M Styblo

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Characterization of the impaired glucose homeostasis produced in C57BL/6 mice by chronic exposure to arsenic and high-fat diet
    David S Paul
    Department of Nutrition, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599 7461, USA
    Environ Health Perspect 119:1104-9. 2011
  2. pmc Speciation of arsenic in exfoliated urinary bladder epithelial cells from individuals exposed to arsenic in drinking water
    Araceli Hernández-Zavala
    Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Environ Health Perspect 116:1656-60. 2008
  3. pmc Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico
    Luz M Del Razo
    Departamento de Toxicologia, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico DF, Mexico
    Environ Health 10:73. 2011
  4. ncbi request reprint Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells
    M Styblo
    Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Arch Toxicol 74:289-99. 2000
  5. ncbi request reprint Selenium modifies the metabolism and toxicity of arsenic in primary rat hepatocytes
    M Styblo
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Appl Pharmacol 172:52-61. 2001
  6. pmc Molecular mechanisms of the diabetogenic effects of arsenic: inhibition of insulin signaling by arsenite and methylarsonous acid
    David S Paul
    Department of Nutrition, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7461, USA
    Environ Health Perspect 115:734-42. 2007
  7. ncbi request reprint Activation of superoxide dismutase in selenium-deficient mice infected with influenza virus
    Miroslav Styblo
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
    J Trace Elem Med Biol 21:52-62. 2007
  8. pmc The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update
    Miroslav Styblo
    Department of Pediatrics, Center for Environmental Medicine and Lung Biology, Burnett Womack Clinical Sciences Building, University of North Carolina, Chapel Hill, NC 27599 7220, USA
    Environ Health Perspect 110:767-71. 2002
  9. ncbi request reprint Metabolism of arsenic in primary cultures of human and rat hepatocytes
    M Styblo
    Department of Pediatrics, School of Medicine, and Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Chem Res Toxicol 12:560-5. 1999
  10. ncbi request reprint Arsenicals inhibit thioredoxin reductase in cultured rat hepatocytes
    S Lin
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Chem Res Toxicol 14:305-11. 2001

Research Grants

  1. Metabolism and Toxicity of Arsenic in the Human Liver
    Miroslav Styblo; Fiscal Year: 2010
  2. ARSENIC, OXIDATIVE STRESS, AND TRANSCRIPTIONAL CONTROL
    Miroslav Styblo; Fiscal Year: 2000
  3. Environmental arsenic and diabetes mellitus
    Miroslav Styblo; Fiscal Year: 2009
  4. Environmental arsenic and diabetes mellitus
    Miroslav Styblo; Fiscal Year: 2010
  5. Environmental arsenic and diabetes mellitus
    Miroslav Styblo; Fiscal Year: 2009
  6. Metabolism and Toxicity of Arsenic in the Human Liver
    Miroslav Styblo; Fiscal Year: 2009
  7. Metabolism and Toxicity of Arsenic in Human Liver
    Miroslav Styblo; Fiscal Year: 2007
  8. Metabolism and Toxicity of Arsenic in Human Liver
    Miroslav Styblo; Fiscal Year: 2006
  9. Metabolism and Toxicity of Arsenic in Human Liver
    Miroslav Styblo; Fiscal Year: 2004
  10. Metabolism and Toxicity of Arsenic in Human Liver
    Miroslav Styblo; Fiscal Year: 2005

