T Scott Stroup

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Effectiveness of olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia after discontinuing perphenazine: a CATIE study
    T Scott Stroup
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC
    Am J Psychiatry 164:415-27. 2007
  2. ncbi request reprint Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial
    Richard S E Keefe
    Department of Psychiatry, John Umstead Hospital, Duke University Medical Center, Durham, NC 27710, USA
    Arch Gen Psychiatry 64:633-47. 2007
  3. doi request reprint The effectiveness of antipsychotic medications in patients who use or avoid illicit substances: results from the CATIE study
    Marvin S Swartz
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham NC 27710, United States
    Schizophr Res 100:39-52. 2008
  4. ncbi request reprint Effects of antipsychotic medications on psychosocial functioning in patients with chronic schizophrenia: findings from the NIMH CATIE study
    Marvin S Swartz
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Am J Psychiatry 164:428-36. 2007
  5. doi request reprint What CATIE found: results from the schizophrenia trial
    Marvin S Swartz
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Psychiatr Serv 59:500-6. 2008
  6. pmc Comparison of antipsychotic medication effects on reducing violence in people with schizophrenia
    Jeffrey W Swanson
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, 905 West Main Street, Durham, NC 27710, USA
    Br J Psychiatry 193:37-43. 2008
  7. ncbi request reprint A national study of violent behavior in persons with schizophrenia
    Jeffrey W Swanson
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Arch Gen Psychiatry 63:490-9. 2006
  8. ncbi request reprint Substance use and psychosocial functioning in schizophrenia among new enrollees in the NIMH CATIE study
    Marvin S Swartz
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychiatr Serv 57:1110-6. 2006
  9. ncbi request reprint Substance use in persons with schizophrenia: baseline prevalence and correlates from the NIMH CATIE study
    Marvin S Swartz
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    J Nerv Ment Dis 194:164-72. 2006
  10. pmc Feasibility and pilot efficacy results from the multisite Cognitive Remediation in the Schizophrenia Trials Network (CRSTN) randomized controlled trial
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Psychiatry 73:1016-22. 2012

Detail Information

Publications47

  1. ncbi request reprint Effectiveness of olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia after discontinuing perphenazine: a CATIE study
    T Scott Stroup
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC
    Am J Psychiatry 164:415-27. 2007
    ..This randomized, double-blind study compared olanzapine, quetiapine, and risperidone in patients who had just discontinued the older antipsychotic perphenazine...
  2. ncbi request reprint Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial
    Richard S E Keefe
    Department of Psychiatry, John Umstead Hospital, Duke University Medical Center, Durham, NC 27710, USA
    Arch Gen Psychiatry 64:633-47. 2007
    ..The relative effect of the second-generation (atypical) antipsychotic drugs and older agents on neurocognition has not been comprehensively determined...
  3. doi request reprint The effectiveness of antipsychotic medications in patients who use or avoid illicit substances: results from the CATIE study
    Marvin S Swartz
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham NC 27710, United States
    Schizophr Res 100:39-52. 2008
    ..This double-blind study compared a second generation (atypical) antipsychotic drugs compared to a representative older agent for patients with schizophrenia who use or avoid illicit substances...
  4. ncbi request reprint Effects of antipsychotic medications on psychosocial functioning in patients with chronic schizophrenia: findings from the NIMH CATIE study
    Marvin S Swartz
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Am J Psychiatry 164:428-36. 2007
    ..This study examined the relative effects of the second-generation antipsychotic drugs and an older representative agent on psychosocial functioning in patients with chronic schizophrenia...
  5. doi request reprint What CATIE found: results from the schizophrenia trial
    Marvin S Swartz
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Psychiatr Serv 59:500-6. 2008
    ..Patient characteristics and clinical circumstances affected drug effectiveness; these patient factors are important in making treatment choices...
  6. pmc Comparison of antipsychotic medication effects on reducing violence in people with schizophrenia
    Jeffrey W Swanson
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, 905 West Main Street, Durham, NC 27710, USA
    Br J Psychiatry 193:37-43. 2008
    ..Violence is an uncommon but significant problem associated with schizophrenia...
  7. ncbi request reprint A national study of violent behavior in persons with schizophrenia
    Jeffrey W Swanson
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Arch Gen Psychiatry 63:490-9. 2006
    ..Violent behavior is uncommon, yet problematic, among schizophrenia patients. The complex effects of clinical, interpersonal, and social-environmental risk factors for violence in this population are poorly understood...
