Xiao Su

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Inhibition of inflammatory responses by ambroxol, a mucolytic agent, in a murine model of acute lung injury induced by lipopolysaccharide
    Xiao Su
    Research Institute of Respiratory Diseases, Zhongshan Hospital, Fudan University, 200032 Shanghai, PR China
    Intensive Care Med 30:133-40. 2004
  2. pmc Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats
    Xiao Su
    Cardiovascular Research Institute, University of California San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
    Am J Respir Cell Mol Biol 37:186-92. 2007
  3. ncbi request reprint Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice
    Xiao Su
    Cardiovascular Research Institute, Univ of California, San Francisco, CA 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 290:L769-L776. 2006
  4. pmc Role of protease activated receptor 2 in experimental acute lung injury and lung fibrosis
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Anat Rec (Hoboken) 292:580-6. 2009
  5. pmc CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 180:6947-53. 2008
  6. pmc Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, California 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1-5. 2009
  7. ncbi request reprint Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice
    Naveen Gupta
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 179:1855-63. 2007
  8. ncbi request reprint Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 175:2598-605. 2005
  9. pmc Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes
    Anna Krasnodembskaya
    Cardiovascular Research Institute and Department of Anesthesiology, University of California San Francisco, 505 Parnassus Ave, CA 94143, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1003-13. 2012
  10. pmc Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury
    R Gisli Jenkins
    Lung Biology Center, UCSF, San Francisco, California 94158, USA
    J Clin Invest 116:1606-14. 2006

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Inhibition of inflammatory responses by ambroxol, a mucolytic agent, in a murine model of acute lung injury induced by lipopolysaccharide
    Xiao Su
    Research Institute of Respiratory Diseases, Zhongshan Hospital, Fudan University, 200032 Shanghai, PR China
    Intensive Care Med 30:133-40. 2004
    ..The aim of this study is to investigate whether ambroxol inhibits inflammatory responses in a murine model of lipopolysaccharide-induced acute lung injury (ALI)...
  2. pmc Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats
    Xiao Su
    Cardiovascular Research Institute, University of California San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
    Am J Respir Cell Mol Biol 37:186-92. 2007
    ..These results indicate that activation of alpha7 nAChR may provide a new therapeutic pathway for the treatment of acute lung injury...
  3. ncbi request reprint Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice
    Xiao Su
    Cardiovascular Research Institute, Univ of California, San Francisco, CA 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 290:L769-L776. 2006
    ..coli pneumonia in mice by two mechanisms: 1) reducing lung vascular injury and 2) upregulating the resolution of alveolar edema...
  4. pmc Role of protease activated receptor 2 in experimental acute lung injury and lung fibrosis
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Anat Rec (Hoboken) 292:580-6. 2009
    ..Thus, PAR2 does not appear to play a critical role in the pathogeneses of experimental acid-induced acute lung injury, E. coli pneumonia, and bleomycin-induced acute lung injury and pulmonary fibrosis in mice...
  5. pmc CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 180:6947-53. 2008
    ..coli pneumonia had an improved survival rate. Taken together, deficiency of CD47 protects mice from LPS-induced acute lung injury and E. coli pneumonia. Targeting CD47 may be a novel pathway for treatment of acute lung injury...
  6. pmc Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, California 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1-5. 2009
    ..In summary, BAL RAGE is an indicator of ALI, and it may be useful in distinguishing direct from indirect models of ALI as well as assessing the response to specific therapies...
  7. ncbi request reprint Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice
    Naveen Gupta
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 179:1855-63. 2007
    ..In conclusion, treatment with intrapulmonary MSC markedly decreases the severity of endotoxin-induced acute lung injury and improves survival in mice...
  8. ncbi request reprint Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 175:2598-605. 2005
    ..These effects were either partly or completely neuropeptide dependent, suggesting that PAR2 can cause lung inflammation by a neurogenic mechanism...
  9. pmc Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes
    Anna Krasnodembskaya
    Cardiovascular Research Institute and Department of Anesthesiology, University of California San Francisco, 505 Parnassus Ave, CA 94143, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1003-13. 2012
    ..Thus intravenous MSC increased survival from gram-negative peritoneal sepsis, in part by a monocyte-dependent increase in bacterial phagocytosis...
  10. pmc Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury
    R Gisli Jenkins
    Lung Biology Center, UCSF, San Francisco, California 94158, USA
    J Clin Invest 116:1606-14. 2006
    ....
  11. pmc Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
    Inflamm Res 60:619-32. 2011
    ..In this study, we investigated whether a lack of functional CFTR in neutrophils would promote lipopolysaccharide (LPS)-induced lung inflammation and injury...
