucleus, the AICD acts indirectly by activating Fe65...
  7. pmc Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming
    Ferenc Deak
    Howard Hughes Medical Institute, Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 184:751-64. 2009
    ....
  8. pmc Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease
    Angela Ho
    Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 28:14392-400. 2008
    ..These results suggest that the three Mint/X11 proteins regulate Abeta production by a novel mechanism that may have implications for therapeutic approaches to altering APP cleavage in Alzheimer's disease...
  9. pmc RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning
    Pascal S Kaeser
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:14680-5. 2008
    ....
  10. pmc Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins
    Irina Dulubova
    Department of Biochemistry, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas 75390, USA
    Proc Natl Acad Sci U S A 100:32-7. 2003
    ....
  11. ncbi request reprint N-glycosylation is essential for vesicular targeting of synaptotagmin 1
    Weiping Han
    Center for Basic Neuroscience, Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Neuron 41:85-99. 2004
    ..Our data suggest that the intravesicular N-glycosylation site of synaptotagmin 1 collaborates with its cytoplasmic C(2) domains in directing synaptotagmin 1 to synaptic vesicles via a novel N-glycosylation-dependent mechanism...
  12. pmc Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2
    Alexander A Chubykin
    Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Neuron 54:919-31. 2007
    ..This hypothesis reconciles the overexpression and knockout phenotypes and suggests that neuroligins contribute to the use-dependent formation of neural circuits...
  13. pmc Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis
    Ok Ho Shin
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Struct Mol Biol 17:280-8. 2010
    ....
  14. pmc SV2 renders primed synaptic vesicles competent for Ca2+ -induced exocytosis
    Wen Pin Chang
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 29:883-97. 2009
    ..Viewed together, these observations suggest that SV2 functions in a maturation step of primed vesicles that converts the vesicles into a Ca(2+)- and synaptotagmin-responsive state...
  15. ncbi request reprint Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4
    Han Dai
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nat Struct Mol Biol 11:844-9. 2004
    ....
  16. pmc Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution
    Rong Guan
    Department of Biochemistry, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Biochemistry 46:8988-98. 2007
    ..Our results provide a structural basis to understand the function of RIM C2B domains and suggest that dimerization may be a crucial aspect of RIM function...
  17. ncbi request reprint Structural determinants of synaptobrevin 2 function in synaptic vesicle fusion
    Ferenc Deak
    Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 26:6668-76. 2006
    ..Furthermore, the fusion reactions underlying evoked and spontaneous release differ mechanistically...
  18. pmc Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro
    Jacqueline Burré
    Department of Molecular and Cellular Physiology, and Howard Hughes Medical Institute, Stanford University, 1050 Arastradero Road, Palo Alto, CA 94304 5543, USA
    Science 329:1663-7. 2010
    ..Thus, synucleins may function to sustain normal SNARE-complex assembly in a presynaptic terminal during aging...
  19. ncbi request reprint Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmission
    Peter Bronk
    Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurophysiol 98:794-806. 2007
    ..Together, these results suggest that SNAP-25 has a more significant role in calcium-secretion coupling than synaptobrevin-2...
  20. ncbi request reprint A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
    Jiong Tang
    The Center for Basic Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 126:1175-87. 2006
    ....
  21. ncbi request reprint Synaptotagmin function in dense core vesicle exocytosis studied in cracked PC12 cells
    Ok Ho Shin
    Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, Texas 75390, USA
    Nat Neurosci 5:649-56. 2002
    ....
  22. pmc Conformational switch of syntaxin-1 controls synaptic vesicle fusion
    Stefan H Gerber
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Science 321:1507-10. 2008
    ..Thus, the closed conformation of syntaxin-1 gates the initiation of the synaptic vesicle fusion reaction, which is then mediated by SNARE-complex/Munc18-1 assemblies...
  23. pmc Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion
    Ferenc Deak
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    EMBO J 25:2856-66. 2006
    ....
  24. pmc RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions
    Pascal S Kaeser
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 28:13435-47. 2008
    ..Thus, our data indicate that the RIM1 gene encodes two different isoforms that perform overlapping but distinct functions in neurotransmitter release...
  25. ncbi request reprint Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions
    Ok Ho Shin
    Center for Basic Neuroscience, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 37:99-108. 2003
    ..Thus, triggering of the fast component of release by Sr(2+) as a Ca(2+) agonist involves the formation of synaptotagmin/phospholipid complexes, but does not require stimulated SNARE binding...
  26. pmc A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice
    Katsuhiko Tabuchi
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 318:71-6. 2007
    ..These data suggest that increased inhibitory synaptic transmission may contribute to human ASDs and that the R451C knockin mice may be a useful model for studying autism-related behaviors...
  27. ncbi request reprint A conformational switch in the Piccolo C2A domain regulated by alternative splicing
    Jesus Garcia
    Department of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nat Struct Mol Biol 11:45-53. 2004
    ..These results reveal a novel mechanism of action of C2 domains and uncover a structural principle that may underlie the alteration of protein function by short alternatively spliced sequences...
