Research Topics
| Jonathan R StrosbergSummaryAffiliation: University of South Florida Country: USA Publications
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Detail Information
Publications
Effective treatment of locally advanced endocrine tumors of the pancreas with chemoradiotherapyJonathan Strosberg
H Lee Moffitt Cancer Center and Research Institute, Tampa, Fla, USA
Neuroendocrinology 85:216-20. 2007....
A review of the current clinical trials for gastroenteropancreatic neuroendocrine tumoursJonathan R Strosberg
H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Expert Opin Investig Drugs 16:219-24. 2007..This review summarises the present scope of clinical research in this field...
Metastatic carcinoid tumor to the ovary: a clinicopathologic analysis of seventeen casesJonathan Strosberg
H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Gynecol Oncol 106:65-8. 2007..To evaluate the clinical behavior and histologic characteristics of metastatic carcinoid tumors to the ovary...
Prognostic validity of the American Joint Committee on Cancer staging classification for midgut neuroendocrine tumorsJonathan R Strosberg
Department of GI Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
J Clin Oncol 31:420-5. 2013..This classification has not been validated in a population consisting solely of midgut NETs. The purpose of this study was to test the prognostic validity of the classification in such a population...
Incidental detection of pancreatic neuroendocrine tumors: an analysis of incidence and outcomesAsima Cheema
Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Ann Surg Oncol 19:2932-6. 2012..The frequency of incidental detection is unknown. It is also unclear whether patients with incidentally discovered, early-stage, asymptomatic tumors should be treated similarly to patients who present with tumor-related symptoms...
Relapse-free survival in patients with nonmetastatic, surgically resected pancreatic neuroendocrine tumors: an analysis of the AJCC and ENETS staging classificationsJonathan R Strosberg
Department of GI Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Ann Surg 256:321-5. 2012....
First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomasJonathan R Strosberg
Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Cancer 117:268-75. 2011..The authors retrospectively evaluated the efficacy of capecitabine and temozolomide in 30 patients with metastatic pancreatic endocrine carcinomas to assess response rate, progression free survival (PFS), and overall survival (OS)...
Prognostic validity of a novel American Joint Committee on Cancer Staging Classification for pancreatic neuroendocrine tumorsJonathan R Strosberg
Moffitt Cancer Center, 12902 Magnolia Dr, Tampa, FL, USA
J Clin Oncol 29:3044-9. 2011..This classification has not yet been validated...
A review of systemic and liver-directed therapies for metastatic neuroendocrine tumors of the gastroenteropancreatic tractJonathan R Strosberg
Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA
Cancer Control 18:127-37. 2011..New evidence demonstrates that these agents can also inhibit tumor growth. Other novel agents targeting the VEGF and mTOR pathways have recently been investigated in multicenter phase III studies...
Selective hepatic artery embolization for treatment of patients with metastatic carcinoid and pancreatic endocrine tumorsJonathan R Strosberg
Hematology Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612-9497, USA
Cancer Control 13:72-8. 2006..Morbidity is low when appropriate supportive care is provided. Hepatic artery embolization often results in regressions in patients with unresectable liver metastases from carcinoid or pancreatic endocrine tumors...
A phase II study of RO4929097 in metastatic colorectal cancerJonathan R Strosberg
Dept of GI Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, United States
Eur J Cancer 48:997-1003. 2012..RO4929097 is a selective inhibitor of γ-secretase. We tested the activity of RO4929097 in patients with metastatic, refractory colorectal cancer...
Aggressive surgical resection in the management of pancreatic neuroendocrine tumors: when is it indicated?Pamela J Hodul
Gastrointestinal Tumor Program, Departmentsof Surgery, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Cancer Control 15:314-21. 2008..This paper discusses whether aggressive surgical intervention is indicated for PNETs and investigates what prognostic factors may assist in predicting which patients with invasive disease will benefit most from surgical intervention...
Does Barrett's esophagus respond to chemoradiation therapy for adenocarcinoma of the esophagus?James S Barthel
Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Gastrointest Endosc 71:235-40. 2010..The response of esophageal adenocarcinoma to chemoradiation therapy is well described; however, the effect of chemoradiation on tumor-associated BE has not been specifically reported...
Intermittent bowel obstruction due to a retained wireless capsule endoscope in a patient with a small bowel carcinoid tumourJonathan R Strosberg
H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
Can J Gastroenterol 21:113-5. 2007..To the authors' knowledge, this is the first case presentation of chronic, partial small bowel obstruction caused by unrecognized retention of a capsule endoscope...
Multimodality approach for locally advanced esophageal cancerKhaldoun Almhanna
Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, United States
World J Gastroenterol 18:5679-87. 2012..The role of adjuvant chemotherapy following curative resection is still unclear. External beam radiation therapy alone is considered palliative and is typically reserved for patients with a poor performance status...
The NANETS consensus guidelines for the diagnosis and management of poorly differentiated (high-grade) extrapulmonary neuroendocrine carcinomasJonathan R Strosberg
Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center, Tampa, FL, USA
Pancreas 39:799-800. 2010..In patients with localized tumors undergoing surgical resection, adjuvant treatment (chemotherapy with or without radiation) is warranted in most cases...
Multimodality management of a polyfunctional pancreatic endocrine carcinoma with markedly elevated serum vasoactive intestinal polypeptide and calcitonin levelsAejaz Nasir
Department of Interdisciplinary Oncology, Neuroendocrine Cancer Research Group, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
Pancreas 36:309-13. 2008..In summary, this is a unique case of metastatic VIP- and calcitonin-secreting pancreatic ECA with dramatic sustained clinical, biochemical, and objective tumor response to peptide receptor radionuclide therapy...
Correlation between grade and prognosis in metastatic gastroenteropancreatic neuroendocrine tumorsJonathan Strosberg
H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Hum Pathol 40:1262-8. 2009..Both mitotic rates and Ki-67 indexes are inversely associated with survival and can be analyzed independently for assignment of grade...
Survival and prognostic factor analysis in patients with metastatic pancreatic endocrine carcinomasJonathan Strosberg
Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Pancreas 38:255-8. 2009..Our objective was to evaluate the stage-specific prognosis of patients with metastatic PECAs and to assess the impact of clinical and pathologic prognostic factors...
Improved outcome with cytoreduction versus embolization for symptomatic hepatic metastases of carcinoid and neuroendocrine tumorsDana A Osborne
Digestive Disorders Center, Tampa General Hospital, 1 Davis Island, Tampa, Florida 33601, USA
Ann Surg Oncol 13:572-81. 2006..Cytoreduction should be pursued whenever possible even if complete resection may not be achievable...
Somatostatin receptor profiling in hepatic metastases from small intestinal and pancreatic neuroendocrine neoplasms: immunohistochemical approach with potential clinical utilityAejaz Nasir
Gastrointestinal Tumor Program, Neuroendocrine Cancer Research, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
Cancer Control 13:52-60. 2006..In patients with SSTR-negative ETs, the clinical response is generally absent or suboptimal, while nonfunctioning ETs with SSTR positivity show a variable response to such therapy...
