Research Topics
Genomes and GenesSpecies | M A SuckowSummaryAffiliation: University of Notre Dame Country: USA Publications
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Publications
Bupivacaine-enhanced small intestinal submucosa biomaterial as a hernia repair deviceMark A Suckow
Freimann Life Science Center, University of Notre Dame, Notre Dame, IN 46556, USA
J Biomater Appl 27:231-7. 2012..In summary, bupivacaine is readily elaborated from SIS-B; and impregnation of SIS with bupivacaine does not substantially alter the biocompatibility of the biomaterial or its mechanical strength following implantation...
Prevention of human PC-346C prostate cancer growth in mice by a xenogeneic tissue vaccineMark A Suckow
Freimann Life Science Center, University of Notre Dame, Notre Dame, IN 46556, USA
Cancer Immunol Immunother 56:1275-83. 2007..In summary, the results suggest that use of a xenogeneic tissue vaccine can stimulate protective immunity against human prostate cancer cells...- Repair of experimental Achilles tenotomy with porcine renal capsule material in a rat modelM A Suckow
University of Notre Dame, 400 Freimann Life Science Center, Notre Dame, IN 46556, USA
J Mater Sci Mater Med 18:1105-10. 2007..The results show that RCM is equivalent to SIS as a material for repair of Achilles tendon injury and merits further study in other tendon injury models... 
Field trial of a Pasteurella multocida extract vaccine in rabbitsMark A Suckow
Laboratory Animal Program, Purdue University, West Lafayette, IN, USA
J Am Assoc Lab Anim Sci 47:18-21. 2008..In summary, PTE can be used to stimulate protective immunity to a heterologous strain of P. multocida, with stronger immunity generated by SC than IN vaccination...- Tissue vaccines for cancerMark A Suckow
University of Notre Dame, Freimann Life Science Center, Notre Dame, IN, USA
Expert Rev Vaccines 6:925-37. 2007..For these reasons, the idea that tissue vaccines for cancer have potentially great utility has merit and should be explored further... - Immunization with a tissue vaccine enhances the effect of irradiation on prostate tumorsMark A Suckow
Freimann Life Science Center, University of Notre Dame, Notre Dame, IN 46556, USA
In Vivo 22:171-7. 2008..Immunization with a tissue vaccine prior to radiation treatment enhances the therapeutic effect of radiation... - Inhibition of prostate cancer metastasis by administration of a tissue vaccineMark A Suckow
Freimann Life Science Center, University of Notre Dame, Notre Dame, IN 46530, USA
Clin Exp Metastasis 25:913-8. 2008..These results suggest that tissue vaccines may be useful for the treatment of prostate cancer... - Use of an extracellular matrix material as a vaccine carrier and adjuvantMark A Suckow
Freimann Life Science Center, University of Notre Dame, Notre Dame, IN 46556, USA
Anticancer Res 28:2529-34. 2008.... - PAIII prostate tumors express prostate specific antigen (PSA) in Lobund-Wistar ratsMark A Suckow
Freimann Life Science Center, University of Notre Dame, Notre Dame, Indiana 46556, USA
Can J Vet Res 73:39-41. 2009..All 5 PAIII tumors demonstrated labeling for PSA, supporting a prostatic origin for the PAIII cell line... - Addition of nimesulide to small intestinal submucosa biomaterial inhibits postsurgical adhesiogenesis in ratsMark A Suckow
Freimann Life Science Center, University of Notre Dame, Notre Dame, IN 46556, USA
J Biomed Mater Res B Appl Biomater 93:18-23. 2010..In conclusion, addition of the nonsteroidal anti-inflammatory, COX-2 selective drug, NM, to SIS attenuates adhesion extent and tenacity when compared with surgical placement of SIS or PPM alone... - Tissue distribution of fetal liver cells following in utero transplantation in miceMark A Suckow
W M Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA
Exp Biol Med (Maywood) 230:860-4. 2005..In summary, the possibility that cells administered in utero may inadvertently colonize nontarget tissues suggests that clinical application of this method will need to be approached with diligence... - The anti-ischemia agent ranolazine promotes the development of intestinal tumors in APC(Min/+) miceMark A Suckow