  28. ncbi request reprint Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide
    Jun Lu
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    J Mol Biol 352:455-66. 2005
    ..This groove is formed, in part, by a set of side-chains that is conserved selectively in RIM PDZ domains and that hence determines, at least in part, their unique specificity...
  29. ncbi request reprint Solution structure of the Vam7p PX domain
    Jun Lu
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Biochemistry 41:5956-62. 2002
    ....
  30. ncbi request reprint Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport
    Mikhail Khvotchev
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 279:47101-8. 2004
    ..Our data suggest that, different from Notch, cleavage of APP is independent of cell surface regulation by extracellular ligands but may be controlled by intracellular signaling...
  31. pmc RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia
    Jacqueline Blundell
    Departments of Neurology and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390 8813, USA
    J Neurosci 30:5326-33. 2010
    ....
  32. pmc Complexin controls the force transfer from SNARE complexes to membranes in fusion
    Anton Maximov
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 323:516-21. 2009
    ..Thus, complexin probably activates and clamps the force transfer from assembled trans-SNARE complexes onto fusing membranes...
  33. ncbi request reprint Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein
    Irina Dulubova
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA Irina Dulubova UTSouthwestern edu
    Biochemistry 43:9583-8. 2004
    ..The identification of this domain and the availability of its atomic structure will facilitate analysis of APP function and of the role of the extracellular region in the regulation of APP cleavage...
  34. pmc A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
    Irina Dulubova
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8816, USA
    EMBO J 24:2839-50. 2005
    ..The modular architecture of alpha-RIMs, with nested binding sites for Rab3 and other targets, may be a general feature of Rab effectors that share homology with the alpha-RIM N-terminal sequence...
  35. ncbi request reprint Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism
    Alexander A Chubykin
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390 9111, USA
    J Biol Chem 280:22365-74. 2005
    ....
  36. ncbi request reprint Structure/function analysis of Ca2+ binding to the C2A domain of synaptotagmin 1
    Rafael Fernandez-Chacon
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 22:8438-46. 2002
    ..Our data also demonstrate that subtle changes in the biochemical properties of synaptotagmin 1 can result in significant alterations in synaptic responses...
  37. pmc Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release
    Zhiping P Pang
    Department of Molecular Genetics, Center for Basic Neuroscience, Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX 75390 9111, USA
    EMBO J 25:2039-50. 2006
    ....
  38. ncbi request reprint Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties
    Ok Ho Shin
    Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 280:1641-51. 2005
    ....
  39. ncbi request reprint Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1
    Qiming Li
    Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 279:10542-50. 2004
    ..Our data demonstrate that APLPs and APP are processed similarly to act via the same nuclear target, suggesting that BACE 1 cleavage regulates a common function of APP and APLPs in neurons...
  40. ncbi request reprint Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids
    Demet Arac
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nat Struct Mol Biol 13:209-17. 2006
    ..We propose a model wherein synaptotagmin cooperates with the SNAREs in bringing the synaptic vesicle and plasma membranes together and accelerates membrane fusion through the highly positive electrostatic potential of its C(2)B domain...
  41. ncbi request reprint Are neuronal SNARE proteins Ca2+ sensors?
    Xiaocheng Chen
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Mol Biol 347:145-58. 2005
    ..These results suggest that the SNAREs do not act directly as Ca2+ receptors but SNARE complex assembly is coupled tightly to Ca2+-sensing during neurotransmitter release...
  42. pmc Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis
    Anton Maximov
    Departments of Neuroscience, Molecular Genetics, Pharmacology, and Biochemistry and Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 105:3986-91. 2008
    ....
  43. pmc A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones
    Yun Wang
    The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 99:14464-9. 2002
    ....
  44. pmc Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch
    Jun Lu
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    PLoS Biol 4:e192. 2006
    ....
  45. pmc Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release
    Anton Maximov
    Center for Basic Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 176:113-24. 2007
    ..Our data suggest that spontaneous synaptic-vesicle exocytosis is selectively modulated by a Ca(2+)-independent synaptotagmin isoform, synaptotagmin-12, which is controlled by cAMP-dependent phosphorylation...
  46. pmc How Tlg2p/syntaxin 16 'snares' Vps45
    Irina Dulubova
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    EMBO J 21:3620-31. 2002
    ..Thus, this mechanism represents the most widespread mode of coupling between syntaxins and SM proteins...
  47. ncbi request reprint Selective capability of SynCAM and neuroligin for functional synapse assembly
    Yildirim Sara
    Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 25:260-70. 2005
    ..These results suggest that both NL1 and SynCAM act similarly and specifically in artificial synapse induction but that this process does not reflect a shared physiological function of these molecules...
  48. ncbi request reprint Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis
    Markus Missler
    Center for Basic Neuroscience, Department of Molecular Genetics, Dallas, Texas 75390 9111, USA
    Nature 423:939-48. 2003
    ..These data suggest that alpha-neurexins organize presynaptic terminals by functionally coupling Ca2+ channels to the presynaptic machinery...
  49. pmc Alpha-latrotoxin stimulates a novel pathway of Ca2+-dependent synaptic exocytosis independent of the classical synaptic fusion machinery
    Ferenc Deak
    Department of Neuroscience and Molecular Genetics and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 29:8639-48. 2009
    ....
