Suresh Subramani

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Pexophagy: the selective degradation of peroxisomes
    Andreas Till
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0322, USA
    Int J Cell Biol 2012:512721. 2012
  2. pmc A yeast MAPK cascade regulates pexophagy but not other autophagy pathways
    Ravi Manjithaya
    Section of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 189:303-10. 2010
  3. pmc Dynamics of the peroxisomal import cycle of PpPex20p: ubiquitin-dependent localization and regulation
    Sebastien Leon
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093
    J Cell Biol 172:67-78. 2006
  4. pmc Unconventional secretion of Pichia pastoris Acb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation
    Ravi Manjithaya
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 188:537-46. 2010
  5. pmc Peroxisome assembly: matrix and membrane protein biogenesis
    Changle Ma
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, CA 92093, USA
    J Cell Biol 193:7-16. 2011
  6. pmc Non-autophagic roles of autophagy-related proteins
    Suresh Subramani
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, California 92093 0322, USA
    EMBO Rep 14:143-51. 2013
  7. pmc Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane
    A Koller
    Department of Biology, University of California San Diego, La Jolla, California 92093 0322, USA
    J Cell Biol 146:99-112. 1999
  8. ncbi request reprint Convergence of model systems for peroxisome biogenesis
    S Subramani
    Department of Biology, University of California at San Diego, Rm 4314, Bonner Hall, 9500 Gilman Drive, La Jolla, CA 92093 0322, USA
    Curr Opin Cell Biol 8:513-8. 1996
  9. ncbi request reprint A ubiquitin-like protein involved in membrane fusion
    Suresh Subramani
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, CA 92093, USA
    Cell 130:18-20. 2007
  10. pmc Hitchhiking fads en route to peroxisomes
    Suresh Subramani
    Section of Molecular Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 156:415-7. 2002

Research Grants

  1. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 2003
  2. Shuttling of Peroxisomal Targeting Sequence Receptors
    Suresh Subramani; Fiscal Year: 2004
  3. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 1993
  4. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 1992
  5. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 2001
  6. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 2002
  7. Shuttling of Peroxisomal Targeting Sequence Receptors
    Suresh Subramani; Fiscal Year: 2002
  8. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 2000
  9. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 1999
  10. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 1990

Collaborators

Detail Information

Publications65

  1. pmc Pexophagy: the selective degradation of peroxisomes
    Andreas Till
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0322, USA
    Int J Cell Biol 2012:512721. 2012
    ..We compare different modes of pexophagy and mention shared and distinct features of pexophagy in yeast model systems, mammalian cells, and other organisms...
  2. pmc A yeast MAPK cascade regulates pexophagy but not other autophagy pathways
    Ravi Manjithaya
    Section of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 189:303-10. 2010
    ..We propose that pexophagy requires the simultaneous activation of this MAPK pathway and a hexose-sensing mechanism acting through protein kinase A and cyclic adenosine monophosphate...
  3. pmc Dynamics of the peroxisomal import cycle of PpPex20p: ubiquitin-dependent localization and regulation
    Sebastien Leon
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093
    J Cell Biol 172:67-78. 2006
    ..Our data are consistent with a model in which Pex20p enters peroxisomes and recycles back to the cytosol in an ubiquitin-dependent manner...
  4. pmc Unconventional secretion of Pichia pastoris Acb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation
    Ravi Manjithaya
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 188:537-46. 2010
    ..Moreover, yeast Acb1 and several proteins required for its secretion are necessary for sporulation in P. pastoris. Our findings implicate currently unknown, evolutionarily conserved pathways in unconventional secretion...
  5. pmc Peroxisome assembly: matrix and membrane protein biogenesis
    Changle Ma
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, CA 92093, USA
    J Cell Biol 193:7-16. 2011
    ..Defining the molecular events in peroxisome assembly may enhance our understanding of the etiology of human peroxisome biogenesis disorders...
  6. pmc Non-autophagic roles of autophagy-related proteins
    Suresh Subramani
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, California 92093 0322, USA
    EMBO Rep 14:143-51. 2013
    ..We focus on the non-autophagic functions of autophagy proteins in cell survival and apoptosis, modulation of cellular traffic, protein secretion, cell signalling, transcription, translation and membrane reorganization...
