Subbaya Subramanian

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach
    Milcah C Scott
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 5545, USA
    Bone 49:356-67. 2011
  2. pmc MicroRNA-708 regulates CD38 expression through signaling pathways JNK MAP kinase and PTEN/AKT in human airway smooth muscle cells
    Mythili Dileepan
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, 1971 Commonwealth Avenue, St, Paul 55108, MN, USA
    Respir Res 15:107. 2014
  3. pmc Competing endogenous RNA database
    Aaron L Sarver
    Masonic Cancer Center
    Bioinformation 8:731-3. 2012
  4. doi request reprint MicroRNA-mediated gene regulations in human sarcomas
    Subbaya Subramanian
    Department of Surgery, University of Minnesota, 11 212 Moos Tower Mail Code MMC 195, 515 Delaware St, S E, Minneapolis, MN 55455, USA
    Cell Mol Life Sci 69:3571-85. 2012
  5. pmc Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours
    Subbaya Subramanian
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA
    J Pathol 220:58-70. 2010
  6. doi request reprint MicroRNAs as gatekeepers of apoptosis
    Subbaya Subramanian
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cell Physiol 223:289-98. 2010
  7. pmc Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation
    Tiffany N Mackenzie
    Department of Pharmacology, University of Minnesota, MMC 195, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Mol Cancer Ther 12:1266-75. 2013
  8. pmc Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma
    Venugopal Thayanithy
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, USA
    Bone 50:171-81. 2012
  9. pmc MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma
    Aaron L Sarver
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Orphanet J Rare Dis 8:7. 2013
  10. pmc Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines
    Venugopal Thayanithy
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 7:e43720. 2012

