Hua Su

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart
    Hua Su
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0793, USA
    Int J Cardiol 133:191-7. 2009
  2. ncbi AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid
    H Su
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143 0793, USA
    J Gene Med 10:33-41. 2008
  3. ncbi AAV serotype-1 mediates early onset of gene expression in mouse hearts and results in better therapeutic effect
    H Su
    Cardiovascular Research Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Gene Ther 13:1495-502. 2006
  4. doi Combining angiogenic gene and stem cell therapies for myocardial infarction
    Jennifer Pons
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    J Gene Med 11:743-53. 2009
  5. pmc Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain
    Wanqiu Chen
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, CA 94110, USA
    Arterioscler Thromb Vasc Biol 33:305-10. 2013
  6. pmc Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9
    Peng Gao
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, California 94110, USA
    J Cereb Blood Flow Metab 29:1482-90. 2009
  7. pmc Endothelial progenitor cell transplantation improves long-term stroke outcome in mice
    Yongfeng Fan
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA
    Ann Neurol 67:488-97. 2010
  8. pmc Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury
    Jianqin Ye
    Division of Cardiology, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e30329. 2012
  9. pmc Contribution of bone marrow-derived cells associated with brain angiogenesis is primarily through leukocytes and macrophages
    Qi Hao
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA
    Arterioscler Thromb Vasc Biol 28:2151-7. 2008
  10. ncbi Recombinant adeno-associated viral vector encoding human VEGF165 induces neomicrovessel formation in the adult mouse brain
    Fanxia Shen
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Front Biosci 11:3190-8. 2006

Collaborators

Detail Information

Publications59

  1. pmc Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart
    Hua Su
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0793, USA
    Int J Cardiol 133:191-7. 2009
    ..We conclude that ang-1 and VEGF can compensate for each others' shortcomings and yield a better therapeutic effect by acting together...
  2. ncbi AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid
    H Su
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143 0793, USA
    J Gene Med 10:33-41. 2008
    ..AAV-mediated VEGF gene transfer can also induce neovascular formation in the pig myocardium...
  3. ncbi AAV serotype-1 mediates early onset of gene expression in mouse hearts and results in better therapeutic effect
    H Su
    Cardiovascular Research Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Gene Ther 13:1495-502. 2006
    ..Thus, AAV1 mediates earlier and higher transgene expression in myocardium and better therapeutic effects...
  4. doi Combining angiogenic gene and stem cell therapies for myocardial infarction
    Jennifer Pons
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    J Gene Med 11:743-53. 2009
    ....
  5. pmc Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain
    Wanqiu Chen
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, CA 94110, USA
    Arterioscler Thromb Vasc Biol 33:305-10. 2013
    ..We tested the hypothesis that vascular endothelial growth factor impairs vascular integrity in the Alk1-deficient brain through reduction of mural cell coverage...
  6. pmc Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9
    Peng Gao
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, California 94110, USA
    J Cereb Blood Flow Metab 29:1482-90. 2009
    ..Our findings suggest that mild nonischemic VH results in a pro-angiogenic stage in the brain by upregulating HIF-1 and its downstream targets, VEGF and SDF-1alpha, increasing leukocyte infiltration and MMP-9 activity...
  7. pmc Endothelial progenitor cell transplantation improves long-term stroke outcome in mice
    Yongfeng Fan
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA
    Ann Neurol 67:488-97. 2010
    ..However, the cause of EPC migration and the function of EPCs after ischemia are unclear. In this study, we demonstrated the effects of EPCs on ischemic brain injury in a mouse model of transient middle cerebral artery occlusion (tMCAO)...
  8. pmc Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury
    Jianqin Ye
    Division of Cardiology, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e30329. 2012
    ..Cardiospheres (CSs) have been proposed to have cardiac regenerative properties; however, their cellular composition and how they may be influenced by the tissue milieu remains unclear...
  9. pmc Contribution of bone marrow-derived cells associated with brain angiogenesis is primarily through leukocytes and macrophages
    Qi Hao
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA
    Arterioscler Thromb Vasc Biol 28:2151-7. 2008
    ..We investigated the role of bone marrow-derived cells (BMDCs) in an angiogenic focus, induced by VEGF stimulation...