  7. pmc Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane
    A Koller
    Department of Biology, University of California San Diego, La Jolla, California 92093 0322, USA
    J Cell Biol 146:99-112. 1999
    ..The Saccharomyces cerevisiae hypothetical protein, Yaf5p, is the functional homologue of P. pastoris Pex22p...
  8. ncbi request reprint Convergence of model systems for peroxisome biogenesis
    S Subramani
    Department of Biology, University of California at San Diego, Rm 4314, Bonner Hall, 9500 Gilman Drive, La Jolla, CA 92093 0322, USA
    Curr Opin Cell Biol 8:513-8. 1996
    ..Protein unfolding is not a prerequisite for import of peroxisomal matrix proteins, suggesting novel mechanisms for the translocation of polypeptides across the peroxisomal membrane...
  9. ncbi request reprint A ubiquitin-like protein involved in membrane fusion
    Suresh Subramani
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, CA 92093, USA
    Cell 130:18-20. 2007
    ..2007) show that Atg8 conjugated to PE mediates tethering between adjacent membranes and stimulates membrane hemifusion, an event that may mimic expansion of the autophagosomal membrane during autophagy...
  10. pmc Hitchhiking fads en route to peroxisomes
    Suresh Subramani
    Section of Molecular Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 156:415-7. 2002
    ..A paper in this issue addresses, in a very thorough fashion, the assembly, cofactor binding, and import of an oligomeric protein, acyl-CoA oxidase (Aox), into the peroxisome matrix (Titorenko et al., 2002, this issue)...
  11. ncbi request reprint Import of peroxisomal matrix and membrane proteins
    S Subramani
    Department of Biology, University of California, San Diego, La Jolla, California 92093 0322, USA
    Annu Rev Biochem 69:399-418. 2000
    ..Given the rapid progress in the field, this review also highlights some of the unanswered questions that remain to be tackled...
  12. pmc Dysferlin domain-containing proteins, Pex30p and Pex31p, localized to two compartments, control the number and size of oleate-induced peroxisomes in Pichia pastoris
    Mingda Yan
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0322, USA
    Mol Biol Cell 19:885-98. 2008
    ..The growth environment-specific role of these peroxins, their dual localization, and the function of their dysferlin domains provide novel insights into peroxisome morphogenesis...
  13. pmc Phosphorylation-dependent Pex11p and Fis1p interaction regulates peroxisome division
    Saurabh Joshi
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 23:1307-15. 2012
    ..We propose a model for the role of PpPex11p in the regulation of peroxisome division through a phosphorylation-dependent interaction with the fission machinery, providing novel insights into peroxisome morphogenesis...
  14. pmc PpAtg30 tags peroxisomes for turnover by selective autophagy
    Jean Claude Farre
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, San Diego, CA 92093 0322, USA
    Dev Cell 14:365-76. 2008
    ..Therefore, PpAtg30 is a key player in the selection of peroxisomes as cargo and in their delivery to the autophagy machinery for pexophagy...
  15. pmc Peroxisome size provides insights into the function of autophagy-related proteins
    Taras Y Nazarko
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0322, USA
    Mol Biol Cell 20:3828-39. 2009
    ..As a rule, the larger the cargo, the more cargo-specific Atg proteins become essential for its sequestration...
  16. ncbi request reprint Autophagy-related pathways and specific role of sterol glucoside in yeasts
    Taras Y Nazarko
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0322, USA
    Autophagy 3:263-5. 2007
    ..Therefore, we speculate that SG might facilitate elongation of any double membrane from the PAS and this enhancer function of SG becomes essential when extremely large double membranes are formed...
  17. pmc Cell-free sorting of peroxisomal membrane proteins from the endoplasmic reticulum
    Gaurav Agrawal
    Section of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093 0322, USA
    Proc Natl Acad Sci U S A 108:9113-8. 2011
    ..Our findings provide a biochemical platform to uncover the mechanism of PMP budding from the ER...