  50. ncbi request reprint A complete genetic analysis of neuronal Rab3 function
    Oliver M Schlüter
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 24:6629-37. 2004
    ..Furthermore, our data demonstrate that Rab3 is not in itself essential for synaptic membrane traffic but functions to modulate the basic release machinery...
  51. pmc Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration
    Katsuhiko Tabuchi
    Department of Molecular and Cellular Physiology, and Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, California 94304 5543, USA
    J Neurosci 29:7290-301. 2009
    ....
  52. ncbi request reprint Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation
    Anton Maximov
    Center for Basic Neuroscience, Department of Molecular Genetics, 6000 Harry Hines Blvd Dallas, TX 75390 9111, USA
    J Neurosci Methods 161:75-87. 2007
    ..The preparation described in this paper should be useful for analysis of synaptic transmission in inter-neuronal synapses formed by different types of neurons...
  53. ncbi request reprint Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration
    Sreeganga Chandra
    Center for Basic Neuroscience, Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell 123:383-96. 2005
    ....
  54. ncbi request reprint Snares and Munc18 in synaptic vesicle fusion
    Josep Rizo
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nat Rev Neurosci 3:641-53. 2002
  55. pmc E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains
    Sang Won Min
    Department of Neuroscience and Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 104:3823-8. 2007
    ....
  56. ncbi request reprint Evidence for SNARE zippering during Ca2+-triggered exocytosis in PC12 cells
    Maria F Matos
    Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Neuropharmacology 45:777-86. 2003
    ....
  57. pmc Unexpected Ca2+-binding properties of synaptotagmin 9
    Ok Ho Shin
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 101:2554-9. 2004
    ..Nevertheless, the C2A domain of Syt 9 functions as a Ca2+-binding module, suggesting that Syts 1 and 9 are Ca2+ sensors with similar Ca2+-binding sequences but distinct properties that indicate nonoverlapping functions...
  58. pmc Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release
    Ok Ho Shin
    Departments of Neuroscience, Molecular Genetics, Biochemistry, and Pharmacology, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 106:16469-74. 2009
    ....
  59. ncbi request reprint Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses
    Zhiping P Pang
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 26:13493-504. 2006
    ..Thus, synaptotagmin-2 is an essential synaptotagmin isoform that functions in concert with other synaptotagmins in the Ca2+ triggering of neurotransmitter release...
  60. pmc Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling
    Tuhin Virmani
    Center for Basic Neuroscience, Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    EMBO J 22:5347-57. 2003
    ..These results suggest that alternative splicing of synaptotagmin 7 acts as a molecular switch, which targets vesicles to fast and slow recycling pathways...
  61. ncbi request reprint Crystal structure of the RIM2 C2A-domain at 1.4 A resolution
    Han Dai
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Biochemistry 44:13533-42. 2005
    ....
  62. pmc Unusually rapid evolution of Neuroligin-4 in mice
    Marc F Bolliger
    Departments of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:6421-6. 2008
    ....
  63. ncbi request reprint A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis
    Zhiping P Pang
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 26:12556-65. 2006
    ..These data establish that fast vesicle exocytosis is driven by a dual Ca2+-dependent activity of synaptotagmin-1, namely Ca2+-dependent binding both to SNARE complexes and to phospholipids...
  64. pmc Deletion of CASK in mice is lethal and impairs synaptic function
    Deniz Atasoy
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 104:2525-30. 2007
    ....
  65. pmc A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
    Jianyuan Sun
    Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 450:676-82. 2007
    ..We propose a dual-Ca2+-sensor model of release that quantitatively describes the contributions of synchronous and asynchronous release under conditions of different presynaptic Ca2+ dynamics...
  66. pmc Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons
    Jay R Gibson
    Department of Neuroscience and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Neurosci 29:13883-97. 2009
    ..Thus, NL2 is not necessary for establishing unitary inhibitory synaptic connections but is selectively required for "scaling up" unitary connections originating from a subset of interneurons...
  67. doi request reprint Proteasome inhibition alleviates SNARE-dependent neurodegeneration
    Manu Sharma
    Department of Molecular and Cellular Physiology, and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305 5453, USA
    Sci Transl Med 4:147ra113. 2012
    ....
  68. pmc CASK Functions as a Mg2+-independent neurexin kinase
    Konark Mukherjee
    Department of Neuroscience, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9111, USA
    Cell 133:328-39. 2008
    ..Moreover, our study suggests that other pseudokinases (10% of the kinome) could also be catalytically active...
  69. ncbi request reprint Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release
    Anton Maximov
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Neuron 48:547-54. 2005
    ..We propose that synaptotagmin 1 occupies release "slots" at the active zone, possibly in a Ca(2+)-independent complex with SNARE proteins that are freed when action potential-induced Ca(2+) influx activates synaptotagmin 1...
  70. ncbi request reprint The presynaptic active zone protein RIM1alpha is critical for normal learning and memory
    Craig M Powell
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 42:143-53. 2004
    ....