  10. ncbi Recombinant adeno-associated viral vector encoding human VEGF165 induces neomicrovessel formation in the adult mouse brain
    Fanxia Shen
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Front Biosci 11:3190-8. 2006
    ..Our data underline the importance of angiogenesis in the brain tissue and indicate that VEGF gene transfer might present a valuable approach to treat brain ischemic disorders...
  11. pmc Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation
    Qi Hao
    University of California, San Francisco, Department of Anesthesia and Perioperative Care, 1001 Potrero Ave, Rm 3C 38, San Francisco, CA 94110, USA
    Am J Physiol Heart Circ Physiol 295:H2250-6. 2008
    ....
  12. pmc AAV-mediated netrin-1 overexpression increases peri-infarct blood vessel density and improves motor function recovery after experimental stroke
    Hui Sun
    Department of Neurological Surgery, San Francisco, CA, USA
    Neurobiol Dis 44:73-83. 2011
    ..However, it had little effect on post-stroke spatial learning and memory. Our results suggest that AAV mediated netrin-1 overexpression improves peri-infarct vascular density and post stroke motor function...
  13. pmc Attenuation of brain response to vascular endothelial growth factor-mediated angiogenesis and neurogenesis in aged mice
    Peng Gao
    Department of Anesthesia and Perioperative Care, University of California, Center for Cerebrovascular Research, San Francisco, Calif 94110, USA
    Stroke 40:3596-600. 2009
    ..Alterations of neuroangiogenic response play important roles in the development of aging-related neurodisorders and affect gene-based therapies. We tested brain response to vascular endothelial growth factor (VEGF) in aged mice...
  14. ncbi Adeno-associated viral vector-delivered hypoxia-inducible gene expression in ischemic hearts
    Hua Su
    Cardiovascular Research Institute Department of Medicine, University of California, San Francisco, USA
    Methods Mol Biol 366:331-42. 2007
    ....
  15. pmc Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse
    Eun Jung Choi
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, CA 94110, USA
    Cerebrovasc Dis 33:540-7. 2012
    ..We hypothesized that Eng deletion plus VEGF stimulation would induce a similar degree of cerebrovascular dysplasia as the Alk1-deleted brain...
  16. ncbi Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice
    Fanxia Shen
    University of California, San Francisco, Department of Anesthesia and Perioperative Care, 1001 Potrero Ave, San Francisco, CA 94110, USA
    Stroke 37:2601-6. 2006
    ..We investigated the use of a hypoxia-responsive element to control VEGF expression given for neuroprotection...
  17. pmc Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts
    Hua Su
    Cardiovascular Research Institute, Department of Medicine, University of California, 513 Parnassus Avenue, San Francisco, CA 94143 0793, USA
    Proc Natl Acad Sci U S A 101:16280-5. 2004
    ..Hence, MLCVEGF can mediate cardiac-specific and hypoxia-inducible VEGF expression, neoangiogenesis, infarct-size reduction, and cardiac functional improvement...
  18. ncbi De novo cerebrovascular malformation in the adult mouse after endothelial Alk1 deletion and angiogenic stimulation
    Wanqiu Chen
    From the Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research W C, Z H, K J, M C, M W, L M, W L Y, H S, Departments of Radiology Z S, Pediatrics T A, Neurological Surgery W L Y, and Neurology W L Y, University of California, San Francisco
    Stroke 45:900-2. 2014
    ..We hypothesized that deletion of Alk1 in endothelial cell (EC) alone plus focal vascular endothelial growth factor stimulation is sufficient to induce brain AVM in the adult mouse...
  19. pmc Overexpression of netrin-1 induces neovascularization in the adult mouse brain
    Yongfeng Fan
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94110, USA
    J Cereb Blood Flow Metab 28:1543-51. 2008
    ..Our findings suggest that netrin-1 plays an important role in promoting blood vessel formation in the adult rodent central nervous system, and could have broad implication in cerebrovascular development and remodeling...
  20. pmc Coexpression of angiopoietin-1 with VEGF increases the structural integrity of the blood-brain barrier and reduces atrophy volume
    Fanxia Shen
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, California 94110, USA
    J Cereb Blood Flow Metab 31:2343-51. 2011
    ..85). Thus, coexpression of ANG1 with VEGF improved BBB integrity and resulted in better neuroprotection compared with VEGF expression alone...