Walther Cancer Center, 400 Freimann Life Science Center, University of Notre Dame, Notre Dame, IN 46556, USA
Cancer Lett 209:165-9. 2004..Tumors from drug-treated mice were also more dysplastic and invasive than those from untreated mice. These findings have implications for the use of ranolazine in patients with a history of malignant neoplasms or adenomatous polyps... - Susceptibility of Lobund-Wistar x Copenhagen hybrid rats to autochthonous prostate carcinogenesisMark A Suckow
Lobund Laboratory, University of Notre Dame, Notre Dame, IN 46556, USA
Prostate 64:203-8. 2005..Transplantation of the Dunning R-3327 prostate tumor cell line is a common model of prostate cancer, though the rat strain (Copenhagen) from which the cell line was derived is resistant to spontaneous and chemically induced prostate cancer... - Prevention of de novo prostate cancer by immunization with tumor-derived vaccinesMark A Suckow
Lobund Institute, University of Notre Dame, 400 Freimann Life Science Center, Notre Dame, IN, 46556, USA
Cancer Immunol Immunother 54:571-6. 2005..These results demonstrate the possibility that prostate cancer can be prevented by immunization with vaccines based on whole tumor-derived vaccines... - Induction of protective immunity in rabbits by coadministration of inactivated Pasteurella multocida toxin and potassium thiocyanate extractL Z Jarvinen
Veterinary Pathobiology, Purdue University, West Lafayette, Indiana 47907, USA
Infect Immun 66:3788-95. 1998..Rabbits in the control groups had moderate to severe liver and lung infections. This study indicates that i.n. immunization with both PMT and CN induces an effective response against homologous P. multocida challenge... - Use of porcine renal capsule matrix as a full-thickness dermal wound-healing material in ratsM A Suckow
I Freimann Life Science Center, University of Notre Dame, Notre Dame, Indiana, USA
J Wound Care 14:137-40. 2005..To compare the utility of porcine renal capsule matrix (RCM) with porcine small intestinal mucosa (SIS) in a rat full-thickness skin wound model... - Small intestinal submucosa does not promote PAIII tumor growth in Lobund-Wistar ratsJason P Hodde
Cook Biotech Incorporated, 3055 Kent Avenue, West Lafayette, Indiana, USA
J Surg Res 120:189-94. 2004..The effect of SIS on the ability of neoplastic (prostate adenocarcinoma) cells to establish, grow, and metastasize was examined in Lobund-Wistar (L-W) rats... - Dietary prevention of hormone refractory prostate cancer in Lobund-Wistar rats: a review of studies in a relevant animal modelMorris Pollard
Lobund Institute, University of Notre Dame, Notre Dame, Indiana, USA
Comp Med 56:461-7. 2006..The accumulated data indicate that soy-based diets are effective in the prevention of prostate cancer... - Immunization of rabbits against a bacterial pathogen with an alginate microparticle vaccineMark A Suckow
400 Freimann Life Science Center, University of Notre Dame, Notre Dame, IN 46556, USA
J Control Release 85:227-35. 2002..multocida recovered from the lungs and nasopharynx following an intranasal challenge. These results demonstrate that PTE incorporated into alginate microparticles and administered orally is immunogenic and confers protective immunity... - Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burdenHector Guillen-Ahlers
W M Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, United States of America
PLoS ONE 5:e9070. 2010..Fas, a member of the tumor necrosis family, is responsible for initiating the apoptotic pathway when bound to its ligand, Fas-L. Defects in the Fas-mediated apoptotic pathway have been reported in colorectal cancer... - Synthesis and evaluation of 5-lipoxygenase translocation inhibitors from acylnitroso hetero-Diels-Alder cycloadductsJoshua K Bolger
Department of Chemistry and Biochemistry, 251 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556, USA