  18. pmc A conserved cysteine residue of Pichia pastoris Pex20p is essential for its recycling from the peroxisome to the cytosol
    Sebastien Leon
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego UCSD, La Jolla, California 92093 0322, USA
    J Biol Chem 282:7424-30. 2007
    ..In addition, expression of this mutant protein in wild-type cells confers a dominant-negative, oleate-specific growth defect, which is a useful tool for a better understanding of peroxisomal receptor recycling...
  19. pmc Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy
    Taras Y Nazarko
    Section of Molecular Biology, Division of Biological Sciences, and 2 San Diego Center for Systems Biology, University of California, San Diego, La Jolla, CA 92093
    J Cell Biol 204:541-57. 2014
    ..We suggest that Atg37/ACBD5 is a new component and positive regulator of the pexophagic RPC. ..
  20. pmc Phosphorylation of mitophagy and pexophagy receptors coordinates their interaction with Atg8 and Atg11
    Jean Claude Farre
    Section of Molecular Biology, Division of Biological Sciences, University California, San Diego, California 92093 0322, USA
    EMBO Rep 14:441-9. 2013
    ..We present a common model for the phosphoregulation of selective autophagy receptors...
  21. pmc Turnover of organelles by autophagy in yeast
    Jean Claude Farre
    Division of Biological Sciences, University of California, San Diego, CA 92093 0322, USA
    Curr Opin Cell Biol 21:522-30. 2009
    ..We review the current knowledge on autophagic removal of peroxisomes, mitochondria, ER and parts of the nucleus with an emphasis on yeasts as a model eukaryote...
  22. pmc The peroxisomal matrix import of Pex8p requires only PTS receptors and Pex14p
    Changle Ma
    University of California, San Diego, La Jolla, 92093 0322, USA
    Mol Biol Cell 20:3680-9. 2009
    ..Our data support the idea that PpPex8p is a special cargo whose translocation into peroxisomes depends only on the PTS receptors and Pex14p and not on intraperoxisomal Pex8p, the RING subcomplex, or the receptor-recycling machinery...
  23. pmc Two independent pathways traffic the intraperoxisomal peroxin PpPex8p into peroxisomes: mechanism and evolutionary implications
    Lan Zhang
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0322, USA
    Mol Biol Cell 17:690-9. 2006
    ..These data suggest a direct interaction between PpPex8p and Pex20p. Our studies shed light on the mechanism and evolution of the dual import pathways for PpPex8p...
  24. ncbi request reprint Characterization of protein-protein interactions: application to the understanding of peroxisome biogenesis
    Sebastien Leon
    Section of Molecular Biology, University of California San Diego, La Jolla, CA, USA
    Methods Mol Biol 389:219-38. 2007
    ..This chapter discusses methods that have been used for the study of such interactions among both soluble and membrane-associated proteins in peroxisome biogenesis. The procedures are equally applicable to other cellular processes...
  25. pmc Recent advances in peroxisomal matrix protein import
    Xueqian Liu
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0322, United States
    Curr Opin Cell Biol 24:484-9. 2012
    ..We focus on the machinery involved in the peroxisomal matrix protein import cycle, highlighting recent advances in peroxisomal matrix protein import, cargo release and receptor recycling/degradation...
  26. pmc Peroxisome matrix and membrane protein biogenesis
    Changle Ma
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0322, USA
    IUBMB Life 61:713-22. 2009
    ..In this manuscript we review the recent progress made in our understanding of the mechanisms by which matrix and membrane proteins are sorted to and assembled into peroxisomes...
  27. ncbi request reprint A cytoplasm to vacuole targeting pathway in P. pastoris
    Jean Claude Farre
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0322, USA
    Autophagy 3:230-4. 2007
    ..The discovery of a Cvt pathway in P. pastoris makes it an excellent model system for the dissection of autophagy-related pathways in a single organism and for the discovery of new Cvt pathway components...
  28. ncbi request reprint Uniqueness of the mechanism of protein import into the peroxisome matrix: transport of folded, co-factor-bound and oligomeric proteins by shuttling receptors
    Sebastien Leon
    Section of Molecular Biology, Division of Biological Sciences, University California, Room 3230 Bonner Hall, 9500 Gilman Drive, UC San Diego, La Jolla, CA 92093 0322, USA
    Biochim Biophys Acta 1763:1552-64. 2006
    ....
