Research Topics
Species | James StullSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Signalling to contractile proteins by muscarinic and purinergic pathways in neurally stimulated bladder smooth muscleMing Ho Tsai
Department of Physiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
J Physiol 590:5107-21. 2012..Activation of muscarinic receptors recruits CPI-17, but not MYPT1-mediated Ca2+ sensitization. Furthermore, nerve-released ACh also initiates signalling cascades leading to phosphorylation-dependent desensitization of MLCK...- Myosin light chain kinase and the role of myosin light chain phosphorylation in skeletal muscleJames T Stull
Department of Physiology, University of Texas Southwestern Medical Center, Dallas, 75390 9040, USA
Arch Biochem Biophys 510:120-8. 2011..Moreover, RLC phosphorylation-mediated enhancements may interact with neural strategies for human skeletal muscle activation to ameliorate either central or peripheral aspects of fatigue... 
Quantitative measurements of Ca(2+)/calmodulin binding and activation of myosin light chain kinase in cellsRamaz Geguchadze
Department of Physiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
FEBS Lett 557:121-4. 2004..There was no evidence for CaM binding but not activating MLCK at low [Ca(2+)](i). At saturating [Ca(2+)](i) MLCK was not fully activated probably due to limited availability of cellular Ca(2+)/CaM...- Myosin phosphatase targeting subunit 1 affects cell migration by regulating myosin phosphorylation and actin assemblyDonglan Xia
Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9040, USA
Exp Cell Res 304:506-17. 2005..Proper expression of MYPT1 or variant 2 is critical for RLC phosphorylation and actin assembly, thus maintaining normal cellular functions by simultaneously controlling cytoskeletal architecture and actomyosin activation... - Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in miceWei Qi He
Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China
Gastroenterology 135:610-20. 2008..We generated tamoxifen-inducible and smooth muscle-specific MLCK knockout (KO) mice and provide direct loss-of-function evidence that shows the primary importance of MLCK in phasic smooth muscle contractions... - Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivoYusuke Mizuno
Dept Physiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
Am J Physiol Cell Physiol 295:C358-64. 2008..Thus the onset of agonist-induced contraction in phasic smooth muscle results from the rapid and coordinated activation of MLCK with hierarchical inhibition of MLCP by CPI-17 and MYPT1 phosphorylation... - Myosin regulatory light chain phosphorylation attenuates cardiac hypertrophyJian Huang
Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 283:19748-56. 2008..Thus, increased myosin RLC phosphorylation per se does not cause cardiac hypertrophy and probably inhibits physiological and pathophysiological hypertrophy by contributing to enhanced contractile performance and efficiency... - Enhanced skeletal muscle contraction with myosin light chain phosphorylation by a calmodulin-sensing kinaseJeffrey W Ryder
Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
J Biol Chem 282:20447-54. 2007..Importantly, RLC phosphorylation plays a prominent role in skeletal muscle force potentiation of fast-twitch type IIb but not type I or IIa fibers... - Properties of long myosin light chain kinase binding to F-actin in vitro and in vivoLula Smith
Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
J Biol Chem 277:35597-604. 2002..Whereas DFRXXL motifs are necessary and sufficient for short MLCK binding to actin-containing filaments, the DFRXXL motifs and the N-terminal extension of long MLCK confer high affinity binding to stress fibers in cells... - Myosin light chain kinase and myosin phosphorylation effect frequency-dependent potentiation of skeletal muscle contractionGang Zhi
Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 102:17519-24. 2005.... - Real-time evaluation of myosin light chain kinase activation in smooth muscle tissues from a transgenic calmodulin-biosensor mouseEiji Isotani
Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9040, USA
Proc Natl Acad Sci U S A 101:6279-84. 2004..These studies demonstrate the feasibility of producing transgenic biosensor mice for investigations of signaling processes in intact systems... - Delphinidin-3-rutinoside relaxes the bovine ciliary smooth muscle through activation of ETB receptor and NO/cGMP pathwayHitoshi Matsumoto
Food and Health Laboratories, Meiji Seika Ltd, 5 3 1, Chiyoda, Saitama 350 0289, Japan
Exp Eye Res 80:313-22. 2005.... - ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout miceGuojin Huang
Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Cell Sci 119:153-61. 2006....
Research Grants
- Roles of Myosin Light Chain Kinases in the HeartJames Stull; Fiscal Year: 2007..Results from these studies will provide novel biochemical insights into the physiological regulation and functional importance of cardiac myosin light chain phosphorylation. ..
- MYOSIN LIGHT CHAIN KINASE FUNCTION IN SMOOTH MUSCLEJames Stull; Fiscal Year: 2009..We consider the possibility that nonmuscle myosin may contribute to the stability of membrane adhesion sites necessary for cellular force transmission by intracellular contractile domains in bladder myocytes. ..
- Roles of Myosin Light Chain Kinases in the HeartJames T Stull; Fiscal Year: 2010..Results from these studies will provide novel biochemical insights into the physiological regulation and functional importance of cardiac myosin light chain phosphorylation. ..
- MYOSIN LIGHT CHAIN KINASE FUNCTION IN SMOOTH MUSCLEJames Stull; Fiscal Year: 2003..abstract_text> ..
- Signaling Mechanisms in Salivary Gland CellsJames T Stull; Fiscal Year: 2010..The proposed work explores novel regulatory mechanisms in Ca2+ signaling and their relevance to regulation of SG fluid and electrolyte secretion. ..