Research Topics
Genomes and Genes
| Hua SuSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Reduced Mural Cell Coverage and Impaired Vessel Integrity After Angiogenic Stimulation in the Alk1-deficient BrainWanqiu Chen
Department of Anesthesia and Perioperative Care, University of California, San Francisco, 1001 Potrero Ave, Box 1363, San Francisco, CA 94110
Arterioscler Thromb Vasc Biol 33:305-10. 2013..We tested the hypothesis that vascular endothelial growth factor impairs vascular integrity in the Alk1-deficient brain through reduction of mural cell coverage...- Endoglin Deficiency in Bone Marrow is Sufficient to Cause Cerebrovascular Dysplasia in the Adult Mouse After Vascular Endothelial Growth Factor StimulationEun Jung Choi
UCSF, Department of Anesthesia and Perioperative Care, 1001 Potrero Avenue, Box1363, San Francisco, CA 94110
Stroke 44:795-8. 2013..We hypothesized that Eng(+/-) BMDCs cause cerebrovascular dysplasia in the adult mouse after VEGF stimulation... 
AAV serotype-1 mediates early onset of gene expression in mouse hearts and results in better therapeutic effectH Su
Cardiovascular Research Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Gene Ther 13:1495-502. 2006..Thus, AAV1 mediates earlier and higher transgene expression in myocardium and better therapeutic effects...- Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heartHua Su
Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0793, USA
Int J Cardiol 133:191-7. 2009..We conclude that ang-1 and VEGF can compensate for each others' shortcomings and yield a better therapeutic effect by acting together... - AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmidH Su
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143 0793, USA
J Gene Med 10:33-41. 2008..AAV-mediated VEGF gene transfer can also induce neovascular formation in the pig myocardium... 
Combining angiogenic gene and stem cell therapies for myocardial infarctionJennifer Pons
Cardiovascular Research Institute, University of California, San Francisco, CA, USA
J Gene Med 11:743-53. 2009....- Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9Peng Gao
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, California 94110, USA
J Cereb Blood Flow Metab 29:1482-90. 2009..Our findings suggest that mild nonischemic VH results in a pro-angiogenic stage in the brain by upregulating HIF-1 and its downstream targets, VEGF and SDF-1alpha, increasing leukocyte infiltration and MMP-9 activity... - Endothelial progenitor cell transplantation improves long-term stroke outcome in miceYongfeng Fan
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA
Ann Neurol 67:488-97. 2010..However, the cause of EPC migration and the function of EPCs after ischemia are unclear. In this study, we demonstrated the effects of EPCs on ischemic brain injury in a mouse model of transient middle cerebral artery occlusion (tMCAO)... - Recombinant adeno-associated viral vector encoding human VEGF165 induces neomicrovessel formation in the adult mouse brainFanxia Shen
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
Front Biosci 11:3190-8. 2006..Our data underline the importance of angiogenesis in the brain tissue and indicate that VEGF gene transfer might present a valuable approach to treat brain ischemic disorders... - Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulationQi Hao
University of California, San Francisco, Department of Anesthesia and Perioperative Care, 1001 Potrero Ave, Rm 3C 38, San Francisco, CA 94110, USA
Am J Physiol Heart Circ Physiol 295:H2250-6. 2008.... - Arteriovenous malformation in the adult mouse brain resembling the human diseaseEspen J Walker
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
Ann Neurol 69:954-62. 2011..We tested the hypothesis that vascular endothelial growth factor (VEGF) stimulation with regional homozygous deletion of Alk1 induces severe dysplasia in the adult mouse brain, akin to human bAVM... - Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injuryJianqin Ye
Division of Cardiology, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 7:e30329. 2012..Cardiospheres (CSs) have been proposed to have cardiac regenerative properties; however, their cellular composition and how they may be influenced by the tissue milieu remains unclear... - Contribution of bone marrow-derived cells associated with brain angiogenesis is primarily through leukocytes and macrophagesQi Hao
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA
Arterioscler Thromb Vasc Biol 28:2151-7. 2008..We investigated the role of bone marrow-derived cells (BMDCs) in an angiogenic focus, induced by VEGF stimulation... - Adeno-associated viral vector-delivered hypoxia-inducible gene expression in ischemic heartsHua Su