  12. pmc Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury
    Mark R Looney
    Cardiovascular Research Institute, Department of Medicine, UCSF, San Francisco, California, USA
    J Clin Invest 116:1615-23. 2006
    ..In conclusion, in a clinically relevant in vivo mouse model of TRALI using an MHC I mAb, the mechanism of lung injury was dependent on neutrophils and their Fc gamma receptors...
  13. pmc Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion
    Jan Hirsch
    Anesthesia and Perioperative Care, Mass Spectrometry Facility, University of California, San Francisco, CA, USA
    Crit Care Med 36:1846-54. 2008
    ..Hepatic ischemia-reperfusion can be associated with acute lung injury. Alveolar epithelial type II cells (ATII) play an important role in maintaining lung homeostasis in acute lung injury...
  14. ncbi request reprint Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Exp Lung Res 30:479-93. 2004
    ..This method should be valuable for experimental lung studies in mice...
  15. pmc Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury
    Joyce S Lee
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143, USA
    Anat Rec (Hoboken) 294:165-72. 2011
    ..This model should be useful to investigators studying ALI who want to simulate the clinical setting in which more than one insult often leads to greater clinical lung injury...
  16. doi request reprint Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome
    Xiaomei Feng
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA
    Anesthesiology 118:1098-105. 2013
    ..In a well-validated rat model of the Metabolic Syndrome, we sought to investigate whether surgery induced a more severe and persistent form of cognitive decline similar to that noted in preliminary clinical studies...
  17. pmc Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice
    Viktor Brovkovych
    Department of Pharmacology, University of Illinois College of Medicine, 835 S Wolcott, Chicago, Illinois 60612, USA
    Am J Physiol Lung Cell Mol Physiol 295:L96-103. 2008
    ..Thus augmented iNOS expression and NO production in MPO(-/-) mice compensate for the lack of HOCl-mediated bacterial killing, and the absence of MPO-derived oxidants mitigates E. coli sepsis-induced lung inflammation and injury...
  18. ncbi request reprint Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injury
    Xiao Su
    Research Institute of Respiratory Diseases, Zhongshan Hospital, Fudan University, Shanghai, P R China
    Intensive Care Med 29:2034-42. 2003
    ..This study examined whether continuous hemofiltration favorably affects cardiopulmonary variables, lung inflammation, and lung fluid balance in a canine model of oleic acid induced acute lung injury...
  19. ncbi request reprint The role of aquaporin-1 (AQP1) expression in a murine model of lipopolysaccharide-induced acute lung injury
    Xiao Su
    Department of Pulmonary Medicine, Research Institute of Respiratory Diseases, Fudan University, Zhongshan Hospital, Shanghai 200032, PR China
    Respir Physiol Neurobiol 142:1-11. 2004
    ..The results suggest that although AQP1 expression is decreased after lung injury, depletion of AQP1 does not alter lung inflammation and lung edema induced by LPS...
  20. ncbi request reprint Role of complement component C5 in cerebral ischemia/reperfusion injury
    Cristina Costa
    Department of Preclinical Sciences, Alexion Pharmaceuticals Inc, Cheshire, CT 06410, USA
    Brain Res 1100:142-51. 2006
    ..Our results show that activated C5 complement components played an important role in cerebral tissue inflammation resulting from ischemia/reperfusion injury...
  21. pmc A rationally designed agonist antibody fragment that functionally mimics thrombopoietin
    Shana Frederickson
    Alexion Antibody Technologies, Inc, 3985 A Sorrento Valley Boulevard, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 103:14307-12. 2006
    ..Furthermore, this study demonstrates a method by which short-lived linear peptides with binding activity may be converted to more stable and potent agonists capable of activating cell surface receptors...
  22. ncbi request reprint Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogs
    Ling Wang
    Research Institute of Respiratory Diseases and Department of Surgical Intensive Care Unit, Zhongshan Hospital, Fudan University, Shanghai, China
    Exp Lung Res 30:31-42. 2004
    ..Thus, dual-ET receptor antagonists such as Tezosentan may be useful in the management of acute pulmonary arterial hypertension, complicating the course of OA-induced lung injury...
  23. ncbi request reprint Pulmonary barriers to pneumonia and sepsis
    Michael A Matthay
    Nat Med 13:780-1. 2007
  24. pmc Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response
    Tao Peng
    Alexion Pharmaceuticals Inc, Cheshire, Connecticut 06410, USA
    J Clin Invest 115:1590-600. 2005
    ..This study suggests that targeting C5 is a potential clinical approach for treating patients with asthma...