Org Biomol Chem 9:2999-3010. 2011..Additionally, the lead compound was tested in vivo in an established colon cancer model and showed very encouraging anti-tumorogenic properties... - Hormone-refractory prostate cancer in the Lobund-Wistar ratMorris Pollard
Lobund Institute, University of Notre Dame, Notre Dame, IN 46556, USA
Exp Biol Med (Maywood) 230:520-6. 2005..Both spontaneous and chemically induced autochthonous HRPC model systems serve as outstanding models for studies on the prevention and therapy of refractory cancer... - Vaccination against prostate cancer using a live tissue factor deficient cell line in Lobund-Wistar ratsJulie E Heinrich
University of Notre Dame Biological Sciences, Notre Dame, IN, USA
Cancer Immunol Immunother 56:725-30. 2007..These results offer the intriguing possibility that the TFD PAIII vaccine is an effective system for the prevention and, possibly, the treatment of prostate cancer... - Cathepsin E is a specific marker of dysplasia in APC mouse intestineLizette Busquets
Walther Cancer Center, Notre Dame, IN 46556, USA
Tumour Biol 27:36-42. 2006..These results authenticate the relationship between transcript abundance and protein levels in transformed tissue and suggest potential utility for catE as a marker for the inception and progression of intestinal cancers... - The characterization of mice with a targeted combined deficiency of protein c and factor XIJ C Chan
Department of Chemistry and Biochemistry, W M Keck Center for Transgene Research, and the Freimann Life Science Center, University of Notre Dame, Notre Dame, Indiana 46556, USA
Am J Pathol 158:469-79. 2001.... - Optical imaging of mammary and prostate tumors in living animals using a synthetic near infrared zinc(II)-dipicolylamine probe for anionic cell surfacesBryan A Smith
Department of Chemistry and Biochemistry, 251 Nieuwland Science Hall, University of Notre Dame, Notre Dame, Indiana 46556, USA
J Am Chem Soc 132:67-9. 2010.... - A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic dispositionMijoon Lee
Department of Chemistry and Biochemistry and Walther Cancer Research Center, University of Notre Dame, Notre Dame, IN 46556, USA
Chem Biol Drug Des 73:189-202. 2009..The metabolism of compound 2 involved hydroxylation at the alpha-methylene, which generates sulfinic acid, thiirane ring-opening, followed by methylation and oxidation, and cysteine conjugation of both the thiirane and phenyl rings... - Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ miceHector Guillen-Ahlers
W M Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA
Carcinogenesis 29:1421-7. 2008.... - Sebaceous adenocarcinoma of the external auditory canal in a New Zealand white rabbitM A Suckow
Freimann Life Science Center, University of Notre Dame, Notre Dame, IN 46556, USA
J Comp Pathol 127:301-3. 2002..A single pulmonary mass had similar histological characteristics. This is the first such tumour reported in a rabbit... - ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivoVandhana Muralidharan-Chari
Department of Biological Sciences, Freimann Life Science Center, and W M Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, USA
Cancer Res 69:2201-9. 2009..These findings document an intricate role for ARF6 and the regulation of ERK activation in orchestrating mechanisms underlying melanoma growth, invasion, and metastases... - Metabolism of (4-phenoxyphenylsulfonyl) methylthiirane, a selective gelatinase inhibitorGiuseppe Celenza
Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
Chem Biol Drug Des 71:187-96. 2008..The cysteine adducts arose through addition of glutathione to the thiirane ring. The molecule is extensively metabolized and.. - Use of mucosal immunization with porcine zona pellucida (PZP) in mice and rabbitsBrent J Martin
Division of Laboratory Animal Medicine, Medical University of Ohio, 3055 Arlington Avenue, Toledo, OH 43614, USA
Anim Reprod Sci 93:372-8. 2006..05). The study shows that porcine zona pellucida is not an effective mucosal antigen in small mammals...