G Subbanagounder

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Hydroxy alkenal phospholipids regulate inflammatory functions of endothelial cells
    Ganesamoorthy Subbanagounder
    Department of Medicine Cardiology, Center for the Health Sciences, Room 47 123, UCLA Medical Center, Los Angeles, CA 90095 1679, USA
    Vascul Pharmacol 38:201-9. 2002
  2. ncbi request reprint Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis. Formation of these oxidized phospholipids in response to interleukin-1beta
    Ganesamoorthy Subbanagounder
    Department of Medicine, Center for the Health Sciences, Rm 47 123, UCLA Medical Center, Los Angeles, CA 90095 1679, USA
    J Biol Chem 277:7271-81. 2002
  3. ncbi request reprint Determinants of bioactivity of oxidized phospholipids. Specific oxidized fatty acyl groups at the sn-2 position
    G Subbanagounder
    Department of Medicine, University of California, Los Angeles, USA
    Arterioscler Thromb Vasc Biol 20:2248-54. 2000
  4. ncbi request reprint Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo
    A D Watson
    Department of Medicine, Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095 1679, USA
    J Biol Chem 272:13597-607. 1997
  5. ncbi request reprint Structural identification of a novel pro-inflammatory epoxyisoprostane phospholipid in mildly oxidized low density lipoprotein
    A D Watson
    Department of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 274:24787-98. 1999
  6. ncbi request reprint A cell-free assay for detecting HDL that is dysfunctional in preventing the formation of or inactivating oxidized phospholipids
    M Navab
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Lipid Res 42:1308-17. 2001
  7. ncbi request reprint HDL and the inflammatory response induced by LDL-derived oxidized phospholipids
    M Navab
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1736, USA
    Arterioscler Thromb Vasc Biol 21:481-8. 2001
  8. ncbi request reprint Evidence that phospholipid oxidation products and/or platelet-activating factor play an important role in early atherogenesis : in vitro and In vivo inhibition by WEB 2086
    G Subbanagounder
    Departments of Medicine Cardiology, Pathology, and Psychiatry and Biobehavioral Sciences and the Neuropsychiatric Institute K F F, University of California, Los Angeles, Calif, USA
    Circ Res 85:311-8. 1999
  9. pmc Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins
    S Horkko
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0682
    J Clin Invest 103:117-28. 1999
  10. ncbi request reprint Evidence for a role of phospholipid oxidation products in atherogenesis
    J A Berliner
    Departments of Medicine and Pathology, UCLA School of Medicine, Los Angeles, California, USA
    Trends Cardiovasc Med 11:142-7. 2001

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Hydroxy alkenal phospholipids regulate inflammatory functions of endothelial cells
    Ganesamoorthy Subbanagounder
    Department of Medicine Cardiology, Center for the Health Sciences, Room 47 123, UCLA Medical Center, Los Angeles, CA 90095 1679, USA
    Vascul Pharmacol 38:201-9. 2002
    ..These studies demonstrate the importance of HOOA-PC as a new potential proinflammatory molecule that regulates leukocyte-endothelial interactions...
  2. ncbi request reprint Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis. Formation of these oxidized phospholipids in response to interleukin-1beta
    Ganesamoorthy Subbanagounder
    Department of Medicine, Center for the Health Sciences, Rm 47 123, UCLA Medical Center, Los Angeles, CA 90095 1679, USA
    J Biol Chem 277:7271-81. 2002
    ..Their accumulation in cells exposed to cytokines and in atherosclerotic lesions suggests that these lipids may play a role in a number of chronic disease processes...
  3. ncbi request reprint Determinants of bioactivity of oxidized phospholipids. Specific oxidized fatty acyl groups at the sn-2 position
    G Subbanagounder
    Department of Medicine, University of California, Los Angeles, USA
    Arterioscler Thromb Vasc Biol 20:2248-54. 2000
    ....
  4. ncbi request reprint Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo
    A D Watson
    Department of Medicine, Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095 1679, USA
    J Biol Chem 272:13597-607. 1997
    ..Overall, these studies suggest that specific oxidized derivatives of arachidonic acid-containing phospholipids may be important initiators of atherogenesis...
  5. ncbi request reprint Structural identification of a novel pro-inflammatory epoxyisoprostane phospholipid in mildly oxidized low density lipoprotein
    A D Watson
    Department of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 274:24787-98. 1999
    ..The identification of this molecule adds epoxyisoprostanes to the growing list of biologically active isoprostanes...
  6. ncbi request reprint A cell-free assay for detecting HDL that is dysfunctional in preventing the formation of or inactivating oxidized phospholipids
    M Navab
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Lipid Res 42:1308-17. 2001
    ....
  7. ncbi request reprint HDL and the inflammatory response induced by LDL-derived oxidized phospholipids
    M Navab
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1736, USA
    Arterioscler Thromb Vasc Biol 21:481-8. 2001
    ..It is proposed that LDL-derived oxidized phospholipids and HDL may be part of a system of nonspecific innate immunity and that the detection of proinflammatory HDL may be a useful marker of susceptibility to atherosclerosis...
  8. ncbi request reprint Evidence that phospholipid oxidation products and/or platelet-activating factor play an important role in early atherogenesis : in vitro and In vivo inhibition by WEB 2086
    G Subbanagounder
    Departments of Medicine Cardiology, Pathology, and Psychiatry and Biobehavioral Sciences and the Neuropsychiatric Institute K F F, University of California, Los Angeles, Calif, USA
    Circ Res 85:311-8. 1999
    ....
  9. pmc Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins
    S Horkko
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0682
    J Clin Invest 103:117-28. 1999
    ....
  10. ncbi request reprint Evidence for a role of phospholipid oxidation products in atherogenesis
    J A Berliner
    Departments of Medicine and Pathology, UCLA School of Medicine, Los Angeles, California, USA
    Trends Cardiovasc Med 11:142-7. 2001
    ..The mechanism by which these phospholipid oxidation products activate cells has revealed the presence of several different receptors and signal transduction pathways...
  11. ncbi request reprint Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis
    D M Shih
    Division of Cardiology, Department of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 275:17527-35. 2000
    ..These data demonstrate that PON1 deficiency promotes LDL oxidation and atherogenesis in apoE KO mice...
  12. ncbi request reprint Oxidized phospholipid-induced endothelial cell/monocyte interaction is mediated by a cAMP-dependent R-Ras/PI3-kinase pathway
    Amy L Cole
    David Geffen School of Medicine at University of California Los Angeles, Los Angeles, Calif, USA
    Arterioscler Thromb Vasc Biol 23:1384-90. 2003
    ..The present studies identify important signal transduction components regulating this pathway...
  13. ncbi request reprint Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2
    Kimberly A Walton
    Department of Medicine, University of California, Los Angeles, CA 90095 1732, USA
    Arterioscler Thromb Vasc Biol 23:1197-203. 2003
    ..The current studies identify specific phospholipids that inhibit chemokine induction by Toll-like receptor-4 (TLR4) and -2 (TLR2) ligands inECs and macrophages...
  14. pmc Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory
    Mi Kyung Chang
    Division of Endocrinology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    J Exp Med 200:1359-70. 2004
    ..These results suggest that apoptotic cell death generates oxidatively modified moieties, which can induce autoimmune responses and a local inflammatory response by recruiting monocytes via monocyte-endothelial cell interaction...
  15. ncbi request reprint Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice
    Trudy M Forte
    Life Sciences Division MS 1 222, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Lipid Res 43:477-85. 2002
    ..We conclude that impairment of LCAT activity and accumulation of oxidized phospholipids are part of an early atherogenic phenotype in these models...