Affiliation: University of Texas Southwestern Medical Center
Struyk A, Cannon S. A Na+ channel mutation linked to hypokalemic periodic paralysis exposes a proton-selective gating pore. J Gen Physiol. 2007;130:11-20 pubmed
..Rather, it is possible that a sustained proton leak may contribute to instability of V(REST) indirectly, for instance, by interfering with intracellular pH homeostasis. ..
Struyk A, Markin V, Francis D, Cannon S. Gating pore currents in DIIS4 mutations of NaV1.4 associated with periodic paralysis: saturation of ion flux and implications for disease pathogenesis. J Gen Physiol. 2008;132:447-64 pubmed publisher