Affiliation: University of California
- Evaluation of [(18)F]gefitinib as a molecular imaging probe for the assessment of the epidermal growth factor receptor status in malignant tumorsHelen Su
Department of Molecular Medicine and Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Eur J Nucl Med Mol Imaging 35:1089-99. 2008..In this study, we asked whether PET with [(18)F]gefitinib may be used to study noninvasively the pharmacokinetics of gefitinib in vivo and to image the EGFR status of cancer cells...
- Derivation of a compartmental model for quantifying 64Cu-DOTA-RGD kinetics in tumor-bearing miceGregory Z Ferl
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California 90095 6948, USA
J Nucl Med 50:250-8. 2009..To better understand the PET signal obtained with radiolabeled RGD peptides, we have constructed a compartmental model that can describe the time-activity curves in tumors after an intravenous injection...
- Changes in tumor metabolism as readout for Mammalian target of rapamycin kinase inhibition by rapamycin in glioblastomaLiu Hua Wei
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Clin Cancer Res 14:3416-26. 2008..The mechanisms underlying changes in metabolic activity were analyzed by measuring expression and functional activity of enzymes and transporters involved in the uptake of the studied imaging probes...
- Noninvasive imaging of alphaVbeta3 function as a predictor of the antimigratory and antiproliferative effects of dasatinibRebecca A Dumont
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 6948, USA
Cancer Res 69:3173-9. 2009..50+/-17.68 mm(2) in controls; P=0.001). [(64)Cu]DOTA-c(RGDfK) may provide a sensitive means of monitoring tumor response to SFK inhibition in alpha(V)beta(3)-expressing cancers early in the course of therapy...
- Monitoring tumor glucose utilization by positron emission tomography for the prediction of treatment response to epidermal growth factor receptor kinase inhibitorsHelen Su
Department of Molecular Medicine and Pharmacology, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, 650 Charles Young Drive, Los Angeles, CA 90095, USA
Clin Cancer Res 12:5659-67. 2006....
- A supramolecular approach for preparation of size-controlled nanoparticlesHao Wang
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA
Angew Chem Int Ed Engl 48:4344-8. 2009..Positron emission tomography (PET) was employed to study the biodistribution and lymph node drainage of the SNPs in mice. The sizes of the SNPs affect their in vivo characteristics (see picture)...
- Anesthesia and other considerations for in vivo imaging of small animalsIsabel J Hildebrandt
Department of Molecular and Medical Pharmacology at the David Geffen School of Medicine at the University of California, Los Angeles, CA 90095 6942, USA
ILAR J 49:17-26. 2008..Reproducible experimental conditions require clear, consistent reporting, in the study design and throughout the experiment, of the animal strain and gender, fasting, anesthesia, and how often individual animals were imaged...
- Monitoring the antitumor response of naive and memory CD8 T cells in RAG1-/- mice by positron-emission tomographyHelen Su
Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
J Immunol 176:4459-67. 2006..Positron-emission tomography-based immunologic imaging is a noninvasive modality providing unique and meaningful information on the dynamics of the antitumor CTL response...
- Quantitation of cell number by a positron emission tomography reporter gene strategyHelen Su
Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
Mol Imaging Biol 6:139-48. 2004..In this study, we determined the correlation of PET signal to cell number, and characterized the cellular limit of detection for PET imaging...
- Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imagingDerek W Bartlett
Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 210 41, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 104:15549-54. 2007..Optimization of internalization may therefore be key for the development of effective nanoparticle-based targeted therapeutics...
- Quantitative imaging of the T cell antitumor response by positron-emission tomographyPurnima Dubey
Department of Microbiology and Molecular Genetics, Molecular Biology Institute, University of Padua, I 35128 Padua, Italy
Proc Natl Acad Sci U S A 100:1232-7. 2003....