  29. ncbi request reprint The importomer--a peroxisomal membrane complex involved in protein translocation into the peroxisome matrix
    Naganand Rayapuram
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, Room 3230 Bonner Hall, 9500 Gilman Drive, UC San Diego, La Jolla, CA 92093 0322, USA
    Biochim Biophys Acta 1763:1613-9. 2006
    ..We provide below a brief historical perspective regarding the importomer and its role in peroxisome biogenesis. We also identify areas in which further work is needed to uncover the physiological role of the importomer...
  30. pmc Molecular mechanism and physiological role of pexophagy
    Ravi Manjithaya
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0322, USA
    FEBS Lett 584:1367-73. 2010
    ..These insights and additional observations in the literature provide a framework for an understanding of the physiological role(s) of pexophagy...
  31. ncbi request reprint Localization of proteins and organelles using fluorescence microscopy
    Jean Claude Farre
    Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA, USA
    Methods Mol Biol 389:239-50. 2007
    ..Also included are protocols for the labeling of different subcellular organelles with vital stains...
  32. pmc Roles of Pichia pastoris Uvrag in vacuolar protein sorting and the phosphatidylinositol 3-kinase complex in phagophore elongation in autophagy pathways
    Jean Claude Farre
    Section of Molecular Biology, Division of Biological Sciences, University California, San Diego, CA, USA
    Autophagy 6:86-99. 2010
    ..Rather, the defects in all autophagic pathways observed when PpUvrag was overexpressed support its presence in a complex that competes with the PI3K complex required for autophagy...
  33. pmc The requirement of sterol glucoside for pexophagy in yeast is dependent on the species and nature of peroxisome inducers
    Taras Y Nazarko
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0322, USA
    Mol Biol Cell 18:106-18. 2007
    ....
  34. ncbi request reprint Peroxisome remnants in pex3delta cells and the requirement of Pex3p for interactions between the peroxisomal docking and translocation subcomplexes
    Partha P Hazra
    Section of Molecular Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093 0322, USA
    Traffic 3:560-74. 2002
    ..We discuss roles for Pex3p in the assembly of specific peroxisomal membrane protein subcomplexes whose formation is necessary for matrix protein import...
  35. pmc Redox-regulated cargo binding and release by the peroxisomal targeting signal receptor, Pex5
    Changle Ma
    From the Section of Molecular Biology, Division of Biological Sciences, University California, San Diego, La Jolla, California 92093 0322
    J Biol Chem 288:27220-31. 2013
    ..This interaction is also important for the release of PTS1 proteins. We suggest a redox-regulated model for Pex5 function during the peroxisomal matrix protein import cycle. ..
  36. ncbi request reprint Peroxisome turnover by micropexophagy: an autophagy-related process
    Jean Claude Farre
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0322, USA
    Trends Cell Biol 14:515-23. 2004
    ....
  37. pmc Role of autophagy in unconventional protein secretion
    Ravi Manjithaya
    Section of Molecular Biology, Division of Biological Sciences, University California, San Diego, CA USA
    Autophagy 6:650-1. 2010
    ..Both implicate autophagy proteins and autophagosome formation in the process, while also uncovering roles for other interesting proteins in the unconventional secretion of Acb1...
  38. pmc Autophagy: a broad role in unconventional protein secretion?
    Ravi Manjithaya
    Section of Molecular Biology, University of California, San Diego, La Jolla, CA 92093 0322, USA
    Trends Cell Biol 21:67-73. 2011
    ..Here, we discuss these findings, evaluate the strength of evidence, consider their implications for the field of protein trafficking, and suggest the next steps required to probe this interesting pathway...
  39. pmc Unique requirements for mono- and polyubiquitination of the peroxisomal targeting signal co-receptor, Pex20
    Xueqian Liu
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0322, USA
    J Biol Chem 288:7230-40. 2013
    ..This is the first description of the complete ubiquitination pathway of Pex20, which provides a better understanding of the recycling and degradation of this PTS2 cargo co-receptor...