Collaborators

Detail Information

Publications30

  1. pmc Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach
    Milcah C Scott
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 5545, USA
    Bone 49:356-67. 2011
    ..This in turn may enhance prognosis and prediction, and identify relevant therapeutic targets...
  2. pmc MicroRNA-708 regulates CD38 expression through signaling pathways JNK MAP kinase and PTEN/AKT in human airway smooth muscle cells
    Mythili Dileepan
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, 1971 Commonwealth Avenue, St, Paul 55108, MN, USA
    Respir Res 15:107. 2014
    ..We investigated miR-708 expression, its regulation of CD38 expression and the underlying mechanisms involved in such regulation in human ASM cells...
  3. pmc Competing endogenous RNA database
    Aaron L Sarver
    Masonic Cancer Center
    Bioinformation 8:731-3. 2012
    ..AVAILABILITY: http://www.oncomir.umn.edu/cefinder/..
  4. doi request reprint MicroRNA-mediated gene regulations in human sarcomas
    Subbaya Subramanian
    Department of Surgery, University of Minnesota, 11 212 Moos Tower Mail Code MMC 195, 515 Delaware St, S E, Minneapolis, MN 55455, USA
    Cell Mol Life Sci 69:3571-85. 2012
    ..In this review, we will discuss the current knowledge of miRNA-gene regulatory networks in various sarcoma types and give a perspective of the complex multilayer miRNA-mediated gene regulation in sarcomas...
  5. pmc Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours
    Subbaya Subramanian
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA
    J Pathol 220:58-70. 2010
    ..Collectively, our findings suggest that deregulation of miRNAs has a potential role in the malignant transformation process in peripheral nerve sheath tumours...
  6. doi request reprint MicroRNAs as gatekeepers of apoptosis
    Subbaya Subramanian
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cell Physiol 223:289-98. 2010
    ..Many of these apoptotic genes, irrespective of their positive or negative functional role in apoptosis, are regulated by miRNAs. In this review, we discuss the emerging role of miRNA-mediated gene networks in the control of apoptosis...
  7. pmc Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation
    Tiffany N Mackenzie
    Department of Pharmacology, University of Minnesota, MMC 195, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Mol Cancer Ther 12:1266-75. 2013
    ..This is the first description of an miRNA-mediated mechanism of HSP70 regulation in cancer, making miR-142-3p an attractive target for PDAC therapeutic intervention...
  8. pmc Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma
    Venugopal Thayanithy
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, USA
    Bone 50:171-81. 2012
    ..Together, our data support a model where the deregulation of a network involving 14q32 miRNAs, cMYC and miR-17-92 miRNAs could contribute to osteosarcoma pathogenesis...
  9. pmc MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma
    Aaron L Sarver
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Orphanet J Rare Dis 8:7. 2013
    ..We showed previously that clusters of miRNAs at the 14q32 locus are downregulated in human osteosarcoma...
  10. pmc Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines
    Venugopal Thayanithy
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 7:e43720. 2012
    ..These results suggested that the combination of these chromatin-modifying drugs may be a useful adjuvant in the treatment of rapidly progressive OS...
  11. pmc Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states
    Aaron L Sarver
    Biostatistics and Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    BMC Cancer 9:401. 2009
    ..Differential miRNA expression in cancer versus normal tissue is a common event and may be pivotal for tumor onset and progression...
  12. pmc Dose-dependent differential mRNA target selection and regulation by let-7a-7f and miR-17-92 cluster microRNAs
    Jingmin Shu
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    RNA Biol 9:1275-87. 2012
    ....
  13. doi request reprint S-MED: sarcoma microRNA expression database
    Aaron L Sarver
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
    Lab Invest 90:753-61. 2010
    ..This comprehensive database is the first of its kind specifically devoted to miRNA expression patterns in sarcomas is available through the URL link http://www.oncomir.umn.edu/...
  14. doi request reprint Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcoma
    Lihua Li
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Lab Invest 92:571-83. 2012
    ..Taken together our data suggest that the RMS state is stabilized by the deregulation of multiple miRNAs and their target genes, supporting a tumor suppressor role for these miRNA...
  15. doi request reprint MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migration
    Aaron L Sarver
    Biostatistics and Bioinformatics, University of Minnesota, Minneapolis, Minnesota, USA
    Cancer Res 70:9570-80. 2010
    ..miR-183 has a potential oncogenic role through the regulation of 2 tumor suppressor genes, EGR1 and PTEN, and the deregulation of this fundamental miRNA regulatory network may be central to many tumor types...
  16. doi request reprint Sequential expression of miR-182 and miR-503 cooperatively targets FBXW7, contributing to the malignant transformation of colon adenoma to adenocarcinoma
    Lihua Li
    Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    J Pathol 234:488-501. 2014
    ..Array data are available at: http://www.oncomir.umn.edu/..
  17. pmc Genome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell lines
    Liang Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    PLoS ONE 4:e5878. 2009
    ..However, past studies have focused on the miRNA target genes and used loss- or gain-of-function approach that may not reflect natural association between miRNA and mRNAs...
  18. pmc Mature microRNAs identified in highly purified nuclei from HCT116 colon cancer cells
    Chang Won Park
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    RNA Biol 7:606-14. 2010
    ..These results will likely provide a basis for further studies concerning the intracellular trafficking and nuclear location of miRNAs...
  19. pmc Regulation of heme oxygenase-1 protein expression by miR-377 in combination with miR-217
    Joan D Beckman
    Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 286:3194-202. 2011
    ..In summary, these data suggests that the combination of miR-377 and miR-217 help regulate HO-1 protein expression in the presence of hemin...
  20. pmc Tumor-stromal cross talk: direct cell-to-cell transfer of oncogenic microRNAs via tunneling nanotubes
    Venugopal Thayanithy
    Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minn
    Transl Res 164:359-65. 2014
    ..These studies demonstrate that TnTs mediate direct transfer of genetic material between tumor and stromal cells. ..
  21. doi request reprint Triptolide abrogates growth of colon cancer and induces cell cycle arrest by inhibiting transcriptional activation of E2F
    Amanda R Oliveira
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Lab Invest 95:648-59. 2015
    ..Therefore, we conclude that Triptolide and Minnelide are effective against colon cancer in multiple pre-clinical models. ..
  22. doi request reprint Pancreatic cancer: modulation of KRAS, MicroRNAs, and intercellular communication in the setting of tumor heterogeneity
    Emil Lou
    From the Division of Hematology, Oncology and Transplantation, Departmentof Medicine Department of Surgery and Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Minnesota, Minneapolis, MN
    Pancreas 42:1218-26. 2013
    ....
  23. pmc Minnelide reduces tumor burden in preclinical models of osteosarcoma
    Sulagna Banerjee
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, United States
    Cancer Lett 335:412-20. 2013
    ..Triptolide/Minnelide effectively downregulated the levels of pro-survival proteins such as heat shock proteins, cMYC, survivin and targets the NF-κB pathway...
  24. doi request reprint MicroRNAs in cardiovascular diseases: biology and potential clinical applications
    Reena V Kartha
    Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, USA
    J Cardiovasc Transl Res 3:256-70. 2010
    ..In this review we will summarize the role played by miRNAs in the heart and discuss the scope of utilizing miRNA-based strategies in the clinics for the benefit of mankind...
  25. doi request reprint Identification, by systematic RNA sequencing, of novel candidate biomarkers and therapeutic targets in human soft tissue tumors
    Anne E Sarver
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN, USA
    Lab Invest 95:1077-88. 2015
    ....
  26. pmc Genomewide microRNA down-regulation as a negative feedback mechanism in the early phases of liver regeneration
    Jingmin Shu
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Hepatology 54:609-19. 2011
    ....
  27. doi request reprint MicroRNAs in the pathobiology of sarcomas
    Anne E Sarver
    Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Lab Invest 95:987-94. 2015
    ....
  28. pmc Tumor exosomes induce tunneling nanotubes in lipid raft-enriched regions of human mesothelioma cells
    Venugopal Thayanithy
    Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Cell Res 323:178-88. 2014
    ..Our findings provide supportive evidence of exosomes as potential chemotactic stimuli for TnT formation, and also lipid raft formation as a potential biomarker for TnT-forming cells...