Cardiovascular Research Institute Department of Medicine, University of California, San Francisco, USA
Methods Mol Biol 366:331-42. 2007.... - AAV-mediated netrin-1 overexpression increases peri-infarct blood vessel density and improves motor function recovery after experimental strokeHui Sun
Department of Neurological Surgery, San Francisco, CA, USA
Neurobiol Dis 44:73-83. 2011..However, it had little effect on post-stroke spatial learning and memory. Our results suggest that AAV mediated netrin-1 overexpression improves peri-infarct vascular density and post stroke motor function... - Attenuation of brain response to vascular endothelial growth factor-mediated angiogenesis and neurogenesis in aged micePeng Gao
Department of Anesthesia and Perioperative Care, University of California, Center for Cerebrovascular Research, San Francisco, Calif 94110, USA
Stroke 40:3596-600. 2009..Alterations of neuroangiogenic response play important roles in the development of aging-related neurodisorders and affect gene-based therapies. We tested brain response to vascular endothelial growth factor (VEGF) in aged mice... - Coexpression of angiopoietin-1 with VEGF increases the structural integrity of the blood-brain barrier and reduces atrophy volumeFanxia Shen
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, California 94110, USA
J Cereb Blood Flow Metab 31:2343-51. 2011..85). Thus, coexpression of ANG1 with VEGF improved BBB integrity and resulted in better neuroprotection compared with VEGF expression alone... - Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in miceFanxia Shen
University of California, San Francisco, Department of Anesthesia and Perioperative Care, 1001 Potrero Ave, San Francisco, CA 94110, USA
Stroke 37:2601-6. 2006..Hypoxia-responsive element is a viable strategy of restricting VEGF expression to areas of ischemia to minimize adverse effects of therapy on adjacent normal parenchyma... - Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse heartsHua Su
Cardiovascular Research Institute, Department of Medicine, University of California, 513 Parnassus Avenue, San Francisco, CA 94143 0793, USA
Proc Natl Acad Sci U S A 101:16280-5. 2004..Hence, MLCVEGF can mediate cardiac-specific and hypoxia-inducible VEGF expression, neoangiogenesis, infarct-size reduction, and cardiac functional improvement... - Overexpression of netrin-1 induces neovascularization in the adult mouse brainYongfeng Fan
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94110, USA
J Cereb Blood Flow Metab 28:1543-51. 2008..Our findings suggest that netrin-1 plays an important role in promoting blood vessel formation in the adult rodent central nervous system, and could have broad implication in cerebrovascular development and remodeling... - Intravenous delivery of adeno-associated viral vector serotype 9 mediates effective gene expression in ischemic stroke lesion and brain angiogenic fociFanxia Shen
University of California, San Francisco, Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, San Francisco, CA 94110, USA
Stroke 44:252-4. 2013..We tested if ssAAV9 effectively mediates gene expression in the ischemic stroke lesion and angiogenic foci... - Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouseEun Jung Choi
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, CA 94110, USA
Cerebrovasc Dis 33:540-7. 2012..We hypothesized that Eng deletion plus VEGF stimulation would induce a similar degree of cerebrovascular dysplasia as the Alk1-deleted brain... - Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brainYiqian Zhu
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA
J Neuropathol Exp Neurol 68:626-32. 2009..These data suggest that restoring HoxA5 can attenuate experimental brain hemangioma development... - Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart modelHua Su
Cardiovascular Research Institute, University of California, 513 Parnassus Avenue, Room U432, San Francisco, CA 94143-0793, USA
Proc Natl Acad Sci U S A 99:9480-5. 2002..Hence, HRE is a good candidate for the control of angiogenic factor gene expression in ischemic myocardium... - Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimbDavid S Chang
Pacific Vascular Research Laboratory, Division of Vascular Surgery, Department of Surgery, University of California San Francisco, San Francisco, California 94143, USA
Mol Ther 7:44-51. 2003..We conclude that intra-arterial AAV-mediated gene transfer of AAV-VEGF(165) normalizes muscle oxygen tension and leads to arteriogenesis in rats with severe hindlimb ischemia... - Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124Frank Kuhnert
Department of Medicine, Hematology Division, Stanford University, Stanford, CA 94305, USA