  40. pmc Special delivery from mitochondria to peroxisomes
    Uwe Schumann
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Trends Cell Biol 18:253-6. 2008
    ..We discuss the potential role of this vesicle population in the context of pathways for the exchange of metabolites and/or macromolecules between these compartments...
  41. pmc Defects in GABA metabolism affect selective autophagy pathways and are alleviated by mTOR inhibition
    Ronak Lakhani
    Division of Biological Sciences, Section of Molecular Biology, University of California San Diego, La Jolla, CA, USA
    EMBO Mol Med 6:551-66. 2014
    ....
  42. ncbi request reprint The control of peroxisome number and size during division and proliferation
    Mingda Yan
    Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093 0322, USA
    Curr Opin Cell Biol 17:376-83. 2005
    ..Related DRPs also function in the division of mitochondria and chloroplasts. Many other proteins and signals regulate peroxisome division and proliferation, but their modes of action are still being studied...
  43. pmc Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders
    E A Wiemer
    Department of Biology, University of California at San Diego, La Jolla 92093 0322, USA
    J Cell Biol 130:51-65. 1995
    ..Our findings represent the only case in which the molecular basis of the protein-import deficiency in human peroxisomal disorders is understood...
  44. pmc A balancing act for autophagin
    Andreas Till
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA
    J Clin Invest 120:2273-6. 2010
    ..The intriguing aspect of this work is that an autophagy block impairs the secretion and assembly of otoconial proteins, emphasizing a role for autophagy in functions distinct from macromolecule degradation...
  45. pmc Pex19p interacts with Pex3p and Pex10p and is essential for peroxisome biogenesis in Pichia pastoris
    W B Snyder
    Department of Biology, University of California, San Diego, La Jolla, California 92093 0322, USA
    Mol Biol Cell 10:1745-61. 1999
    ..cerevisiae. These small vesicular and tubular (early) remnants are morphologically distinct from other Pppex mutant (late) remnants, suggesting that Pex19p functions at an early stage of peroxisome biogenesis...
  46. pmc A mobile PTS2 receptor for peroxisomal protein import in Pichia pastoris
    Y Elgersma
    Department of Biology, University of California at San Diego, La Jolla, California 92093 0322, USA
    J Cell Biol 140:807-20. 1998
    ..The corresponding PpPex7p mutant proteins were stably expressed in P. pastoris, but they failed to complement the pex7Delta mutant and were impaired in binding to the PTS2 sequence...
  47. pmc Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import
    M Fransen
    Department of Biology, University of California at San Diego, La Jolla, CA 92093 0322, USA
    Proc Natl Acad Sci U S A 95:8087-92. 1998
    ..These studies demonstrate that the ab-MF3-immunoreactive, 57-kDa peroxisomal membrane protein is Pex14p. Furthermore, this peroxin interacts with Pex5p and Pex13p(SH3) and is directly required for peroxisomal protein import...
  48. ncbi request reprint The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol
    V Dammai
    Section of Molecular Biology, Division of Biology, Room 3230 Bonner Hall, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 105:187-96. 2001
    ..This unusual shuttling mechanism for the PTS1 receptor distinguishes protein import into peroxisomes from that into most other organelles, with the exception of the nucleus...
  49. pmc Hepatitis B virus disrupts mitochondrial dynamics: induces fission and mitophagy to attenuate apoptosis
    Seong Jun Kim
    Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, California, United States of America
    PLoS Pathog 9:e1003722. 2013
    ..Altered mitochondrial dynamics associated with HBV infection may contribute to mitochondrial injury and liver disease pathogenesis. ..
  50. pmc Rallying the exocyst as an autophagy scaffold
    Jean Claude Farre
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0322, USA
    Cell 144:172-4. 2011
    ....
  51. ncbi request reprint The CUP1 promoter of Saccharomyces cerevisiae is inducible by copper in Pichia pastoris
    A Koller
    Department of Biology, University of California San Diego, La Jolla, CA 92093 0322, USA
    Yeast 16:651-6. 2000
    ..We show that the promoter is indeed inducible by copper when used in P. pastoris and that the level of induction is dependent on the amount of copper in the medium...
