W E Stumpf

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. doi request reprint Drugs in the brain--cellular imaging with receptor microscopic autoradiography
    Walter E Stumpf
    University of North Carolina Chapel Hill, NC 27516, USA
    Prog Histochem Cytochem 47:1-26. 2012
  2. ncbi request reprint In vivo target recognition with high-resolution imaging: significance for drug development
    Walter E Stumpf
    University of North Carolina, Chapel Hill, NC, USA
    Eur J Drug Metab Pharmacokinet 35:15-22. 2010
  3. ncbi request reprint Vitamin D and the digestive system
    Walter E Stumpf
    University of North Carolina, Chapel Hill, NC, USA
    Eur J Drug Metab Pharmacokinet 33:85-100. 2008
  4. ncbi request reprint Salivary glands epithelial and myoepithelial cells are major vitamin D targets
    Walter E Stumpf
    University of North Carolina at Chapel Hill, NC, USA
    Eur J Drug Metab Pharmacokinet 32:123-9. 2007
  5. ncbi request reprint Skin research and drug localization with receptor microscopic autoradiography
    Walter E Stumpf
    University of North Carolina at Chapel Hill, NC 27516, USA
    Exp Dermatol 17:133-8. 2008
  6. ncbi request reprint Memo to the FDA and ICH: appeal for in vivo drug target identification and target pharmacokinetics Recommendations for improved procedures and requirements
    Walter E Stumpf
    2612 Damascus Church Rd, Chapel Hill, NC 27516, USA
    Drug Discov Today 12:594-8. 2007
  7. ncbi request reprint Receptor localization of steroid hormones and drugs: discoveries through the use of thaw-mount and dry-mount autoradiography
    W E Stumpf
    University of North Carolina at Chapel Hill, USA
    Braz J Med Biol Res 31:197-206. 1998
  8. ncbi request reprint The dose makes the medicine
    Walter E Stumpf
    University of North Carolina at Chapel Hill and International Institute of Drug Distribution, Cytopharmacology and Cytotoxicology, 2612 Damascus Church Road, Chapel Hill, NC 27516, USA
    Drug Discov Today 11:550-5. 2006
  9. ncbi request reprint Drug localization and targeting with receptor microscopic autoradiography
    Walter E Stumpf
    University of North Carolina at Chapel Hill, NC, USA
    J Pharmacol Toxicol Methods 51:25-40. 2005
  10. ncbi request reprint Receptor microscopic autoradiography for the study of percutaneous absorption, in vivo skin penetration, and cellular-intercellular deposition
    Naohiko Hayakawa
    Product Research Department, Chugai Pharmaceutical Co, Ltd, Fuji Gotemba Research Laboratories, 1 135, Komakado, Gotemba, Shizuoka 412 8513, Japan
    J Pharmacol Toxicol Methods 50:131-7. 2004

