Affiliation: University of Southern California
Shen H, Cavallero S, Estrada K, Sandovici I, Kumar S, Makita T, et al
. Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion. Cardiovasc Res. 2015;105:271-8 pubmed publisher
..Each involves instructive cues that originate outside the heart and thereby act on the epicardium in an endocrine manner, a mode of regulation that is mostly unknown in embryogenesis. ..
Yamaguchi Y, Cavallero S, Patterson M, Shen H, Xu J, Kumar S, et al
. Adipogenesis and epicardial adipose tissue: a novel fate of the epicardium induced by mesenchymal transformation and PPARÎ³ activation. Proc Natl Acad Sci U S A. 2015;112:2070-5 pubmed publisher
..Human embryonic ventricular epicardial cells natively express PPARÎ³, which explains the abundant presence of fat seen in human hearts at birth and throughout life. ..
Ma M, Li P, Shen H, Estrada K, Xu J, Kumar S, et al
. Dysregulated endocardial TGFÎ² signaling and mesenchymal transformation result in heart outflow tract septation failure. Dev Biol. 2016;409:272-276 pubmed publisher
Wang J, Nagy A, Larsson J, Dudas M, Sucov H, Kaartinen V. Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. BMC Dev Biol. 2006;6:51 pubmed
..Our results demonstrate that ALK5-mediated signaling in neural crest cells plays an essential cell-autonomous role in the pharyngeal and cardiac outflow tract development. ..
Chen Y, Ishii M, Sucov H, Maxson R. Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium. BMC Dev Biol. 2008;8:75 pubmed publisher
..Our findings demonstrate redundant roles of Msx1 and Msx2 in regulating signals required for development of the AV myocardium and formation of the AV valves. ..
Cavallero S, Shen H, Yi C, Lien C, Kumar S, Sucov H. CXCL12 Signaling Is Essential for Maturation of the Ventricular Coronary Endothelial Plexus and Establishment of Functional Coronary Circulation. Dev Cell. 2015;33:469-77 pubmed publisher
..Failed maturation of the coronary system explains the late-gestation lethality of these mutants. ..