Science 330:985-9. 2010..Further, the functional tropism of GPR124 marks this receptor as a therapeutic target for CNS-related vascular pathologies... - Evidence of endothelial progenitor cells in the human brain and spinal cord arteriovenous malformationsPeng Gao
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California, USA
Neurosurgery 67:1029-35. 2010..Endothelial progenitor cells (EPCs) can be recruited by stromal cell-derived factor-1 (SDF-1), and participate in vascular remodeling in both physiological and pathological settings... - Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation ruptureYi Guo
University of California, San Francisco, CA 94110, USA
Stroke 43:1240-6. 2012.... - Soluble endoglin modulates aberrant cerebral vascular remodelingYongmei Chen
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California San Francisco, San Francisco, CA, USA
Ann Neurol 66:19-27. 2009.... - VEGF improves survival of mesenchymal stem cells in infarcted heartsJennifer Pons
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA
Biochem Biophys Res Commun 376:419-22. 2008..In conclusion, VEGF protects MSCs from culture-induce cellular stress and improves their viability in ischemic myocardium, which results in improvements of their therapeutic effect for the treatment of MI... - Bone marrow-derived cells contribute to vascular endothelial growth factor-induced angiogenesis in the adult mouse brain by supplying matrix metalloproteinase-9Qi Hao
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
Stroke 42:453-8. 2011..The angiogenic response to vascular endothelial growth factor (VEGF) stimulation is reduced in matrix metalloproteinase-9 (MMP-9) knockout mice. We hypothesized that BMDCs contribute to VEGF-induced angiogenesis by supplying MMP-9... - Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesisHua Su
Center of Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
Am J Pathol 176:1018-27. 2010..These three lines of evidence from human studies and a mouse model suggest that reduced expression of integrin beta8 may be involved in the pathogenesis of sporadic BAVMs... - Neutrophil depletion decreases VEGF-induced focal angiogenesis in the mature mouse brainQi Hao
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, CA 94110, USA
J Cereb Blood Flow Metab 27:1853-60. 2007..In addition, brain MMP-9 activity was attenuated after neutrophil depletion, suggesting that neutrophil is an important source of MMP-9... - Forskolin stimulation promotes urea transporter UT-A1 ubiquitination, endocytosis, and degradation in MDCK cellsHua Su
Department of Medicine, Renal Division, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Physiol Renal Physiol 303:F1325-32. 2012.... - Bevacizumab attenuates VEGF-induced angiogenesis and vascular malformations in the adult mouse brainEspen J Walker
Center for Cerebrovascular Research, University of California, San Francisco, Department of Anesthesia and Perioperative Care, 1001 Potrero Avenue, Room 3C 38, San Francisco, CA 94110, USA
Stroke 43:1925-30. 2012.... - MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitorsCeline Delaloy
Gladstone Institute of Neurological Disease and Department of Neurology, University of California San Francisco, CA 94158, USA
Cell Stem Cell 6:323-35. 2010..These results identify miR-9 as a novel regulator that coordinates the proliferation and migration of hNPCs... - Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic developmentHelen Kim
Center for Cerebrovascular Research, University of California, San Francisco, Calif, USA
Stroke 40:S95-7. 2009.... - Adeno-associated viral vector-mediated hypoxia-regulated VEGF gene transfer promotes angiogenesis following focal cerebral ischemia in miceF Shen
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, CA 94110, USA
Gene Ther 15:30-9. 2008..VEGF overexpression through AAVH9-VEGF gene transfer showed stable focal angiogenic effects in post-ischemic repair process, providing an opportunity to rebuild injured brain tissue... - Treatment of focal brain ischemia with viral vector-mediated gene transferHua Su
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, USA
Methods Mol Biol 686:429-46. 2011..This chapter also illustrates the methods to produce mouse middle cerebral artery occlusion (MCAO), injection of viral vector into the mouse brain, and standard assays for determining the success of brain ischemia and gene transfer... - Brain arteriovenous malformation pathogenesis: a response-to-injury paradigmHelen Kim
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
Acta Neurochir Suppl 111:83-92. 2011..Based on the various lines of evidence reviewed in this paper, we propose a "response-to-injury" model of brain AVM pathogenesis... - Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunctionVincent Degos
