Subbaya Subramanian

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach
    Milcah C Scott
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 5545, USA
    Bone 49:356-67. 2011
  2. pmc MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma
    Aaron L Sarver
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Orphanet J Rare Dis 8:7. 2013
  3. doi request reprint MicroRNA-mediated gene regulations in human sarcomas
    Subbaya Subramanian
    Department of Surgery, University of Minnesota, 11 212 Moos Tower Mail Code MMC 195, 515 Delaware St, S E, Minneapolis, MN, 55455, USA
    Cell Mol Life Sci 69:3571-85. 2012
  4. doi request reprint MicroRNAs as gatekeepers of apoptosis
    Subbaya Subramanian
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cell Physiol 223:289-98. 2010
  5. doi request reprint Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours
    Subbaya Subramanian
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA
    J Pathol 220:58-70. 2010
  6. pmc Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma
    Venugopal Thayanithy
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, USA
    Bone 50:171-81. 2012
  7. pmc Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states
    Aaron L Sarver
    Biostatistics and Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    BMC Cancer 9:401. 2009
  8. pmc Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines
    Venugopal Thayanithy
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 7:e43720. 2012
  9. pmc Dose-dependent differential mRNA target selection and regulation by let-7a-7f and miR-17-92 cluster microRNAs
    Jingmin Shu
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    RNA Biol 9:1275-87. 2012
  10. doi request reprint S-MED: sarcoma microRNA expression database
    Aaron L Sarver
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
    Lab Invest 90:753-61. 2010

Collaborators

Detail Information

Publications19

  1. pmc Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach
    Milcah C Scott
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 5545, USA
    Bone 49:356-67. 2011
    ..This in turn may enhance prognosis and prediction, and identify relevant therapeutic targets...
  2. pmc MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma
    Aaron L Sarver
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Orphanet J Rare Dis 8:7. 2013
    ..We showed previously that clusters of miRNAs at the 14q32 locus are downregulated in human osteosarcoma...
  3. doi request reprint MicroRNA-mediated gene regulations in human sarcomas
    Subbaya Subramanian
    Department of Surgery, University of Minnesota, 11 212 Moos Tower Mail Code MMC 195, 515 Delaware St, S E, Minneapolis, MN, 55455, USA
    Cell Mol Life Sci 69:3571-85. 2012
    ..In this review, we will discuss the current knowledge of miRNA-gene regulatory networks in various sarcoma types and give a perspective of the complex multilayer miRNA-mediated gene regulation in sarcomas...
  4. doi request reprint MicroRNAs as gatekeepers of apoptosis
    Subbaya Subramanian
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cell Physiol 223:289-98. 2010
    ..Many of these apoptotic genes, irrespective of their positive or negative functional role in apoptosis, are regulated by miRNAs. In this review, we discuss the emerging role of miRNA-mediated gene networks in the control of apoptosis...
  5. doi request reprint Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours
    Subbaya Subramanian
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA
    J Pathol 220:58-70. 2010
    ..Collectively, our findings suggest that deregulation of miRNAs has a potential role in the malignant transformation process in peripheral nerve sheath tumours...
  6. pmc Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma
    Venugopal Thayanithy
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, USA
    Bone 50:171-81. 2012
    ..Together, our data support a model where the deregulation of a network involving 14q32 miRNAs, cMYC and miR-17-92 miRNAs could contribute to osteosarcoma pathogenesis...
  7. pmc Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states
    Aaron L Sarver
    Biostatistics and Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    BMC Cancer 9:401. 2009
    ..Differential miRNA expression in cancer versus normal tissue is a common event and may be pivotal for tumor onset and progression...
  8. pmc Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines
    Venugopal Thayanithy
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 7:e43720. 2012
    ..These results suggested that the combination of these chromatin-modifying drugs may be a useful adjuvant in the treatment of rapidly progressive OS...
  9. pmc Dose-dependent differential mRNA target selection and regulation by let-7a-7f and miR-17-92 cluster microRNAs
    Jingmin Shu
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    RNA Biol 9:1275-87. 2012
    ....
  10. doi request reprint S-MED: sarcoma microRNA expression database
    Aaron L Sarver
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
    Lab Invest 90:753-61. 2010
    ..This comprehensive database is the first of its kind specifically devoted to miRNA expression patterns in sarcomas is available through the URL link http://www.oncomir.umn.edu/...
  11. doi request reprint Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcoma
    Lihua Li
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Lab Invest 92:571-83. 2012
    ..Taken together our data suggest that the RMS state is stabilized by the deregulation of multiple miRNAs and their target genes, supporting a tumor suppressor role for these miRNA...
  12. doi request reprint MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migration
    Aaron L Sarver
    Biostatistics and Bioinformatics, University of Minnesota, Minneapolis, Minnesota, USA
    Cancer Res 70:9570-80. 2010
    ..miR-183 has a potential oncogenic role through the regulation of 2 tumor suppressor genes, EGR1 and PTEN, and the deregulation of this fundamental miRNA regulatory network may be central to many tumor types...
  13. pmc Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation
    Tiffany N Mackenzie
    Department of Pharmacology, University of Minnesota, MMC 195, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Mol Cancer Ther 12:1266-75. 2013
    ..This is the first description of an miRNA-mediated mechanism of HSP70 regulation in cancer, making miR-142-3p an attractive target for PDAC therapeutic intervention...
  14. pmc Genome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell lines
    Liang Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    PLoS ONE 4:e5878. 2009
    ..However, past studies have focused on the miRNA target genes and used loss- or gain-of-function approach that may not reflect natural association between miRNA and mRNAs...
  15. pmc Regulation of heme oxygenase-1 protein expression by miR-377 in combination with miR-217
    Joan D Beckman
    Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 286:3194-202. 2011
    ..In summary, these data suggests that the combination of miR-377 and miR-217 help regulate HO-1 protein expression in the presence of hemin...
  16. pmc Mature microRNAs identified in highly purified nuclei from HCT116 colon cancer cells
    Chang Won Park
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    RNA Biol 7:606-14. 2010
    ..These results will likely provide a basis for further studies concerning the intracellular trafficking and nuclear location of miRNAs...
  17. doi request reprint Minnelide reduces tumor burden in preclinical models of osteosarcoma
    Sulagna Banerjee
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, United States
    Cancer Lett 335:412-20. 2013
    ..Triptolide/Minnelide effectively downregulated the levels of pro-survival proteins such as heat shock proteins, cMYC, survivin and targets the NF-κB pathway...
  18. doi request reprint MicroRNAs in cardiovascular diseases: biology and potential clinical applications
    Reena V Kartha
    Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, USA
    J Cardiovasc Transl Res 3:256-70. 2010
    ..In this review we will summarize the role played by miRNAs in the heart and discuss the scope of utilizing miRNA-based strategies in the clinics for the benefit of mankind...
  19. pmc Genomewide microRNA down-regulation as a negative feedback mechanism in the early phases of liver regeneration
    Jingmin Shu
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Hepatology 54:609-19. 2011
    ....