  21. pmc Endoglin deficiency in bone marrow is sufficient to cause cerebrovascular dysplasia in the adult mouse after vascular endothelial growth factor stimulation
    Eun Jung Choi
    UCSF, Department of Anesthesia and Perioperative Care, San Francisco, CA 94110, USA
    Stroke 44:795-8. 2013
    ..We hypothesized that Eng(+/-) BMDCs cause cerebrovascular dysplasia in the adult mouse after VEGF stimulation...
  22. pmc Arteriovenous malformation in the adult mouse brain resembling the human disease
    Espen J Walker
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
    Ann Neurol 69:954-62. 2011
    ..We tested the hypothesis that vascular endothelial growth factor (VEGF) stimulation with regional homozygous deletion of Alk1 induces severe dysplasia in the adult mouse brain, akin to human bAVM...
  23. pmc Bone fracture exacerbates murine ischemic cerebral injury
    Vincent Degos
    Center for Cerebrovascular Research and Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California 94110, USA
    Anesthesiology 118:1362-72. 2013
    ..We tested the hypothesis that bone fracture, shortly after ischemic stroke, enhances stroke-related injuries by augmenting the neuroinflammatory response...
  24. pmc Intravenous delivery of adeno-associated viral vector serotype 9 mediates effective gene expression in ischemic stroke lesion and brain angiogenic foci
    Fanxia Shen
    University of California, San Francisco, Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, San Francisco, CA 94110, USA
    Stroke 44:252-4. 2013
    ..We tested if ssAAV9 effectively mediates gene expression in the ischemic stroke lesion and angiogenic foci...
  25. pmc Evidence of endothelial progenitor cells in the human brain and spinal cord arteriovenous malformations
    Peng Gao
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 67:1029-35. 2010
    ..Endothelial progenitor cells (EPCs) can be recruited by stromal cell-derived factor-1 (SDF-1), and participate in vascular remodeling in both physiological and pathological settings...
  26. pmc Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124
    Frank Kuhnert
    Department of Medicine, Hematology Division, Stanford University, Stanford, CA 94305, USA
    Science 330:985-9. 2010
    ..Further, the functional tropism of GPR124 marks this receptor as a therapeutic target for CNS-related vascular pathologies...
  27. ncbi Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb
    David S Chang
    Pacific Vascular Research Laboratory, Division of Vascular Surgery, Department of Surgery, University of California San Francisco, San Francisco, California 94143, USA
    Mol Ther 7:44-51. 2003
    ..We conclude that intra-arterial AAV-mediated gene transfer of AAV-VEGF(165) normalizes muscle oxygen tension and leads to arteriogenesis in rats with severe hindlimb ischemia...
  28. pmc Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model
    Hua Su
    Cardiovascular Research Institute, University of California, 513 Parnassus Avenue, Room U432, San Francisco, CA 94143 0793, USA
    Proc Natl Acad Sci U S A 99:9480-5. 2002
    ..Hence, HRE is a good candidate for the control of angiogenic factor gene expression in ischemic myocardium...
  29. pmc Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain
    Yiqian Zhu
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA
    J Neuropathol Exp Neurol 68:626-32. 2009
    ..These data suggest that restoring HoxA5 can attenuate experimental brain hemangioma development...
  30. ncbi Neutrophil depletion decreases VEGF-induced focal angiogenesis in the mature mouse brain
    Qi Hao
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, CA 94110, USA
    J Cereb Blood Flow Metab 27:1853-60. 2007
    ..In addition, brain MMP-9 activity was attenuated after neutrophil depletion, suggesting that neutrophil is an important source of MMP-9...
  31. pmc Bone marrow-derived cells contribute to vascular endothelial growth factor-induced angiogenesis in the adult mouse brain by supplying matrix metalloproteinase-9
    Qi Hao
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Stroke 42:453-8. 2011
    ..The angiogenic response to vascular endothelial growth factor (VEGF) stimulation is reduced in matrix metalloproteinase-9 (MMP-9) knockout mice. We hypothesized that BMDCs contribute to VEGF-induced angiogenesis by supplying MMP-9...
  32. pmc Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis
    Hua Su
    Center of Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
    Am J Pathol 176:1018-27. 2010
    ..These three lines of evidence from human studies and a mouse model suggest that reduced expression of integrin beta8 may be involved in the pathogenesis of sporadic BAVMs...