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California 94110, USA
Anesthesiology 118:527-36. 2013..The authors hypothesize that hippocampal recruitment of bone marrow-derived macrophages plays a causal role in these processes, resulting in memory dysfunction... - Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissueMichael P Kahle
Department of Neuroscience and Experimental Therapeutics, Texas A and M College of Medicine, College Station, Texas 77843, USA
Neuroreport 23:627-30. 2012..Furthermore, increases in all components were strongly correlated. Excessive generation of proangiogenic DV in BAVM suggests that DV may participate in its pathology and may represent a future therapeutic target... - Permanent coronary artery occlusion: cardiovascular MR imaging is platform for percutaneous transendocardial delivery and assessment of gene therapy in canine modelMaythem Saeed
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94134 0628, USA
Radiology 249:560-71. 2008..To provide evidence that vascular endothelial growth factor (VEGF) genes delivered transendocardially with magnetic resonance (MR) imaging guidance may neovascularize or improve vascular recruitment in occlusive infarction... - Depolymerization of cortical actin inhibits UT-A1 urea transporter endocytosis but promotes forskolin-stimulated membrane traffickingGang Xu
Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Physiol Cell Physiol 302:C1012-8. 2012.... - Non-muscle myosin II regulates survival threshold of pluripotent stem cellsAndrea Walker
Department of Biochemistry, University of California, Riverside, Riverside, California 29521, USA
Nat Commun 1:71. 2010..These results underscore the importance of the molecular motor, NMII, as a novel target for chemically engineering the survival and self-renewal of hPS cells... - Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodiesH Su
Department of Medicine, VA Medical Center, University of California, San Francisco
Mol Reprod Dev 33:252-8. 1992..Its location in the seminiferous tubules suggests a possible role in early germ cell development... - A hypoxia-regulated adeno-associated virus vector for cancer-specific gene therapyH Ruan
Brain Tumor Research Center of the Department of Neurological Surgery
Neoplasia 3:255-63. 2001..Under anoxic conditions, this vector produced 79- to 110-fold increase in gene expression. We believe this hypoxia-regulated rAAV vector will provide a useful delivery vehicle for cancer-specific gene therapy... - Discovery and biological characterization of a novel series of androgen receptor modulatorsC Zhou
The National Center for Drug Screening and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Br J Pharmacol 154:440-50. 2008..The purpose of this study was to provide a preliminary characterization of a new class of non-steroidal androgen receptor modulators discovered in a high-throughput screening campaign... - Nested chromosomal deletions induced with retroviral vectors in miceH Su
Program in Developmental Biology, Department of Molecular Genetics, Baylor College of Medicine, Houston, Texas, USA
Nat Genet 24:92-5. 2000..Our approach can be extended to any region of the mouse genome... - [Differential expression analysis and cloning of murine thymic aged-related genes]Y H Li
Department of Immunology, Institute of Basic Medical Sciences, CAMS, PUMC, Beijing 100005, China
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 23:158-62. 2001..CONCLUSION: Expression of murine thymic genes has displayed a marked difference with age. These genes might be participated in thymic atrophy... - Expression and stress-dependent induction of potassium channel transcripts in the common ice plantH Su
Department of Plant Sciences, Biosciences West, 1041 East Lowell Street, University of Arizona, Tucson, Arizona 85721-0088, USA
Plant Physiol 125:604-14. 2001.... - Use of gene fusions of the structural gene sdaA to purify L-serine deaminase 1 from Escherichia coli K-12H Su
Biology Department, Concordia University, Montreal, Canada
Eur J Biochem 211:521-7. 1993..Like the enzyme in crude extracts, this purified enzyme is catalytically inactive, and is activated by incubation with iron and dithiothreitol... - The Chlamydia trachomatis hyp operon is homologous to the groE stress response operon of Escherichia coliR P Morrison
Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840
Infect Immun 58:2701-5. 1990.... - A novel L-serine deaminase activity in Escherichia coli K-12H Su
Department of Biological Sciences, Concordia University, Montreal, Quebec, Canada
J Bacteriol 173:2473-80. 1991..Both mutations lie near 60.5 min on the E. coli genetic map. The two L-SD enzymes have similar enzyme parameters, and both require posttranslational activation...