Carlos S Subauste

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint CD154 and type-1 cytokine response: from hyper IgM syndrome to human immunodeficiency virus infection
    Carlos S Subauste
    Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    J Infect Dis 185:S83-9. 2002
  2. ncbi request reprint TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha
    Rosa M Andrade
    Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 175:6014-21. 2005
  3. pmc CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes
    Rosa M Andrade
    Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Clin Invest 116:2366-77. 2006
  4. ncbi request reprint Pathogen-specific induction of CD154 is impaired in CD4+ T cells from human immunodeficiency virus-infected patients
    Carlos S Subauste
    Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Infect Dis 189:61-70. 2004
  5. pmc CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates
    Rosa M Andrade
    Department of Internal Medicine, University of Cincinnati College of Medicine, P O Box 670560, Cincinnati, OH 45267 0560, USA
    Infect Immun 73:3115-23. 2005
  6. ncbi request reprint Role of CD40-dependent down-regulation of CD154 in impaired induction of CD154 in CD4(+) T cells from HIV-1-infected patients
    Carlos S Subauste
    Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 178:1645-53. 2007
  7. pmc CD40 restrains in vivo growth of Toxoplasma gondii independently of gamma interferon
    Carlos S Subauste
    Department of Internal Medicine, University of Cincinnati College of Medicine, P O Box 670560, Cincinnati, OH 45267 0560, USA
    Infect Immun 74:1573-9. 2006
  8. ncbi request reprint CD154 activates macrophage antimicrobial activity in the absence of IFN-gamma through a TNF-alpha-dependent mechanism
    Rosa M Andrade
    Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
    J Immunol 171:6750-6. 2003
  9. ncbi request reprint CD40-TRAF6 and autophagy-dependent anti-microbial activity in macrophages
    Carlos S Subauste
    Department of Ophthalmology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
    Autophagy 3:245-8. 2007

Collaborators

Detail Information

Publications9

  1. ncbi request reprint CD154 and type-1 cytokine response: from hyper IgM syndrome to human immunodeficiency virus infection
    Carlos S Subauste
    Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    J Infect Dis 185:S83-9. 2002
    ....
  2. ncbi request reprint TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha
    Rosa M Andrade
    Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 175:6014-21. 2005
    ..These results support a paradigm where TNFR-associated factor 6 signaling downstream of CD40 alters the pattern of response of macrophages to TNF-alpha leading to induction of antimicrobial activity...
  3. pmc CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes
    Rosa M Andrade
    Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Clin Invest 116:2366-77. 2006
    ..Thus, cell-mediated immunity through CD40 stimulation can reroute an intracellular pathogen to the lysosomal compartment, resulting in macrophage antimicrobial activity...
  4. ncbi request reprint Pathogen-specific induction of CD154 is impaired in CD4+ T cells from human immunodeficiency virus-infected patients
    Carlos S Subauste
    Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Infect Dis 189:61-70. 2004
    ..gondii in cells from HIV-infected patients. Together, defective induction of CD154 is likely to contribute to impaired cell-mediated immunity against opportunistic pathogens in HIV-infected patients...
  5. pmc CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates
    Rosa M Andrade
    Department of Internal Medicine, University of Cincinnati College of Medicine, P O Box 670560, Cincinnati, OH 45267 0560, USA
    Infect Immun 73:3115-23. 2005
    ....
  6. ncbi request reprint Role of CD40-dependent down-regulation of CD154 in impaired induction of CD154 in CD4(+) T cells from HIV-1-infected patients
    Carlos S Subauste
    Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 178:1645-53. 2007
    ..In addition, dysregulation of CD154 in HIV-1 infection likely contributes to immunodeficiency because diminished expression of CD154 induced by CD40 is of functional relevance, resulting in decreased dendritic cell maturation...
  7. pmc CD40 restrains in vivo growth of Toxoplasma gondii independently of gamma interferon
    Carlos S Subauste
    Department of Internal Medicine, University of Cincinnati College of Medicine, P O Box 670560, Cincinnati, OH 45267 0560, USA
    Infect Immun 74:1573-9. 2006
    ..These results suggest that CD40-CD154 interaction regulates IFN-gamma-independent mechanisms of host protection through induction of macrophage antimicrobial activity and modulation of TNF-alpha signaling...
  8. ncbi request reprint CD154 activates macrophage antimicrobial activity in the absence of IFN-gamma through a TNF-alpha-dependent mechanism
    Rosa M Andrade
    Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
    J Immunol 171:6750-6. 2003
    ..These results demonstrate that CD154 triggers TNF-alpha-dependent antimicrobial activity in macrophages and suggest that CD154 regulates the mechanisms of host protection that take place when IFN-gamma signaling is deficient...
  9. ncbi request reprint CD40-TRAF6 and autophagy-dependent anti-microbial activity in macrophages
    Carlos S Subauste
    Department of Ophthalmology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
    Autophagy 3:245-8. 2007
    ..We now report that vacuole-lysosome fusion is dependent on synergy between TRAF6 signaling downstream of CD40 and TNF-alpha. These studies identified a new paradigm by which T cells eradicate an intracellular pathogen within macrophages...