  8. ncbi request reprint Substance use and psychosocial functioning in schizophrenia among new enrollees in the NIMH CATIE study
    Marvin S Swartz
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychiatr Serv 57:1110-6. 2006
    ..This study examined the relationship between substance use and psychosocial functioning in schizophrenia...
  9. ncbi request reprint Substance use in persons with schizophrenia: baseline prevalence and correlates from the NIMH CATIE study
    Marvin S Swartz
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    J Nerv Ment Dis 194:164-72. 2006
    ....
  10. pmc Feasibility and pilot efficacy results from the multisite Cognitive Remediation in the Schizophrenia Trials Network (CRSTN) randomized controlled trial
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Psychiatry 73:1016-22. 2012
    ..However, the feasibility of large-scale multisite studies using cognitive remediation at clinical trials sites has not been established...
  11. ncbi request reprint Baseline neurocognitive deficits in the CATIE schizophrenia trial
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 31:2033-46. 2006
    ..Multiple analyses suggested that a broad cognitive deficit characterizes this sample. These deficits are modestly related to negative symptoms and essentially independent of positive symptom severity...
  12. pmc Randomized controlled trials for schizophrenia: study designs targeted to distinct goals
    T Scott Stroup
    Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599 7160, USA
    Schizophr Bull 34:266-74. 2008
    ..The different objectives of trials should be considered in the interpretation of the complete body of randomized evidence on antipsychotic drugs...
  13. ncbi request reprint NCAM1 and neurocognition in schizophrenia
    Patrick F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Biol Psychiatry 61:902-10. 2007
    ..Neural cell adhesion molecule 1 (NCAM1, aliases NCAM and CD56) may be a candidate gene for schizophrenia or for neurocognition in schizophrenia as supported by linkage and functional findings...
  14. ncbi request reprint Service use and health status of persons with severe mental illness in full-risk and no-risk medicaid programs
    Joseph P Morrissey
    Cecil G Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, 27599 7590, USA
    Psychiatr Serv 53:293-8. 2002
    ....
  15. ncbi request reprint Heterogeneity of treatment effects in schizophrenia
    T Scott Stroup
    Department of Psychiatry, University of North Carolina at Chapel Hill, 10301 Neuroscience Hospital, Chapel Hill, North Carolina 27599 7160, USA
    Am J Med 120:S26-31. 2007
    ..Collectively, the CATIE results highlight variable response in the treatment of schizophrenia and demonstrate the need for individualized therapy based on variations in drug efficacy and tolerability among patients...
  16. ncbi request reprint The National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project: schizophrenia trial design and protocol development
    T Scott Stroup
    Department of Psychiatry, University of North Carolina School of Medicine, Neurosciences Hospital, Chapel Hill 27599 7160, USA
    Schizophr Bull 29:15-31. 2003
    ..If the phase 2 study drug is discontinued, subjects may enter phase 3, in which clinicians help subjects select an open-label treatment based on individuals' experiences in phases 1 and 2...
  17. ncbi request reprint Guest editors' introduction: what can large pragmatic clinical trials do for public mental health care?
    Jeffrey A Lieberman
    Department of Psychiatry, University of North Carolina School of Medicine, Neurosciences Hospital, Chapel Hill, NC 27599 7160, USA
    Schizophr Bull 29:1-6. 2003
  18. doi request reprint The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognition
    James J Crowley
    Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599 7264, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1298-300. 2008
    ..We were unable to replicate previous associations of rs6994992 with schizophrenia and, moreover, did not find significant associations with age of onset, an estimate of pre-morbid IQ, or neurocognition...
  19. pmc Paliperidone for treatment of schizophrenia
    Abraham M Nussbaum
    Department of Psychiatry, University of North Carolina Hospitals, Chapel Hill, NC 27599 7160, USA
    Schizophr Bull 34:419-22. 2008
    ..Regarding the critical comparison of oral paliperidone to risperidone, we have no information and are thus unable to determine if paliperidone has any advantages or disadvantages compared to its well-known parent compound...
  20. ncbi request reprint Revised PORT recommendations
    T Scott Stroup
    University of North Carolina at Chapel Hill, 10626 Neurosciences Hospital, Campus Box 7160, Chapel Hill, NC 27599 7160, USA
    Schizophr Bull 30:609-11. 2004
  21. pmc Results of phase 3 of the CATIE schizophrenia trial
    T Scott Stroup
    Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, USA
    Schizophr Res 107:1-12. 2009
    ..We describe the characteristics of the patients who selected each treatment option and their outcomes...
