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Genomes and Genes | Xiao SuSummaryAffiliation: University of California Country: USA Publications
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Publications
Inhibition of inflammatory responses by ambroxol, a mucolytic agent, in a murine model of acute lung injury induced by lipopolysaccharideXiao Su
Research Institute of Respiratory Diseases, Zhongshan Hospital, Fudan University, 200032 Shanghai, PR China
Intensive Care Med 30:133-40. 2004..05). CONCLUSION: Ambroxol inhibited proinflammatory cytokines, reduced lung inflammation and accelerated recovery from LPS-induced ALI...
Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and ratsXiao Su
Cardiovascular Research Institute, University of California San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
Am J Respir Cell Mol Biol 37:186-92. 2007..These results indicate that activation of alpha7 nAChR may provide a new therapeutic pathway for the treatment of acute lung injury...- Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in miceXiao Su
Cardiovascular Research Institute, Univ of California, San Francisco, CA 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 290:L769-L776. 2006..coli pneumonia in mice by two mechanisms: 1) reducing lung vascular injury and 2) upregulating the resolution of alveolar edema... - Role of protease activated receptor 2 in experimental acute lung injury and lung fibrosisXiao Su
Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
Anat Rec (Hoboken) 292:580-6. 2009..Thus, PAR2 does not appear to play a critical role in the pathogeneses of experimental acid-induced acute lung injury, E. coli pneumonia, and bleomycin-induced acute lung injury and pulmonary fibrosis in mice... - Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injuryXiao Su
Cardiovascular Research Institute, University of California, San Francisco, California 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 297:L1-5. 2009..In summary, BAL RAGE is an indicator of ALI, and it may be useful in distinguishing direct from indirect models of ALI as well as assessing the response to specific therapies... - CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumoniaXiao Su
Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 180:6947-53. 2008..coli pneumonia had an improved survival rate. Taken together, deficiency of CD47 protects mice from LPS-induced acute lung injury and E. coli pneumonia. Targeting CD47 may be a novel pathway for treatment of acute lung injury... - Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in miceNaveen Gupta
Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 179:1855-63. 2007..In conclusion, treatment with intrapulmonary MSC markedly decreases the severity of endotoxin-induced acute lung injury and improves survival in mice... - Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanismsXiao Su
Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 175:2598-605. 2005..These effects were either partly or completely neuropeptide dependent, suggesting that PAR2 can cause lung inflammation by a neurogenic mechanism... - Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytesAnna Krasnodembskaya
Cardiovascular Research Institute and Department of Anesthesiology, University of California San Francisco, 505 Parnassus Ave, CA 94143, USA
Am J Physiol Lung Cell Mol Physiol 302:L1003-13. 2012..Thus intravenous MSC increased survival from gram-negative peritoneal sepsis, in part by a monocyte-dependent increase in bacterial phagocytosis... - Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injuryR Gisli Jenkins
Lung Biology Center, UCSF, San Francisco, California 94158, USA
J Clin Invest 116:1606-14. 2006.... - Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in miceXiao Su
Cardiovascular Research Institute, University of California, San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
Inflamm Res 60:619-32. 2011..In this study, we investigated whether a lack of functional CFTR in neutrophils would promote lipopolysaccharide (LPS)-induced lung inflammation and injury... - Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injuryMark R Looney
Cardiovascular Research Institute, Department of Medicine, UCSF, San Francisco, California, USA
J Clin Invest 116:1615-23. 2006..In conclusion, in a clinically relevant in vivo mouse model of TRALI using an MHC I mAb, the mechanism of lung injury was dependent on neutrophils and their Fc gamma receptors... - Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusionJan Hirsch
Anesthesia and Perioperative Care, Mass Spectrometry Facility, University of California, San Francisco, CA, USA
Crit Care Med 36:1846-54. 2008..Hepatic ischemia-reperfusion can be associated with acute lung injury. Alveolar epithelial type II cells (ATII) play an important role in maintaining lung homeostasis in acute lung injury... - Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injuryJoyce S Lee
Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143, USA
Anat Rec (Hoboken) 294:165-72. 2011..This model should be useful to investigators studying ALI who want to simulate the clinical setting in which more than one insult often leads to greater clinical lung injury... - Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized miceXiao Su
Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0130, USA
Exp Lung Res 30:479-93. 2004..This method should be valuable for experimental lung studies in mice... - Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injuryXiao Su
Research Institute of Respiratory Diseases, Zhongshan Hospital, Fudan University, Shanghai, P.R. China
Intensive Care Med 29:2034-42. 2003.... - The role of aquaporin-1 (AQP1) expression in a murine model of lipopolysaccharide-induced acute lung injuryXiao Su
Department of Pulmonary Medicine, Research Institute of Respiratory Diseases, Fudan University, Zhongshan Hospital, Shanghai 200032, PR China
Respir Physiol Neurobiol 142:1-11. 2004..The results suggest that although AQP1 expression is decreased after lung injury, depletion of AQP1 does not alter lung inflammation and lung edema induced by LPS... - Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null miceViktor Brovkovych
Department of Pharmacology, University of Illinois College of Medicine, 835 S Wolcott, Chicago, Illinois 60612, USA
Am J Physiol Lung Cell Mol Physiol 295:L96-103. 2008..Thus augmented iNOS expression and NO production in MPO(-/-) mice compensate for the lack of HOCl-mediated bacterial killing, and the absence of MPO-derived oxidants mitigates E. coli sepsis-induced lung inflammation and injury... - Role of complement component C5 in cerebral ischemia/reperfusion injuryCristina Costa
Department of Preclinical Sciences, Alexion Pharmaceuticals Inc, Cheshire, CT 06410, USA
Brain Res 1100:142-51. 2006..Our results show that activated C5 complement components played an important role in cerebral tissue inflammation resulting from ischemia/reperfusion injury... - Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogsLing Wang
Research Institute of Respiratory Diseases and Department of Surgical Intensive Care Unit, Zhongshan Hospital, Fudan University, Shanghai, China
Exp Lung Res 30:31-42. 2004..Thus, dual-ET receptor antagonists such as Tezosentan may be useful in the management of acute pulmonary arterial hypertension, complicating the course of OA-induced lung injury... - Pulmonary barriers to pneumonia and sepsisMichael A Matthay
Nat Med 13:780-1. 2007 - Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway responseTao Peng
Alexion Pharmaceuticals Inc, Cheshire, Connecticut 06410, USA
J Clin Invest 115:1590-600. 2005..This study suggests that targeting C5 is a potential clinical approach for treating patients with asthma... - A rationally designed agonist antibody fragment that functionally mimics thrombopoietinShana Frederickson
Alexion Antibody Technologies, Inc, 3985-A Sorrento Valley Boulevard, San Diego, CA 92121, USA
Proc Natl Acad Sci U S A 103:14307-12. 2006..Furthermore, this study demonstrates a method by which short-lived linear peptides with binding activity may be converted to more stable and potent agonists capable of activating cell surface receptors...