Collaborators

Detail Information

Publications31

  1. pmc Characterization of the impaired glucose homeostasis produced in C57BL/6 mice by chronic exposure to arsenic and high-fat diet
    David S Paul
    Department of Nutrition, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599 7461, USA
    Environ Health Perspect 119:1104-9. 2011
    ..Growing evidence suggests that chronic exposure to inorganic arsenic (iAs) also produces symptoms consistent with diabetes. Thus, iAs exposure may further increase the risk of diabetes in obese individuals...
  2. pmc Speciation of arsenic in exfoliated urinary bladder epithelial cells from individuals exposed to arsenic in drinking water
    Araceli Hernández-Zavala
    Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Environ Health Perspect 116:1656-60. 2008
    ..However, the adverse effects of iAs exposure are ultimately determined by the concentrations of iAs metabolites in target tissues...
  3. pmc Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico
    Luz M Del Razo
    Departamento de Toxicologia, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico DF, Mexico
    Environ Health 10:73. 2011
    ..Our study examined associations between chronic exposure to iAs in drinking water, metabolism of iAs, and prevalence of diabetes in arsenicosis-endemic areas of Mexico...
  4. ncbi request reprint Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells
    M Styblo
    Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Arch Toxicol 74:289-99. 2000
    ....
  5. ncbi request reprint Selenium modifies the metabolism and toxicity of arsenic in primary rat hepatocytes
    M Styblo
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Appl Pharmacol 172:52-61. 2001
    ..These data suggest that pre- or coexposure to inorganic selenium may enhance the toxic effects of iAs, increasing its retention in tissues and suppressing its methylation, which may be a pathway for detoxification of iAs...
  6. pmc Molecular mechanisms of the diabetogenic effects of arsenic: inhibition of insulin signaling by arsenite and methylarsonous acid
    David S Paul
    Department of Nutrition, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7461, USA
    Environ Health Perspect 115:734-42. 2007
    ....
  7. ncbi request reprint Activation of superoxide dismutase in selenium-deficient mice infected with influenza virus
    Miroslav Styblo
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
    J Trace Elem Med Biol 21:52-62. 2007
    ..However, SOD activation that leads to increased production of H(2)O(2) may also contribute to pathogenesis and to influenza virus mutation in lungs of Se-deficient mice...
  8. pmc The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update
    Miroslav Styblo
    Department of Pediatrics, Center for Environmental Medicine and Lung Biology, Burnett Womack Clinical Sciences Building, University of North Carolina, Chapel Hill, NC 27599 7220, USA
    Environ Health Perspect 110:767-71. 2002
    ....
  9. ncbi request reprint Metabolism of arsenic in primary cultures of human and rat hepatocytes
    M Styblo
    Department of Pediatrics, School of Medicine, and Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Chem Res Toxicol 12:560-5. 1999
    ....
  10. ncbi request reprint Arsenicals inhibit thioredoxin reductase in cultured rat hepatocytes
    S Lin
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Chem Res Toxicol 14:305-11. 2001
    ..Hence, the capacity of cells to produce or consume the intermediates in the pathway for As methylation may be an important determinant of susceptibility to the toxic effects of As...
  11. ncbi request reprint Differential effects of trivalent and pentavalent arsenicals on cell proliferation and cytokine secretion in normal human epidermal keratinocytes
    L Vega
    Laboratory of Toxicology and Environmental Immunology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27709, USA
    Toxicol Appl Pharmacol 172:225-32. 2001
    ....
  12. ncbi request reprint Determination of trivalent methylated arsenicals in biological matrices
    L M Del Razo
    Center for Environmental Medicine and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Appl Pharmacol 174:282-93. 2001
    ..The reliable quantitation of inorganic and methylated arsenicals that contain As(III) in biological samples will aid the study of the toxicity of these species and may provide a new biomarker of the effects of chronic exposure to As...
  13. pmc Selenium deficiency alters epithelial cell morphology and responses to influenza
    I Jaspers
    Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Free Radic Biol Med 42:1826-37. 2007
    ..These data demonstrate that selenium deficiency has a significant impact on the morphology and influenza-induced host defense responses in human airway epithelial cells...
  14. pmc Expression of AS3MT alters transcriptional profiles in human urothelial cells exposed to arsenite
    Sd Hester
    Cancer Biology Branch, ECD, NHEERL, US EPA, RTP, North Carolina, USA
    Hum Exp Toxicol 28:49-61. 2009
    ..Further analysis of these responses will help to characterize the role of AS3MT-catalyzed methylation in modulation of iAs(III) toxicity...
  15. ncbi request reprint Selenium compounds modulate the activity of recombinant rat AsIII-methyltransferase and the methylation of arsenite by rat and human hepatocytes
    Felecia S Walton
    Department of Pediatrics, Curriculum in Toxicology, Division of Drug Delivery and Disposition, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Chem Res Toxicol 16:261-5. 2003
    ....
  16. pmc Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals
    David J Thomas
    Pharmacokinetics Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Exp Biol Med (Maywood) 232:3-13. 2007