  33. doi VEGF improves survival of mesenchymal stem cells in infarcted hearts
    Jennifer Pons
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA
    Biochem Biophys Res Commun 376:419-22. 2008
    ..In conclusion, VEGF protects MSCs from culture-induce cellular stress and improves their viability in ischemic myocardium, which results in improvements of their therapeutic effect for the treatment of MI...
  34. pmc Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation rupture
    Yi Guo
    University of California, San Francisco, CA 94110, USA
    Stroke 43:1240-6. 2012
    ....
  35. pmc Soluble endoglin modulates aberrant cerebral vascular remodeling
    Yongmei Chen
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California San Francisco, San Francisco, CA, USA
    Ann Neurol 66:19-27. 2009
    ....
  36. pmc Forskolin stimulation promotes urea transporter UT-A1 ubiquitination, endocytosis, and degradation in MDCK cells
    Hua Su
    Department of Medicine, Renal Division, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 303:F1325-32. 2012
    ....
  37. pmc MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors
    Celine Delaloy
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California San Francisco, CA 94158, USA
    Cell Stem Cell 6:323-35. 2010
    ..These results identify miR-9 as a novel regulator that coordinates the proliferation and migration of hNPCs...
  38. pmc Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic development
    Helen Kim
    Center for Cerebrovascular Research, University of California, San Francisco, Calif, USA
    Stroke 40:S95-7. 2009
    ....
  39. pmc Adeno-associated viral vector-mediated hypoxia-regulated VEGF gene transfer promotes angiogenesis following focal cerebral ischemia in mice
    F Shen
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, CA 94110, USA
    Gene Ther 15:30-9. 2008
    ..VEGF overexpression through AAVH9-VEGF gene transfer showed stable focal angiogenic effects in post-ischemic repair process, providing an opportunity to rebuild injured brain tissue...
  40. pmc Bevacizumab attenuates VEGF-induced angiogenesis and vascular malformations in the adult mouse brain
    Espen J Walker
    Center for Cerebrovascular Research, University of California, San Francisco, Department of Anesthesia and Perioperative Care, 1001 Potrero Avenue, Room 3C 38, San Francisco, CA 94110, USA
    Stroke 43:1925-30. 2012
    ....
  41. doi Treatment of focal brain ischemia with viral vector-mediated gene transfer
    Hua Su
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, USA
    Methods Mol Biol 686:429-46. 2011
    ..This chapter also illustrates the methods to produce mouse middle cerebral artery occlusion (MCAO), injection of viral vector into the mouse brain, and standard assays for determining the success of brain ischemia and gene transfer...
  42. pmc Novel brain arteriovenous malformation mouse models for type 1 hereditary hemorrhagic telangiectasia
    Eun Jung Choi
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 9:e88511. 2014
    ..Further, our data indicate that macrophage Eng deletion is insufficient and that endothelial Eng homozygous deletion is required for HHT1 brain AVM development. ..
  43. pmc Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Acta Neurochir Suppl 111:83-92. 2011
    ..Based on the various lines of evidence reviewed in this paper, we propose a "response-to-injury" model of brain AVM pathogenesis...
  44. pmc Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction
    Vincent Degos
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California 94110, USA
    Anesthesiology 118:527-36. 2013
    ..The authors hypothesize that hippocampal recruitment of bone marrow-derived macrophages plays a causal role in these processes, resulting in memory dysfunction...
  45. pmc Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue
    Michael P Kahle
    Department of Neuroscience and Experimental Therapeutics, Texas A and M College of Medicine, College Station, Texas 77843, USA
    Neuroreport 23:627-30. 2012
    ..Furthermore, increases in all components were strongly correlated. Excessive generation of proangiogenic DV in BAVM suggests that DV may participate in its pathology and may represent a future therapeutic target...
  46. pmc Permanent coronary artery occlusion: cardiovascular MR imaging is platform for percutaneous transendocardial delivery and assessment of gene therapy in canine model
    Maythem Saeed
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94134 0628, USA
    Radiology 249:560-71. 2008
    ..To provide evidence that vascular endothelial growth factor (VEGF) genes delivered transendocardially with magnetic resonance (MR) imaging guidance may neovascularize or improve vascular recruitment in occlusive infarction...