  22. pmc Evaluation of "subject advocate" procedures in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia study
    T Scott Stroup
    Department of Psychiatry, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599 7160, USA
    Schizophr Bull 32:147-52. 2006
    ..Nonspecific benefits included good public relations and engagement of family members. Improved training regarding the procedures may be needed to achieve specific goals of enhanced patient autonomy and retention in the study...
  23. ncbi request reprint Clinical trials for antipsychotic drugs: design conventions, dilemmas and innovations
    T Scott Stroup
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, North Carolina 27599 7160, USA
    Nat Rev Drug Discov 5:133-46. 2006
    ..Practical and large, simple trials that evaluate the comparative effectiveness of antipsychotic drugs in real-world settings can help to meet these needs once a drug has reached the market...
  24. ncbi request reprint Effectiveness of olanzapine, quetiapine, risperidone, and ziprasidone in patients with chronic schizophrenia following discontinuation of a previous atypical antipsychotic
    T Scott Stroup
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599 7160, USA
    Am J Psychiatry 163:611-22. 2006
    ..This randomized, double-blind study compared olanzapine, quetiapine, risperidone, and ziprasidone in patients who had just discontinued a different atypical antipsychotic...
  25. ncbi request reprint Assessing clinical and functional outcomes in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial
    Marvin S Swartz
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3173, Durham, NC 27710, USA
    Schizophr Bull 29:33-43. 2003
    ....
  26. pmc Report from the working group conference on multisite trial design for cognitive remediation in schizophrenia
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Schizophr Bull 37:1057-65. 2011
    ..4) Before a multisite efficacy trial is initiated, a pilot study could demonstrate the feasibility of conducting a trial using a cognitive remediation intervention...
  27. ncbi request reprint Schizophrenia, Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and number needed to treat: how can CATIE inform clinicians?
    L Citrome
    Department of Psychiatry, New York University School of Medicine, New York, NY, USA
    Int J Clin Pract 60:933-40. 2006
    ..NNT and NNH can help place the wide array of CATIE results into clinical context, and permits quantification of the differences observed between the antipsychotics that were tested...
  28. ncbi request reprint Clinical correlates of tardive dyskinesia in schizophrenia: baseline data from the CATIE schizophrenia trial
    Del D Miller
    University of Iowa Carver College of Medicine, Psychiatry Research, 2 105 MEB, 500 Newton Rd, Iowa City, IA 52242 1000, USA
    Schizophr Res 80:33-43. 2005
    ..To examine the clinical characteristics of individuals with schizophrenia that develop tardive dyskinesia (TD) associated with antipsychotic treatment...
  29. doi request reprint Employment outcomes in a randomized trial of second-generation antipsychotics and perphenazine in the treatment of individuals with schizophrenia
    Sandra G Resnick
    New England Mental Illness Research Education and Clinical Center, Yale University School of Medicine, VA Connecticut Health Care System, NEPEC 182, 950 Campbell Ave, West Haven, CT 06516, USA
    J Behav Health Serv Res 35:215-25. 2008
    ..Consistent with other CATIE results, there were no differences in employment or participation in PSR among these five medications, including the FGA perphenazine...
  30. pmc Change in metabolic syndrome parameters with antipsychotic treatment in the CATIE Schizophrenia Trial: prospective data from phase 1
    Jonathan M Meyer
    Department of Psychiatry, University of California, San Diego, USA
    Schizophr Res 101:273-86. 2008
    ..Given concerns over antipsychotic metabolic effects, this analysis explored MS status and outcomes in phase 1 of the CATIE Schizophrenia Trial...
  31. ncbi request reprint Assessment of Medicaid managed behavioral health care for persons with serious mental illness
    H Stephen Leff
    Human Services Research Institute, 2336 Massachusetts Avenue, Cambridge, Massachusetts 02140, USA
    Psychiatr Serv 56:1245-53. 2005
    ..This five-site study compared Medicaid managed behavioral health programs and fee-for-service programs on use and quality of services, satisfaction, and symptoms and functioning of adults with serious mental illness...
  32. ncbi request reprint Effectiveness of antipsychotic drugs in patients with chronic schizophrenia
    Jeffrey A Lieberman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    N Engl J Med 353:1209-23. 2005
    ..We compared a first-generation antipsychotic, perphenazine, with several newer drugs in a double-blind study...
  33. ncbi request reprint The Texas Medication Algorithm Project antipsychotic algorithm for schizophrenia: 2006 update
    Troy A Moore
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, USA
    J Clin Psychiatry 68:1751-62. 2007
    ....