    ..Additional information on the structure and function of the enzyme will be needed to develop a more comprehensive model for this pathway...
  17. ncbi request reprint Inhibition of insulin-dependent glucose uptake by trivalent arsenicals: possible mechanism of arsenic-induced diabetes
    Felecia S Walton
    Department of Pediatrics, University of North Carolina, Chapel Hill, NC 27599 7224, USA
    Toxicol Appl Pharmacol 198:424-33. 2004
    ..This mechanism may be, in part, responsible for the development of type-2 diabetes in individuals chronically exposed to iAs...
  18. ncbi request reprint Methylated metabolites of arsenic trioxide are more potent than arsenic trioxide as apoptotic but not differentiation inducers in leukemia and lymphoma cells
    Guo Qiang Chen
    Department of Pathophysiology, Shanghai Second Medical University, Shanghai, China
    Cancer Res 63:1853-9. 2003
    ..MAs(III)O as an apoptotic inducer should be considered in the treatment of other hematologic malignancies like lymphoma...
  19. ncbi request reprint Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype
    Jiaxin Li
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Toxicol Appl Pharmacol 204:164-9. 2005
    ..This lineage-specific loss of function caused by the deletion event must have occurred in the Pan lineage after Homo-Pan divergence about 5 million years ago...
  20. ncbi request reprint Endogenous reductants support the catalytic function of recombinant rat cyt19, an arsenic methyltransferase
    Stephen B Waters
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Chem Res Toxicol 17:404-9. 2004
    ..Thus, cyt19 appears to possess both AsIII methyltransferase and AsV reductase activities...
  21. ncbi request reprint Elucidating the pathway for arsenic methylation
    David J Thomas
    Pharmacokinetics Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 198:319-26. 2004
    ..A scheme linking cyt19 and thioredoxin-thioredoxin reductase in the methylation and reduction of arsenicals is proposed...
  22. ncbi request reprint Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation
    Lamia Benbrahim-Tallaa
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, MD F0 09, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 206:288-98. 2005
    ..However, overexpression of K-ras occurred without mutations and through a mechanism other than promoter region hypomethylation...
  23. ncbi request reprint Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations
    Kanae Mure
    New York University School of Medicine, Nelson Institute of Environmental Medicine, Tuxedo, New York 10987, USA
    Environ Mol Mutagen 41:322-31. 2003
    ..Our results suggest that long-term exposure to low concentrations of arsenite may affect signaling pathways that result in a progressive genomic instability...
  24. pmc Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2
    Jingbo Pi
    Laboratory of Comparative Carcinogenesis, NCI at NIEHS, NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 45:651-8. 2008
    ....
  25. pmc Tissue dosimetry, metabolism and excretion of pentavalent and trivalent dimethylated arsenic in mice after oral administration
    Michael F Hughes
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 227:26-35. 2008
    ..TMAO was detected in tissues of the high dose DMA(V) group. The low acute toxicity of DMA(V) in the mouse appears to be due in part to its minimal retention and rapid elimination...
  26. ncbi request reprint Glutathione-S-transferase pi inhibits As2O3-induced apoptosis in lymphoma cells: involvement of hydrogen peroxide catabolism
    Li Zhou
    Department of Medicine, Division of Hematology Oncology, Box 1178, Mount Sinai School of Medicine, One Gustave L Levy Pl, New York, NY 10029 6547, USA
    Blood 105:1198-203. 2005
    ..These data suggest that GSTP1 blocks As(2)O(3)-induced apoptosis in lymphoma cells by decreasing intracellular amounts of H(2)O(2) by catabolism and H(2)O(2) production by decreasing the intracellular retention of As(2)O(3)...
  27. ncbi request reprint A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol
    Shan Lin
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 277:10795-803. 2002
    ..Because methylation of arsenic is a critical feature of its metabolism, characterization of this enzyme will improve our understanding of this metalloid's metabolism and its actions as a toxin and a carcinogen...
  28. ncbi request reprint Pharmacokinetic modeling of arsenite uptake and metabolism in hepatocytes--mechanistic insights and implications for further experiments
    Michael R Easterling
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Pharmacokinet Pharmacodyn 29:207-34. 2002
    ....
  29. pmc Methylarsonous acid transport by aquaglyceroporins
    Zijuan Liu
    Department of Biochemistry and Molecular Biology, Wayne State University, School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Environ Health Perspect 114:527-31. 2006
    ..Identification of MAs(III) as an AQP9 substrate is an important step in understanding physiologic responses to arsenic in mammals, including humans...
  30. pmc Tissue dosimetry, metabolism and excretion of pentavalent and trivalent monomethylated arsenic in mice after oral administration
    Michael F Hughes
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 208:186-97. 2005
    ..Based on urinary analysis, administered dose of MMA(V) did not affect the level of its metabolites excreted. In the tested range, dose affects the absorption, distribution and route of excretion of MMA(V) but not its metabolism...
  31. pmc Arsenicals in maternal and fetal mouse tissues after gestational exposure to arsenite
    Vicenta Devesa
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Toxicology 224:147-55. 2006
    ..Tissue concentration-dependent processes could affect kinetics of transfer of inorganic arsenic or its metabolites from mother to fetus...