  47. pmc Brain arteriovenous malformation modeling, pathogenesis, and novel therapeutic targets
    Wanqiu Chen
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, 1001 Potrero Avenue, Box 1363, San Francisco, CA, 94110, USA
    Transl Stroke Res 5:316-29. 2014
    ..In this review, we summarize bAVM model development and bAVM pathogenesis and potential therapeutic targets that have been identified during model development. ..
  48. pmc Induction of brain arteriovenous malformation in the adult mouse
    Wanqiu Chen
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, CA, USA
    Methods Mol Biol 1135:309-16. 2014
    ..Here, we introduce a method that induces the bAVM phenotype through regional deletion of activin-like kinase 1 (Alk1, the causal gene for HHT2) and vascular endothelial growth factor (VEGF) stimulation. ..
  49. pmc Depolymerization of cortical actin inhibits UT-A1 urea transporter endocytosis but promotes forskolin-stimulated membrane trafficking
    Gang Xu
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Cell Physiol 302:C1012-8. 2012
    ....
  50. pmc Non-muscle myosin II regulates survival threshold of pluripotent stem cells
    Andrea Walker
    Department of Biochemistry, University of California, Riverside, Riverside, California 29521, USA
    Nat Commun 1:71. 2010
    ..These results underscore the importance of the molecular motor, NMII, as a novel target for chemically engineering the survival and self-renewal of hPS cells...
  51. ncbi Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodies
    H Su
    Department of Medicine, VA Medical Center, University of California, San Francisco
    Mol Reprod Dev 33:252-8. 1992
    ..Its location in the seminiferous tubules suggests a possible role in early germ cell development...
  52. pmc A hypoxia-regulated adeno-associated virus vector for cancer-specific gene therapy
    H Ruan
    Brain Tumor Research Center of the Department of Neurological Surgery
    Neoplasia 3:255-63. 2001
    ..Under anoxic conditions, this vector produced 79- to 110-fold increase in gene expression. We believe this hypoxia-regulated rAAV vector will provide a useful delivery vehicle for cancer-specific gene therapy...
  53. pmc A novel L-serine deaminase activity in Escherichia coli K-12
    H Su
    Department of Biological Sciences, Concordia University, Montreal, Quebec, Canada
    J Bacteriol 173:2473-80. 1991
    ..Both mutations lie near 60.5 min on the E. coli genetic map. The two L-SD enzymes have similar enzyme parameters, and both require posttranslational activation...
  54. pmc The Chlamydia trachomatis hyp operon is homologous to the groE stress response operon of Escherichia coli
    R P Morrison
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840
    Infect Immun 58:2701-5. 1990
    ....
  55. pmc Discovery and biological characterization of a novel series of androgen receptor modulators
    C Zhou
    The National Center for Drug Screening and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
    Br J Pharmacol 154:440-50. 2008
    ..The purpose of this study was to provide a preliminary characterization of a new class of non-steroidal androgen receptor modulators discovered in a high-throughput screening campaign...
  56. ncbi Use of gene fusions of the structural gene sdaA to purify L-serine deaminase 1 from Escherichia coli K-12
    H Su
    Biology Department, Concordia University, Montreal, Canada
    Eur J Biochem 211:521-7. 1993
    ..Like the enzyme in crude extracts, this purified enzyme is catalytically inactive, and is activated by incubation with iron and dithiothreitol...
  57. ncbi Nested chromosomal deletions induced with retroviral vectors in mice
    H Su
    Program in Developmental Biology, Department of Molecular Genetics, Baylor College of Medicine, Houston, Texas, USA
    Nat Genet 24:92-5. 2000
    ..Our approach can be extended to any region of the mouse genome...
  58. pmc Expression and stress-dependent induction of potassium channel transcripts in the common ice plant
    H Su
    Department of Plant Sciences, Biosciences West, 1041 East Lowell Street, University of Arizona, Tucson, Arizona 85721-0088, USA
    Plant Physiol 125:604-14. 2001
    ....
  59. ncbi [Differential expression analysis and cloning of murine thymic aged-related genes]
    Y H Li
    Department of Immunology, Institute of Basic Medical Sciences, CAMS, PUMC, Beijing 100005, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 23:158-62. 2001
    ..CONCLUSION: Expression of murine thymic genes has displayed a marked difference with age. These genes might be participated in thymic atrophy...