Garret D Stuber

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance
    Alice M Stamatakis
    University of North Carolina Neurobiology Curriculum, UNC Neuroscience Center, UNC at Chapel Hill, Chapel Hill, North Carolina, USA
    Nat Neurosci 15:1105-7. 2012
  2. pmc Distinct extended amygdala circuits for divergent motivational states
    Joshua H Jennings
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nature 496:224-8. 2013
  3. pmc Cortical operation of the ventral striatal switchboard
    Garret D Stuber
    Departments of Psychiatry and Cell Biology and Physiology, Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Electronic address
    Neuron 78:6-7. 2013
  4. pmc Integrating optogenetic and pharmacological approaches to study neural circuit function: current applications and future directions
    Garret D Stuber
    Departments of Psychiatry and Cell Biology and Physiology, UNC Neuroscience Center University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Pharmacol Rev 65:156-70. 2013
  5. pmc Optogenetic modulation of neural circuits that underlie reward seeking
    Garret D Stuber
    Department of Psychiatry, University of North Carolina Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Biol Psychiatry 71:1061-7. 2012
  6. pmc Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking
    Garret D Stuber
    Department of Psychiatry, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nature 475:377-80. 2011
  7. pmc Neural encoding of cocaine-seeking behavior is coincident with phasic dopamine release in the accumbens core and shell
    Catarina A Owesson-White
    Department of Psychology, The University of North Carolina, Chapel Hill, NC 27599, USA
    Eur J Neurosci 30:1117-27. 2009
  8. pmc Activation of VTA GABA neurons disrupts reward consumption
    Ruud van Zessen
    Departments of Psychiatry and Cellular and Molecular Physiology, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuron 73:1184-94. 2012
  9. ncbi request reprint Extinction of cocaine self-administration reveals functionally and temporally distinct dopaminergic signals in the nucleus accumbens
    Garret D Stuber
    Curriculum in Neurobiology, The University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Neuron 46:661-9. 2005
  10. ncbi request reprint Dopamine operates as a subsecond modulator of food seeking
    Mitchell F Roitman
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    J Neurosci 24:1265-71. 2004