  34. ncbi request reprint Determining when impairment constitutes incapacity for informed consent in schizophrenia research
    Scott Y H Kim
    Department of Psychiatry, Bioethics Program, and Center for Behavioral and Decision Sciences in Medicine, University of Michigan, 300 North Ingalls, Ann Arbor, MI 48109 0429, and Massachusetts General Hospital, Boston, USA
    Br J Psychiatry 191:38-43. 2007
    ..Although people with schizophrenia display impaired abilities for consent, it is not known how much impairment constitutes incapacity...
  35. pmc Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biol Psychiatry 63:32-41. 2008
    ..The central role of RGS4 in regulating signaling via Gi/o coupled neurotransmitter receptors led us to hypothesize that there may be RGS4 genotypes predictive of specific disease phenotypes and antipsychotic treatment responses...
  36. ncbi request reprint AKT1 and neurocognition in schizophrenia
    Andrea Poyastro Pinheiro
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC, USA
    Aust N Z J Psychiatry 41:169-77. 2007
    ..Therefore, the association of genetic variation in AKT1 with neurocognition was investigated in patients with schizophrenia...
  37. ncbi request reprint Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment
    Joseph P McEvoy
    Clinical Research Service, John Umstead Hospital, 1003 12th St, Bldg 32, Butner, NC 27705, USA
    Am J Psychiatry 163:600-10. 2006
    ....
  38. ncbi request reprint Schizophrenia, VI: Treatments
    Jeffrey A Lieberman
    UT Southwestern Medical Center, Department of Psychiatry, Dallas TX 75390 9070, USA
    Am J Psychiatry 160:1748. 2003
  39. ncbi request reprint Effectiveness of switching antipsychotic medications
    Susan M Essock
    Department of Psychiatry, Division of Health Services Research, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Am J Psychiatry 163:2090-5. 2006
    ....
  40. ncbi request reprint Cost-effectiveness of second-generation antipsychotics and perphenazine in a randomized trial of treatment for chronic schizophrenia
    Robert A Rosenheck
    University of North Carolina, Chapel Hill, USA
    Am J Psychiatry 163:2080-9. 2006
    ..Second-generation antipsychotics have largely replaced first-generation antipsychotics for the treatment of schizophrenia, but a large-scale cost/effectiveness analysis has not been attempted...
  41. ncbi request reprint Effects of antipsychotic medication on psychiatric service utilization and cost
    Aileen Rothbard
    Center for MH Policy and Services Research, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Ment Health Policy Econ 8:83-93. 2005
    ..Given that acquisition costs of atypical antipsychotics are generally higher than typical antipsychotics, uncertainty exists whether the newer atypicals are cost effective alternatives when used in ordinary practice settings...
  42. ncbi request reprint Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease
    Lon S Schneider
    Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    N Engl J Med 355:1525-38. 2006
    ..We assessed the effectiveness of atypical antipsychotic drugs in outpatients with Alzheimer's disease...
  43. pmc Impact of antipsychotic treatment on nonfasting triglycerides in the CATIE Schizophrenia Trial phase 1
    Jonathan M Meyer
    Department of Psychiatry, University of California, San Diego, VA San Diego Healthcare System, San Diego, CA 92161, United States
    Schizophr Res 103:104-9. 2008
    ..Given concerns over antipsychotic effects on serum TG, this analysis explored changes in nonfasting TG in phase 1 of the CATIE Schizophrenia Trial...
  44. ncbi request reprint The schizophrenia drug-treatment paradox: pharmacological treatment based on best possible evidence may be hardest to practise in high-income countries
    Clive E Adams
    Br J Psychiatry 189:391-2. 2006
    ..Because it is years after a drug is first launched that the full effects become known with confidence, the evidence upon which to base practice in low- and middle-income countries may be less biased than that in richer nations...
  45. ncbi request reprint Low rates of treatment for hypertension, dyslipidemia and diabetes in schizophrenia: data from the CATIE schizophrenia trial sample at baseline
    Henry A Nasrallah
    University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Schizophr Res 86:15-22. 2006
    ....
  46. ncbi request reprint The Clinical Antipsychotic Trials Of Intervention Effectiveness (CATIE) Schizophrenia Trial: clinical comparison of subgroups with and without the metabolic syndrome
    Jonathan M Meyer
    VA San Diego Healthcare System, USA
    Schizophr Res 80:9-18. 2005
    ....
  47. ncbi request reprint Schizophrenia, drug therapy, and monitoring
    Daniel W Bradford
    N Engl J Med 350:415-6. 2004