Collaborators

Detail Information

Publications16

  1. doi request reprint Drugs in the brain--cellular imaging with receptor microscopic autoradiography
    Walter E Stumpf
    University of North Carolina Chapel Hill, NC 27516, USA
    Prog Histochem Cytochem 47:1-26. 2012
    ..New spectrometric methods, like MALDI-MSI, are unlikely to furnish the same information as receptor microautoradiography does, but can provide important correlative molecular information...
  2. ncbi request reprint In vivo target recognition with high-resolution imaging: significance for drug development
    Walter E Stumpf
    University of North Carolina, Chapel Hill, NC, USA
    Eur J Drug Metab Pharmacokinet 35:15-22. 2010
    ....
  3. ncbi request reprint Vitamin D and the digestive system
    Walter E Stumpf
    University of North Carolina, Chapel Hill, NC, USA
    Eur J Drug Metab Pharmacokinet 33:85-100. 2008
    ....
  4. ncbi request reprint Salivary glands epithelial and myoepithelial cells are major vitamin D targets
    Walter E Stumpf
    University of North Carolina at Chapel Hill, NC, USA
    Eur J Drug Metab Pharmacokinet 32:123-9. 2007
    ....
  5. ncbi request reprint Skin research and drug localization with receptor microscopic autoradiography
    Walter E Stumpf
    University of North Carolina at Chapel Hill, NC 27516, USA
    Exp Dermatol 17:133-8. 2008
    ..Examples of autoradiograms include in vivo applications of 3H-vitamin D, 3H-OCT (oxacalcitriol), 3H-oestradiol and 3H-retinoic acid. For topical applications, routes of delivery and sites of deposition and retention are demonstrated...
  6. ncbi request reprint Memo to the FDA and ICH: appeal for in vivo drug target identification and target pharmacokinetics Recommendations for improved procedures and requirements
    Walter E Stumpf
    2612 Damascus Church Rd, Chapel Hill, NC 27516, USA
    Drug Discov Today 12:594-8. 2007
    ..False negatives and false positives of favored 'expedient' procedures allow drugs to reach the market with misleading and inaccurate information about the total drug effect...
  7. ncbi request reprint Receptor localization of steroid hormones and drugs: discoveries through the use of thaw-mount and dry-mount autoradiography
    W E Stumpf
    University of North Carolina at Chapel Hill, USA
    Braz J Med Biol Res 31:197-206. 1998
    ..Receptor autoradiography with cellular resolution has become an indispensable tool in drug research and development, since information can be obtained that is difficult or impossible to gain otherwise...
  8. ncbi request reprint The dose makes the medicine
    Walter E Stumpf
    University of North Carolina at Chapel Hill and International Institute of Drug Distribution, Cytopharmacology and Cytotoxicology, 2612 Damascus Church Road, Chapel Hill, NC 27516, USA
    Drug Discov Today 11:550-5. 2006
    ..It also allows considerations of systems biology [i.e. integral (gestalt) pharmacology] exemplified by the drug homunculus, as in the case of vitamin D, that might lead to new paradigms and drug design...
  9. ncbi request reprint Drug localization and targeting with receptor microscopic autoradiography
    Walter E Stumpf
    University of North Carolina at Chapel Hill, NC, USA
    J Pharmacol Toxicol Methods 51:25-40. 2005
    ....
  10. ncbi request reprint Receptor microscopic autoradiography for the study of percutaneous absorption, in vivo skin penetration, and cellular-intercellular deposition
    Naohiko Hayakawa
    Product Research Department, Chugai Pharmaceutical Co, Ltd, Fuji Gotemba Research Laboratories, 1 135, Komakado, Gotemba, Shizuoka 412 8513, Japan
    J Pharmacol Toxicol Methods 50:131-7. 2004
    ..We tested this using (3)H-Maxacalcitol...
  11. ncbi request reprint Limitations and advantages of whole body autoradiography in the study of tissue distribution of drugs. Response to Dr. Solon
    Walter E Stumpf
    J Pharmacol Toxicol Methods 48:185-6; author reply 187-9. 2002
  12. ncbi request reprint In vivo time-course of receptor binding in the parathyroid gland of the vitamin D analogue [(3)H]1,25-dihydroxy-22-oxavitamin D(3) compared with [(3)H]1,25-dihydroxyvitamin D(3), determined by micro-autoradiography
    Nobuo Koike
    Fuji Gotemba Laboratories, Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka, Japan
    Nephrol Dial Transplant 17:53-7. 2002
    ....
  13. ncbi request reprint Sweat gland epithelial and myoepithelial cells are vitamin D targets
    Nobuo Koike
    Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Company Ltd, Shizuoka, Japan
    Exp Dermatol 16:94-7. 2007
    ..The results suggest genomic regulation of cell proliferation and differentiation, as well as of secretory and excretory functions, indicating potential therapies for impaired secretion as in hypohidrosis of aged and diseased skin...
  14. ncbi request reprint The main role of vitamin D: seasonal regulation of vital functions. High-resolution target recognition leads to a new paradigm and advanced drug development
    Walter E Stumpf
    Eur J Drug Metab Pharmacokinet 32:1-6. 2007
  15. ncbi request reprint Limitations of whole-body autoradiography without receptor microautoradiography
    Walter E Stumpf
    J Pharmacol Toxicol Methods 48:127-8; author reply 129-30. 2002
  16. ncbi request reprint Estradiol receptor binding to the epithelium of uterine lumen and glands: region- and time-related changes during preimplantation and periimplantation periods studied by autoradiography
    Telma M T Zorn
    Laboratory of Biology of Reproduction, Department of Histology and Embryology, Institute of Biomedical Sciences, University of Sao Paulo, 05508 900, Sao Paulo, Brazil
    Histochem Cell Biol 120:1-12. 2003
    ..The strong (3)H-estradiol binding to glandular epithelium suggests that estradiol exerts pronounced effects on glandular activities in the periimplantation period...