  52. pmc Pex17p is required for import of both peroxisome membrane and lumenal proteins and interacts with Pex19p and the peroxisome targeting signal-receptor docking complex in Pichia pastoris
    W B Snyder
    Department of Biology, University of California, San Diego, La Jolla, California 92093 0322, USA
    Mol Biol Cell 10:4005-19. 1999
    ..These distinct pools may serve different purposes for the import of matrix proteins or PMPs...
  53. pmc Role of the PAS1 gene of Pichia pastoris in peroxisome biogenesis
    J A Heyman
    Department of Biology, University of California, San Diego, La Jolla 92093 0322
    J Cell Biol 127:1259-73. 1994
    ..1991) for the S. cerevisiae pas1 mutant, in which they were unable to detect peroxisome-like structures. We discuss the role of PAS1 in peroxisome biogenesis in light of the new information regarding peroxisome ghosts in pas1 cells...
  54. ncbi request reprint Isolation and characterization of Pas2p, a peroxisomal membrane protein essential for peroxisome biogenesis in the methylotrophic yeast Pichia pastoris
    E A Wiemer
    Department of Biology, University of California at San Diego, La Jolla, California 92093 0322, USA
    J Biol Chem 271:18973-80. 1996
    ..The role of peroxisomal membrane targeting signals and transmembrane domains in anchoring PMPs to the peroxisomal membrane is discussed...
  55. pmc Two AAA family peroxins, PpPex1p and PpPex6p, interact with each other in an ATP-dependent manner and are associated with different subcellular membranous structures distinct from peroxisomes
    K N Faber
    Department of Biology, University of California, San Diego, La Jolla 92093 0322, USA
    Mol Cell Biol 18:936-43. 1998
    ..We discuss the possible role of the ATP-dependent interaction between PpPex1p and PpPex6p in regulating peroxisome biogenesis events...
  56. pmc Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S.cerevisiae, causes proliferation of the endoplasmic reticulum membrane
    Y Elgersma
    Department of Biology, University of California at San Diego, Bonner Hall, 9500 Gilman Drive, La Jolla, CA 92093 0322, USA
    EMBO J 16:7326-41. 1997
    ..Furthermore, the peroxisomal membrane targeting signal of Pex15p overlaps with an ER targeting signal on this protein. These results indicate that Pex15p may be targeted to peroxisomes via the ER, or to both organelles...
  57. ncbi request reprint Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor
    F G Sajjadi
    Department of Biology, University of California, San Diego, La Jolla 92093
    New Biol 3:769-78. 1991
    ..However, a shorter transcript was found to be expressed at reduced levels in the testis. This new Eph-related receptor may play an important role during development and in signal transduction pathways...
  58. pmc Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase
    M Fransen
    Department of Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0322, USA
    Biochem J 340:561-8. 1999
    ....
  59. pmc A conserved tripeptide sorts proteins to peroxisomes
    S J Gould
    Department of Biology and Center for Molecular Genetics, University of California, La Jolla, California 92093
    J Cell Biol 108:1657-64. 1989
    ..These results indicate that peroxisomal protein import, unlike other types of transmembrane translocation, is dependent upon a conserved amino acid sequence...
  60. pmc Mxr1p, a key regulator of the methanol utilization pathway and peroxisomal genes in Pichia pastoris
    Geoffrey Paul Lin-Cereghino
    Department of Biochemistry and Molecular Biology, Oregon Graduate Institute of Science and Technology, 2000 N W Walker Road, Beaverton, Oregon 97006, USA
    Mol Cell Biol 26:883-97. 2006
    ..We propose that MXR1 is the P. pastoris homologue of S. cerevisiae ADR1 but that it has gained new functions and lost others through evolution as a result of changes in the spectrum of genes that it controls...
  61. doi request reprint Activity versus peroxisomal targeting of PerCR
    Michael E Baker
    Structure 16:331-2. 2008
  62. ncbi request reprint Atg28, a novel coiled-coil protein involved in autophagic degradation of peroxisomes in the methylotrophic yeast Pichia pastoris
    Oleh V Stasyk
    Institute of Cell Biology, National Academy of Sciences of Ukraine, Lviv, Ukraine
    Autophagy 2:30-8. 2006
    ..The identification of ATG28 suggests that pexophagy may involve species-specific components, since this gene appears to have only weak homologues in other yeasts...
