Joshua M Stuart
Affiliation: University of California
- A global analysis of genetic interactions in Caenorhabditis elegansAlexandra B Byrne
Department of Medical Genetics and Microbiology, The Terrence Donnelly Centre for Cellular and Biomolecular Research, 160 College St, University of Toronto, Toronto, ON, M5S 3E1, Canada
J Biol 6:8. 2007..Here, we describe a reliable high-throughput approach capable of revealing both weak and strong genetic interactions in the nematode Caenorhabditis elegans...
- A search engine to identify pathway genes from expression data on multiple organismsChunnuan Chen
Department of Biomolecular Engineering, University of California, Santa Cruz, California 95064, USA
BMC Syst Biol 1:20. 2007..In many cases, the coregulatation of a set of genes across a set of conditions can be used to infer roles for genes of unknown function...
- Information-based methods for predicting gene function from systematic gene knock-downsMatthew T Weirauch
Department of Biomolecular Engineering, University of California, Santa Cruz, CA 95064, USA
BMC Bioinformatics 9:463. 2008..An open question is how to optimally make use of phenotypic observations, possibly in combination with other functional genomics datasets, to identify genes that share a common role...
- Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cellsE Camilla Forsberg
Institute for Biology of Stem Cells, Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America
PLoS ONE 5:e8785. 2010..These results identify potential key regulators of HSC and give insights into the clinically important processes of HSC mobilization for transplantation and leukemic development from cancer stem cells...
- The synthetic genetic interaction network reveals small molecules that target specific pathways in Sacchromyces cerevisiaeCraig M Tamble
Department of Chemistry and Biochemistry, University of California Santa Cruz, 1156 High St, Santa Cruz, CA 95064, USA
Mol Biosyst 7:2019-30. 2011..When assayed in human HCT-116 colorectal cancer cells, 1A08 caused DNA-damage resistant DNA synthesis and blocked the DNA-damage checkpoint selectively in S-phase...