Research Grants17

  1. Metabolism and Toxicity of Arsenic in the Human Liver
    Miroslav Styblo; Fiscal Year: 2010
    ..Results of this work may help to protect people against toxicity of arsenic and to improve the efficiency of leukemia therapy. . ..
  2. ARSENIC, OXIDATIVE STRESS, AND TRANSCRIPTIONAL CONTROL
    Miroslav Styblo; Fiscal Year: 2000
    ....
  3. Environmental arsenic and diabetes mellitus
    Miroslav Styblo; Fiscal Year: 2009
    ....
  4. Environmental arsenic and diabetes mellitus
    Miroslav Styblo; Fiscal Year: 2010
    ....
  5. Environmental arsenic and diabetes mellitus
    Miroslav Styblo; Fiscal Year: 2009
    ....
  6. Metabolism and Toxicity of Arsenic in the Human Liver
    Miroslav Styblo; Fiscal Year: 2009
    ..Results of this work may help to protect people against toxicity of arsenic and to improve the efficiency of leukemia therapy. . ..
  7. Metabolism and Toxicity of Arsenic in Human Liver
    Miroslav Styblo; Fiscal Year: 2007
    ..abstract_text> ..
  8. Metabolism and Toxicity of Arsenic in Human Liver
    Miroslav Styblo; Fiscal Year: 2006
    ..abstract_text> ..
  9. Metabolism and Toxicity of Arsenic in Human Liver
    Miroslav Styblo; Fiscal Year: 2004
    ..abstract_text> ..
  10. Metabolism and Toxicity of Arsenic in Human Liver
    Miroslav Styblo; Fiscal Year: 2005
    ..abstract_text> ..
  11. Metabolism and Toxicity of Arsenic in Human Liver
    Miroslav Styblo; Fiscal Year: 2004
    ..abstract_text> ..
  12. Metabolism and Toxicity of Arsenic in Human Liver
    Miroslav Styblo; Fiscal Year: 2003
    ..abstract_text> ..
  13. ARSENIC, OXIDATIVE STRESS, AND TRANSCRIPTIONAL CONTROL
    Miroslav Styblo; Fiscal Year: 2002
    ....
  14. Mechanism of Arsenic-Induced Diabetes
    Miroslav Styblo; Fiscal Year: 2002
    ....
  15. ARSENIC, OXIDATIVE STRESS, AND TRANSCRIPTIONAL CONTROL
    Miroslav Styblo; Fiscal Year: 2001
    ....
  16. Environmental arsenic and diabetes mellitus
    Miroslav Styblo; Fiscal Year: 2010
    ....