  63. ncbi request reprint A unified nomenclature for yeast autophagy-related genes
    Daniel J Klionsky
    Dev Cell 5:539-45. 2003

Research Grants28

  1. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 2003
    ..To investigate the targeting and topology of peroxisomal membrane proteins 6. To study the role of the P. pastoris PAS1 and PAS5 proteins in peroxisome biogenesis ..
  2. Shuttling of Peroxisomal Targeting Sequence Receptors
    Suresh Subramani; Fiscal Year: 2004
    ..What peroxins are necessary for the shuttling of Pex5p into and out of peroxisomes?5. Does Pex7p cycle into and out of the peroxisome matrix in yeast and in mammals? If so, what is the mechanism by which Pex7p shuttles? ..
  3. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 1993
    ....
  4. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 1992
    ....
  5. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 2001
    ..To investigate the targeting and topology of peroxisomal membrane proteins 6. To study the role of the P. pastoris PAS1 and PAS5 proteins in peroxisome biogenesis ..
  6. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 2002
    ..To investigate the targeting and topology of peroxisomal membrane proteins 6. To study the role of the P. pastoris PAS1 and PAS5 proteins in peroxisome biogenesis ..
  7. Shuttling of Peroxisomal Targeting Sequence Receptors
    Suresh Subramani; Fiscal Year: 2002
    ..What peroxins are necessary for the shuttling of Pex5p into and out of peroxisomes?5. Does Pex7p cycle into and out of the peroxisome matrix in yeast and in mammals? If so, what is the mechanism by which Pex7p shuttles? ..
  8. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 2000
    ..To investigate the targeting and topology of peroxisomal membrane proteins 6. To study the role of the P. pastoris PAS1 and PAS5 proteins in peroxisome biogenesis ..
  9. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 1999
    ..To investigate the targeting and topology of peroxisomal membrane proteins 6. To study the role of the P. pastoris PAS1 and PAS5 proteins in peroxisome biogenesis ..
  10. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 1990
    ....
  11. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 1991
    ....
  12. Mechanisms Involved in Pexophagy
    Suresh Subramani; Fiscal Year: 2009
    ....
  13. Mechanisms Involved in Pexophagy
    Suresh Subramani; Fiscal Year: 2007
    ....
  14. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 2007
    ..4. Elucidate further the role of ubiquitination in peroxisome biogenesis. ..
  15. Mechanisms Involved in Pexophagy
    Suresh Subramani; Fiscal Year: 2006
    ....
  16. Shuttling of Peroxisomal Targeting Sequence Receptors
    Suresh Subramani; Fiscal Year: 2006
    ..What peroxins are necessary for the shuttling of Pex5p into and out of peroxisomes?5. Does Pex7p cycle into and out of the peroxisome matrix in yeast and in mammals? If so, what is the mechanism by which Pex7p shuttles? ..
  17. Shuttling of Peroxisomal Targeting Sequence Receptors
    Suresh Subramani; Fiscal Year: 2005
    ..What peroxins are necessary for the shuttling of Pex5p into and out of peroxisomes?5. Does Pex7p cycle into and out of the peroxisome matrix in yeast and in mammals? If so, what is the mechanism by which Pex7p shuttles? ..
  18. Shuttling of Peroxisomal Targeting Sequence Receptors
    Suresh Subramani; Fiscal Year: 2003
    ..What peroxins are necessary for the shuttling of Pex5p into and out of peroxisomes?5. Does Pex7p cycle into and out of the peroxisome matrix in yeast and in mammals? If so, what is the mechanism by which Pex7p shuttles? ..
  19. TARGETING OF PROTEINS INTO PEROXISOMES
    Suresh Subramani; Fiscal Year: 1999
    ..We hope to define the role of a ubiquitin- conjugating enzyme, Pex4p, in peroxisome biogenesis. ..
  20. Mechanisms Involved in Pexophagy
    Suresh Subramani; Fiscal Year: 2010
    ....