Arie F Struyk

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc A Na+ channel mutation linked to hypokalemic periodic paralysis exposes a proton-selective gating pore
    Arie F Struyk
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Gen Physiol 130:11-20. 2007
  2. ncbi Paradoxical depolarization of BA2+- treated muscle exposed to low extracellular K+: insights into resting potential abnormalities in hypokalemic paralysis
    Arie F Struyk
    Department of Neurology, University of Texas Southwestern Medical Center, 6001 Forest Park Avenue, ND4 214B, Dallas, TX 75390 8813, USA
    Muscle Nerve 37:326-37. 2008
  3. pmc Gating pore currents in DIIS4 mutations of NaV1.4 associated with periodic paralysis: saturation of ion flux and implications for disease pathogenesis
    Arie F Struyk
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Gen Physiol 132:447-64. 2008
  4. pmc A calcium channel mutant mouse model of hypokalemic periodic paralysis
    Fenfen Wu
    Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8813, USA
    J Clin Invest 122:4580-91. 2012
  5. pmc Slow inactivation does not block the aqueous accessibility to the outer pore of voltage-gated Na channels
    Arie F Struyk
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Gen Physiol 120:509-16. 2002
  6. pmc A sodium channel knockin mutant (NaV1.4-R669H) mouse model of hypokalemic periodic paralysis
    Fenfen Wu
    Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, Texas 75390 8813, USA
    J Clin Invest 121:4082-94. 2011

Research Grants

Collaborators

Detail Information

Publications6

  1. pmc A Na+ channel mutation linked to hypokalemic periodic paralysis exposes a proton-selective gating pore
    Arie F Struyk
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Gen Physiol 130:11-20. 2007
    ..Rather, it is possible that a sustained proton leak may contribute to instability of V(REST) indirectly, for instance, by interfering with intracellular pH homeostasis...
  2. ncbi Paradoxical depolarization of BA2+- treated muscle exposed to low extracellular K+: insights into resting potential abnormalities in hypokalemic paralysis
    Arie F Struyk
    Department of Neurology, University of Texas Southwestern Medical Center, 6001 Forest Park Avenue, ND4 214B, Dallas, TX 75390 8813, USA
    Muscle Nerve 37:326-37. 2008
    ....
  3. pmc Gating pore currents in DIIS4 mutations of NaV1.4 associated with periodic paralysis: saturation of ion flux and implications for disease pathogenesis
    Arie F Struyk
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Gen Physiol 132:447-64. 2008
    ....
  4. pmc A calcium channel mutant mouse model of hypokalemic periodic paralysis
    Fenfen Wu
    Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8813, USA
    J Clin Invest 122:4580-91. 2012
    ..4 R669H HypoPP mouse model. This "gating pore current" may be a common mechanism for paradoxical depolarization and susceptibility to HypoPP arising from missense mutations in the S4 voltage sensor of either calcium or sodium channels...
  5. pmc Slow inactivation does not block the aqueous accessibility to the outer pore of voltage-gated Na channels
    Arie F Struyk
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Gen Physiol 120:509-16. 2002
    ..We interpret these results as evidence that the outer mouth of the Na pore remains open while the channel is slow inactivated...
  6. pmc A sodium channel knockin mutant (NaV1.4-R669H) mouse model of hypokalemic periodic paralysis
    Fenfen Wu
    Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, Texas 75390 8813, USA
    J Clin Invest 121:4082-94. 2011
    ..4 channels...

Research Grants1

  1. Molecular Mechanisms of Na Channel Slow Inactivation
    ARIE STRUYK; Fiscal Year: 2005
    ..abstract_text> ..