Collaborators

Detail Information

Publications24

  1. pmc Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance
    Alice M Stamatakis
    University of North Carolina Neurobiology Curriculum, UNC Neuroscience Center, UNC at Chapel Hill, Chapel Hill, North Carolina, USA
    Nat Neurosci 15:1105-7. 2012
    ..Thus, activity of LHb efferents to the midbrain is aversive but can also serve to negatively reinforce behavioral responding...
  2. pmc Distinct extended amygdala circuits for divergent motivational states
    Joshua H Jennings
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nature 496:224-8. 2013
    ..These data demonstrate that functionally opposing BNST to VTA circuits regulate rewarding and aversive motivational states, and may serve as a crucial circuit node for bidirectionally normalizing maladaptive behaviours...
  3. pmc Cortical operation of the ventral striatal switchboard
    Garret D Stuber
    Departments of Psychiatry and Cell Biology and Physiology, Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Electronic address
    Neuron 78:6-7. 2013
    ....
  4. pmc Integrating optogenetic and pharmacological approaches to study neural circuit function: current applications and future directions
    Garret D Stuber
    Departments of Psychiatry and Cell Biology and Physiology, UNC Neuroscience Center University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Pharmacol Rev 65:156-70. 2013
    ....
  5. pmc Optogenetic modulation of neural circuits that underlie reward seeking
    Garret D Stuber
    Department of Psychiatry, University of North Carolina Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Biol Psychiatry 71:1061-7. 2012
    ....
  6. pmc Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking
    Garret D Stuber
    Department of Psychiatry, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nature 475:377-80. 2011
    ..Thus, optogenetic manipulation of anatomically distinct synaptic inputs to the NAc reveals functionally distinct properties of these inputs in controlling reward-seeking behaviours...
  7. pmc Neural encoding of cocaine-seeking behavior is coincident with phasic dopamine release in the accumbens core and shell
    Catarina A Owesson-White
    Department of Psychology, The University of North Carolina, Chapel Hill, NC 27599, USA
    Eur J Neurosci 30:1117-27. 2009
    ....
  8. pmc Activation of VTA GABA neurons disrupts reward consumption
    Ruud van Zessen
    Departments of Psychiatry and Cellular and Molecular Physiology, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuron 73:1184-94. 2012
    ....
  9. ncbi request reprint Extinction of cocaine self-administration reveals functionally and temporally distinct dopaminergic signals in the nucleus accumbens
    Garret D Stuber
    Curriculum in Neurobiology, The University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Neuron 46:661-9. 2005
    ....
  10. ncbi request reprint Dopamine operates as a subsecond modulator of food seeking
    Mitchell F Roitman
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    J Neurosci 24:1265-71. 2004
    ..Rather, dopamine returned to baseline levels. Together, the results strongly implicate subsecond dopamine signaling in the nucleus accumbens as a real-time modulator of food-seeking behavior...
  11. pmc Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is attributable to a direct increase in phasic dopamine release events
    Brandon J Aragona
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3290, USA
    J Neurosci 28:8821-31. 2008
    ..Together, these results demonstrate that cocaine administration results in a temporally and regionally specific increase in phasic dopamine release that is significantly regulated by dopamine autoreceptors...
  12. ncbi request reprint Rapid dopamine signaling in the nucleus accumbens during contingent and noncontingent cocaine administration
    Garret D Stuber
    Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuropsychopharmacology 30:853-63. 2005
    ....
  13. pmc A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward
    Alice M Stamatakis
    Neurobiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuron 80:1039-53. 2013
    ..These results suggest that noncanonical inhibitory signaling by these hybrid dopaminergic-GABAergic neurons act to suppress LHb output under rewarding conditions...
  14. doi request reprint The inhibitory circuit architecture of the lateral hypothalamus orchestrates feeding
    Joshua H Jennings
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Science 341:1517-21. 2013
    ..These findings help explain how dysregulated activity at a number of unique nodes can result in a cascading failure within a defined brain network to produce maladaptive feeding. ..
  15. doi request reprint Activation of prefrontal cortical parvalbumin interneurons facilitates extinction of reward-seeking behavior
    Dennis R Sparta
    Departments of Psychiatry and Cell Biology and Physiology, University of North Carolina Neuroscience Center, Bowles Center for Alcohol Studies, and Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 Synaptic Transmission 1, Neuroscience Drug Discovery Denmark, Lundbeck, Copendhagen Valby, Denmark 2500 and Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark 2200
    J Neurosci 34:3699-705. 2014
    ..These data suggest that suppression of excitatory mPFC networks via increased activity of PV+ FSIs may enhance reward-related behavioral flexibility. ..
  16. pmc Presynaptic inhibition of gamma-aminobutyric acid release in the bed nucleus of the stria terminalis by kappa opioid receptor signaling
    Chia Li
    Curriculum in Neurobiology, School of Medicine, University of North Carolina Chapel Hill, NC 27599, USA
    Biol Psychiatry 71:725-32. 2012
    ..This suggests that KOR activation in this region may play a role in the regulation of emotional behaviors. To date, however, there has been no investigation of the ability of KOR to modulate synaptic transmission in the BNST...
  17. doi request reprint Similar roles of substantia nigra and ventral tegmental dopamine neurons in reward and aversion
    Anton Ilango
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, U S Department of Health and Human Services, Baltimore, Maryland 21014, and Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
    J Neurosci 34:817-22. 2014
    ..These observations suggest that the excitation and inhibition of SNc dopamine neurons elicit positive and negative affective effects, respectively, similar to those of VTA dopamine neurons. ..
  18. ncbi request reprint Overoxidation of carbon-fiber microelectrodes enhances dopamine adsorption and increases sensitivity
    Michael L A V Heien
    Department of Chemistry and Neuroscience Center, Chapel Hill, NC 27599, USA
    Analyst 128:1413-9. 2003
    ..other neurochemicals, and a change in their cyclic voltammograms. Stimulated release in the caudate-putamen was pharmacologically characterized in vivo using Ro-04-1284 and pargyline, and was consistent with that expected for dopamine...
  19. doi request reprint Optogenetic strategies to investigate neural circuitry engaged by stress
    Dennis R Sparta
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Electronic address
    Behav Brain Res 255:19-25. 2013
    ....
  20. pmc Amygdala and bed nucleus of the stria terminalis circuitry: Implications for addiction-related behaviors
    Alice M Stamatakis
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Neurobiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuropharmacology 76:320-8. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  21. doi request reprint Construction of implantable optical fibers for long-term optogenetic manipulation of neural circuits
    Dennis R Sparta
    Department of Psychiatry, University of North Carolina at Chapel Hill, USA
    Nat Protoc 7:12-23. 2012
    ..Successful use of implantable optical fibers will allow for long-term control of mammalian neural circuits in vivo, which is integral to the study of the neurobiology of behavior...
  22. ncbi request reprint Subsecond dopamine release promotes cocaine seeking
    Paul E M Phillips
    Department of Psychology, Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Nature 422:614-8. 2003
    ..These findings reveal an unprecedented role for dopamine in the regulation of drug taking in real time...
  23. pmc Ventromedial prefrontal cortex pyramidal cells have a temporal dynamic role in recall and extinction of cocaine-associated memory
    Michel C van den Oever
    Departments of Molecular and Cellular Neurobiology and Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, 1081 HV, The Netherlands, Department Bioengineering, Stanford University School of Medicine, Stanford, California 94305, Departments of Psychiatry and Cell Biology and Physiology, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
    J Neurosci 33:18225-33. 2013
    ....
  24. doi request reprint Tools for resolving functional activity and connectivity within intact neural circuits
    Joshua H Jennings
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Neurobiology Curriculum, University of North Carolina at Chapel Hill Chapel Hill, NC 27599, USA
    Curr Biol 24:R41-50. 2014
    ..We propose a holistic, multifaceted approach for unraveling how behavioral states are manifested through the cooperative interactions between discrete neurocircuit elements...